| UniProt ID | PA24F_HUMAN | |
|---|---|---|
| UniProt AC | Q68DD2 | |
| Protein Name | Cytosolic phospholipase A2 zeta | |
| Gene Name | PLA2G4F | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 849 | |
| Subcellular Localization |
Cytoplasm, cytosol. Lysosome membrane Peripheral membrane protein Cytoplasmic side. Translocates to lysosomal membranes in a calcium-dependent fashion.. |
|
| Protein Description | Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity).. | |
| Protein Sequence | MLWALWPRWLADKMLPLLGAVLLQKREKRGPLWRHWRRETYPYYDLQVKVLRATNIRGTDLLSKADCYVQLWLPTASPSPAQTRIVANCSDPEWNETFHYQIHGAVKNVLELTLYDKDILGSDQLSLLLFDLRSLKCGQPHKHTFPLNHQDSQELQVEFVLEKSQVPASEVITNGVLVAHPCLRIQGTLRGDGTAPREEYGSRQLQLAVPGAYEKPQLLPLQPPTEPGLPPTFTFHVNPVLSSRLHVELMELLAAVQSGPSAELEAQTSKLGEGGILLSSLPLGQEEQCSVALGEGQEVALSMKVEMSSGDLDLRLGFDLSDGEQEFLDRRKQVVSKALQQVLGLSEALDSGQVPVVAVLGSGGGTRAMSSLYGSLAGLQELGLLDTVTYLSGVSGSTWCISTLYRDPAWSQVALQGPIERAQVHVCSSKMGALSTERLQYYTQELGVRERSGHSVSLIDLWGLLVEYLLYQEENPAKLSDQQEAVRQGQNPYPIYTSVNVRTNLSGEDFAEWCEFTPYEVGFPKYGAYVPTELFGSELFMGRLLQLQPEPRICYLQGMWGSAFATSLDEIFLKTAGSGLSFLEWYRGSVNITDDCQKPQLHNPSRLRTRLLTPQGPFSQAVLDIFTSRFTSAQSFNFTRGLCLHKDYVAGREFVAWKDTHPDAFPNQLTPMRDCLYLVDGGFAINSPFPLALLPQRAVDLILSFDYSLEAPFEVLKMTEKYCLDRGIPFPSIEVGPEDMEEARECYLFAKAEDPRSPIVLHFPLVNRTFRTHLAPGVERQTAEEKAFGDFVINRPDTPYGMMNFTYEPQDFYRLVALSRYNVLNNVETLKCALQLALDRHQARERAGA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 188 | Phosphorylation | PCLRIQGTLRGDGTA CEEEEECEECCCCCC | 9.26 | - | |
| 243 | Phosphorylation | HVNPVLSSRLHVELM ECCCCCCCHHHHHHH | 34.40 | 24719451 | |
| 336 | Phosphorylation | DRRKQVVSKALQQVL HHHHHHHHHHHHHHH | 17.23 | - | |
| 362 | Phosphorylation | PVVAVLGSGGGTRAM CEEEEEECCCHHHHH | 30.06 | - | |
| 366 | Phosphorylation | VLGSGGGTRAMSSLY EEECCCHHHHHHHHH | 20.66 | - | |
| 605 | Phosphorylation | KPQLHNPSRLRTRLL CCCCCCHHHHHHHCC | 49.63 | 24719451 | |
| 613 | Phosphorylation | RLRTRLLTPQGPFSQ HHHHHCCCCCCCHHH | 20.39 | 24719451 | |
| 619 | Phosphorylation | LTPQGPFSQAVLDIF CCCCCCHHHHHHHHH | 21.99 | 18452278 | |
| 627 | Phosphorylation | QAVLDIFTSRFTSAQ HHHHHHHHHCCCCCC | 21.23 | 18452278 | |
| 628 | Phosphorylation | AVLDIFTSRFTSAQS HHHHHHHHCCCCCCC | 18.04 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PA24F_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PA24F_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PA24F_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PA24F_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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