SACA9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SACA9_HUMAN
• UniProt AC: Q96E40
• Protein Name: Sperm acrosome-associated protein 9
• Gene Name: SPACA9 {ECO:0000312|HGNC:HGNC:1367}
• Organism: Homo sapiens (Human).
• Sequence Length: 222
• Subcellular Localization: Cytoplasm . Cytoplasmic vesicle, secretory vesicle, acrosome . In caudal sperms localizes onto sperm head. Is also present on midpiece and principle piece of sperm tails. Acrosome and sperm tail localization is regulated by Y-chromosome.
• Protein Sequence: MNEVKESLRSIEQKYKLFQQQQLTFTAALEHCRENAHDKIRPISSIGQVQSYMEHYCNSSTDRRVLLMFLDICSELNKLCQHFEAVHSGTPVTNNLLEKCKTLVSQSNDLSSLRAKYPHDVVNHLSCDEARNHYGGVVSLIPLILDLMKEWIAHSEKLPRKVLQHVSEPQAHQESTRGAARPAQAIGTQPRATKHKCRQLTKASLKPRGCSKPPWRPPGGKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MNEVKESLRSIE ---CHHHHHHHHHHH		25038526
5	Ubiquitination	---MNEVKESLRSIE ---CHHHHHHHHHHH		-
44	Phosphorylation	HDKIRPISSIGQVQS CCCCCCCCHHHHHHH		25693802
45	Phosphorylation	DKIRPISSIGQVQSY CCCCCCCHHHHHHHH		25693802
88	Phosphorylation	QHFEAVHSGTPVTNN HHHHHHHCCCCCCHH		25693802
90	Phosphorylation	FEAVHSGTPVTNNLL HHHHHCCCCCCHHHH		25693802
93	Phosphorylation	VHSGTPVTNNLLEKC HHCCCCCCHHHHHHH		25693802
99	Acetylation	VTNNLLEKCKTLVSQ CCHHHHHHHHHHHHC		25038526
99	Ubiquitination	VTNNLLEKCKTLVSQ CCHHHHHHHHHHHHC		-
102	Phosphorylation	NLLEKCKTLVSQSND HHHHHHHHHHHCCCC		29083192
105	Phosphorylation	EKCKTLVSQSNDLSS HHHHHHHHCCCCHHH		29083192
107	Phosphorylation	CKTLVSQSNDLSSLR HHHHHHCCCCHHHHH		30622161
111	Phosphorylation	VSQSNDLSSLRAKYP HHCCCCHHHHHHHCC		30301811
112	Phosphorylation	SQSNDLSSLRAKYPH HCCCCHHHHHHHCCH		25954137
116	Acetylation	DLSSLRAKYPHDVVN CHHHHHHHCCHHHHH		25038526
116	Ubiquitination	DLSSLRAKYPHDVVN CHHHHHHHCCHHHHH		-
201	Phosphorylation	KHKCRQLTKASLKPR HHHHHHHHHCCCCCC		28122231
204	Phosphorylation	CRQLTKASLKPRGCS HHHHHHCCCCCCCCC		29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SACA9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SACA9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SACA9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
MUCL1_HUMAN	MUCL1	physical	26186194
NXN_HUMAN	NXN	physical	26186194
RIOX2_HUMAN	MINA	physical	26186194
RIOX2_HUMAN	MINA	physical	28514442
MUCL1_HUMAN	MUCL1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.