dbPTM

PTN23_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PTN23_HUMAN
UniProt AC	Q9H3S7
Protein Name	Tyrosine-protein phosphatase non-receptor type 23
Gene Name	PTPN23
Organism	Homo sapiens (Human).
Sequence Length	1636
Subcellular Localization	Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome.
Protein Description	Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis..
Protein Sequence	MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPRDFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYNLGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFTMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQLMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQAGAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKKLFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVASYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRPTAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPLLQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQDAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLHQRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPSDDPLSLLDPLWTLNKT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	2-Hydroxyisobutyrylation	FHFQPAVKKFVLKNY CCCCHHHHHHHHHHH	42.47	-
28	Ubiquitination	HFQPAVKKFVLKNYG CCCHHHHHHHHHHHC	33.82	-
32	Ubiquitination	AVKKFVLKNYGENPE HHHHHHHHHHCCCHH	42.70	21890473
32	Ubiquitination	AVKKFVLKNYGENPE HHHHHHHHHHCCCHH	42.70	21890473
46	Ubiquitination	EAYNEELKKLELLRQ HHHHHHHHHHHHHHH	59.60	21906983
47	Ubiquitination	AYNEELKKLELLRQN HHHHHHHHHHHHHHC	60.87	-
66	Phosphorylation	PRDFEGCSVLRKYLG CCCCCHHHHHHHHHH	34.73	28348404
70	Malonylation	EGCSVLRKYLGQLHY CHHHHHHHHHHHHHH	40.44	26320211
70	Ubiquitination	EGCSVLRKYLGQLHY CHHHHHHHHHHHHHH	40.44	-
165	Phosphorylation	REHFPQAYSVDMSRQ HHHCCCCEECCCCHH	12.18	29978859
166	Phosphorylation	EHFPQAYSVDMSRQI HHCCCCEECCCCHHH	18.04	29978859
170	Phosphorylation	QAYSVDMSRQILTLN CCEECCCCHHHHHHH	19.30	29978859
199	Malonylation	KSMLDNRKSFLVARI HHHHCCCHHHHHHHH	52.38	26320211
207	Phosphorylation	SFLVARISAQVVDYY HHHHHHHHHHHHHHH	13.70	23322592
213	Phosphorylation	ISAQVVDYYKEACRA HHHHHHHHHHHHHHH	12.58	30174305
214	Phosphorylation	SAQVVDYYKEACRAL HHHHHHHHHHHHHHH	9.63	30174305
215	Ubiquitination	AQVVDYYKEACRALE HHHHHHHHHHHHHHC	32.38	21890473
226	Phosphorylation	RALENPDTASLLGRI HHHCCCCHHHHHHHH	21.28	28857561
228	Phosphorylation	LENPDTASLLGRIQK HCCCCHHHHHHHHHH	26.64	28857561
235	Ubiquitination	SLLGRIQKDWKKLVQ HHHHHHHHHHHHHHH	64.28	-
279	Ubiquitination	YFQSALDKLNEAIKL HHHHHHHHHHHHHHH	54.80	21890473
279	Ubiquitination	YFQSALDKLNEAIKL HHHHHHHHHHHHHHH	54.80	21890473
285	Ubiquitination	DKLNEAIKLAKGQPD HHHHHHHHHHCCCCC	49.82	21906983
288	Malonylation	NEAIKLAKGQPDTVQ HHHHHHHCCCCCHHH	69.39	32601280
288	Ubiquitination	NEAIKLAKGQPDTVQ HHHHHHHCCCCCHHH	69.39	21906983
293	Phosphorylation	LAKGQPDTVQDALRF HHCCCCCHHHHHHHH	27.10	-
308	Ubiquitination	TMDVIGGKYNSAKKD HHHHHCCCCCCCCCC	35.73	-
313	Ubiquitination	GGKYNSAKKDNDFIY CCCCCCCCCCCCCCC	61.55	-
314	Ubiquitination	GKYNSAKKDNDFIYH CCCCCCCCCCCCCCC	62.57	-
320	Phosphorylation	KKDNDFIYHEAVPAL CCCCCCCCCCCCCCC	8.13	27642862
340	Ubiquitination	VKGAPLVKPLPVNPT CCCCCCCCCCCCCCC	48.82	2190698
359	Ubiquitination	TGPDIFAKLVPMAAH CCHHHHHHHHHHHHH	38.99	-
369	Phosphorylation	PMAAHEASSLYSEEK HHHHHHHHHCCCHHH	20.21	28857561
370	Phosphorylation	MAAHEASSLYSEEKA HHHHHHHHCCCHHHH	38.07	28857561
372	Phosphorylation	AHEASSLYSEEKAKL HHHHHHCCCHHHHHH	18.91	23403867
373	Phosphorylation	HEASSLYSEEKAKLL HHHHHCCCHHHHHHH	44.57	23403867
472	Ubiquitination	EDELLEQKFQEAVGQ HHHHHHHHHHHHHHH	39.37	-
484	Phosphorylation	VGQAGAISITSKAEL HHHCCCEECCCHHHH	21.19	28555341
486	Phosphorylation	QAGAISITSKAELAE HCCCEECCCHHHHHH	19.86	28857561
487	Phosphorylation	AGAISITSKAELAEV CCCEECCCHHHHHHH	28.35	28857561
500	Ubiquitination	EVRREWAKYMEVHEK HHHHHHHHHHHHHHH	46.32	-
509	Phosphorylation	MEVHEKASFTNSELH HHHHHHHCCCHHHHH	43.61	-
511	Phosphorylation	VHEKASFTNSELHRA HHHHHCCCHHHHHHH	35.03	-
513	Phosphorylation	EKASFTNSELHRAMN HHHCCCHHHHHHHHH	38.18	-
530	Phosphorylation	VGNLRLLSGPLDQVR CCCEEECCCCHHHHH	42.85	28857561
546	Phosphorylation	ALPTPALSPEDKAVL HCCCCCCCHHHHHHH	28.49	21815630
550	Ubiquitination	PALSPEDKAVLQNLK CCCCHHHHHHHHHHH	38.44	-
557	Acetylation	KAVLQNLKRILAKVQ HHHHHHHHHHHHHHH	44.96	25953088
557	Ubiquitination	KAVLQNLKRILAKVQ HHHHHHHHHHHHHHH	44.96	-
587	Phosphorylation	LIQKDDITASLVTTD HHHHCCCCEEEECCC	19.72	20068231
589	Phosphorylation	QKDDITASLVTTDHS HHCCCCEEEECCCHH	18.09	20068231
592	Phosphorylation	DITASLVTTDHSEMK CCCEEEECCCHHHHH	31.62	23312004
593	Phosphorylation	ITASLVTTDHSEMKK CCEEEECCCHHHHHH	25.00	20068231
596	Phosphorylation	SLVTTDHSEMKKLFE EEECCCHHHHHHHHH	42.04	23312004
600	Ubiquitination	TDHSEMKKLFEEQLK CCHHHHHHHHHHHHH	58.03	-
608	"N6,N6-dimethyllysine"	LFEEQLKKYDQLKVY HHHHHHHHHHHHHHH	63.75	-
608	Methylation	LFEEQLKKYDQLKVY HHHHHHHHHHHHHHH	63.75	23644510
613	"N6,N6-dimethyllysine"	LKKYDQLKVYLEQNL HHHHHHHHHHHHHCH	24.17	-
613	Methylation	LKKYDQLKVYLEQNL HHHHHHHHHHHHHCH	24.17	23644510
645	Phosphorylation	AAVRRVLSDLDQKWN HHHHHHHHHHHHHHH	33.02	-
679	Phosphorylation	SQEGRDFYADLESKV CCCCCCHHHHHHHHH	11.96	18669648
693	Phosphorylation	VAALLERTQSTCQAR HHHHHHHHHHHHHHH	19.93	-
696	Phosphorylation	LLERTQSTCQAREAA HHHHHHHHHHHHHHH	9.98	-
730	Methylation	PKPLLPRREESEAVE CCCCCCCHHHHHHHH	50.52	115489637
733	Phosphorylation	LLPRREESEAVEAGD CCCCHHHHHHHHCCC	26.55	23312004
747	Phosphorylation	DPPEELRSLPPDMVA CCHHHHHCCCCCCCC	58.83	26657352
950	Methylation	PAGFPAPRIGPQPQP CCCCCCCCCCCCCCC	48.91	24129315
1081	Phosphorylation	SAGQSTPSPHLVPSP CCCCCCCCCCCCCCC	25.66	26425664
1087	Phosphorylation	PSPHLVPSPAPSPGP CCCCCCCCCCCCCCC	26.64	26425664
1091	Phosphorylation	LVPSPAPSPGPGPVP CCCCCCCCCCCCCCC	44.59	26425664
1121	Phosphorylation	AAAADLLSSSPESQH CHHHHHHHCCCCHHC	35.75	23401153
1122	O-linked_Glycosylation	AAADLLSSSPESQHG HHHHHHHCCCCHHCC	50.29	30059200
1122	Phosphorylation	AAADLLSSSPESQHG HHHHHHHCCCCHHCC	50.29	22167270
1123	Phosphorylation	AADLLSSSPESQHGG HHHHHHCCCCHHCCC	29.34	22167270
1126	Phosphorylation	LLSSSPESQHGGTQS HHHCCCCHHCCCCCC	30.75	22167270
1131	O-linked_Glycosylation	PESQHGGTQSPGGGQ CCHHCCCCCCCCCCC	30.39	30059200
1131	Phosphorylation	PESQHGGTQSPGGGQ CCHHCCCCCCCCCCC	30.39	22167270
1133	Phosphorylation	SQHGGTQSPGGGQPL HHCCCCCCCCCCCCC	25.91	22167270
1144	Phosphorylation	GQPLLQPTKVDAAEG CCCCCCCCEECCCCC	30.64	23927012
1165	Phosphorylation	RLIERDPYEHPERLR HHHHCCCCCCHHHHH	31.03	28796482
1210	Phosphorylation	EHDARGRSIAIARCY HHCCCCHHHHHHHHH	21.13	21406692
1217	Phosphorylation	SIAIARCYSLKNRHQ HHHHHHHHHCCCCCC	16.10	21406692
1218	Phosphorylation	IAIARCYSLKNRHQD HHHHHHHHCCCCCCC	36.17	24719451
1220	Ubiquitination	IARCYSLKNRHQDVM HHHHHHCCCCCCCCC	46.09	-
1229	Phosphorylation	RHQDVMPYDSNRVVL CCCCCCCCCCCCEEE	17.57	21945579
1231	Phosphorylation	QDVMPYDSNRVVLRS CCCCCCCCCCEEECC	22.23	21945579
1290	Phosphorylation	SVIVMLVSEAEMEKQ EEEEEECCHHHHHHH	27.42	-
1305	Phosphorylation	KVARYFPTERGQPMV HHHHHCCCCCCCCCH	28.54	23532336
1317	Phosphorylation	PMVHGALSLALSSVR CCHHHHHHHHHHHCC	15.86	23532336
1321	Phosphorylation	GALSLALSSVRSTET HHHHHHHHHCCCCHH	22.60	24719451
1322	Phosphorylation	ALSLALSSVRSTETH HHHHHHHHCCCCHHH	23.54	21406692
1335	Phosphorylation	THVERVLSLQFRDQS HHHHHHHHHHCCCHH	19.78	24247654
1446	Phosphorylation	KLHLRFCYEAVVRHV HHHHHHHHHHHHHHH	12.29	27642862
1466	S-nitrosylation	RHGVPPPCKPLASAS HHCCCCCCCCCCCCC	9.76	22178444
1471	Phosphorylation	PPCKPLASASISQKN CCCCCCCCCCCCCCC	30.17	28857561
1473	Phosphorylation	CKPLASASISQKNHL CCCCCCCCCCCCCCC	21.93	28857561
1475	Phosphorylation	PLASASISQKNHLPQ CCCCCCCCCCCCCCC	32.38	28857561
1484	Phosphorylation	KNHLPQDSQDLVLGG CCCCCCCCCCCCCCC	21.98	21712546
1496	O-linked_Glycosylation	LGGDVPISSIQATIA CCCCCCHHHHHHEEH	18.47	30059200
1496	Phosphorylation	LGGDVPISSIQATIA CCCCCCHHHHHHEEH	18.47	24173317
1497	Phosphorylation	GGDVPISSIQATIAK CCCCCHHHHHHEEHH	21.31	24173317
1506	Phosphorylation	QATIAKLSIRPPGGL HHEEHHCCCCCCCCC	18.82	27251275
1515	Phosphorylation	RPPGGLESPVASLPG CCCCCCCCCCCCCCC	29.71	27251275
1519	Phosphorylation	GLESPVASLPGPAEP CCCCCCCCCCCCCCC	35.02	27251275
1533	Phosphorylation	PPGLPPASLPESTPI CCCCCCCCCCCCCCC	50.67	28348404
1537	Phosphorylation	PPASLPESTPIPSSS CCCCCCCCCCCCCCC	37.23	26074081
1538	Phosphorylation	PASLPESTPIPSSSP CCCCCCCCCCCCCCC	24.47	28464451
1542	Phosphorylation	PESTPIPSSSPPPLS CCCCCCCCCCCCCCC	44.14	27966365
1543	Phosphorylation	ESTPIPSSSPPPLSS CCCCCCCCCCCCCCC	41.32	28464451
1544	Phosphorylation	STPIPSSSPPPLSSP CCCCCCCCCCCCCCC	45.85	28464451
1549	Phosphorylation	SSSPPPLSSPLPEAP CCCCCCCCCCCCCCC	35.37	29496963
1550	Phosphorylation	SSPPPLSSPLPEAPQ CCCCCCCCCCCCCCC	37.83	22210691
1569	Phosphorylation	PPVPEAPSSGPPSSS CCCCCCCCCCCCCCH	55.78	26657352
1570	Phosphorylation	PVPEAPSSGPPSSSL CCCCCCCCCCCCCHH	55.02	27251275
1574	Phosphorylation	APSSGPPSSSLELLA CCCCCCCCCHHHHHH	35.37	26657352
1575	Phosphorylation	PSSGPPSSSLELLAS CCCCCCCCHHHHHHH	44.72	24275569
1576	Phosphorylation	SSGPPSSSLELLASL CCCCCCCHHHHHHHC	30.15	27251275
1589	Phosphorylation	SLTPEAFSLDSSLRG HCCHHHHCCCHHHCC	38.01	23090842
1592	Phosphorylation	PEAFSLDSSLRGKQR HHHHCCCHHHCCCHH	36.24	23090842
1593	Phosphorylation	EAFSLDSSLRGKQRM HHHCCCHHHCCCHHH	23.04	23090842
1595	Methylation	FSLDSSLRGKQRMSK HCCCHHHCCCHHHHH	52.81	54558363
1601	Phosphorylation	LRGKQRMSKHNFLQA HCCCHHHHHHCHHHH	32.71	-
1615	Methylation	AHNGQGLRATRPSDD HHCCCCCCCCCCCCC	40.51	24129315
1617	Phosphorylation	NGQGLRATRPSDDPL CCCCCCCCCCCCCCH	36.36	29083192
1618	Methylation	GQGLRATRPSDDPLS CCCCCCCCCCCCCHH	27.95	54558379
1620	Phosphorylation	GLRATRPSDDPLSLL CCCCCCCCCCCHHHH	51.89	25159151
1625	Phosphorylation	RPSDDPLSLLDPLWT CCCCCCHHHHHHHHH	32.07	29083192
1632	Phosphorylation	SLLDPLWTLNKT--- HHHHHHHHCCCC---	28.30	22199227
1635	Ubiquitination	DPLWTLNKT------ HHHHHCCCC------	59.74	-
1636	Phosphorylation	PLWTLNKT------- HHHHCCCC-------	42.65	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PTN23_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PTN23_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PTN23_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHM4B_HUMAN	CHMP4B	physical	17174262
TS101_HUMAN	TSG101	physical	17174262
SH3G2_HUMAN	SH3GL2	physical	17174262
ALG2_HUMAN	ALG2	physical	17174262
PDC6I_HUMAN	PDCD6IP	physical	17174262
GAG_HV1H2	gag	physical	19403673
VP26A_HUMAN	VPS26A	physical	22939629
AURKA_HUMAN	AURKA	physical	22939629
EGFR_HUMAN	EGFR	physical	23477725
STAM2_HUMAN	STAM2	physical	23477725
HGS_HUMAN	HGS	physical	23477725
UBP8_HUMAN	USP8	physical	23477725
P4R3B_HUMAN	SMEK2	physical	22863883
CEP55_HUMAN	CEP55	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
UBAP1_HUMAN	UBAP1	physical	21757351
HGS_HUMAN	HGS	physical	26456826
STAM1_HUMAN	STAM	physical	26456826
UBAP1_HUMAN	UBAP1	physical	26456826
TS101_HUMAN	TSG101	physical	26456826
EPN4_HUMAN	CLINT1	physical	27880917
CLCA_HUMAN	CLTA	physical	27880917
CLCB_HUMAN	CLTB	physical	27880917
CLH1_HUMAN	CLTC	physical	27880917
P3H1_HUMAN	P3H1	physical	27880917
ZFY16_HUMAN	ZFYVE16	physical	27880917
UBAP1_HUMAN	UBAP1	physical	27839950

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PTN23_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1123 AND SER-1133, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1123; THR-1131 ANDSER-1133, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1126, AND MASSSPECTROMETRY.	17525332 [Abstract]