MYO15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO15_HUMAN
• UniProt AC: Q9UKN7
• Protein Name: Unconventional myosin-XV
• Gene Name: MYO15A
• Organism: Homo sapiens (Human).
• Sequence Length: 3530
• Subcellular Localization: Cell projection, stereocilium. Cytoplasm, cytoskeleton. Localizes to stereocilium tips in cochlear and vestibular hair cells..
• Protein Description: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity)..
• Protein Sequence: MAKEEDEEKKAKKGKKGKKAPEPEKPKRSLKGTSRLFMGFRDRTPKISKKGQFRSASAFFWGLHTGPQKTKRKRKARTVLKSTSKLMTQMRMGKKKRAMKGKKPSFMVIRFPGRRGYGRLRPRARSLSKASTAINWLTKKFLLKKAEESGSEQATVDAWLQRSSSRMGSRKLPFPSGAEILRPGGRLRRFPRSRSIYASGEPLGFLPFEDEAPFHHSGSRKSLYGLEGFQDLGEYYDYHRDGDDYYDRQSLHRYEEQEPYLAGLGPYSPAWPPYGDHYYGYPPEDPYDYYHPDYYGGPFDPGYTYGYGYDDYEPPYAPPSGYSSPYSYHDGYEGEAHPYGYYLDPYAPYDAPYPPYDLPYHTPYDVPYFDPYGVHYTVPYAEGVYGGGDEAIYPPEVPYFYPEESASAFVYPWVPPPIPSPHNPYAHAMDDIAELEEPEDAGVERQGTSFRLPSAAFFEQQGMDKPARSKLSLIRKFRLFPRPQVKLFGKEKLEVPLPPSLDIPLPLGDADEEEDEEELPPVSAVPYGHPFWGFLTPRQRNLQRALSAFGAHRGLGFGPEFGRPVPRPATSLARFLKKTLSEKKPIARLRGSQKARAGGPAVREAAYKRFGYKLAGMDPEKPGTPIVLRRAQPRARSSNDARRPPAPQPAPRTLSHWSALLSPPVPPRPPSSGPPPAPPLSPALSGLPRPASPYGSLRRHPPPWAAPAHVPPAPQASWWAFVEPPAVSPEVPPDLLAFPGPRPSFRGSRRRGAAFGFPGASPRASRRRAWSPLASPQPSLRSSPGLGYCSPLAPPSPQLSLRTGPFQPPFLPPARRPRSLQESPAPRRAAGRLGPPGSPLPGSPRPPSPPLGLCHSPRRSSLNLPSRLPHTWRRLSEPPTRAVKPQVRLPFHRPPRAGAWRAPLEHRESPREPEDSETPWTVPPLAPSWDVDMPPTQRPPSPWPGGAGSRRGFSRPPPVPENPFLQLLGPVPSPTLQPEDPAADMTRVFLGRHHEPGPGQLTKSAGPTPEKPEEEATLGDPQLPAETKPPTPAPPKDVTPPKDITPPKDVLPEQKTLRPSLSYPLAACDQTRATWPPWHRWGTLPQAAAPLAPIRAPEPLPKGGERRQAAPGRFAVVMPRVQKLSSFQRVGPATLKPQVQPIQDPKPRACSLRWSCLWLRADAYGPWPRVHTHPQSCHLGPGAACLSLRGSWEEVGPPSWRNKMHSIRNLPSMRFREQHGEDGVEDMTQLEDLQETTVLSNLKIRFERNLIYTYIGSILVSVNPYQMFGIYGPEQVQQYNGRALGENPPHLFAVANLAFAKMLDAKQNQCIIISGESGSGKTEATKLILRYLAAMNQKREVMQQIKILEATPLLESFGNAKTVRNDNSSRFGKFVEIFLEGGVISGAITSQYLLEKSRIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFSSEDQDSIFRILASILHLGNVYFEKYETDAQEVASVVSAREIQAVAELLQISPEGLQKAITFKVTETMREKIFTPLTVESAVDARDAIAKVLYALLFSWLITRVNALVSPRQDTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQIDWQEITFADNQPCINLISLKPYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLYSKPKMPLPEFTIKHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVRSRTRVVAHLFSSHAPQAAPQRLGKSSSVTRLYKAHTVAAKFQQSLLDLVEKMERCNPLFMRCLKPNHKKEPGLFEPDVVMAQLRYSGVLETVRIRKEGFPVRLPFQGFIDRYCCLVALKHDLPANGDMCVSVLSRLCKVMPNMYRVGVSKLFLKEHLYQLLESMREHVLNLAALTLQRCLRGFFIKRRFRSLRHKIILLQSRARGYLARQRYQQMRRSLVKFRSLVHAYVSRRRYLKLRAEWRCQVEGALLWEQEELSKREVVAVGHLEVPAELAGLLQAVAGLGLAQVPQVAPVRTPRLQAEPRVTLPLDINNYPMAKFVQCHFKEPAFGMLTVPLRTPLTQLPAEHHAEAVSIFKLILRFMGDPHLHGARENIFGNYIVQKGLAVPELRDEILAQLANQVWHNHNAHNAERGWLLLAACLSGFAPSPCFNKYLLKFVSDYGRNGFQAVCQHRLMQAMGRAQQQGSGAARTLPPTQLEWTATYEKASMALDVGCFNGDQFSCPVHSWSTGEEVAGDILRHRGLADGWRGWTVAMKNGVQWAELAGHDYVLDLVSDLELLRDFPRQKSYFIVGTEGPAASRGGPKVVFGNSWDSDEDMSTRPQPQEHMPKVLDSDGYSSHNQDGTNGETEAQRGTATHQESDSLGEPAVPHKGLDCYLDSLFDPVLSYGDADLEKPTAIAYRMKGGGQPGGGSSSGTEDTPRRPPEPKPIPGLDASTLALQQAFIHKQAVLLAREMTLQATALQQQPLSAALRSLPAEKPPAPEAQPTSVGTGPPAKPVLLRATPKPLAPAPLAKAPRLPIKPVAAPVLAQDQASPETTSPSPELVRYSTLNSEHFPQPTQQIKNIVRQYQQPFRGGRPEALRKDGGKVFMKRPDPHEEALMILKGQMTHLAAAPGTQVSREAVALVKPVTSAPRPSMAPTSALPSRSLEPPEELTQTRLHRLINPNFYGYQDAPWKIFLRKEVFYPKDSYSHPVQLDLLFRQILHDTLSEACLRISEDERLRMKALFAQNQLDTQKPLVTESVKRAVVSTARDTWEVYFSRIFPATGSVGTGVQLLAVSHVGIKLLRMVKGGQEAGGQLRVLRAYSFADILFVTMPSQNMLEFNLASEKVILFSARAHQVKTLVDDFILELKKDSDYVVAVRNFLPEDPALLAFHKGDIIHLQPLEPPRVGYSAGCVVRRKVVYLEELRRRGPDFGWRFGTIHGRVGRFPSELVQPAAAPDFLQLPTEPGRGRAAAVAAAVASAAAAQEVGRRREGPPVRARSADHGEDALALPPYTMLEFAQKYFRDPQRRPQDGLRLKSKEPRESRTLEDMLCFTKTPLQESLIELSDSSLSKMATDMFLAVMRFMGDAPLKGQSDLDVLCNLLKLCGDHEVMRDECYCQVVKQITDNTSSKQDSCQRGWRLLYIVTAYHSCSEVLHPHLTRFLQDVSRTPGLPFQGIAKACEQNLQKTLRFGGRLELPSSIELRAMLAGRSSKRQLFLLPGGLERHLKIKTCTVALDVVEEICAEMALTRPEAFNEYVIFVVTNRGQHVCPLSRRAYILDVASEMEQVDGGYMLWFRRVLWDQPLKFENELYVTMHYNQVLPDYLKGLFSSVPASRPSEQLLQQVSKLASLQHRAKDHFYLPSVREVQEYIPAQLYRTTAGSTWLNLVSQHRQQTQALSPHQARAQFLGLLSALPMFGSSFFFIQSCSNIAVPAPCILAINHNGLNFLSTETHELMVKFPLKEIQSTRTQRPTANSSYPYVEIALGDVAAQRTLQLQLEQGLELCRVVAVHVENLLSAHEKRLTLPPSEITLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Acetylation	EKKAKKGKKGKKAPE HHHHHCCCCCCCCCC	68.20	69595
16	Acetylation	KKAKKGKKGKKAPEP HHHHCCCCCCCCCCC	82.00	69599
19	Acetylation	KKGKKGKKAPEPEKP HCCCCCCCCCCCCCC	77.25	7484057
78	Phosphorylation	KRKRKARTVLKSTSK HHHHHHHHHHHHHHH	34.74	29083192
82	Phosphorylation	KARTVLKSTSKLMTQ HHHHHHHHHHHHHHH	33.48	29083192
83	Phosphorylation	ARTVLKSTSKLMTQM HHHHHHHHHHHHHHH	28.44	29083192
84	Phosphorylation	RTVLKSTSKLMTQMR HHHHHHHHHHHHHHH	30.77	29083192
88	Phosphorylation	KSTSKLMTQMRMGKK HHHHHHHHHHHHCHH	29.65	29083192
126	Phosphorylation	RLRPRARSLSKASTA CCCHHHHHHHHHHHH	35.69	-
128	Phosphorylation	RPRARSLSKASTAIN CHHHHHHHHHHHHHH	27.67	-
131	Phosphorylation	ARSLSKASTAINWLT HHHHHHHHHHHHHHH	23.31	-
132	Phosphorylation	RSLSKASTAINWLTK HHHHHHHHHHHHHHH	36.09	-
138	Phosphorylation	STAINWLTKKFLLKK HHHHHHHHHHHHHHH	24.65	-
163	Phosphorylation	VDAWLQRSSSRMGSR HHHHHHHHHCCCCCC	21.50	-
164	Phosphorylation	DAWLQRSSSRMGSRK HHHHHHHHCCCCCCC	24.93	-
246	Phosphorylation	HRDGDDYYDRQSLHR CCCCCCCCCHHHHHC	16.19	-
472	Phosphorylation	KPARSKLSLIRKFRL CCHHHHHHHHHHHCC	26.03	24719451
540	Methylation	GFLTPRQRNLQRALS CCCCHHHHHHHHHHH	47.29	115389233
544	Methylation	PRQRNLQRALSAFGA HHHHHHHHHHHHHCC	40.43	115389239
553	Methylation	LSAFGAHRGLGFGPE HHHHCCCCCCCCCCC	41.31	115389245
563	Methylation	GFGPEFGRPVPRPAT CCCCCCCCCCCCCHH	34.07	115389251
577	Methylation	TSLARFLKKTLSEKK HHHHHHHHHHHCCCC	40.79	-
577	Trimethylation	TSLARFLKKTLSEKK HHHHHHHHHHHCCCC	40.79	-
578	Trimethylation	SLARFLKKTLSEKKP HHHHHHHHHHCCCCC	57.77	-
578	Methylation	SLARFLKKTLSEKKP HHHHHHHHHHCCCCC	57.77	-
584	Methylation	KKTLSEKKPIARLRG HHHHCCCCCHHHHCC	37.29	-
584	Trimethylation	KKTLSEKKPIARLRG HHHHCCCCCHHHHCC	37.29	-
658	Phosphorylation	PRTLSHWSALLSPPV CCCCCCHHHHCCCCC	12.01	-
761	Phosphorylation	AFGFPGASPRASRRR CCCCCCCCHHHHHHH	22.34	20068231
800	Phosphorylation	APPSPQLSLRTGPFQ CCCCCCCCCCCCCCC	15.57	24719451
861	Phosphorylation	CHSPRRSSLNLPSRL CCCCCCHHCCCCCCC	21.33	26546556
876	Phosphorylation	PHTWRRLSEPPTRAV CCHHHHCCCCCCCCC	46.36	22985185
880	Phosphorylation	RRLSEPPTRAVKPQV HHCCCCCCCCCCCCE	41.81	22985185
941	Phosphorylation	PPTQRPPSPWPGGAG CCCCCCCCCCCCCCC	42.13	-
949	Phosphorylation	PWPGGAGSRRGFSRP CCCCCCCCCCCCCCC	20.47	-
954	Phosphorylation	AGSRRGFSRPPPVPE CCCCCCCCCCCCCCC	46.86	23403867
973	Phosphorylation	QLLGPVPSPTLQPED HHHCCCCCCCCCCCC	30.65	23403867
1031	Phosphorylation	PAETKPPTPAPPKDV CCCCCCCCCCCCCCC	40.38	20873877
1039	Phosphorylation	PAPPKDVTPPKDITP CCCCCCCCCCCCCCC	43.96	30631047
1045	Phosphorylation	VTPPKDITPPKDVLP CCCCCCCCCCHHCCC	43.61	30631047
1095	Methylation	AAPLAPIRAPEPLPK CCCCCCCCCCCCCCC	42.93	24383733
1199	Phosphorylation	WEEVGPPSWRNKMHS HHHHCCCHHHHHHHH	41.63	26091039
1301	Ubiquitination	VANLAFAKMLDAKQN HHHHHHHHHHCCCCC	33.28	-
1322	Phosphorylation	GESGSGKTEATKLIL CCCCCCHHHHHHHHH	34.08	20068231
1325	Phosphorylation	GSGKTEATKLILRYL CCCHHHHHHHHHHHH	21.83	20068231
1331	Phosphorylation	ATKLILRYLAAMNQK HHHHHHHHHHHHHHH	9.39	27174698
1368	Phosphorylation	KTVRNDNSSRFGKFV EEECCCCCCCCCEEE	26.25	29514088
1369	Phosphorylation	TVRNDNSSRFGKFVE EECCCCCCCCCEEEH	37.57	29514088
1396	Ubiquitination	TSQYLLEKSRIVFQA HHHHHHHHCEEEEEE	45.03	-
1493	Phosphorylation	GNVYFEKYETDAQEV CCCEEEECCCCHHHH	19.50	23312004
1495	Phosphorylation	VYFEKYETDAQEVAS CEEEECCCCHHHHHH	33.28	23312004
1502	Phosphorylation	TDAQEVASVVSAREI CCHHHHHHHHCHHHH	28.38	-
1505	Phosphorylation	QEVASVVSAREIQAV HHHHHHHCHHHHHHH	21.32	-
1651	Phosphorylation	QPCINLISLKPYGIL CCEEEEEEECCCCCE	33.24	24719451
1818	Phosphorylation	VVMAQLRYSGVLETV CCEEEEECCCCEEEE	20.54	23403867
1819	Phosphorylation	VMAQLRYSGVLETVR CEEEEECCCCEEEEE	18.91	23403867
1824	Phosphorylation	RYSGVLETVRIRKEG ECCCCEEEEEEECCC	15.78	23403867
1877	Phosphorylation	CKVMPNMYRVGVSKL HHHCCCCHHHCHHHH	14.58	-
1891	Phosphorylation	LFLKEHLYQLLESMR HHHHHHHHHHHHHHH	10.06	29083192
1964	Phosphorylation	SLVHAYVSRRRYLKL HHHHHHHHCCCHHHH	13.85	-
2087	Phosphorylation	EHHAEAVSIFKLILR HHHHHHHHHHHHHHH	29.38	24719451
2324	Phosphorylation	PKVVFGNSWDSDEDM CEEEECCCCCCCCCC	32.41	22964224
2327	Phosphorylation	VFGNSWDSDEDMSTR EECCCCCCCCCCCCC	36.32	22964224
2482	Phosphorylation	ALQQQPLSAALRSLP HHHHCHHHHHHHCCC	20.41	-
2699	Phosphorylation	FLRKEVFYPKDSYSH EEECCCCCCCCCCCC	17.97	-
2935	Phosphorylation	DFGWRFGTIHGRVGR CCCCCCCCCCCCCCC	13.69	26074081
2997	Phosphorylation	GPPVRARSADHGEDA CCCCCCCCCCCCCCC	36.74	-
3011	Phosphorylation	ALALPPYTMLEFAQK CCCCCCCHHHHHHHH	22.51	27251275
3246	Phosphorylation	ICAEMALTRPEAFNE HHHHHCCCCHHHHCC	34.34	22468782
3260	Phosphorylation	EYVIFVVTNRGQHVC CEEEEEEECCCCEEE	17.56	22468782
3270	Phosphorylation	GQHVCPLSRRAYILD CCEEECCCCCEEEHH	12.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO15_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO15_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MYO15_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 600316: Deafness, autosomal recessive, 3 (DFNB3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.