| UniProt ID | UFD2_YEAST | |
|---|---|---|
| UniProt AC | P54860 | |
| Protein Name | E4 ubiquitin-protein ligase UFD2 | |
| Gene Name | UFD2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 961 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to CDC48 and elongates mono- and diubiquitinated ERAD substrates presented by the UFD1-NPL4-CDC48/p97 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to RAD23 and DSK2, which target them to the proteasome. Has E3 ubiquitin-protein ligase activity, accepting ubiquitin from its cognate E2 ubiquitin-conjugating enzyme UBC4. Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety. Promotes ubiquitin chain elongation at 'Lys-48' on the DOA10 substrate PEX29. Also involved in the proteolytic processing of the ER-bound transcription factor SPT23.. | |
| Protein Sequence | MTAIEDILQITTDPSDTRGYSLLKSEEVPQGSTLGVDFIDTLLLYQLTENEKLDKPFEYLNDCFRRNQQQKRITKNKPNAESLHSTFQEIDRLVIGYGVVALQIENFCMNGAFINYITGIVSNVNSYTDFLSQIIQRAILEGTALDLLNAVFPTLLEYCNKHVSHFDLNESVIYNNVLTIFELFVTFKPIAEIFTKIDGFFADYSCKPQDFERKTILGPILSLSPIEAAVAIRNYGDNLLRSKQQTAMIHESLQAEHKVVIDRLFFIVDKLVRGSLNSRTDMISYFAHIANKNHLRRADHPPFKELSSNGFMSNITLLLVRFSQPFLDISYKKIDKIDANYFNNPSLFIDLSGETRLNSDFKEADAFYDKNRKTADSKPNFISDCFFLTLTYLHYGLGGTLSFEEKMGSEIKALKEEIEKVKKIAANHDVFARFITAQLSKMEKALKTTESLRFALQGFFAHRSLQLEVFDFICGASTFLIRVVDPEHEFPFKQIKLPLIPDQIGVENVDNADFLRAHAPVPFKYYPEFVVEGPVNYSLYISKYQTSPIFRNPRLGSFVEFTTMVLRCPELVSNPHLKGKLVQLLSVGAMPLTDNSPGFMMDIFEHDELVNKNLLYALLDFYVIVEKTGSSSQFYDKFNSRYSISIILEELYYKIPSYKNQLIWQSQNNADFFVRFVARMLNDLTFLLDEGLSNLAEVHNIQNELDNRARGAPPTREEEDKELQTRLASASRQAKSSCGLADKSMKLFEIYSKDIPAAFVTPEIVYRLASMLNYNLESLVGPKCGELKVKDPQSYSFNPKDLLKALTTVYINLSEQSEFISAVAKDERSFNRNLFVRAVDILGRKTGLASPEFIEKLLNFANKAEEQRKADEEEDLEYGDVPDEFLDPLMYTIMKDPVILPASKMNIDRSTIKAHLLSDSTDPFNRMPLKLEDVTPNEELRQKILCFKKQKKEEAKHKASE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 214 | Ubiquitination | KPQDFERKTILGPIL CCHHHCCCCCCHHHH | 32.49 | 23749301 | |
| 270 | Acetylation | RLFFIVDKLVRGSLN HHHHHHHHHHHCCCC | 37.68 | 24489116 | |
| 292 | Ubiquitination | YFAHIANKNHLRRAD HHHHHHCHHCHHHCC | 36.40 | 17644757 | |
| 332 | Ubiquitination | PFLDISYKKIDKIDA CCCCCCCCCCCCCCC | 36.14 | 17644757 | |
| 333 | Ubiquitination | FLDISYKKIDKIDAN CCCCCCCCCCCCCCC | 48.15 | 17644757 | |
| 336 | Ubiquitination | ISYKKIDKIDANYFN CCCCCCCCCCCCCCC | 46.06 | 17644757 | |
| 362 | Acetylation | TRLNSDFKEADAFYD CCCCCCHHHCHHHHC | 57.91 | 24489116 | |
| 362 | Ubiquitination | TRLNSDFKEADAFYD CCCCCCHHHCHHHHC | 57.91 | 23749301 | |
| 370 | Ubiquitination | EADAFYDKNRKTADS HCHHHHCCCCCCCCC | 47.47 | 15699485 | |
| 412 | Ubiquitination | EKMGSEIKALKEEIE HHHHHHHHHHHHHHH | 43.55 | 17644757 | |
| 415 | Ubiquitination | GSEIKALKEEIEKVK HHHHHHHHHHHHHHH | 59.15 | 17644757 | |
| 420 | Ubiquitination | ALKEEIEKVKKIAAN HHHHHHHHHHHHHHC | 66.08 | 17644757 | |
| 422 | Ubiquitination | KEEIEKVKKIAANHD HHHHHHHHHHHHCCH | 49.91 | 17644757 | |
| 423 | Ubiquitination | EEIEKVKKIAANHDV HHHHHHHHHHHCCHH | 40.33 | 17644757 | |
| 441 | Acetylation | FITAQLSKMEKALKT HHHHHHHHHHHHHHH | 60.72 | 24489116 | |
| 441 | Ubiquitination | FITAQLSKMEKALKT HHHHHHHHHHHHHHH | 60.72 | 24961812 | |
| 447 | Ubiquitination | SKMEKALKTTESLRF HHHHHHHHHHHHHHH | 59.26 | 23749301 | |
| 493 | Ubiquitination | PEHEFPFKQIKLPLI CCCCCCCCCCCCCCC | 51.88 | 17644757 | |
| 493 | Acetylation | PEHEFPFKQIKLPLI CCCCCCCCCCCCCCC | 51.88 | 24489116 | |
| 496 | Ubiquitination | EFPFKQIKLPLIPDQ CCCCCCCCCCCCCCC | 41.37 | 17644757 | |
| 573 | Phosphorylation | LRCPELVSNPHLKGK HHCHHHHCCCCCCCH | 58.21 | 21126336 | |
| 578 | Ubiquitination | LVSNPHLKGKLVQLL HHCCCCCCCHHEHHH | 51.47 | 17644757 | |
| 637 | Ubiquitination | SSSQFYDKFNSRYSI CCHHHHHHHCCCEEE | 34.76 | 23749301 | |
| 721 | Ubiquitination | PTREEEDKELQTRLA CCCHHHHHHHHHHHH | 64.70 | 23749301 | |
| 735 | Ubiquitination | ASASRQAKSSCGLAD HHHHHHHHHHCCCCH | 34.27 | 23749301 | |
| 743 | Ubiquitination | SSCGLADKSMKLFEI HHCCCCHHHHHHHHH | 47.01 | 23749301 | |
| 746 | Ubiquitination | GLADKSMKLFEIYSK CCCHHHHHHHHHHCC | 58.05 | 17644757 | |
| 753 | Ubiquitination | KLFEIYSKDIPAAFV HHHHHHCCCCCHHHC | 42.58 | 17644757 | |
| 788 | Ubiquitination | GPKCGELKVKDPQSY CCCCCCCEECCCCCC | 42.83 | 24961812 | |
| 790 | Ubiquitination | KCGELKVKDPQSYSF CCCCCEECCCCCCCC | 63.20 | 23749301 | |
| 800 | Ubiquitination | QSYSFNPKDLLKALT CCCCCCHHHHHHHHH | 63.21 | 17644757 | |
| 804 | Ubiquitination | FNPKDLLKALTTVYI CCHHHHHHHHHHEEE | 48.96 | 17644757 | |
| 825 | Ubiquitination | EFISAVAKDERSFNR HHHHHHHCCCCHHCC | 54.23 | 17644757 | |
| 845 | Ubiquitination | AVDILGRKTGLASPE HHHHHCCCCCCCCHH | 45.18 | 23749301 | |
| 856 | Ubiquitination | ASPEFIEKLLNFANK CCHHHHHHHHHHHHH | 54.16 | 17644757 | |
| 863 | Acetylation | KLLNFANKAEEQRKA HHHHHHHHHHHHHHC | 54.46 | 24489116 | |
| 863 | Ubiquitination | KLLNFANKAEEQRKA HHHHHHHHHHHHHHC | 54.46 | 17644757 | |
| 869 | Ubiquitination | NKAEEQRKADEEEDL HHHHHHHHCCHHHHC | 60.94 | 17644757 | |
| 904 | Ubiquitination | PVILPASKMNIDRST CEEECCHHCCCCHHH | 37.76 | 24961812 | |
| 913 | Ubiquitination | NIDRSTIKAHLLSDS CCCHHHHHHHHHCCC | 29.82 | 23749301 | |
| 930 | Ubiquitination | PFNRMPLKLEDVTPN CCCCCCCCHHCCCCC | 43.91 | 23749301 | |
| 943 | Ubiquitination | PNEELRQKILCFKKQ CCHHHHHHHHHHHHH | 31.08 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UFD2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UFD2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UFD2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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