dbPTM

SRGP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRGP3_HUMAN
UniProt AC	O43295
Protein Name	SLIT-ROBO Rho GTPase-activating protein 3
Gene Name	SRGAP3
Organism	Homo sapiens (Human).
Sequence Length	1099
Subcellular Localization
Protein Description	GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons..
Protein Sequence	MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPHSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTEHISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEKMFPNSSADKSGTM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MSSQTKFKKDKEI --CCCCCCCHHHHHH	47.77	29967540
17	Phosphorylation	DKEIIAEYEAQIKEI HHHHHHHHHHHHHHH	13.93	30619164
63	Phosphorylation	KAEIELEYSRSLEKL HHHHHHHHHHHHHHH	23.24	-
76	Phosphorylation	KLAERFSSKIRSSRE HHHHHHHHHHHHCCH	29.41	23025827
80	Phosphorylation	RFSSKIRSSREHQFK HHHHHHHHCCHHHCC	36.90	-
129	Phosphorylation	NNVIVRLSQISEDVI CCHHHHHHHCCHHHH	18.20	24114839
141	"N6,N6-dimethyllysine"	DVIRLFKKSKEIGLQ HHHHHHHHHHHHCHH	60.47	-
141	Methylation	DVIRLFKKSKEIGLQ HHHHHHHHHHHHCHH	60.47	-
157	Phosphorylation	HEELLKVTNELYTVM HHHHHHHHHHHHHHH	22.76	-
161	Phosphorylation	LKVTNELYTVMKTYH HHHHHHHHHHHHHHH	7.36	30266825
162	Phosphorylation	KVTNELYTVMKTYHM HHHHHHHHHHHHHHH	27.09	30266825
195	Phosphorylation	EEKQFNKSGDLSMNL HHHHHCHHCCHHHHH	38.35	23882029
199	Phosphorylation	FNKSGDLSMNLLRHE HCHHCCHHHHHHHCC	15.46	23882029
213	Phosphorylation	EDRPQRRSSVKKIEK CCCHHHHHHHHHHHH	41.49	23882029
214	Phosphorylation	DRPQRRSSVKKIEKM CCHHHHHHHHHHHHH	35.82	23882029
216	Acetylation	PQRRSSVKKIEKMKE HHHHHHHHHHHHHHH	50.40	19608861
220	Acetylation	SSVKKIEKMKEKRQA HHHHHHHHHHHHHHH	59.76	19608861
222	Acetylation	VKKIEKMKEKRQAKY HHHHHHHHHHHHHHH	71.76	19608861
224	Acetylation	KIEKMKEKRQAKYSE HHHHHHHHHHHHHCC	44.27	19608861
359	Phosphorylation	QTELLMRYHQLQSRL HHHHHHHHHHHHHHH	4.67	-
379	Phosphorylation	ENEEVRKTLDATMQT CCHHHHHHHHHHHHH	21.21	22210691
383	Phosphorylation	VRKTLDATMQTLQDM HHHHHHHHHHHHHHH	14.96	22210691
386	Phosphorylation	TLDATMQTLQDMLTV HHHHHHHHHHHHCCC	18.63	22210691
392	Phosphorylation	QTLQDMLTVEDFDVS HHHHHHCCCCCCCHH	18.40	23090842
399	Phosphorylation	TVEDFDVSDAFQHSR CCCCCCHHHHHHCCC	25.68	23090842
405	Phosphorylation	VSDAFQHSRSTESVK HHHHHHCCCCHHHHH	19.69	22210691
407	Phosphorylation	DAFQHSRSTESVKSA HHHHCCCCHHHHHHH	39.27	28176443
408	Phosphorylation	AFQHSRSTESVKSAA HHHCCCCHHHHHHHH	31.04	22210691
410	Phosphorylation	QHSRSTESVKSAASE HCCCCHHHHHHHHHH	34.63	23090842
413	Phosphorylation	RSTESVKSAASETYM CCHHHHHHHHHHHHH	27.23	26471730
416	Phosphorylation	ESVKSAASETYMSKI HHHHHHHHHHHHHHH	30.13	27251275
446	Phosphorylation	YFTKFKEYVNGSNLI EEHHHHHHHCCCCHH	10.37	-
455	Ubiquitination	NGSNLITKLQAKHDL CCCCHHHHHHHHHHH	31.44	-
459	Acetylation	LITKLQAKHDLLKQT HHHHHHHHHHHHHHH	25.37	7851079
459	Ubiquitination	LITKLQAKHDLLKQT HHHHHHHHHHHHHHH	25.37	32142685
464	Acetylation	QAKHDLLKQTLGEGE HHHHHHHHHHHCCCC	48.84	7851091
497	Phosphorylation	MRRPRPLSVYSHKLF CCCCCCCEEHHHHCC	22.99	24719451
499	Phosphorylation	RPRPLSVYSHKLFNG CCCCCEEHHHHCCCC	11.15	27642862
530	Ubiquitination	VESCIRYINLYGLQQ HHHHHHHHHHHCCHH	1.74	30230243
554	Ubiquitination	QVEVNDIKNSFERGE EEEHHHHHCHHHCCC	49.77	30230243
602	Phosphorylation	ERFQDLISTIKLENP HHHHHHHHHHCCCCH	31.23	22817900
735	Phosphorylation	EVDHDNGTEPHTSDE EECCCCCCCCCCCHH	53.23	32142685
755	Phosphorylation	EAIAKFDYMGRSPRE HHHHCCCCCCCCHHH	12.47	-
759	Phosphorylation	KFDYMGRSPRELSFK CCCCCCCCHHHHCCC	23.68	26270265
764	Phosphorylation	GRSPRELSFKKGASL CCCHHHHCCCCCCEE	30.21	24719451
770	Phosphorylation	LSFKKGASLLLYHRA HCCCCCCEEEEEECC	28.37	28857561
774	Phosphorylation	KGASLLLYHRASEDW CCCEEEEEECCCCCH	6.82	-
778	Phosphorylation	LLLYHRASEDWWEGR EEEEECCCCCHHCCC	35.72	25332170
813	Phosphorylation	AFSDSLSQKADSEAS HHHHHHHHHCCCCCC	50.69	32142685
817	Phosphorylation	SLSQKADSEASSGPL HHHHHCCCCCCCCCC	39.66	27732954
820	Phosphorylation	QKADSEASSGPLLDD HHCCCCCCCCCCCCC	31.60	27732954
821	Phosphorylation	KADSEASSGPLLDDK HCCCCCCCCCCCCCH	52.02	27732954
834	Phosphorylation	DKASSKNDLQSPTEH CHHCCCCCCCCCCHH	50.23	32142685
837	Phosphorylation	SSKNDLQSPTEHISD CCCCCCCCCCHHHHH	40.88	28355574
839	Phosphorylation	KNDLQSPTEHISDYG CCCCCCCCHHHHHHC	45.50	28450419
843	Phosphorylation	QSPTEHISDYGFGGV CCCCHHHHHHCCCCC	27.04	28450419
845	Phosphorylation	PTEHISDYGFGGVMG CCHHHHHHCCCCCCC	13.94	28450419
850	Phosphorylation	SDYGFGGVMGRVRLR HHHCCCCCCCCEEEC	3.63	32142685
858	Phosphorylation	MGRVRLRSDGAAIPR CCCEEECCCCCCCCC	45.01	23898821
868	Phosphorylation	AAIPRRRSGGDTHSP CCCCCCCCCCCCCCC	45.37	30576142
872	Phosphorylation	RRRSGGDTHSPPRGL CCCCCCCCCCCCCCC	27.77	23927012
874	Phosphorylation	RSGGDTHSPPRGLGP CCCCCCCCCCCCCCC	38.40	30576142
882	Phosphorylation	PPRGLGPSIDTPPRA CCCCCCCCCCCCCCC	31.16	28464451
885	Phosphorylation	GLGPSIDTPPRAAAC CCCCCCCCCCCCCCC	33.26	28102081
894	Phosphorylation	PRAAACPSSPHKIPL CCCCCCCCCCCCCCC	57.28	28450419
895	Phosphorylation	RAAACPSSPHKIPLT CCCCCCCCCCCCCCC	19.03	28464451
902	Phosphorylation	SPHKIPLTRGRIESP CCCCCCCCCCCCCCH	26.23	27251275
908	Phosphorylation	LTRGRIESPEKRRMA CCCCCCCCHHHHHCC	35.67	30576142
916	Phosphorylation	PEKRRMATFGSAGSI HHHHHCCCCCCCCCC	21.13	27251275
919	Phosphorylation	RRMATFGSAGSINYP HHCCCCCCCCCCCCC	25.84	23927012
922	Phosphorylation	ATFGSAGSINYPDKK CCCCCCCCCCCCCHH	13.84	23927012
925	Phosphorylation	GSAGSINYPDKKALS CCCCCCCCCCHHHHC	15.90	27251275
930	Phosphorylation	INYPDKKALSEGHSM CCCCCHHHHCCCCCH	23.28	32142685
939	Phosphorylation	SEGHSMRSTCGSTRH CCCCCHHHCCCCCCC	21.29	29209046
940	Phosphorylation	EGHSMRSTCGSTRHS CCCCHHHCCCCCCCC	15.55	29209046
943	Phosphorylation	SMRSTCGSTRHSSLG CHHHCCCCCCCCCCC	25.14	29209046
944	Phosphorylation	MRSTCGSTRHSSLGD HHHCCCCCCCCCCCC	20.06	29209046
947	Phosphorylation	TCGSTRHSSLGDHKS CCCCCCCCCCCCCCH	24.78	24719451
948	Phosphorylation	CGSTRHSSLGDHKSL CCCCCCCCCCCCCHH	30.19	24719451
954	Phosphorylation	SSLGDHKSLEAEALA CCCCCCCHHHHHHHH	28.20	22617229
969	Phosphorylation	EDIEKTMSTALHELR HHHHHHHHHHHHHHH	18.76	22468782
970	Phosphorylation	DIEKTMSTALHELRE HHHHHHHHHHHHHHH	23.55	22468782
983	Phosphorylation	RELERQNTVKQAPDV HHHHHCCCCCCCCCE	22.27	-
991	Phosphorylation	VKQAPDVVLDTLEPL CCCCCCEEECCCCCC	5.37	32142685
1005	Phosphorylation	LKNPPGPVSSEPASP CCCCCCCCCCCCCCC	14.08	32142685
1006	Phosphorylation	KNPPGPVSSEPASPL CCCCCCCCCCCCCCC	31.92	27732954
1007	Phosphorylation	NPPGPVSSEPASPLH CCCCCCCCCCCCCCE	48.08	27732954
1011	Phosphorylation	PVSSEPASPLHTIVI CCCCCCCCCCEEEEE	38.42	30576142
1015	Phosphorylation	EPASPLHTIVIRDPD CCCCCCEEEEECCCC	25.31	27732954
1028	Phosphorylation	PDAAMRRSSSSSTEM CCHHHHHCCCCCCHH	24.98	23927012
1029	Phosphorylation	DAAMRRSSSSSTEMM CHHHHHCCCCCCHHH	32.21	23927012
1030	Phosphorylation	AAMRRSSSSSTEMMT HHHHHCCCCCCHHHH	29.56	23927012
1031	Phosphorylation	AMRRSSSSSTEMMTT HHHHCCCCCCHHHHH	43.13	23927012
1032	Phosphorylation	MRRSSSSSTEMMTTF HHHCCCCCCHHHHHC	30.27	23927012
1033	Phosphorylation	RRSSSSSTEMMTTFK HHCCCCCCHHHHHCH	29.82	25106551
1037	Phosphorylation	SSSTEMMTTFKPALS CCCCHHHHHCHHHHH	27.98	23090842
1038	Phosphorylation	SSTEMMTTFKPALSA CCCHHHHHCHHHHHH	16.27	23090842
1050	Phosphorylation	LSARLAGAQLRPPPM HHHHHCCCCCCCCCC	10.30	32142685
1068	Phosphorylation	RPVVQHRSSSSSSSG CCCEECCCCCCCCCC	32.23	30576142
1069	Phosphorylation	PVVQHRSSSSSSSGV CCEECCCCCCCCCCC	33.91	23927012
1070	Phosphorylation	VVQHRSSSSSSSGVG CEECCCCCCCCCCCC	35.17	30576142
1071	Phosphorylation	VQHRSSSSSSSGVGS EECCCCCCCCCCCCC	35.87	23927012
1072	Phosphorylation	QHRSSSSSSSGVGSP ECCCCCCCCCCCCCC	30.39	23927012
1073	Phosphorylation	HRSSSSSSSGVGSPA CCCCCCCCCCCCCCC	32.81	30576142
1074	Phosphorylation	RSSSSSSSGVGSPAV CCCCCCCCCCCCCCC	39.17	30576142
1078	Phosphorylation	SSSSGVGSPAVTPTE CCCCCCCCCCCCCCH	13.79	23927012
1082	Phosphorylation	GVGSPAVTPTEKMFP CCCCCCCCCCHHCCC	26.97	30576142
1084	Phosphorylation	GSPAVTPTEKMFPNS CCCCCCCCHHCCCCC	38.58	27251275
1092	Phosphorylation	EKMFPNSSADKSGTM HHCCCCCCCCCCCCC	47.31	-
1098	Phosphorylation	SSADKSGTM------ CCCCCCCCC------	27.14	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SRGP3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRGP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRGP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924
SRGP2_HUMAN	SRGAP2	physical	26186194
ACAD8_HUMAN	ACAD8	physical	26186194
CLOCK_HUMAN	CLOCK	physical	26186194
SPAG5_HUMAN	SPAG5	physical	26186194
CC85C_HUMAN	CCDC85C	physical	26186194
ASPP1_HUMAN	PPP1R13B	physical	26186194
ASPP2_HUMAN	TP53BP2	physical	26186194
CCD22_HUMAN	CCDC22	physical	26186194
PGTB1_HUMAN	PGGT1B	physical	26186194
SRGP2_HUMAN	SRGAP2	physical	28514442
PGTB1_HUMAN	PGGT1B	physical	28514442
CC85C_HUMAN	CCDC85C	physical	28514442
ASPP1_HUMAN	PPP1R13B	physical	28514442
CLOCK_HUMAN	CLOCK	physical	28514442
ASPP2_HUMAN	TP53BP2	physical	28514442
ACAD8_HUMAN	ACAD8	physical	28514442
SPAG5_HUMAN	SPAG5	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRGP3_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-220; LYS-222 AND LYS-224,AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-837 AND SER-858, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-602, AND MASSSPECTROMETRY.	18088087 [Abstract]