AT1A3_HUMAN - dbPTM
AT1A3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AT1A3_HUMAN
UniProt AC P13637
Protein Name Sodium/potassium-transporting ATPase subunit alpha-3
Gene Name ATP1A3
Organism Homo sapiens (Human).
Sequence Length 1013
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients..
Protein Sequence MGDKKDDKDSPKKNKGKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6 (in isoform 3)Phosphorylation-74.1425850435
8 (in isoform 3)Phosphorylation-70.9525850435
9 (in isoform 3)Phosphorylation-76.7325850435
10PhosphorylationDKKDDKDSPKKNKGK
CCCCCCCCCCCCCCC		44.3428985074
37PhosphorylationAMTEHKMSVEEVCRK
HHHHHCCCHHHHHHH		31.0525332170
45PhosphorylationVEEVCRKYNTDCVQG
HHHHHHHHCCCCCCC		12.1627732954
56PhosphorylationCVQGLTHSKAQEILA
CCCCCCHHHHHHHHH		25.1725332170
57UbiquitinationVQGLTHSKAQEILAR
CCCCCHHHHHHHHHC		46.62-
71PhosphorylationRDGPNALTPPPTTPE
CCCCCCCCCCCCCHH		31.19-
139PhosphorylationITGCFSYYQEAKSSK
HHHHCHHHHHHHHHH		9.93-
144PhosphorylationSYYQEAKSSKIMESF
HHHHHHHHHHHHHHH		43.8628152594
145PhosphorylationYYQEAKSSKIMESFK
HHHHHHHHHHHHHHH		26.0428152594
146UbiquitinationYQEAKSSKIMESFKN
HHHHHHHHHHHHHHH		53.8421890473
150PhosphorylationKSSKIMESFKNMVPQ
HHHHHHHHHHHCCCC		24.9228152594
152UbiquitinationSKIMESFKNMVPQQA
HHHHHHHHHCCCCCE		54.1121890473
152UbiquitinationSKIMESFKNMVPQQA
HHHHHHHHHCCCCCE		54.1121890473
152UbiquitinationSKIMESFKNMVPQQA
HHHHHHHHHCCCCCE		54.1121890473
197PhosphorylationPADLRIISAHGCKVD
CCCEEEEEECCCEEC		16.3129523821
202UbiquitinationIISAHGCKVDNSSLT
EEEECCCEECCCCCC		58.16-
206PhosphorylationHGCKVDNSSLTGESE
CCCEECCCCCCCCCC		23.4323401153
207PhosphorylationGCKVDNSSLTGESEP
CCEECCCCCCCCCCC		35.8823927012
209PhosphorylationKVDNSSLTGESEPQT
EECCCCCCCCCCCCC		40.6323927012
212PhosphorylationNSSLTGESEPQTRSP
CCCCCCCCCCCCCCC		56.7923927012
216PhosphorylationTGESEPQTRSPDCTH
CCCCCCCCCCCCCCC		43.7818510355
218PhosphorylationESEPQTRSPDCTHDN
CCCCCCCCCCCCCCC		28.6024076635
222PhosphorylationQTRSPDCTHDNPLET
CCCCCCCCCCCCCCC		39.3824076635
265PhosphorylationGRIATLASGLEVGKT
HHHHHHHHCCCCCCC		47.2021082442
349UbiquitinationARKNCLVKNLEAVET
HHCCCEECCHHHHHH		42.7521890473
349UbiquitinationARKNCLVKNLEAVET
HHCCCEECCHHHHHH		42.7521890473
349UbiquitinationARKNCLVKNLEAVET
HHCCCEECCHHHHHH		42.7521890473
359PhosphorylationEAVETLGSTSTICSD
HHHHHHCCCCCCCCC		23.4628857561
360PhosphorylationAVETLGSTSTICSDK
HHHHHCCCCCCCCCC		28.2628857561
361PhosphorylationVETLGSTSTICSDKT
HHHHCCCCCCCCCCC		19.9228857561
362PhosphorylationETLGSTSTICSDKTG
HHHCCCCCCCCCCCC		26.5428857561
365PhosphorylationGSTSTICSDKTGTLT
CCCCCCCCCCCCCCC		37.9928857561
367UbiquitinationTSTICSDKTGTLTQN
CCCCCCCCCCCCCCC		32.3421890473
368PhosphorylationSTICSDKTGTLTQNR
CCCCCCCCCCCCCCC		40.1528857561
370PhosphorylationICSDKTGTLTQNRMT
CCCCCCCCCCCCCEE		31.6828857561
372PhosphorylationSDKTGTLTQNRMTVA
CCCCCCCCCCCEEEE		24.5228857561
434UbiquitinationQDNIPVLKRDVAGDA
CCCCCEECCCCCCCC		46.95-
442PhosphorylationRDVAGDASESALLKC
CCCCCCCCHHHHHHH		36.5024076635
444PhosphorylationVAGDASESALLKCIE
CCCCCCHHHHHHHHH		23.0125332170
448UbiquitinationASESALLKCIELSSG
CCHHHHHHHHHHCCC		33.73-
458UbiquitinationELSSGSVKLMRERNK
HHCCCCHHHHHHHCC		37.96-
466AcetylationLMRERNKKVAEIPFN
HHHHHCCCEEECCCC		50.677465817
478PhosphorylationPFNSTNKYQLSIHET
CCCCCCCEEEEEEEC		19.4329083192
481PhosphorylationSTNKYQLSIHETEDP
CCCCEEEEEEECCCC		13.3329083192
485PhosphorylationYQLSIHETEDPNDNR
EEEEEEECCCCCCCE		31.3729083192
516UbiquitinationSTILLQGKEQPLDEE
HHHHHCCCCCCCCHH		39.97-
548PhosphorylationRVLGFCHYYLPEEQF
HHHHHHCEECCHHHC		14.1019605366
549PhosphorylationVLGFCHYYLPEEQFP
HHHHHCEECCHHHCC		7.6625884760
580PhosphorylationLCFVGLMSMIDPPRA
CEEEHHHHCCCCCHH		20.0318669648
595UbiquitinationAVPDAVGKCRSAGIK
CCCCHHHHHHHCCCE		21.6321890473
598PhosphorylationDAVGKCRSAGIKVIM
CHHHHHHHCCCEEEE		40.0720068231
602UbiquitinationKCRSAGIKVIMVTGD
HHHHCCCEEEEEECC		25.4521890473
607PhosphorylationGIKVIMVTGDHPITA
CCEEEEEECCCCCCH		21.3620068231
613PhosphorylationVTGDHPITAKAIAKG
EECCCCCCHHHHHHC		26.9320068231
615UbiquitinationGDHPITAKAIAKGVG
CCCCCCHHHHHHCCE		31.5121890473
615UbiquitinationGDHPITAKAIAKGVG
CCCCCCHHHHHHCCE		31.5121890473
615UbiquitinationGDHPITAKAIAKGVG
CCCCCCHHHHHHCCE		31.5121890473
619UbiquitinationITAKAIAKGVGIISE
CCHHHHHHCCEEEEC		48.2721890473
619UbiquitinationITAKAIAKGVGIISE
CCHHHHHHCCEEEEC		48.2721890473
619UbiquitinationITAKAIAKGVGIISE
CCHHHHHHCCEEEEC		48.2721890473
625PhosphorylationAKGVGIISEGNETVE
HHCCEEEECCCCCHH		37.2125072903
630PhosphorylationIISEGNETVEDIAAR
EEECCCCCHHHHHHH		32.9424076635
643PhosphorylationARLNIPVSQVNPRDA
HHCCCCHHHCCHHHC		24.0530266825
656PhosphorylationDAKACVIHGTDLKDF
HCCEEEEECCCHHHC		16.8327251275
665PhosphorylationTDLKDFTSEQIDEIL
CCHHHCCHHHHHHHH		27.74-
688UbiquitinationARTSPQQKLIIVEGC
EECCCCCEEEEEECC		36.0821890473
688UbiquitinationARTSPQQKLIIVEGC
EECCCCCEEEEEECC		36.0821890473
688UbiquitinationARTSPQQKLIIVEGC
EECCCCCEEEEEECC		36.0821890473
695S-palmitoylationKLIIVEGCQRQGAIV
EEEEEECCCCCCCEE		1.5829575903
705PhosphorylationQGAIVAVTGDGVNDS
CCCEEEEECCCCCCC		21.5924076635
712PhosphorylationTGDGVNDSPALKKAD
ECCCCCCCHHHHHCC		13.5829255136
716UbiquitinationVNDSPALKKADIGVA
CCCCHHHHHCCCEEE		48.2821890473
717UbiquitinationNDSPALKKADIGVAM
CCCHHHHHCCCEEEC		52.7421890473
729PhosphorylationVAMGIAGSDVSKQAA
EECCCCCCHHHHHHH		26.3022210691
732PhosphorylationGIAGSDVSKQAADMI
CCCCCHHHHHHHCEE		24.8422210691
763UbiquitinationRLIFDNLKKSIAYTL
EEEECCHHHHHHHHH		51.2121890473
763UbiquitinationRLIFDNLKKSIAYTL
EEEECCHHHHHHHHH		51.2121890473
763UbiquitinationRLIFDNLKKSIAYTL
EEEECCHHHHHHHHH		51.2121890473
794PhosphorylationNIPLPLGTITILCID
CCCCCCCCEEEEEEE		23.72-
819PhosphorylationLAYEAAESDIMKRQP
HHHHHHHHHHHHCCC		27.92-
823UbiquitinationAAESDIMKRQPRNPR
HHHHHHHHCCCCCCC		48.49-
833UbiquitinationPRNPRTDKLVNERLI
CCCCCCHHHHHHHHH		54.4421890473
933PhosphorylationICKTRRNSVFQQGMK
EECCCCCHHHHHHCC		23.6125954137
940UbiquitinationSVFQQGMKNKILIFG
HHHHHHCCCCEEEEE		63.012190698
942UbiquitinationFQQGMKNKILIFGLF
HHHHCCCCEEEEECC		33.11-
1011PhosphorylationGGWVEKETYY-----
CCCCEEECCC-----		38.91-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
933SPhosphorylationKinasePKA-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AT1A3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AT1A3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VA0D1_HUMANATP6V0D1physical
26344197
VATA_HUMANATP6V1Aphysical
26344197
TCPH_HUMANCCT7physical
26344197
VDAC1_HUMANVDAC1physical
26344197
VDAC2_HUMANVDAC2physical
26344197
Drug and Disease Associations
Kegg Disease
H00831 Primary dystonia
OMIM Disease
128235Dystonia 12 (DYT12)
614820Alternating hemiplegia of childhood 2 (AHC2)
601338Cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss (CAPOS)
Kegg Drug
D00112 G-Strophanthin (JAN); Ouabain; Ouabain octahydrate
D00297 Digitoxin (JP16/USP/INN); Crystodigin (TN)
D00298 Digoxin (JP16/USP); Lanoxicaps (TN); Lanoxin (TN)
D01240 Deslanoside (JP16/USP/INN); Cedilanid-d (TN)
D01379 Proscillaridin (JAN/USAN/INN); Talusin (TN)
D01972 Lanatoside C (JP16/INN); Digilanogen C (TN)
D02587 Metildigoxin (JP16); Lanirapid (TN)
D06881 Acetyldigitoxin (INN); Acylanid (TN)
D07147 Gitoformate (INN)
D07555 Acetyldigoxin; Cedigossima (TN)
D07556 beta-Acetyldigoxin; Acetyldigoxin beta isomer; Corotal (TN)
D09847 Metildigoxin (INN); Medigoxin (BAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AT1A3_HUMAN

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Related Literatures of Post-Translational Modification

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