APC16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APC16_HUMAN
• UniProt AC: Q96DE5
• Protein Name: Anaphase-promoting complex subunit 16
• Gene Name: ANAPC16
• Organism: Homo sapiens (Human).
• Sequence Length: 110
• Subcellular Localization: Cytoplasm . Nucleus . Chromosome, centromere, kinetochore .
• Protein Description: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains..
• Protein Sequence: MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFSYQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPSSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAASSSSSS ------CCCCCCCCC	18.95	22814378
9	Phosphorylation	AASSSSSSAGGVSGS CCCCCCCCCCCCCCC	32.64	25627689
33	Ubiquitination	SDLAPPRKALFTYPK HHCCCCCEEEEECCC	56.04	-
40	Ubiquitination	KALFTYPKGAGEMLE EEEEECCCCHHHCCC	51.48	21906983
45	Sulfoxidation	YPKGAGEMLEDGSER CCCCHHHCCCCCCHH	4.93	21406390
57	Phosphorylation	SERFLCESVFSYQVA CHHEEEEHHHHHHHH	27.71	22067460
61	Phosphorylation	LCESVFSYQVASTLK EEEHHHHHHHHHHHH	8.78	27642862
68	Ubiquitination	YQVASTLKQVKHDQQ HHHHHHHHHHHHHHH	53.81	-
71	Acetylation	ASTLKQVKHDQQVAR HHHHHHHHHHHHHHH	38.68	25953088
97	Ubiquitination	EADEWRFKPIEQLLG HHCCCCCCCHHHHHC	36.19	21906983
106	Phosphorylation	IEQLLGFTPSSG--- HHHHHCCCCCCC---	22.06	21712546
108	Phosphorylation	QLLGFTPSSG----- HHHCCCCCCC-----	44.63	21712546
109	Phosphorylation	LLGFTPSSG------ HHCCCCCCC------	50.12	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APC16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APC16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APC16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APC7_HUMAN	ANAPC7	physical	25490258
CDC27_HUMAN	CDC27	physical	25490258
APC7_HUMAN	ANAPC7	physical	26344197
CDC26_HUMAN	CDC26	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.