STE6_YEAST - dbPTM
STE6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STE6_YEAST
UniProt AC P12866
Protein Name Alpha-factor-transporting ATPase
Gene Name STE6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1290
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description STE6 is required in yeast MATA cells for production of A-factor pheromone. STE6 is involved in the transport of the farnesyl-derivation of the A-factor pheromone..
Protein Sequence MNFLSFKTTKHYHIFRYVNIRNDYRLLMIMIIGTVATGLVPAITSILTGRVFDLLSVFVANGSHQGLYSQLVQRSMAVMALGAASVPVMWLSLTSWMHIGERQGFRIRSQILEAYLEEKPMEWYDNNEKLLGDFTQINRCVEELRSSSAEASAITFQNLVAICALLGTSFYYSWSLTLIILCSSPIITFFAVVFSRMIHVYSEKENSETSKAAQLLTWSMNAAQLVRLYCTQRLERKKFKEIILNCNTFFIKSCFFVAANAGILRFLTLTMFVQGFWFGSAMIKKGKLNINDVITCFHSCIMLGSTLNNTLHQIVVLQKGGVAMEKIMTLLKDGSKRNPLNKTVAHQFPLDYATSDLTFANVSFSYPSRPSEAVLKNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYDGYNGSISINGHNIQTIDQKLLIENITVVEQRCTLFNDTLRKNILLGSTDSVRNADCSTNENRHLIKDACQMALLDRFILDLPDGLETLIGTGGVTLSGGQQQRVAIARAFIRDTPILFLDEAVSALDIVHRNLLMKAIRHWRKGKTTIILTHELSQIESDDYLYLMKEGEVVESGTQSELLADPTTTFSTWYHLQNDYSDAKTIVDTETEEKSIHTVESFNSQLETPKLGSCLSNLGYDETDQLSFYEAIYQKRSNVRTRRVKVEEENIGYALKQQKNTESSTGPQLLSIIQIIKRMIKSIRYKKILILGLLCSLIAGATNPVFSYTFSFLLEGIVPSTDGKTGSSHYLAKWSLLVLGVAAADGIFNFAKGFLLDCCSEYWVMDLRNEVMEKLTRKNMDWFSGENNKASEISALVLNDLRDLRSLVSEFLSAMTSFVTVSTIGLIWALVSGWKLSLVCISMFPLIIIFSAIYGGILQKCETDYKTSVAQLENCLYQIVTNIKTIKCLQAEFHFQLTYHDLKIKMQQIASKRAIATGFGISMTNMIVMCIQAIIYYYGLKLVMIHEYTSKEMFTTFTLLLFTIMSCTSLVSQIPDISRGQRAASWIYRILDEKHNTLEVENNNARTVGIAGHTYHGKEKKPIVSIQNLTFAYPSAPTAFVYKNMNFDMFCGQTLGIIGESGTGKSTLVLLLTKLYNCEVGKIKIDGTDVNDWNLTSLRKEISVVEQKPLLFNGTIRDNLTYGLQDEILEIEMYDALKYVGIHDFVISSPQGLDTRIDTTLLSGGQAQRLCIARALLRKSKILILDECTSALDSVSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKDGKVVERGNFDTLYNNRGELFQIVSNQSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
61N-linked_GlycosylationLLSVFVANGSHQGLY
HHHHHHCCCCCHHHH		47.39-
342UbiquitinationSKRNPLNKTVAHQFP
CCCCCCCHHHHHCCC		52.6517644757
376UbiquitinationRPSEAVLKNVSLNFS
CCCCHHHCCEEEEEE		49.0217644757
451UbiquitinationLFNDTLRKNILLGST
HCCHHHHHCEEECCC		51.9923749301
457PhosphorylationRKNILLGSTDSVRNA
HHCEEECCCHHHCCC		29.0719779198
613PhosphorylationNDYSDAKTIVDTETE
CCCCCCEEEECCCCC		28.1412435609
617PhosphorylationDAKTIVDTETEEKSI
CCEEEECCCCCHHHE		33.6319795423
619PhosphorylationKTIVDTETEEKSIHT
EEEECCCCCHHHECC		52.0819795423
623PhosphorylationDTETEEKSIHTVESF
CCCCCHHHECCHHHH		23.9222369663
626PhosphorylationTEEKSIHTVESFNSQ
CCHHHECCHHHHHHH		25.0522369663
629PhosphorylationKSIHTVESFNSQLET
HHECCHHHHHHHCCC		25.9522369663
632PhosphorylationHTVESFNSQLETPKL
CCHHHHHHHCCCCCC		33.8522369663
636PhosphorylationSFNSQLETPKLGSCL
HHHHHCCCCCCCHHH		34.0222369663
655PhosphorylationYDETDQLSFYEAIYQ
CCCCCHHHHHHHHHH		21.8323749301
663UbiquitinationFYEAIYQKRSNVRTR
HHHHHHHHHCCCCCC		40.6023749301
673UbiquitinationNVRTRRVKVEEENIG
CCCCCEEEEEHHHHH		41.9623749301
802UbiquitinationLRNEVMEKLTRKNMD
HHHHHHHHHHHCCCC		36.7423749301
812PhosphorylationRKNMDWFSGENNKAS
HCCCCCCCCCCCCHH		40.7328889911
882PhosphorylationIIIFSAIYGGILQKC
HHHHHHHHHHHHHHH		14.7128132839
1022UbiquitinationIYRILDEKHNTLEVE
HHHHHCCCCCEEEEE		41.6523749301
1166UbiquitinationIEMYDALKYVGIHDF
EEHHHHHHHCCCCEE		39.3417644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseSSM4P40318
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STE6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STE6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STE6_YEASTSTE6physical
8798485
RPN1_YEASTRPN1genetic
9763443
DOA10_YEASTSSM4physical
19515821
HAC1_YEASTHAC1genetic
19073890
RPN4_YEASTRPN4genetic
19073890
SSH1_YEASTSSH1genetic
19073890
HSP72_YEASTSSA2physical
22940862
HSP71_YEASTSSA1physical
22940862
DOA10_YEASTSSM4physical
18191224
HSP71_YEASTSSA1physical
18191224
MAS5_YEASTYDJ1physical
18191224
HSP82_YEASTHSP82physical
18191224
VPS9_YEASTVPS9physical
23831759
YGI1_YEASTYGL081Wphysical
23831759
UBR1_YEASTUBR1physical
23988329
CDC48_YEASTCDC48physical
23988329
SAN1_YEASTSAN1physical
23653356
MET30_YEASTMET30genetic
27708008
BET3_YEASTBET3genetic
27708008
SED5_YEASTSED5genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RPC6_YEASTRPC34genetic
27708008
YG1X_YEASTYGR050Cgenetic
27708008
KPC1_YEASTPKC1genetic
27708008
TAF5_YEASTTAF5genetic
27708008
MCM7_YEASTMCM7genetic
27708008
APC11_YEASTAPC11genetic
27708008
PRP9_YEASTPRP9genetic
27708008
RPN6_YEASTRPN6genetic
27708008
NSE4_YEASTNSE4genetic
27708008
CDC53_YEASTCDC53genetic
27708008
LCB2_YEASTLCB2genetic
27708008
RIFK_YEASTFMN1genetic
27708008
NSE3_YEASTNSE3genetic
27708008
TFB1_YEASTTFB1genetic
27708008
GPI8_YEASTGPI8genetic
27708008
PSB3_YEASTPUP3genetic
27708008
ACT_YEASTACT1genetic
27708008
SAD1_YEASTSAD1genetic
27708008
SMD1_YEASTSMD1genetic
27708008
MPPA_YEASTMAS2genetic
27708008
RPN1_YEASTRPN1genetic
27708008
MOB1_YEASTMOB1genetic
27708008
HSP77_YEASTSSC1genetic
27708008
MPPB_YEASTMAS1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
RSC9_YEASTRSC9genetic
27708008
ARPC2_YEASTARC35genetic
27708008
DBP6_YEASTDBP6genetic
27708008
CH10_YEASTHSP10genetic
27708008
PROF_YEASTPFY1genetic
27708008
YPK3_YEASTYPK3genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
VPS41_YEASTVPS41genetic
27708008
MNN10_YEASTMNN10genetic
27708008
CEM1_YEASTCEM1genetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
LPLA_YEASTAIM22genetic
27708008
ILM1_YEASTILM1genetic
27708008
PFD6_YEASTYKE2genetic
27708008
NU188_YEASTNUP188genetic
27708008
PET8_YEASTPET8genetic
27708008
PMS1_YEASTPMS1genetic
27708008
PFD4_YEASTGIM3genetic
27708008
FRE7_YEASTFRE7genetic
27708008
DGK1_YEASTDGK1genetic
27708008
RAD1_YEASTRAD1genetic
27708008
CDC48_YEASTCDC48physical
28077573
NPL4_YEASTNPL4physical
28077573
UFD1_YEASTUFD1physical
28077573
SWC5_YEASTSWC5genetic
29674565
TFB1_YEASTTFB1genetic
29674565
PPN1_YEASTPPN1genetic
29674565
RSP5_YEASTRSP5genetic
29674565
EXO1_YEASTEXO1genetic
29674565
MAK16_YEASTMAK16genetic
29674565
CSG2_YEASTCSG2genetic
29674565
TRS20_YEASTTRS20genetic
29674565
MXR2_YEASTMXR2genetic
29674565
VAC17_YEASTVAC17genetic
29674565
CSM1_YEASTCSM1genetic
29674565
GET3_YEASTGET3genetic
29674565
DAD1_YEASTDAD1genetic
29674565
ARX1_YEASTARX1genetic
29674565
CDC1_YEASTCDC1genetic
29674565
H2A1_YEASTHTA1genetic
29674565
YD391_YEASTYDR391Cgenetic
29674565
SHO1_YEASTSHO1genetic
29674565
MAD1_YEASTMAD1genetic
29674565
SLX9_YEASTSLX9genetic
29674565
YOR1_YEASTYOR1genetic
29674565
SLT2_YEASTSLT2genetic
29674565
RGI2_YEASTRGI2genetic
29674565
CHS6_YEASTCHS6genetic
29674565
RAV1_YEASTRAV1genetic
29674565
EI2BA_YEASTGCN3genetic
29674565
RIC1_YEASTRIC1genetic
29674565
PPID_YEASTCPR6genetic
29674565
YPT6_YEASTYPT6genetic
29674565
CSM3_YEASTCSM3genetic
29674565
NUP53_YEASTNUP53genetic
29674565
SFL1_YEASTSFL1genetic
29674565
SLP1_YEASTSLP1genetic
29674565
ULA1_YEASTULA1genetic
29674565
SUR1_YEASTSUR1genetic
29674565
YP071_YEASTYPL071Cgenetic
29674565
TBF1_YEASTTBF1genetic
29674565
TGS1_YEASTTGS1genetic
29674565
NCBP2_YEASTCBC2genetic
29674565
OXR1_YEASTOXR1genetic
29674565
RU2A_YEASTLEA1genetic
29674565
NEW1_YEASTNEW1genetic
29674565
YAR1_YEASTYAR1genetic
29674565
BRR1_YEASTBRR1genetic
29674565
ROX1_YEASTROX1genetic
29674565
HDA3_YEASTHDA3genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STE6_YEAST

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Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1022, AND MASSSPECTROMETRY.

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