| UniProt ID | VMS1_YEAST | |
|---|---|---|
| UniProt AC | Q04311 | |
| Protein Name | Protein VMS1 | |
| Gene Name | VMS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 632 | |
| Subcellular Localization |
Cytoplasm. Mitochondrion. Endoplasmic reticulum membrane Peripheral membrane protein. translocates from the cytosol to mitochondria upon mitochondrial stress. |
|
| Protein Description | Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Component of an evolutionarily conserved system for ubiquitin-mediated mitochondria-associated protein degradation (MAD), which is necessary to maintain mitochondrial, cellular, and organismal viability.. | |
| Protein Sequence | MNSQKASKMTGSLKKNDLYIFDLSEQLLNSLKLMSFDSTLREVEVEKTSDNDRNKESGDLQIARKKVTSNVMRCSVCQMSFDSRNEQKAHYQTDYHLMNVKRNLRGLDILSVEEFDALISKEHGIKSEDENSGGEQTSSDHEESEEASDRDPDLQTNNYMETIIENDLQKLGFQKDESDAISHINTQSPYIYFKSKYLQKNEVLAIYKSLFNKRSLSNPNEALTFWNSQENPMAISALFMVGGGHFAGAIVSHQRLNVKGNAHKKDETLIEQAVNFLEHKTFHRYTTRRKQGGSQSAMDNAKGKANSAGSALRRYNESALKTDIQGVLKDWEPYLSKCDNIFIRARNVSDKKIFTDNTVLNKGDERIKSFPFTTNRPTVLELKKAWCELSYLKILPKPEPLAVKETVQKLEVSNKKDEFKEKQEPLLEEIQTEEIISLLKKGRAPLLISFLKKNKLDGNFRLKPESKYSLTPTMLHYASQQGMKQMALILLSNIKCDPTIKNRLGRTAWDLNRNDDVRHAFQIARYNLGESFTNWDETHIGQPLSREQVDEINEKKKAIENEKAEKLIKLELEAAKEKQRFAKDAERGPGKKLTNIPSIQQQNLNSLTDEQRRRLMREQRARAAEERMKKKY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 57 | Phosphorylation | DNDRNKESGDLQIAR CCCCCCCCCCHHHHH | 38.94 | 28889911 | |
| 139 | Phosphorylation | SGGEQTSSDHEESEE CCCCCCCCCHHHHHH | 46.50 | 28889911 | |
| 294 | Phosphorylation | TRRKQGGSQSAMDNA CCCCCCCCHHHHHCH | 27.99 | 27017623 | |
| 296 | Phosphorylation | RKQGGSQSAMDNAKG CCCCCCHHHHHCHHC | 27.53 | 27017623 | |
| 349 | Phosphorylation | FIRARNVSDKKIFTD EEEECCCCCCCCCCC | 47.46 | 19684113 | |
| 355 | Phosphorylation | VSDKKIFTDNTVLNK CCCCCCCCCCCCCCC | 31.64 | 19684113 | |
| 369 | Phosphorylation | KGDERIKSFPFTTNR CCCHHHHCCCCCCCC | 35.46 | 27017623 | |
| 373 | Phosphorylation | RIKSFPFTTNRPTVL HHHCCCCCCCCCCHH | 24.33 | 27017623 | |
| 374 | Phosphorylation | IKSFPFTTNRPTVLE HHCCCCCCCCCCHHH | 29.61 | 27017623 | |
| 452 | Acetylation | PLLISFLKKNKLDGN CHHHHHHHHCCCCCC | 52.90 | 24489116 | |
| 492 | Phosphorylation | QMALILLSNIKCDPT HHHHHHHHCCCCCHH | 32.82 | 21440633 | |
| 592 | Ubiquitination | AERGPGKKLTNIPSI HHCCCCCCCCCCCHH | 67.47 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VMS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VMS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VMS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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