NPL4_YEAST - dbPTM
NPL4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NPL4_YEAST
UniProt AC P33755
Protein Name Nuclear protein localization protein 4
Gene Name NPL4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 580
Subcellular Localization Cytoplasm, perinuclear region. Endoplasmic reticulum membrane
Peripheral membrane protein
Cytoplasmic side. Nucleus membrane
Peripheral membrane protein
Cytoplasmic side. Localizes mainly at the nuclear periphery and the endoplasmic reticulum mem
Protein Description Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD..
Protein Sequence MLIRFRSKNGTHRVSCQENDLFGTVIEKLVGNLDPNADVDTFTVCEKPGQGIHAVSELADRTVMDLGLKHGDMLILNYSDKPANEKDGVNVEIGSVGIDSKGIRQHRYGPLRIKELAVDEELEKEDGLIPRQKSKLCKHGDRGMCEYCSPLPPWDKEYHEKNKIKHISFHSYLKKLNENANKKENGSSYISPLSEPDFRINKRCHNGHEPWPRGICSKCQPSAITLQQQEFRMVDHVEFQKSEIINEFIQAWRYTGMQRFGYMYGSYSKYDNTPLGIKAVVEAIYEPPQHDEQDGLTMDVEQVKNEMLQIDRQAQEMGLSRIGLIFTDLSDAGAGDGSVFCKRHKDSFFLSSLEVIMAARHQTRHPNVSKYSEQGFFSSKFVTCVISGNLEGEIDISSYQVSTEAEALVTADMISGSTFPSMAYINDTTDERYVPEIFYMKSNEYGITVKENAKPAFPVDYLLVTLTHGFPNTDTETNSKFVSSTGFPWSNRQAMGQSQDYQELKKYLFNVASSGDFNLLHEKISNFHLLLYINSLQILSPDEWKLLIESAVKNEWEESLLKLVSSAGWQTLVMILQESG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28UbiquitinationLFGTVIEKLVGNLDP
CHHHHHHHHHCCCCC		37.0317644757
56PhosphorylationGQGIHAVSELADRTV
CCCHHHHHHHHHCCH		27.8928889911
69UbiquitinationTVMDLGLKHGDMLIL
CHHHHCCCCCCEEEE		43.6817644757
81UbiquitinationLILNYSDKPANEKDG
EEEECCCCCCCCCCC		39.8417644757
86UbiquitinationSDKPANEKDGVNVEI
CCCCCCCCCCCCEEE		60.6417644757
95PhosphorylationGVNVEIGSVGIDSKG
CCCEEEECEEECCCC		23.8824961812
100PhosphorylationIGSVGIDSKGIRQHR
EECEEECCCCCCCCC		30.7524961812
124AcetylationAVDEELEKEDGLIPR
EECHHHHHCCCCCHH		73.9724489116
218UbiquitinationWPRGICSKCQPSAIT
CCCCCCCCCCCCEEE		32.2623749301
269UbiquitinationYMYGSYSKYDNTPLG
EEECCCCCCCCCCCC		48.6823749301
278UbiquitinationDNTPLGIKAVVEAIY
CCCCCCHHHHEEHHH		33.0717644757
342UbiquitinationGDGSVFCKRHKDSFF
CCCCCCCCCCCCCEE		46.1823749301
450UbiquitinationNEYGITVKENAKPAF
CCCCEEECCCCCCCC		36.2817644757
454UbiquitinationITVKENAKPAFPVDY
EEECCCCCCCCCCCE		48.7617644757
480UbiquitinationTDTETNSKFVSSTGF
CCCCCCCCCCCCCCC		52.4317644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NPL4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NPL4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NPL4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC48_YEASTCDC48physical
11805826
PDC1_YEASTPDC1physical
11805826
UFD1_YEASTUFD1physical
11805826
UFD1_YEASTUFD1physical
10688190
CDC48_YEASTCDC48physical
11733065
UFD1_YEASTUFD1physical
11733065
CDC48_YEASTCDC48physical
11598205
UFD1_YEASTUFD1physical
11598205
MGA2_YEASTMGA2genetic
11598205
ACO1_YEASTOLE1genetic
11598205
RPN4_YEASTRPN4genetic
11598205
SPT23_YEASTSPT23genetic
11598205
CDC48_YEASTCDC48genetic
11733065
UBC7_YEASTUBC7genetic
14557538
CUE1_YEASTCUE1genetic
14557538
HRD1_YEASTHRD1genetic
14557538
DOA10_YEASTSSM4genetic
14557538
CDC48_YEASTCDC48physical
16429126
UFD1_YEASTUFD1physical
16429126
HRD1_YEASTHRD1physical
16619026
HRD3_YEASTHRD3physical
16619026
DER1_YEASTDER1physical
16619026
CDC48_YEASTCDC48physical
16619026
CDC48_YEASTCDC48physical
16179952
UBX2_YEASTUBX2physical
16179952
UFD1_YEASTUFD1physical
16179952
CDC48_YEASTCDC48physical
11283351
UFD1_YEASTUFD1physical
11283351
GET3_YEASTGET3genetic
16816426
NCBP1_YEASTSTO1genetic
16816426
PRP6_YEASTPRP6genetic
16816426
IFH1_YEASTIFH1genetic
16816426
SPT23_YEASTSPT23genetic
16816426
UBP3_YEASTUBP3genetic
16816426
UBP4_YEASTDOA4genetic
16816426
SRN2_YEASTSRN2genetic
16816426
VPS27_YEASTVPS27genetic
16816426
UBC7_YEASTUBC7genetic
16816426
CUE1_YEASTCUE1genetic
16816426
MGA2_YEASTMGA2genetic
19325107
VPS1_YEASTVPS1genetic
19325107
CDC48_YEASTCDC48physical
21211725
UFD1_YEASTUFD1physical
21211725
UBX2_YEASTUBX2physical
21211725
UBX5_YEASTUBX5physical
21211725
UFD1_YEASTUFD1physical
22940862
PT130_YEASTPET130physical
22940862
CDC48_YEASTCDC48physical
22940862
NPL4_YEASTNPL4physical
22940862
CDC48_YEASTCDC48physical
16179953
HRD3_YEASTHRD3physical
16179953
HRD1_YEASTHRD1physical
16179953
UFD1_YEASTUFD1physical
17289586
CDC48_YEASTCDC48physical
17289586
MGA2_YEASTMGA2physical
17289586
SPT23_YEASTSPT23physical
17289586
CDC48_YEASTCDC48physical
16427015
SPT23_YEASTSPT23genetic
11733065
HMDH2_YEASTHMG2physical
28077573
STE6_YEASTSTE6physical
28077573
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NPL4_YEAST

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Related Literatures of Post-Translational Modification

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