| UniProt ID | SAD1_YEAST | |
|---|---|---|
| UniProt AC | P43589 | |
| Protein Name | Pre-mRNA-splicing factor SAD1 | |
| Gene Name | SAD1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 448 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Promotes the assembly of newly synthesized U4 snRNA into the U4/U6 snRNP particle. Required for splicing of pre-mRNA.. | |
| Protein Sequence | MEVDNKRRHSEDELKQEAVKKIKSQEPNYAYLETVVREKLDFDSEKICCITLSPLNVYCCLVCGHYYQGRHEKSPAFIHSIDENHHVFLNLTSLKFYMLPQNVQILHDGEVQLLNSIKFAAYPTYCPKDLEDFPRQCFDLSNRTYLNGFIGFTNAATYDYAHSVLLLISHMVPVRDHFLLNHFDNQGEFIKRLSICVKKIWSPKLFKHHLSVDDFVSYLKVREGLNLNPIDPRLFLLWLFNKICSSSNDLKSILNHSCKGKVKIAKVENKPEASESVTGKVIVKPFWVLTLDLPEFSPFEDGNSVDDLPQINITKLLTKFTKSRSSSTSTVFELTRLPQFLIFHFNRFDRNSDHPVKNRNQTLVEFSSELEILHVKYRLKANVVHVVIKQPSTDGNAFNGDEKSHWITQLYDNKSEKWIEIDGINTTEREAELLFLKETFIQVWEKQE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MEVDNKRR -------CCCCCCCC | 11.62 | 22814378 | |
| 10 | Phosphorylation | VDNKRRHSEDELKQE CCCCCCCCHHHHHHH | 44.95 | 17287358 | |
| 20 | Acetylation | ELKQEAVKKIKSQEP HHHHHHHHHHHHCCC | 56.69 | 25381059 | |
| 427 | Phosphorylation | EIDGINTTEREAELL EECCCCCCHHHHHHH | 28.67 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SAD1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SAD1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SAD1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY. | |
