GARE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GARE1_HUMAN
• UniProt AC: Q9H706
• Protein Name: GRB2-associated and regulator of MAPK protein 1
• Gene Name: GAREM1
• Organism: Homo sapiens (Human).
• Sequence Length: 876
• Protein Description: Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation..
• Protein Sequence: MDPAPSLGCSLKDVKWSSVAVPLDLLVSTYRLPQIARLDNGECVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYAGQFKLLEQDRDIKEPVQYFNSVEEVAKAFPERVYVMEDITFNVKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHVPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWLEEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPSIPPRTVKPARQQTRSPSPTLSYYSSGLHNISVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQTRSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPRAPKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSKSLRFIGLSEDVISFFVTEKIDGNLLVQLTEEILSEDFKLSKLQVKKIMQFINGWRPKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	EGLRENDYLLIHSCR CCHHHCCEEEEEEEC		-
57	Phosphorylation	NDYLLIHSCRQWTTI CCEEEEEEECCEEEE		-
68	Phosphorylation	WTTITAHSLEEGHYV EEEEEEEECCCCCEE		28152594
74	Phosphorylation	HSLEEGHYVIGPKIE EECCCCCEEECCEEE		26657352
105	Phosphorylation	DIKEPVQYFNSVEEV CCCHHHHHHCCHHHH		19509291
164	Phosphorylation	MGQAEILYAKTFKEK CCHHHHEEEECHHHH		-
167	Phosphorylation	AEILYAKTFKEKSRL HHHEEEECHHHHHHH		-
176	Phosphorylation	KEKSRLNTIFKKIGK HHHHHHHHHHHHHCH		28857561
235	Phosphorylation	QMQEGEHTIRNIVEK HEECCCCHHHHHHHH		29978859
243	Phosphorylation	IRNIVEKTRLPVNVT HHHHHHHHCCCCEEE		-
250	Phosphorylation	TRLPVNVTVPSPPPR HCCCCEEECCCCCCC		-
253	Phosphorylation	PVNVTVPSPPPRNPY CCEEECCCCCCCCCC		26329039
260	Phosphorylation	SPPPRNPYDLHFIRE CCCCCCCCCCEEEEC		-
271	Phosphorylation	FIREGHRYKFVNIQT EEECCCCEEEEECCC		-
302	Phosphorylation	MHFPLHLTVPKFSLP EECCEEEECCCCCCC		24719451
356	Phosphorylation	DWNEECKSPKKGRCS CCCHHCCCCCCCCCC		23663014
363	Phosphorylation	SPKKGRCSGHNHVPN CCCCCCCCCCCCCCC		28555341
380	Phosphorylation	SYARDELTQSFHRLS HHHHHHHHHHHHHEE		28857561
382	Phosphorylation	ARDELTQSFHRLSVC HHHHHHHHHHHEEEE		21722762
399	Phosphorylation	GNNLHGNSEVNLHGC CCCCCCCCCCCCCCC		24719451
449	Phosphorylation	SAGIPGKSELPYEEL HCCCCCCCCCCHHHH		26356563
453	Phosphorylation	PGKSELPYEELWLEE CCCCCCCHHHHHCCC		19509291
471	Phosphorylation	SHQPLTRSLSEKNRC CCCCCCCCHHHHCCH		21722762
473	Phosphorylation	QPLTRSLSEKNRCDQ CCCCCCHHHHCCHHH		25849741
484	Phosphorylation	RCDQFRGSVRSKCAT CHHHHCCCHHHHCCC		26437602
487	Phosphorylation	QFRGSVRSKCATSPL HHCCCHHHHCCCCCC		24719451
491	Phosphorylation	SVRSKCATSPLPIPG CHHHHCCCCCCCCCC		28348404
492	Phosphorylation	VRSKCATSPLPIPGT HHHHCCCCCCCCCCC		25159151
499	Phosphorylation	SPLPIPGTLGAAVKS CCCCCCCCHHHHHCC		22210691
506	Phosphorylation	TLGAAVKSSDTALPP CHHHHHCCCCCCCCC		22210691
507	Phosphorylation	LGAAVKSSDTALPPP HHHHHCCCCCCCCCC		29396449
509	Phosphorylation	AAVKSSDTALPPPPV HHHCCCCCCCCCCCC		29396449
539	Phosphorylation	APPVPPRSAKPLSTS CCCCCCCCCCCCCCC		23186163
544	Phosphorylation	PRSAKPLSTSPSIPP CCCCCCCCCCCCCCC		23186163
545	Phosphorylation	RSAKPLSTSPSIPPR CCCCCCCCCCCCCCC		25159151
546	Phosphorylation	SAKPLSTSPSIPPRT CCCCCCCCCCCCCCC		25159151
548	Phosphorylation	KPLSTSPSIPPRTVK CCCCCCCCCCCCCCC		25159151
561 (in isoform 3)	Phosphorylation	-		22617229
561	Phosphorylation	VKPARQQTRSPSPTL CCCCCCCCCCCCCCC		22496350
563 (in isoform 3)	Phosphorylation	-		23663014
563	Phosphorylation	PARQQTRSPSPTLSY CCCCCCCCCCCCCCH		23663014
565	Phosphorylation	RQQTRSPSPTLSYYS CCCCCCCCCCCCHHC		23663014
565 (in isoform 3)	Phosphorylation	-		25159151
567 (in isoform 3)	Phosphorylation	-		23663014
567	Phosphorylation	QTRSPSPTLSYYSSG CCCCCCCCCCHHCCC		22496350
569 (in isoform 3)	Phosphorylation	-		23090842
569	Phosphorylation	RSPSPTLSYYSSGLH CCCCCCCCHHCCCCC		27080861
570	Phosphorylation	SPSPTLSYYSSGLHN CCCCCCCHHCCCCCE		23312004
570 (in isoform 3)	Phosphorylation	-		23090842
571	Phosphorylation	PSPTLSYYSSGLHNI CCCCCCHHCCCCCEE		23312004
571 (in isoform 3)	Phosphorylation	-		23090842
572 (in isoform 3)	Phosphorylation	-		23090842
572	Phosphorylation	SPTLSYYSSGLHNIS CCCCCHHCCCCCEEE		27080861
573 (in isoform 3)	Phosphorylation	-		23090842
573	Phosphorylation	PTLSYYSSGLHNISV CCCCHHCCCCCEEEE		27080861
591	Phosphorylation	DTNPSESTPVSCYPC CCCCCCCCCCCEEEC		28674419
603	Phosphorylation	YPCNRVKTDSVDLKS EECCCCCCCCCCCCC		23663014
605	Phosphorylation	CNRVKTDSVDLKSPF CCCCCCCCCCCCCCC		23663014
610	Phosphorylation	TDSVDLKSPFGSPSA CCCCCCCCCCCCCCH		23927012
614	Phosphorylation	DLKSPFGSPSAEAVS CCCCCCCCCCHHHHH		19509291
616	Phosphorylation	KSPFGSPSAEAVSSR CCCCCCCCHHHHHHH		23663014
621	Phosphorylation	SPSAEAVSSRLSWPN CCCHHHHHHHCCCCC		23663014
622	Phosphorylation	PSAEAVSSRLSWPNH CCHHHHHHHCCCCCC		23663014
625	Phosphorylation	EAVSSRLSWPNHYSG HHHHHHCCCCCCCCC		23927012
630	Phosphorylation	RLSWPNHYSGASESQ HCCCCCCCCCCCCCC		30576142
631	Phosphorylation	LSWPNHYSGASESQT CCCCCCCCCCCCCCC		30576142
634	Phosphorylation	PNHYSGASESQTRSD CCCCCCCCCCCCCCC		29449344
636	Phosphorylation	HYSGASESQTRSDFL CCCCCCCCCCCCCCC		29449344
638	Phosphorylation	SGASESQTRSDFLLD CCCCCCCCCCCCCCC		29449344
647	Phosphorylation	SDFLLDPSRSYSYPR CCCCCCCCCCCCCCC		21712546
649	Phosphorylation	FLLDPSRSYSYPRQK CCCCCCCCCCCCCCC		21712546
650	Phosphorylation	LLDPSRSYSYPRQKT CCCCCCCCCCCCCCC		-
651	Phosphorylation	LDPSRSYSYPRQKTP CCCCCCCCCCCCCCC		24719451
657	Phosphorylation	YSYPRQKTPGTPKRN CCCCCCCCCCCCCCC		-
660	Phosphorylation	PRQKTPGTPKRNCPA CCCCCCCCCCCCCCC		24719451
681	Phosphorylation	CELLASPTSPVTAEF CEEEECCCCCCEEEE		27251275
682	Phosphorylation	ELLASPTSPVTAEFS EEEECCCCCCEEEEC		27251275
685	Phosphorylation	ASPTSPVTAEFSSSV ECCCCCCEEEECCCC		27251275
698	Phosphorylation	SVSGCPKSASYSLES CCCCCCCCCCEECCC		21722762
700	Phosphorylation	SGCPKSASYSLESTD CCCCCCCCEECCCCC		27794612
701	Phosphorylation	GCPKSASYSLESTDV CCCCCCCEECCCCCH		25159151
702	Phosphorylation	CPKSASYSLESTDVK CCCCCCEECCCCCHH		21722762
705	Phosphorylation	SASYSLESTDVKSLA CCCEECCCCCHHHHH		21722762
719	Phosphorylation	AAGVTKQSTSCPALP HCCCCCCCCCCCCCC		23312004
720	Phosphorylation	AGVTKQSTSCPALPP CCCCCCCCCCCCCCC		23312004
721	Phosphorylation	GVTKQSTSCPALPPR CCCCCCCCCCCCCCC		23312004
739	Phosphorylation	LVEEKVASETSPLPL HHHHHHCCCCCCCCE		23312004
741	Phosphorylation	EEKVASETSPLPLKI HHHHCCCCCCCCEEE		21722762
742	Phosphorylation	EKVASETSPLPLKID HHHCCCCCCCCEEEC		25850435
757	Phosphorylation	GAEEDPKSGSPDLSE CCCCCCCCCCCCCCH		25159151
759	Phosphorylation	EEDPKSGSPDLSEDQ CCCCCCCCCCCCHHH		25159151
763	Phosphorylation	KSGSPDLSEDQYFVK CCCCCCCCHHHHHHH		23312004
767	Phosphorylation	PDLSEDQYFVKKGMQ CCCCHHHHHHHHHHH		21722762
780	Phosphorylation	MQDIFSASYPFSSPL HHHHHHCCCCCCCCE		-
784	Phosphorylation	FSASYPFSSPLHLQL HHCCCCCCCCEEEEE		24719451
785	Phosphorylation	SASYPFSSPLHLQLA HCCCCCCCCEEEEEC		25627689

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GARE1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GARE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GARE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRB2_HUMAN	GRB2	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.