dbPTM

ZFY16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZFY16_HUMAN
UniProt AC	Q7Z3T8
Protein Name	Zinc finger FYVE domain-containing protein 16
Gene Name	ZFYVE16
Organism	Homo sapiens (Human).
Sequence Length	1539
Subcellular Localization	Cytoplasm . Early endosome membrane Peripheral membrane protein . Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P).
Protein Description	May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes..
Protein Sequence	MDSYFKAAVSDLDKLLDDFEQNPDEQDYLQDVQNAYDSNHCSVSSELASSQRTSLLPKDQECVNSCASSETSYGTNESSLNEKTLKGLTSIQNEKNVTGLDLLSSVDGGTSDEIQPLYMGRCSKPICDLISDMGNLVHATNSEEDIKKLLPDDFKSNADSLIGLDLSSVSDTPCVSSTDHDSDTVREQQNDISSELQNREIGGIKELGIKVDTTLSDSYNYSGTENLKDKKIFNQLESIVDFNMSSALTRQSSKMFHAKDKLQHKSQPCGLLKDVGLVKEEVDVAVITAAECLKEEGKTSALTCSLPKNEDLCLNDSNSRDENFKLPDFSFQEDKTVIKQSAQEDSKSLDLKDNDVIQDSSSALHVSSKDVPSSLSCLPASGSMCGSLIESKARGDFLPQHEHKDNIQDAVTIHEEIQNSVVLGGEPFKENDLLKQEKCKSILLQSLIEGMEDRKIDPDQTVIRAESLDGGDTSSTVVESQEGLSGTHVPESSDCCEGFINTFSSNDMDGQDLDYFNIDEGAKSGPLISDAELDAFLTEQYLQTTNIKSFEENVNDSKSQMNQIDMKGLDDGNINNIYFNAEAGAIGESHGINIICEIVDKQNTIENGLSLGEKSTIPVQQGLPTSKSEITNQLSVSDINSQSVGGARPKQLFSLPSRTRSSKDLNKPDVPDTIESEPSTADTVVPITCAIDSTADPQVSFNSNYIDIESNSEGGSSFVTANEDSVPENTCKEGLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLEKEARVCVVCYETISKAQAFERMMSPTGSNLKSNHSDECTTVQPPQENQTSSIPSPATLPVSALKQPGVEGLCSKEQKRVWFADGILPNGEVADTTKLSSGSKRCSEDFSPLSPDVPMTVNTVDHSHSTTVEKPNNETGDITRNEIIQSPISQVPSVEKLSMNTGNEGLPTSGSFTLDDDVFAETEEPSSPTGVLVNSNLPIASISDYRLLCDINKYVCNKISLLPNDEDSLPPLLVASGEKGSVPVVEEHPSHEQIILLLEGESFHPVTFVLNANLLVNVKFIFYSSDKYWYFSTNGLHGLGQAEIIILLLCLPNEDTIPKDIFRLFITIYKDALKGKYIENLDNITFTESFLSSKDHGGFLFITPTFQKLDDLSLPSNPFLCGILIQKLEIPWAKVFPMRLMLRLGAEYKAYPAPLTSIRGRKPLFGEIGHTIMNLLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVLNSSNEHVISIGASFSTEADSHLVCIQNDGIYETQANSATGHPRKVTGASFVVFNGALKTSSGFLAKSSIVEDGLMVQITPETMNGLRLALREQKDFKITCGKVDAVDLREYVDICWVDAEEKGNKGVISSVDGISLQGFPSEKIKLEADFETDEKIVKCTEVFYFLKDQDLSILSTSYQFAKEIAMACSAALCPHLKTLKSNGMNKIGLRVSIDTDMVEFQAGSEGQLLPQHYLNDLDSALIPVIHGGTSNSSLPLEIELVFFIIEHLF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	SYFKAAVSDLDKLLD HHHHHHHHHHHHHHH	27.94	27251275
28	Phosphorylation	QNPDEQDYLQDVQNA HCCCHHHHHHHHHHH	13.12	27251275
36	Phosphorylation	LQDVQNAYDSNHCSV HHHHHHHHHCCCCCH	27.70	27251275
38	Phosphorylation	DVQNAYDSNHCSVSS HHHHHHHCCCCCHHH	18.79	27251275
42	Phosphorylation	AYDSNHCSVSSELAS HHHCCCCCHHHHHHH	19.92	27251275
44	Phosphorylation	DSNHCSVSSELASSQ HCCCCCHHHHHHHCC	11.20	27251275
45	Phosphorylation	SNHCSVSSELASSQR CCCCCHHHHHHHCCC	34.18	27251275
49	Phosphorylation	SVSSELASSQRTSLL CHHHHHHHCCCCCCC	39.36	27251275
50	Phosphorylation	VSSELASSQRTSLLP HHHHHHHCCCCCCCC	20.34	27251275
53	Ubiquitination	ELASSQRTSLLPKDQ HHHHCCCCCCCCCCH	18.98	27667366
54	Phosphorylation	LASSQRTSLLPKDQE HHHCCCCCCCCCCHH	30.05	24719451
73	Phosphorylation	CASSETSYGTNESSL HCCCCCCCCCCHHHC	35.08	22817900
75	Phosphorylation	SSETSYGTNESSLNE CCCCCCCCCHHHCCH	27.81	27251275
78	Phosphorylation	TSYGTNESSLNEKTL CCCCCCHHHCCHHHH	42.04	27251275
79	Phosphorylation	SYGTNESSLNEKTLK CCCCCHHHCCHHHHH	29.09	27251275
83	Ubiquitination	NESSLNEKTLKGLTS CHHHCCHHHHHCHHH	59.07	22817900
86	Ubiquitination	SLNEKTLKGLTSIQN HCCHHHHHCHHHHCC	58.04	21906983
86 (in isoform 1)	Ubiquitination	-	58.04	21890473
86 (in isoform 3)	Ubiquitination	-	58.04	21890473
89	Phosphorylation	EKTLKGLTSIQNEKN HHHHHCHHHHCCCCC	32.24	27251275
90	Phosphorylation	KTLKGLTSIQNEKNV HHHHCHHHHCCCCCC	27.50	27251275
95	Ubiquitination	LTSIQNEKNVTGLDL HHHHCCCCCCCCHHH	65.35	21906983
95 (in isoform 1)	Ubiquitination	-	65.35	21890473
95 (in isoform 3)	Ubiquitination	-	65.35	21890473
104	Phosphorylation	VTGLDLLSSVDGGTS CCCHHHHHCCCCCCC	35.30	28348404
105	Phosphorylation	TGLDLLSSVDGGTSD CCHHHHHCCCCCCCC	24.97	28348404
110	Phosphorylation	LSSVDGGTSDEIQPL HHCCCCCCCCCCHHH	38.24	28348404
111	Phosphorylation	SSVDGGTSDEIQPLY HCCCCCCCCCCHHHH	36.20	28348404
118	Phosphorylation	SDEIQPLYMGRCSKP CCCCHHHHCCCCCHH	12.28	28674151
123	Phosphorylation	PLYMGRCSKPICDLI HHHCCCCCHHHHHHH	39.85	-
124	Ubiquitination	LYMGRCSKPICDLIS HHCCCCCHHHHHHHH	41.87	29967540
131	Phosphorylation	KPICDLISDMGNLVH HHHHHHHHHHHHHHH	28.92	22199227
140	Phosphorylation	MGNLVHATNSEEDIK HHHHHHHCCCHHHHH	25.13	25849741
142	Phosphorylation	NLVHATNSEEDIKKL HHHHHCCCHHHHHHH	37.70	22199227
148	Ubiquitination	NSEEDIKKLLPDDFK CCHHHHHHHCCHHHH	56.44	33845483
156	Phosphorylation	LLPDDFKSNADSLIG HCCHHHHHCHHHHCC	36.92	29449344
160	Phosphorylation	DFKSNADSLIGLDLS HHHHCHHHHCCCCCC	21.34	21712546
167	Phosphorylation	SLIGLDLSSVSDTPC HHCCCCCCCCCCCCC	28.49	18669648
168	Phosphorylation	LIGLDLSSVSDTPCV HCCCCCCCCCCCCCC	32.70	18669648
170	Phosphorylation	GLDLSSVSDTPCVSS CCCCCCCCCCCCCCC	37.40	18669648
172	Phosphorylation	DLSSVSDTPCVSSTD CCCCCCCCCCCCCCC	15.87	29978859
176	Phosphorylation	VSDTPCVSSTDHDSD CCCCCCCCCCCCCCH	33.95	29449344
177	Phosphorylation	SDTPCVSSTDHDSDT CCCCCCCCCCCCCHH	19.91	29449344
178	Phosphorylation	DTPCVSSTDHDSDTV CCCCCCCCCCCCHHH	29.82	29978859
193	Phosphorylation	REQQNDISSELQNRE HHHHHHHCHHHHHHC	22.18	25159151
194	Phosphorylation	EQQNDISSELQNREI HHHHHHCHHHHHHCC	42.53	29396449
205	Acetylation	NREIGGIKELGIKVD HHCCCCCEECCEEEE	50.60	25953088
205	Ubiquitination	NREIGGIKELGIKVD HHCCCCCEECCEEEE	50.60	23000965
210	Ubiquitination	GIKELGIKVDTTLSD CCEECCEEEECCCCC	32.06	23000965
213	Phosphorylation	ELGIKVDTTLSDSYN ECCEEEECCCCCCCC	32.40	22210691
216	Phosphorylation	IKVDTTLSDSYNYSG EEEECCCCCCCCCCC	23.55	29978859
218	Phosphorylation	VDTTLSDSYNYSGTE EECCCCCCCCCCCCC	16.35	21945579
219	Phosphorylation	DTTLSDSYNYSGTEN ECCCCCCCCCCCCCC	24.10	21945579
221	Phosphorylation	TLSDSYNYSGTENLK CCCCCCCCCCCCCCC	10.55	21945579
222	Phosphorylation	LSDSYNYSGTENLKD CCCCCCCCCCCCCCC	35.28	21945579
224	Phosphorylation	DSYNYSGTENLKDKK CCCCCCCCCCCCCHH	18.76	21945579
228	Acetylation	YSGTENLKDKKIFNQ CCCCCCCCCHHHHHH	78.18	20167786
228	Ubiquitination	YSGTENLKDKKIFNQ CCCCCCCCCHHHHHH	78.18	32015554
253	Phosphorylation	SALTRQSSKMFHAKD HHHHHHHHCCCCCHH	21.57	-
254	Ubiquitination	ALTRQSSKMFHAKDK HHHHHHHCCCCCHHH	51.32	23503661
259	Ubiquitination	SSKMFHAKDKLQHKS HHCCCCCHHHHCCCC	46.99	23503661
261	Ubiquitination	KMFHAKDKLQHKSQP CCCCCHHHHCCCCCC	49.71	23503661
265	Ubiquitination	AKDKLQHKSQPCGLL CHHHHCCCCCCCCCH	37.51	23503661
266	Phosphorylation	KDKLQHKSQPCGLLK HHHHCCCCCCCCCHH	36.91	29083192
295	Ubiquitination	TAAECLKEEGKTSAL EHHHHHHHHCCCCCE	60.06	23000965
298	Ubiquitination	ECLKEEGKTSALTCS HHHHHHCCCCCEEEE	42.45	27667366
305	Phosphorylation	KTSALTCSLPKNEDL CCCCEEEECCCCCCC	42.33	27251275
317	Phosphorylation	EDLCLNDSNSRDENF CCCCCCCCCCCCCCC	35.31	25159151
319	Phosphorylation	LCLNDSNSRDENFKL CCCCCCCCCCCCCCC	45.09	21815630
325	Ubiquitination	NSRDENFKLPDFSFQ CCCCCCCCCCCCCHH	71.36	29967540
330	Phosphorylation	NFKLPDFSFQEDKTV CCCCCCCCHHHCCHH	33.14	21815630
335	Ubiquitination	DFSFQEDKTVIKQSA CCCHHHCCHHHHHHH	43.89	29967540
336	Phosphorylation	FSFQEDKTVIKQSAQ CCHHHCCHHHHHHHC	39.52	29083192
341	Phosphorylation	DKTVIKQSAQEDSKS CCHHHHHHHCCCCCC	27.24	23186163
346	Phosphorylation	KQSAQEDSKSLDLKD HHHHCCCCCCCCCCC	24.32	23186163
346	Ubiquitination	KQSAQEDSKSLDLKD HHHHCCCCCCCCCCC	24.32	23000965
348	Phosphorylation	SAQEDSKSLDLKDND HHCCCCCCCCCCCCC	30.94	28450419
350	Ubiquitination	QEDSKSLDLKDNDVI CCCCCCCCCCCCCCC	59.78	23000965
354	Ubiquitination	KSLDLKDNDVIQDSS CCCCCCCCCCCCCCC	43.81	23000965
355	Ubiquitination	SLDLKDNDVIQDSSS CCCCCCCCCCCCCCC	49.37	23000965
360	Phosphorylation	DNDVIQDSSSALHVS CCCCCCCCCCCEEEC	15.15	28857561
361	Phosphorylation	NDVIQDSSSALHVSS CCCCCCCCCCEEECC	28.11	28857561
362	Phosphorylation	DVIQDSSSALHVSSK CCCCCCCCCEEECCC	38.51	28857561
367	Phosphorylation	SSSALHVSSKDVPSS CCCCEEECCCCCCCC	22.41	28857561
373	Phosphorylation	VSSKDVPSSLSCLPA ECCCCCCCCCCCCCC	43.70	27251275
374	Phosphorylation	SSKDVPSSLSCLPAS CCCCCCCCCCCCCCC	20.45	27251275
376	Phosphorylation	KDVPSSLSCLPASGS CCCCCCCCCCCCCCC	18.63	27251275
381	Phosphorylation	SLSCLPASGSMCGSL CCCCCCCCCCCCHHH	29.48	28348404
383	Phosphorylation	SCLPASGSMCGSLIE CCCCCCCCCCHHHHH	14.38	28348404
387	Phosphorylation	ASGSMCGSLIESKAR CCCCCCHHHHHHHHC	22.65	28348404
390	Ubiquitination	SMCGSLIESKARGDF CCCHHHHHHHHCCCC	52.02	23000965
391	Phosphorylation	MCGSLIESKARGDFL CCHHHHHHHHCCCCC	25.31	-
392	Ubiquitination	CGSLIESKARGDFLP CHHHHHHHHCCCCCC	29.34	32015554
429	Ubiquitination	VLGGEPFKENDLLKQ EECCCCCCCCCHHCH	67.34	21963094
435	Ubiquitination	FKENDLLKQEKCKSI CCCCCHHCHHHHHHH	64.80	33845483
441	Phosphorylation	LKQEKCKSILLQSLI HCHHHHHHHHHHHHH	28.12	28348404
441	Ubiquitination	LKQEKCKSILLQSLI HCHHHHHHHHHHHHH	28.12	23000965
445	Ubiquitination	KCKSILLQSLIEGME HHHHHHHHHHHHCCC	32.52	23000965
446	Phosphorylation	CKSILLQSLIEGMED HHHHHHHHHHHCCCC	31.14	22199227
449	Ubiquitination	ILLQSLIEGMEDRKI HHHHHHHHCCCCCCC	58.75	23000965
450	Ubiquitination	LLQSLIEGMEDRKID HHHHHHHCCCCCCCC	20.13	23000965
455	Ubiquitination	IEGMEDRKIDPDQTV HHCCCCCCCCCCCCE	64.88	22053931
460	Ubiquitination	DRKIDPDQTVIRAES CCCCCCCCCEEEEEE	42.95	22817900
461	Phosphorylation	RKIDPDQTVIRAESL CCCCCCCCEEEEEEC	25.86	28555341
465	Ubiquitination	PDQTVIRAESLDGGD CCCCEEEEEECCCCC	10.29	21963094
515	Phosphorylation	MDGQDLDYFNIDEGA CCCCCCCEEECCCCC	13.06	22817900
524	Ubiquitination	NIDEGAKSGPLISDA ECCCCCCCCCCCCHH	45.14	21963094
529	Phosphorylation	AKSGPLISDAELDAF CCCCCCCCHHHHHHH	38.15	28796482
538	Phosphorylation	AELDAFLTEQYLQTT HHHHHHHHHHHHHHC	18.00	28796482
541	Phosphorylation	DAFLTEQYLQTTNIK HHHHHHHHHHHCCCH	8.44	28796482
544	Phosphorylation	LTEQYLQTTNIKSFE HHHHHHHHCCCHHHH	21.15	28796482
545	Phosphorylation	TEQYLQTTNIKSFEE HHHHHHHCCCHHHHH	23.22	28796482
548	Ubiquitination	YLQTTNIKSFEENVN HHHHCCCHHHHHHCC	51.68	29967540
549	Phosphorylation	LQTTNIKSFEENVND HHHCCCHHHHHHCCC	33.81	25849741
555	Ubiquitination	KSFEENVNDSKSQMN HHHHHHCCCCHHHHH	60.46	22817900
557	Phosphorylation	FEENVNDSKSQMNQI HHHHCCCCHHHHHCC	29.06	21815630
558	Ubiquitination	EENVNDSKSQMNQID HHHCCCCHHHHHCCC	47.79	21906983
558 (in isoform 1)	Ubiquitination	-	47.79	21890473
558 (in isoform 3)	Ubiquitination	-	47.79	21890473
560	Ubiquitination	NVNDSKSQMNQIDMK HCCCCHHHHHCCCCC	38.28	21963094
578	Phosphorylation	DGNINNIYFNAEAGA CCCCCEEEEEECCCC	7.91	27642862
614	Ubiquitination	NGLSLGEKSTIPVQQ CCCCCCCCCCCCCCC	51.61	21906983
614 (in isoform 1)	Ubiquitination	-	51.61	21890473
614 (in isoform 3)	Ubiquitination	-	51.61	21890473
616	Phosphorylation	LSLGEKSTIPVQQGL CCCCCCCCCCCCCCC	40.13	-
626	O-linked_Glycosylation	VQQGLPTSKSEITNQ CCCCCCCCHHHHCCC	32.04	30379171
627	Ubiquitination	QQGLPTSKSEITNQL CCCCCCCHHHHCCCC	55.36	21906983
627 (in isoform 1)	Ubiquitination	-	55.36	21890473
627 (in isoform 3)	Ubiquitination	-	55.36	21890473
635	Phosphorylation	SEITNQLSVSDINSQ HHHCCCCCHHHCCCC	15.15	28857561
643	Phosphorylation	VSDINSQSVGGARPK HHHCCCCCCCCCCCH	23.66	-
650	Ubiquitination	SVGGARPKQLFSLPS CCCCCCCHHHCCCCC	54.82	23000965
650 (in isoform 1)	Ubiquitination	-	54.82	21890473
650 (in isoform 3)	Ubiquitination	-	54.82	21890473
654	Phosphorylation	ARPKQLFSLPSRTRS CCCHHHCCCCCCCCC	48.22	29978859
657	Phosphorylation	KQLFSLPSRTRSSKD HHHCCCCCCCCCCCC	52.13	23882029
659	Phosphorylation	LFSLPSRTRSSKDLN HCCCCCCCCCCCCCC	38.96	23882029
661	Phosphorylation	SLPSRTRSSKDLNKP CCCCCCCCCCCCCCC	40.92	23882029
662	Phosphorylation	LPSRTRSSKDLNKPD CCCCCCCCCCCCCCC	27.22	26074081
740	Ubiquitination	EGLVLGQKQPTWVPD CCEECCCCCCCCCCC	57.35	29967540
789	Phosphorylation	NRKCKLQYLEKEARV CCCCHHHHHHHHCCE	27.54	-
806	Ubiquitination	VCYETISKAQAFERM EEHHHCHHHHHHHHH	40.44	21963094
815	Phosphorylation	QAFERMMSPTGSNLK HHHHHHHCCCCCCCC	15.23	25159151
817	Phosphorylation	FERMMSPTGSNLKSN HHHHHCCCCCCCCCC	46.03	29396449
819	Phosphorylation	RMMSPTGSNLKSNHS HHHCCCCCCCCCCCC	41.28	29396449
830	Phosphorylation	SNHSDECTTVQPPQE CCCCCCCCCCCCCCC	28.14	23312004
831	Phosphorylation	NHSDECTTVQPPQEN CCCCCCCCCCCCCCC	28.89	23312004
840	Phosphorylation	QPPQENQTSSIPSPA CCCCCCCCCCCCCCC	35.70	29978859
841	Phosphorylation	PPQENQTSSIPSPAT CCCCCCCCCCCCCCC	19.26	29978859
842	Phosphorylation	PQENQTSSIPSPATL CCCCCCCCCCCCCCC	41.74	29978859
845	Phosphorylation	NQTSSIPSPATLPVS CCCCCCCCCCCCCHH	26.04	25159151
848	Phosphorylation	SSIPSPATLPVSALK CCCCCCCCCCHHHHC	34.67	29978859
852	Phosphorylation	SPATLPVSALKQPGV CCCCCCHHHHCCCCC	26.41	29978859
855	Ubiquitination	TLPVSALKQPGVEGL CCCHHHHCCCCCCCC	54.91	29967540
865	Ubiquitination	GVEGLCSKEQKRVWF CCCCCCCHHHCEEEE	64.27	32015554
885	Phosphorylation	PNGEVADTTKLSSGS CCCCCCCCEECCCCC	18.98	28102081
886	Phosphorylation	NGEVADTTKLSSGSK CCCCCCCEECCCCCC	30.45	28102081
889	Phosphorylation	VADTTKLSSGSKRCS CCCCEECCCCCCCCC	33.92	28102081
890	Phosphorylation	ADTTKLSSGSKRCSE CCCEECCCCCCCCCC	58.48	28102081
892	Phosphorylation	TTKLSSGSKRCSEDF CEECCCCCCCCCCCC	20.90	26074081
896	Phosphorylation	SSGSKRCSEDFSPLS CCCCCCCCCCCCCCC	44.21	23401153
900	Phosphorylation	KRCSEDFSPLSPDVP CCCCCCCCCCCCCCC	36.93	29255136
903	Phosphorylation	SEDFSPLSPDVPMTV CCCCCCCCCCCCCEE	23.57	29255136
909	Phosphorylation	LSPDVPMTVNTVDHS CCCCCCCEEECCCCC	12.44	25002506
912	Phosphorylation	DVPMTVNTVDHSHST CCCCEEECCCCCCCC	23.99	29255136
916	Phosphorylation	TVNTVDHSHSTTVEK EEECCCCCCCCCEEC	18.05	24144214
918	Phosphorylation	NTVDHSHSTTVEKPN ECCCCCCCCCEECCC	28.87	24144214
919	Phosphorylation	TVDHSHSTTVEKPNN CCCCCCCCCEECCCC	29.45	24144214
920	Phosphorylation	VDHSHSTTVEKPNNE CCCCCCCCEECCCCC	29.68	24144214
928	Phosphorylation	VEKPNNETGDITRNE EECCCCCCCCCCHHH	42.13	23927012
932	Phosphorylation	NNETGDITRNEIIQS CCCCCCCCHHHHHCC	31.98	23927012
939	Phosphorylation	TRNEIIQSPISQVPS CHHHHHCCCHHHCCC	17.50	22167270
942	Phosphorylation	EIIQSPISQVPSVEK HHHCCCHHHCCCCEE	28.63	30266825
946	Phosphorylation	SPISQVPSVEKLSMN CCHHHCCCCEEECCC	44.01	29255136
961	Phosphorylation	TGNEGLPTSGSFTLD CCCCCCCCCCCEECC	51.25	28348404
962	Phosphorylation	GNEGLPTSGSFTLDD CCCCCCCCCCEECCC	30.42	28348404
964	Phosphorylation	EGLPTSGSFTLDDDV CCCCCCCCEECCCCC	18.15	28348404
966	Phosphorylation	LPTSGSFTLDDDVFA CCCCCCEECCCCCCC	30.86	28348404
975	Phosphorylation	DDDVFAETEEPSSPT CCCCCCCCCCCCCCC	42.07	28348404
979	Phosphorylation	FAETEEPSSPTGVLV CCCCCCCCCCCCEEE	52.83	26074081
980	Phosphorylation	AETEEPSSPTGVLVN CCCCCCCCCCCEEEC	36.88	26074081
982	Phosphorylation	TEEPSSPTGVLVNSN CCCCCCCCCEEECCC	41.70	26074081
1006	Ubiquitination	RLLCDINKYVCNKIS EEHHHHHHHHHCHHC	39.12	29967540
1011	Ubiquitination	INKYVCNKISLLPND HHHHHHCHHCCCCCC	28.66	29967540
1029	Phosphorylation	LPPLLVASGEKGSVP CCCEEEECCCCCCCC	39.75	-
1043	Phosphorylation	PVVEEHPSHEQIILL CEEECCCCCCEEEEE	41.38	22468782
1120	Phosphorylation	DIFRLFITIYKDALK HHHHHHHHHHHHHHC	15.77	-
1123	Ubiquitination	RLFITIYKDALKGKY HHHHHHHHHHHCCCC	32.45	33845483
1147	Ubiquitination	TESFLSSKDHGGFLF EHHHHHCCCCCCEEE	50.82	29967540
1156	Phosphorylation	HGGFLFITPTFQKLD CCCEEEECCCCCCCC	14.67	-
1201	Phosphorylation	MLRLGAEYKAYPAPL HHHHCCEEECCCCCC	10.61	22817900
1202	Ubiquitination	LRLGAEYKAYPAPLT HHHCCEEECCCCCCC	32.71	23000965
1204	Phosphorylation	LGAEYKAYPAPLTSI HCCEEECCCCCCCCC	8.86	22817900
1209	Phosphorylation	KAYPAPLTSIRGRKP ECCCCCCCCCCCCCC	22.50	18220336
1210	Phosphorylation	AYPAPLTSIRGRKPL CCCCCCCCCCCCCCC	20.26	18220336
1235	Phosphorylation	LLVDLRNYQYTLHNI HHHHHHHHCCEECCH	9.10	22817900
1237	Phosphorylation	VDLRNYQYTLHNIDQ HHHHHHCCEECCHHH	10.83	22817900
1253	Ubiquitination	LIHMEMGKSCIKIPR HHHHHHCCCCEECCH	40.62	23000965
1257	Neddylation	EMGKSCIKIPRKKYS HHCCCCEECCHHHHH	51.49	32015554
1257	Ubiquitination	EMGKSCIKIPRKKYS HHCCCCEECCHHHHH	51.49	23000965
1257 (in isoform 1)	Ubiquitination	-	51.49	21890473
1261	Ubiquitination	SCIKIPRKKYSDVMK CCEECCHHHHHHHHH	51.19	23000965
1262	Ubiquitination	CIKIPRKKYSDVMKV CEECCHHHHHHHHHH	51.79	23000965
1316	Phosphorylation	TGHPRKVTGASFVVF CCCCCEECCCEEEEE	30.02	25954137
1319	Phosphorylation	PRKVTGASFVVFNGA CCEECCCEEEEECCC	21.66	25954137
1328	Ubiquitination	VVFNGALKTSSGFLA EEECCCEEECCCEEC	45.91	32015554
1329	Phosphorylation	VFNGALKTSSGFLAK EECCCEEECCCEECC	29.04	25954137
1330	Phosphorylation	FNGALKTSSGFLAKS ECCCEEECCCEECCC	27.20	25954137
1331	Phosphorylation	NGALKTSSGFLAKSS CCCEEECCCEECCCC	38.50	25954137
1336	Ubiquitination	TSSGFLAKSSIVEDG ECCCEECCCCEECCC	47.05	21963094
1336 (in isoform 1)	Ubiquitination	-	47.05	21890473
1337	Phosphorylation	SSGFLAKSSIVEDGL CCCEECCCCEECCCE	21.49	25954137
1349	Phosphorylation	DGLMVQITPETMNGL CCEEEEECHHHHCHH	9.66	20068231
1352	Phosphorylation	MVQITPETMNGLRLA EEEECHHHHCHHHHH	19.69	20068231
1367	Ubiquitination	LREQKDFKITCGKVD HHHCCCCEEEECCCC	47.44	33845483
1372	Ubiquitination	DFKITCGKVDAVDLR CCEEEECCCCCCCHH	38.80	21963094
1381	Phosphorylation	DAVDLREYVDICWVD CCCCHHHHEEEEEEE	9.29	27251275
1392	Ubiquitination	CWVDAEEKGNKGVIS EEEECHHHCCCCEEE	60.33	33845483
1395	Ubiquitination	DAEEKGNKGVISSVD ECHHHCCCCEEECCC	64.32	29967540
1413	Ubiquitination	LQGFPSEKIKLEADF CCCCCHHHEEEEECC	49.86	29967540
1430	Phosphorylation	DEKIVKCTEVFYFLK CHHHHHHEEEEEEEC	29.48	28270605
1434	Phosphorylation	VKCTEVFYFLKDQDL HHHEEEEEEECCCCC	17.12	28270605
1442	Phosphorylation	FLKDQDLSILSTSYQ EECCCCCHHEEHHHH	29.76	28270605
1445	Phosphorylation	DQDLSILSTSYQFAK CCCCHHEEHHHHHHH	17.40	28270605
1446	Phosphorylation	QDLSILSTSYQFAKE CCCHHEEHHHHHHHH	28.18	28270605
1447	Phosphorylation	DLSILSTSYQFAKEI CCHHEEHHHHHHHHH	17.35	28270605
1448	Phosphorylation	LSILSTSYQFAKEIA CHHEEHHHHHHHHHH	14.03	28270605
1452	Acetylation	STSYQFAKEIAMACS EHHHHHHHHHHHHHH	51.44	7365123

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZFY16_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZFY16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZFY16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
TOM1_HUMAN	TOM1	physical	14613930
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZFY16_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-939, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-939, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-446; SER-815; SER-845;SER-939 AND SER-946, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-939, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1209 AND SER-1210, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-939 AND SER-946, ANDMASS SPECTROMETRY.	15144186 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-219, AND MASSSPECTROMETRY.	19534553 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-219 AND TYR-221, ANDMASS SPECTROMETRY.	15592455 [Abstract]