T22D1_HUMAN - dbPTM
T22D1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID T22D1_HUMAN
UniProt AC Q15714
Protein Name TSC22 domain family protein 1
Gene Name TSC22D1
Organism Homo sapiens (Human).
Sequence Length 1073
Subcellular Localization Cytoplasm. Nucleus.
Protein Description Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter..
Protein Sequence MHQPPESTAAAAAAADISARKMAHPAMFPRRGSGSGSASALNAAGTGVGSNATSSEDFPPPSLLQPPPPAASSTSGPQPPPPQSLNLLSQAQLQAQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHQIHHGHHLQHGHHHPSHVAVASASITGGPPSSPVSRKLSTTGSSDSITPVAPTSAVSSSGSPASVMTNMRAPSTTGGIGINSVTGTSTVNNVNITAVGSFNPNVTSSMLGNVNISTSNIPSAAGVSVGPGVTSGVNVNILSGMGNGTISSSAAVSSVPNAAAGMTGGSVSSQQQQPTVNTSRFRVVKLDSSSEPFKKGRWTCTEFYEKENAVPATEGVLINKVVETVKQNPIEVTSERESTSGSSVSSSVSTLSHYTESVGSGEMGAPTVVVQQQQQQQQQQQQQPALQGVTLQQMDFGSTGPQSIPAVSIPQSISQSQISQVQLQSQELSYQQKQGLQPVPLQATMSAATGIQPSPVNVVGVTSALGQQPSISSLAQPQLPYSQAAPPVQTPLPGAPPPQQLQYGQQQPMVSTQMAPGHVKSVTQNPASEYVQQQPILQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPVQPTAVPAQPAGASVQPVGQAPAAVSAVPTGSQIANIGQQANIPTAVQQPSTQVPPSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSLLTVPPQPQGVEPVAQGIVSQQLPAVSSLPSASSISVTSQVSSTGPSGMPSAPTNLVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIPLSSTQFSAQSLAQAIGSQIEDARRAAEPSLVGLPQTISGDSGGMSAVSDGSSSSLAASASLFPLKVLPLTTPLVDGEDESSSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPPAQPASQGSGPTA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22 (in isoform 2)Phosphorylation-3.2726657352
24 (in isoform 2)Phosphorylation-13.7324719451
42 (in isoform 2)Phosphorylation-27.7121815630
43 (in isoform 2)Phosphorylation-14.2320068231
44 (in isoform 2)Phosphorylation-18.2720068231
47 (in isoform 2)Phosphorylation-22.3721815630
54 (in isoform 2)Ubiquitination-29.3521890473
63 (in isoform 2)Ubiquitination-6.7621890473
64 (in isoform 2)Phosphorylation-9.3620068231
68 (in isoform 2)Phosphorylation-37.5320068231
78 (in isoform 2)Ubiquitination-67.6621890473
87 (in isoform 2)Ubiquitination-6.2121890473
160PhosphorylationEILDVSLSRATDLGE
HHEEHHHHHCCCCCC		16.6224719451
256PhosphorylationITGGPPSSPVSRKLS
CCCCCCCCCCCCCCC		34.79-
263PhosphorylationSPVSRKLSTTGSSDS
CCCCCCCCCCCCCCC		27.2723927012
264PhosphorylationPVSRKLSTTGSSDSI
CCCCCCCCCCCCCCC		45.6828450419
265PhosphorylationVSRKLSTTGSSDSIT
CCCCCCCCCCCCCCC		31.5226657352
267PhosphorylationRKLSTTGSSDSITPV
CCCCCCCCCCCCCCC		28.9623403867
268PhosphorylationKLSTTGSSDSITPVA
CCCCCCCCCCCCCCC		36.4023403867
270PhosphorylationSTTGSSDSITPVAPT
CCCCCCCCCCCCCCC		30.2428464451
272PhosphorylationTGSSDSITPVAPTSA
CCCCCCCCCCCCCCC		18.7028464451
277PhosphorylationSITPVAPTSAVSSSG
CCCCCCCCCCCCCCC		21.4123927012
278PhosphorylationITPVAPTSAVSSSGS
CCCCCCCCCCCCCCC		26.1323927012
281PhosphorylationVAPTSAVSSSGSPAS
CCCCCCCCCCCCCCH		20.6428450419
282PhosphorylationAPTSAVSSSGSPASV
CCCCCCCCCCCCCHH		31.9228450419
283PhosphorylationPTSAVSSSGSPASVM
CCCCCCCCCCCCHHH		35.4728450419
285PhosphorylationSAVSSSGSPASVMTN
CCCCCCCCCCHHHCC		21.1728450419
288PhosphorylationSSSGSPASVMTNMRA
CCCCCCCHHHCCCCC		18.79-
291PhosphorylationGSPASVMTNMRAPST
CCCCHHHCCCCCCCC		24.5722210691
414PhosphorylationFRVVKLDSSSEPFKK
EEEEEECCCCCCHHC		46.3225106551
415PhosphorylationRVVKLDSSSEPFKKG
EEEEECCCCCCHHCC		38.0925850435
416PhosphorylationVVKLDSSSEPFKKGR
EEEECCCCCCHHCCC		53.9227251275
439O-linked_GlycosylationKENAVPATEGVLINK
HCCCCCCCCCCEEHH		27.4828657654
459O-linked_GlycosylationKQNPIEVTSERESTS
HHCCCEEECCCCCCC		16.4528657654
823O-linked_GlycosylationQQLPAVSSLPSASSI
CCCCCCCCCCCCCCE		37.3928657654
936PhosphorylationSGDSGGMSAVSDGSS
CCCCCCCCCCCCCCC		28.88-
983UbiquitinationSVVAIDNKIEQAMDL
EEEEECHHHHHHHHH		43.82-
988SulfoxidationDNKIEQAMDLVKSHL
CHHHHHHHHHHHHHH		4.0130846556
992 (in isoform 3)Ubiquitination-39.1821890473
992 (in isoform 1)Ubiquitination-39.1821890473
992UbiquitinationEQAMDLVKSHLMYAV
HHHHHHHHHHHHHHH		39.1821890473
992UbiquitinationEQAMDLVKSHLMYAV
HHHHHHHHHHHHHHH		39.18-
993PhosphorylationQAMDLVKSHLMYAVR
HHHHHHHHHHHHHHH		17.8620068231
997PhosphorylationLVKSHLMYAVREEVE
HHHHHHHHHHHHHHH		14.3320068231
1007 (in isoform 3)Ubiquitination-53.3921890473
1007 (in isoform 1)Ubiquitination-53.3921890473
1007UbiquitinationREEVEVLKEQIKELI
HHHHHHHHHHHHHHH		53.39-
1011UbiquitinationEVLKEQIKELIEKNS
HHHHHHHHHHHHHCH		46.27-
1016UbiquitinationQIKELIEKNSQLEQE
HHHHHHHHCHHHHHH		55.712190698
1016 (in isoform 3)Ubiquitination-55.7121890473
1016 (in isoform 1)Ubiquitination-55.7121890473
1018PhosphorylationKELIEKNSQLEQENN
HHHHHHCHHHHHHHH		47.40-
1028UbiquitinationEQENNLLKTLASPEQ
HHHHHHHHHHCCHHH		44.66-
1045PhosphorylationQFQAQLQTGSPPATT
HHHHHHHCCCCCCCC		48.4925159151
1047PhosphorylationQAQLQTGSPPATTQP
HHHHHCCCCCCCCCC		30.9725159151
1051PhosphorylationQTGSPPATTQPQGTT
HCCCCCCCCCCCCCC		31.5725159151
1052PhosphorylationTGSPPATTQPQGTTQ
CCCCCCCCCCCCCCC		40.1225159151
1057PhosphorylationATTQPQGTTQPPAQP
CCCCCCCCCCCCCCC		19.6025159151
1058PhosphorylationTTQPQGTTQPPAQPA
CCCCCCCCCCCCCCC		46.0029496963
1066PhosphorylationQPPAQPASQGSGPTA
CCCCCCCCCCCCCCC		41.5826852163
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of T22D1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of T22D1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of T22D1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GSTK1_HUMANGSTK1physical
17353931
DYHC1_HUMANDYNC1H1physical
17353931
EPIPL_HUMANEPPK1physical
17353931
BAG6_HUMANBAG6physical
17353931
METH_HUMANMTRphysical
17353931
DAAF5_HUMANDNAAF5physical
17353931
GCN1_HUMANGCN1L1physical
17353931
NDUA9_HUMANNDUFA9physical
17353931
SYIC_HUMANIARSphysical
17353931
NRBP_HUMANNRBP1physical
17353931
NUP93_HUMANNUP93physical
17353931
CDK2_HUMANCDK2physical
17353931
GHC1_HUMANSLC25A22physical
17353931
HNRPM_HUMANHNRNPMphysical
17353931
EMC1_HUMANEMC1physical
17353931
SFXN1_HUMANSFXN1physical
17353931
RFA3_HUMANRPA3physical
17353931
COPB2_HUMANCOPB2physical
17353931
SRPRB_HUMANSRPRBphysical
17353931
COR2B_HUMANCORO2Bphysical
16169070
CC90B_HUMANCCDC90Bphysical
16169070
APLP1_HUMANAPLP1physical
16169070
M3K12_HUMANMAP3K12physical
16169070
T22D1_HUMANTSC22D1physical
16169070
SETB1_HUMANSETDB1physical
16169070
NKP1_YEASTNKP1physical
18355271
ERG6_YEASTERG6physical
18355271
TGFR1_HUMANTGFBR1physical
21791611
SMAD7_HUMANSMAD7physical
21791611
SPRE1_HUMANSPRED1physical
21900206
A2MG_HUMANA2Mphysical
21900206
SP110_HUMANSP110physical
21900206
CC90B_HUMANCCDC90Bphysical
21900206
EED_HUMANEEDphysical
21900206
GBB2_HUMANGNB2physical
21900206
RL5_HUMANRPL5physical
21900206
HMGX4_HUMANHMGXB4physical
21900206
FBN3_HUMANFBN3physical
21900206
U119A_HUMANUNC119physical
21900206
APLP1_HUMANAPLP1physical
21900206
OTUB1_HUMANOTUB1physical
21900206
GANP_HUMANMCM3APphysical
21900206
ERG28_HUMANC14orf1physical
21900206
GNB5_HUMANGNB5physical
21900206
FA20C_HUMANFAM20Cphysical
21900206
T22D1_HUMANTSC22D1physical
21900206
KPCI_HUMANPRKCIphysical
21900206
DNM3B_HUMANDNMT3Bphysical
21900206
WIZ_HUMANWIZphysical
21900206
TAF5L_HUMANTAF5Lphysical
21900206
UB2D1_HUMANUBE2D1physical
21900206
LRIF1_HUMANLRIF1physical
21900206
SACA9_HUMANC9orf9physical
21900206
VIME_HUMANVIMphysical
21900206
KMT2C_HUMANKMT2Cphysical
21900206
ODPB_HUMANPDHBphysical
21900206
DDAH2_HUMANDDAH2physical
21900206
CHSP1_HUMANCARHSP1physical
21900206
CHD3_HUMANCHD3physical
21900206
SYQ_HUMANQARSphysical
21900206
WDR73_HUMANWDR73physical
21900206
KMT2B_HUMANKMT2Bphysical
21900206
TLE1_HUMANTLE1physical
21900206
DPYL1_HUMANCRMP1physical
21900206
NCOA5_HUMANNCOA5physical
21900206
NIPA_HUMANZC3HC1physical
21900206
FAF1_HUMANFAF1physical
21900206
SETB1_HUMANSETDB1physical
21900206
P53_HUMANTP53physical
22870275
LARP7_HUMANLARP7physical
22863883
TTI1_HUMANTTI1physical
22863883
NTAQ1_HUMANWDYHV1physical
25416956
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of T22D1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263, AND MASSSPECTROMETRY.

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