DENR_YEAST - dbPTM
DENR_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DENR_YEAST
UniProt AC P47089
Protein Name Translation machinery-associated protein 22
Gene Name TMA22
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 198
Subcellular Localization Cytoplasm .
Protein Description
Protein Sequence MLREVIYCGICSYPPEYCEFSGKLKRCKVWLSENHADLYAKLYGTDDNTQEVEAVTNKLAESSIGEAREEKLEKDLLKIQKKQENREQRELAKKLSSKVIIKREARTKRKFIVAISGLEVFDIDMKKLAKTFASRFATGCSVSKNAEKKEEVVIQGDVMDEVETYIHSLLEEKGLKDVKVETIDAKKKKKPAAEGAAK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23UbiquitinationEYCEFSGKLKRCKVW
HHHHCCCCCCCCEEE		50.0323749301
25UbiquitinationCEFSGKLKRCKVWLS
HHCCCCCCCCEEEEC		60.2722817900
28UbiquitinationSGKLKRCKVWLSENH
CCCCCCCEEEECCCC		40.2423749301
41UbiquitinationNHADLYAKLYGTDDN
CCHHHHHHHHCCCCC		28.7815699485
45PhosphorylationLYAKLYGTDDNTQEV
HHHHHHCCCCCHHHH		26.9927214570
49PhosphorylationLYGTDDNTQEVEAVT
HHCCCCCHHHHHHHH		32.8523749301
58AcetylationEVEAVTNKLAESSIG
HHHHHHHHHHHHHHH		39.4424489116
58UbiquitinationEVEAVTNKLAESSIG
HHHHHHHHHHHHHHH		39.4423749301
62PhosphorylationVTNKLAESSIGEARE
HHHHHHHHHHHHHHH		22.9622369663
63PhosphorylationTNKLAESSIGEAREE
HHHHHHHHHHHHHHH		26.5622369663
71AcetylationIGEAREEKLEKDLLK
HHHHHHHHHHHHHHH		58.1324489116
74AcetylationAREEKLEKDLLKIQK
HHHHHHHHHHHHHHH		65.2024489116
144UbiquitinationATGCSVSKNAEKKEE
HCCCCCCCCCCCCCE		59.0015699485
144AcetylationATGCSVSKNAEKKEE
HCCCCCCCCCCCCCE		59.0025381059
148UbiquitinationSVSKNAEKKEEVVIQ
CCCCCCCCCCEEEEE		64.1715699485
149UbiquitinationVSKNAEKKEEVVIQG
CCCCCCCCCEEEEEC		51.0815699485
173UbiquitinationIHSLLEEKGLKDVKV
HHHHHHHCCCCCCEE		61.2315699485
179AcetylationEKGLKDVKVETIDAK
HCCCCCCEEEEECHH		44.4824489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DENR_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DENR_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DENR_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TMA20_YEASTTMA20physical
11805826
GBLP_YEASTASC1physical
11805826
YAP4_YEASTCIN5physical
16554755
RS3A1_YEASTRPS1Aphysical
16429126
TMA20_YEASTTMA20physical
16429126
TMA20_YEASTTMA20physical
16702403
GET2_YEASTGET2genetic
17314980
SWD1_YEASTSWD1genetic
17314980
RL36A_YEASTRPL36Agenetic
27708008
ATC3_YEASTDRS2genetic
27708008
EF1A_YEASTTEF2genetic
27708008
NUM1_YEASTNUM1genetic
27708008
H2A1_YEASTHTA1genetic
27708008
FTHC_YEASTFAU1genetic
27708008
RS23A_YEASTRPS23Agenetic
27708008
RS23B_YEASTRPS23Agenetic
27708008
CHO2_YEASTCHO2genetic
27708008
ARP1_YEASTARP1genetic
27708008
VPS51_YEASTVPS51genetic
27708008
RS21A_YEASTRPS21Agenetic
27708008
BAS1_YEASTBAS1genetic
27708008
RT109_YEASTRTT109genetic
27708008
ALAM_YEASTALT1genetic
27708008
RL37A_YEASTRPL37Agenetic
27708008
RS28B_YEASTRPS28Bgenetic
27708008
RS30A_YEASTRPS30Agenetic
27708008
RS30B_YEASTRPS30Agenetic
27708008
MAC1_YEASTMAC1genetic
27708008
SSO2_YEASTSSO2genetic
27708008
COX7_YEASTCOX7genetic
27708008
DOM34_YEASTDOM34genetic
27708008
RL9B_YEASTRPL9Bgenetic
27708008
ODP2_YEASTLAT1genetic
27708008
RS7B_YEASTRPS7Bgenetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
SUR1_YEASTSUR1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DENR_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62 AND SER-63, AND MASSSPECTROMETRY.

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