RIOX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIOX2_HUMAN
• UniProt AC: Q8IUF8
• Protein Name: Ribosomal oxygenase 2 {ECO:0000312|HGNC:HGNC:19441}
• Gene Name: RIOX2 {ECO:0000312|HGNC:HGNC:19441}
• Organism: Homo sapiens (Human).
• Sequence Length: 465
• Subcellular Localization: Nucleus . Nucleus, nucleolus .
• Protein Description: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles..
• Protein Sequence: MPKKAKPTGSGKEEGPAPCKQMKLEAAGGPSALNFDSPSSLFESLISPIKTETFFKEFWEQKPLLIQRDDPALATYYGSLFKLTDLKSLCSRGMYYGRDVNVCRCVNGKKKVLNKDGKAHFLQLRKDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGSQGLPPHYDDVEVFILQLEGEKHWRLYHPTVPLAREYSVEAEERIGRPVHEFMLKPGDLLYFPRGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISGLVFDTAKEDVELRTGIPRQLLLQVESTTVATRRLSGFLRTLADRLEGTKELLSSDMKKDFIMHRLPPYSAGDGAELSTPGGKLPRLDSVVRLQFKDHIVLTVLPDQDQSDEAQEKMVYIYHSLKNSRETHMMGNEEETEFHGLRFPLSHLDALKQIWNSPAISVKDLKLTTDEEKESLVLSLWTECLIQVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MPKKAKPTGSGKEEG CCCCCCCCCCCCCCC		25002506
10	Phosphorylation	KKAKPTGSGKEEGPA CCCCCCCCCCCCCCC		25002506
12	Acetylation	AKPTGSGKEEGPAPC CCCCCCCCCCCCCCH		23749302
20	Acetylation	EEGPAPCKQMKLEAA CCCCCCHHHCEEEEC		23749302
39	Phosphorylation	ALNFDSPSSLFESLI CCCCCCHHHHHHHHH		27251275
40	Phosphorylation	LNFDSPSSLFESLIS CCCCCHHHHHHHHHC		27251275
44	Phosphorylation	SPSSLFESLISPIKT CHHHHHHHHHCCCCC		26434776
47	Phosphorylation	SLFESLISPIKTETF HHHHHHHCCCCCHHH		29496963
50	Sumoylation	ESLISPIKTETFFKE HHHHCCCCCHHHHHH		-
51	Phosphorylation	SLISPIKTETFFKEF HHHCCCCCHHHHHHH		26434776
53	Phosphorylation	ISPIKTETFFKEFWE HCCCCCHHHHHHHHH		26434776
56	Ubiquitination	IKTETFFKEFWEQKP CCCHHHHHHHHHHCC		-
62	Ubiquitination	FKEFWEQKPLLIQRD HHHHHHHCCEEEECC		-
76	Phosphorylation	DDPALATYYGSLFKL CCHHHHHHHHHHHHH		22817900
77	Phosphorylation	DPALATYYGSLFKLT CHHHHHHHHHHHHHH		22817900
77 (in isoform 3)	Ubiquitination	-		21906983
79	Phosphorylation	ALATYYGSLFKLTDL HHHHHHHHHHHHHCH		24719451
82	Ubiquitination	TYYGSLFKLTDLKSL HHHHHHHHHHCHHHH		-
82	Methylation	TYYGSLFKLTDLKSL HHHHHHHHHHCHHHH		115973029
87	Ubiquitination	LFKLTDLKSLCSRGM HHHHHCHHHHHHCCC		-
87	Methylation	LFKLTDLKSLCSRGM HHHHHCHHHHHHCCC		30785459
87	Acetylation	LFKLTDLKSLCSRGM HHHHHCHHHHHHCCC		25953088
95	Phosphorylation	SLCSRGMYYGRDVNV HHHHCCCCCCCCCCE		22817900
102 (in isoform 3)	Ubiquitination	-		21906983
118	Ubiquitination	KVLNKDGKAHFLQLR EEECCCCCEEEEEEH		-
144	Ubiquitination	FHQPQRFKDELWRIQ ECCCHHHHHHHHHHH		-
185 (in isoform 3)	Ubiquitination	-		21906983
188 (in isoform 3)	Ubiquitination	-		21906983
210	Phosphorylation	VPLAREYSVEAEERI CCCCCCCCHHHHHHH		24719451
238 (in isoform 2)	Phosphorylation	-		22210691
244 (in isoform 2)	Phosphorylation	-		22210691
257 (in isoform 2)	Phosphorylation	-		22210691
299 (in isoform 4)	Phosphorylation	-		25690035
300 (in isoform 4)	Phosphorylation	-		25690035
300	Phosphorylation	QLLLQVESTTVATRR HHEEEEEECHHHHHH		26434776
301 (in isoform 4)	Phosphorylation	-		25690035
301	Phosphorylation	LLLQVESTTVATRRL HEEEEEECHHHHHHH		26434776
302	Phosphorylation	LLQVESTTVATRRLS EEEEEECHHHHHHHH		26434776
309	Phosphorylation	TVATRRLSGFLRTLA HHHHHHHHHHHHHHH		19502796
318	Methylation	FLRTLADRLEGTKEL HHHHHHHHHHHHHHH		115483291
323	Ubiquitination	ADRLEGTKELLSSDM HHHHHHHHHHHCCHH		-
327	O-linked_Glycosylation	EGTKELLSSDMKKDF HHHHHHHCCHHCHHC		30379171
327	Phosphorylation	EGTKELLSSDMKKDF HHHHHHHCCHHCHHC		20068231
328	Phosphorylation	GTKELLSSDMKKDFI HHHHHHCCHHCHHCH		20068231
331	Ubiquitination	ELLSSDMKKDFIMHR HHHCCHHCHHCHHHC		21906983
331 (in isoform 1)	Ubiquitination	-		21906983
332	Ubiquitination	LLSSDMKKDFIMHRL HHCCHHCHHCHHHCC		-
332	Acetylation	LLSSDMKKDFIMHRL HHCCHHCHHCHHHCC		24889819
342	Phosphorylation	IMHRLPPYSAGDGAE HHHCCCCCCCCCCCC		20068231
343	Phosphorylation	MHRLPPYSAGDGAEL HHCCCCCCCCCCCCC		20068231
351	Phosphorylation	AGDGAELSTPGGKLP CCCCCCCCCCCCCCC		20068231
352	Phosphorylation	GDGAELSTPGGKLPR CCCCCCCCCCCCCCC		20068231
356 (in isoform 1)	Ubiquitination	-		21906983
356	Ubiquitination	ELSTPGGKLPRLDSV CCCCCCCCCCCCCCE		21906983
356	Acetylation	ELSTPGGKLPRLDSV CCCCCCCCCCCCCCE		23749302
369	Ubiquitination	SVVRLQFKDHIVLTV CEEEEEECCEEEEEE		-
428	Ubiquitination	LSHLDALKQIWNSPA HHHHHHHHHHHCCCC		-
439 (in isoform 1)	Ubiquitination	-		21906983
439	Ubiquitination	NSPAISVKDLKLTTD CCCCCCHHHCCCCCC		21906983
442 (in isoform 1)	Ubiquitination	-		21906983
442	Ubiquitination	AISVKDLKLTTDEEK CCCHHHCCCCCCHHH		2190698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIOX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIOX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIOX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIOX2_HUMAN	MINA	physical	16189514
A4_HUMAN	APP	physical	21832049
NAA16_HUMAN	NAA16	physical	22939629
TXNL1_HUMAN	TXNL1	physical	22939629
RIOX2_HUMAN	MINA	physical	25416956
EXOC7_HUMAN	EXOC7	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.