GHC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GHC2_HUMAN
• UniProt AC: Q9H1K4
• Protein Name: Mitochondrial glutamate carrier 2
• Gene Name: SLC25A18
• Organism: Homo sapiens (Human).
• Sequence Length: 315
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Description: Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+)..
• Protein Sequence: MTHQDLSITAKLINGGVAGLVGVTCVFPIDLAKTRLQNQHGKAMYKGMIDCLMKTARAEGFFGMYRGAAVNLTLVTPEKAIKLAANDFFRRLLMEDGMQRNLKMEMLAGCGAGMCQVVVTCPMEMLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQGLAGLYRGLGATLLRDIPFSIIYFPLFANLNNLGFNELAGKASFAHSFVSGCVAGSIAAVAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFMKGAGCRALVIAPLFGIAQGVYFIGIGERILKCFD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTHQDLSIT ------CCCCHHHHH	28.39	-
45	Phosphorylation	NQHGKAMYKGMIDCL CHHHHHHHHHHHHHH	14.84	25219547
55	Phosphorylation	MIDCLMKTARAEGFF HHHHHHHHHHHHCCC	13.86	-
65	Phosphorylation	AEGFFGMYRGAAVNL HHCCCCCCCCCEEEE	13.28	20068231
79	Acetylation	LTLVTPEKAIKLAAN EEEECHHHHHHHHHH	57.52	25953088
82	Ubiquitination	VTPEKAIKLAANDFF ECHHHHHHHHHHHHH	36.61	21890473
82	Acetylation	VTPEKAIKLAANDFF ECHHHHHHHHHHHHH	36.61	25953088
143	Phosphorylation	LAVHHQGSASAPSTS EEEEECCCCCCCCCC	16.69	21902226
145	Phosphorylation	VHHQGSASAPSTSRS EEECCCCCCCCCCCC	42.27	24972180
148	Phosphorylation	QGSASAPSTSRSYTT CCCCCCCCCCCCCCC	38.44	24972180
149	Phosphorylation	GSASAPSTSRSYTTG CCCCCCCCCCCCCCC	27.40	24972180
150	Phosphorylation	SASAPSTSRSYTTGS CCCCCCCCCCCCCCC	24.46	24972180
155	Phosphorylation	STSRSYTTGSASTHR CCCCCCCCCCCCCCC	22.39	20068231
157	Phosphorylation	SRSYTTGSASTHRRP CCCCCCCCCCCCCCC	19.56	20068231
160	Phosphorylation	YTTGSASTHRRPSAT CCCCCCCCCCCCHHH	21.08	20068231
302	Phosphorylation	FGIAQGVYFIGIGER HCHHCCEEEEEECHH	9.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GHC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GHC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GHC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GHC2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.