NKP1_YEAST - dbPTM
NKP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NKP1_YEAST
UniProt AC Q12493
Protein Name Inner kinetochore subunit NKP1 {ECO:0000305}
Gene Name NKP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 238
Subcellular Localization Nucleus . Chromosome, centromere, kinetochore . Associated with kinetochores.
Protein Description Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly..
Protein Sequence MTDTYNSISNFIENELTALLSSDDYLMDDLAGELPNEVCRLLKAQVIEKRKDAMSRGKQDLLSKEIYDNESELRASQSQQIMELVGDIPKYSLGSELRNRVEGEPQSTSIERLIEDVLKLPQMEVADEEEVEVENDLKVLSEYSNLRKDLILKCQALQIGESKLSDILSQTNSINSLTTSIKEASEDDDISEYFATYNGKLVVALEEMKLLLEEAVKTFGNSPEKREKIKKILSELKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
55PhosphorylationEKRKDAMSRGKQDLL
HHHHHHHHHCCHHHH		39.3327017623
63PhosphorylationRGKQDLLSKEIYDNE
HCCHHHHHHHHCCCH		35.2227017623
76PhosphorylationNESELRASQSQQIME
CHHHHHHHHHHHHHH		24.7527017623
78PhosphorylationSELRASQSQQIMELV
HHHHHHHHHHHHHHH		22.8927017623
222PhosphorylationAVKTFGNSPEKREKI
HHHHHCCCHHHHHHH		34.5125752575
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NKP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NKP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NKP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NKP2_YEASTNKP2physical
20826334
SRS2_YEASTSRS2genetic
21459050
FABG_YEASTOAR1genetic
27708008
HFA1_YEASTHFA1genetic
27708008
SLA1_YEASTSLA1genetic
27708008
CHK1_YEASTCHK1genetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
VMS1_YEASTVMS1genetic
27708008
RPA14_YEASTRPA14genetic
27708008
SCS2_YEASTSCS2genetic
27708008
SA155_YEASTSAP155genetic
27708008
PALF_YEASTRIM8genetic
27708008
GEP7_YEASTGEP7genetic
27708008
PIL1_YEASTPIL1genetic
27708008
ASK10_YEASTASK10genetic
27708008
TBP7_YEASTYTA7genetic
27708008
YOR1_YEASTYOR1genetic
27708008
ATG32_YEASTATG32genetic
27708008
RL17B_YEASTRPL17Bgenetic
27708008
DOHH_YEASTLIA1genetic
27708008
I23O_YEASTBNA2genetic
27708008
DBP7_YEASTDBP7genetic
27708008
BPT1_YEASTBPT1genetic
27708008
ACE2_YEASTACE2genetic
27708008
ADY4_YEASTADY4genetic
27708008
PSP2_YEASTPSP2genetic
27708008
RIM13_YEASTRIM13genetic
27708008
INO4_YEASTINO4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NKP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-222, AND MASSSPECTROMETRY.

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