GHC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GHC1_HUMAN
• UniProt AC: Q9H936
• Protein Name: Mitochondrial glutamate carrier 1
• Gene Name: SLC25A22
• Organism: Homo sapiens (Human).
• Sequence Length: 323
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+)..
• Protein Sequence: MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQDPQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Acetylation	----MADKQISLPAK ----CCCCCCCCCHH	39.74	25953088
48	Phosphorylation	NGQRVYTSMSDCLIK CCCEEEECHHHHHHH	9.90	28857561
55	Ubiquitination	SMSDCLIKTVRSEGY CHHHHHHHHHHHCCC	28.19	21890473
55	Ubiquitination	SMSDCLIKTVRSEGY CHHHHHHHHHHHCCC	28.19	21890473
59	Phosphorylation	CLIKTVRSEGYFGMY HHHHHHHHCCCCCEE	30.91	21406692
62	Phosphorylation	KTVRSEGYFGMYRGA HHHHHCCCCCEECCC	7.91	21406692
66	Phosphorylation	SEGYFGMYRGAAVNL HCCCCCEECCCEEEE	13.28	21406692
80	Ubiquitination	LTLVTPEKAIKLAAN EEEECHHHHHHHHHH	57.52	22817900
83	Ubiquitination	VTPEKAIKLAANDFF ECHHHHHHHHHHHHH	36.61	21890473
83	Ubiquitination	VTPEKAIKLAANDFF ECHHHHHHHHHHHHH	36.61	21890473
96	Ubiquitination	FFRHQLSKDGQKLTL HHHHHCCCCCHHHHH	74.58	21890473
100	Ubiquitination	QLSKDGQKLTLLKEM HCCCCCHHHHHHHHH	49.31	21890473
100	2-Hydroxyisobutyrylation	QLSKDGQKLTLLKEM HCCCCCHHHHHHHHH	49.31	-
105	Ubiquitination	GQKLTLLKEMLAGCG CHHHHHHHHHHCCCC	44.16	22817900
142	Ubiquitination	GRIAAQRKILAAQGQ HHHHHHHHHHHHHCC	29.96	21890473
188	Ubiquitination	RGIAGLYKGLGATLL CCCHHHHHCCCCHHH	53.34	21890473
264	Phosphorylation	QRGVNEDTYSGILDC HHCCCCCHHHHHHHH	17.26	20068231
265	Phosphorylation	RGVNEDTYSGILDCA HCCCCCHHHHHHHHH	19.74	20068231
266	Phosphorylation	GVNEDTYSGILDCAR CCCCCHHHHHHHHHH	22.81	20068231
286	Ubiquitination	EGPSAFLKGAYCRAL CCCCHHHCHHHHHHH	34.73	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GHC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GHC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GHC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AT1A3_HUMAN	ATP1A3	physical	26186194
GHC2_HUMAN	SLC25A18	physical	26186194
WDTC1_HUMAN	WDTC1	physical	26186194
DNLZ_HUMAN	DNLZ	physical	26186194
GHC2_HUMAN	SLC25A18	physical	28514442
WDTC1_HUMAN	WDTC1	physical	28514442
DNLZ_HUMAN	DNLZ	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00606: Early infantile epileptic encephalopathy; Ohtahara syndrome
• OMIM Disease
• 609304: Epileptic encephalopathy, early infantile, 3 (EIEE3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.