| UniProt ID | PGTB1_HUMAN | |
|---|---|---|
| UniProt AC | P53609 | |
| Protein Name | Geranylgeranyl transferase type-1 subunit beta | |
| Gene Name | PGGT1B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 377 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.. | |
| Protein Sequence | MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | EDERLAGSGEGERLD CCHHHCCCCCCHHHH | 28.23 | 28348404 | |
| 21 | Ubiquitination | EGERLDFLRDRHVRF CCHHHHHHHHHHHHH | 5.78 | 24816145 | |
| 98 | Phosphorylation | NRCGFRGSSYLGIPF CCCCCCCCCCCCCCC | 16.14 | 28857561 | |
| 99 | Phosphorylation | RCGFRGSSYLGIPFN CCCCCCCCCCCCCCC | 27.48 | 28857561 | |
| 120 | Ubiquitination | TAHPYDSGHIAMTYT CCCCCCCCCEEEEEC | 17.21 | 22817900 | |
| 144 | Ubiquitination | DDLSRVNKEACLAGL CCHHHCCHHHHHHHH | 43.78 | 24816145 | |
| 172 | Sulfoxidation | PEGSENDMRFVYCAS CCCCCCCHHHHHHHH | 5.59 | 30846556 | |
| 195 | Ubiquitination | WSGMDMKKAITYIRR CCCCCHHHHHHHHHH | 38.08 | - | |
| 199 | Phosphorylation | DMKKAITYIRRSMSY CHHHHHHHHHHHCCC | 6.06 | 28634120 | |
| 241 | Phosphorylation | GKLEEVFSEKELNRI HHHHHHCCHHHHHHH | 53.59 | 20068231 | |
| 243 | Ubiquitination | LEEVFSEKELNRIKR HHHHCCHHHHHHHHH | 67.32 | 22817900 | |
| 243 (in isoform 1) | Ubiquitination | - | 67.32 | 21906983 | |
| 293 | Ubiquitination | FQYTNFEKNRNYILS HHCCCCHHCCCEEEE | 58.00 | 29967540 | |
| 347 | Phosphorylation | VHPALNVSTRTSERL EECCCCCCCCCCHHH | 15.88 | 28857561 | |
| 360 | Phosphorylation | RLLDLHQSWKTKDSK HHHHHHHHHCCCCCH | 21.57 | 28857561 | |
| 367 | Ubiquitination | SWKTKDSKQCSENVH HHCCCCCHHHCCCCC | 66.51 | - | |
| 376 | Phosphorylation | CSENVHIST------ HCCCCCCCC------ | 17.12 | 25159151 | |
| 377 | Phosphorylation | SENVHIST------- CCCCCCCC------- | 41.86 | 21815630 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PGTB1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PGTB1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PGTB1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PGTB1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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