RS28B_YEAST - dbPTM
RS28B_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RS28B_YEAST
UniProt AC P0C0X0
Protein Name 40S ribosomal protein S28-B {ECO:0000303|PubMed:9559554}
Gene Name RPS28B {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 67
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MDSKTPVTLAKVIKVLGRTGSRGGVTQVRVEFLEDTSRTIVRNVKGPVRENDILVLMESEREARRLR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDSKTPVT
-------CCCCCCCH		13.6510601260
3Phosphorylation-----MDSKTPVTLA
-----CCCCCCCHHH		36.8122369663
4Succinylation----MDSKTPVTLAK
----CCCCCCCHHHH		53.2123954790
5Phosphorylation---MDSKTPVTLAKV
---CCCCCCCHHHHH		27.2622369663
8PhosphorylationMDSKTPVTLAKVIKV
CCCCCCCHHHHHHHH		23.3822369663
112-HydroxyisobutyrylationKTPVTLAKVIKVLGR
CCCCHHHHHHHHHCC		47.83-
11UbiquitinationKTPVTLAKVIKVLGR
CCCCHHHHHHHHHCC		47.8322817900
11AcetylationKTPVTLAKVIKVLGR
CCCCHHHHHHHHHCC		47.8324489116
142-HydroxyisobutyrylationVTLAKVIKVLGRTGS
CHHHHHHHHHCCCCC		34.10-
14UbiquitinationVTLAKVIKVLGRTGS
CHHHHHHHHHCCCCC		34.1023749301
14AcetylationVTLAKVIKVLGRTGS
CHHHHHHHHHCCCCC		34.1022865919
19PhosphorylationVIKVLGRTGSRGGVT
HHHHHCCCCCCCCEE		37.4022369663
21PhosphorylationKVLGRTGSRGGVTQV
HHHCCCCCCCCEEEE		27.4322369663
26PhosphorylationTGSRGGVTQVRVEFL
CCCCCCEEEEEEEEE		25.3122369663
36PhosphorylationRVEFLEDTSRTIVRN
EEEEECCCCCHHHHC		15.6722369663
37PhosphorylationVEFLEDTSRTIVRNV
EEEECCCCCHHHHCC		39.4822369663
39PhosphorylationFLEDTSRTIVRNVKG
EECCCCCHHHHCCCC		24.4822369663
45SuccinylationRTIVRNVKGPVREND
CHHHHCCCCCCCCCC		62.1323954790
59PhosphorylationDILVLMESEREARRL
CEEEEECHHHHHHHC		28.1727017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RS28B_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RS28B_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RS28B_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DCP1_YEASTDCP1physical
10688190
TTL_YEASTPBY1physical
10688190
PIN4_YEASTPIN4genetic
20093466
YBB0_YEASTYBL010Cgenetic
20093466
VMS1_YEASTVMS1genetic
20093466
MNN10_YEASTMNN10genetic
20093466
ARO80_YEASTARO80genetic
20093466
SKI8_YEASTSKI8genetic
20093466
XRN1_YEASTXRN1genetic
20093466
PSA3_YEASTPRE9genetic
20093466
AZR1_YEASTAZR1genetic
20093466
YG5B_YEASTYGR250Cgenetic
20093466
BGL2_YEASTBGL2genetic
20093466
YHE4_YEASTYHL044Wgenetic
20093466
YHE2_YEASTYHL042Wgenetic
20093466
AP18A_YEASTYAP1801genetic
20093466
PIR5_YEASTYJL160Cgenetic
20093466
SDHX_YEASTYJL045Wgenetic
20093466
DENR_YEASTTMA22genetic
20093466
HBS1_YEASTHBS1genetic
20093466
SIC1_YEASTSIC1genetic
20093466
CST9_YEASTCST9genetic
20093466
SST2_YEASTSST2genetic
20093466
GBLP_YEASTASC1genetic
20093466
FKH2_YEASTFKH2genetic
20093466
DOM34_YEASTDOM34genetic
20093466
RS28A_YEASTRPS28Agenetic
20093466
PAT1_YEASTPAT1physical
24830408
DCP1_YEASTDCP1physical
24492965
EDC3_YEASTEDC3physical
24492965
GPI12_YEASTGPI12genetic
27708008
ESA1_YEASTESA1genetic
27708008
SWC3_YEASTSWC3genetic
27708008
SGF29_YEASTSGF29genetic
27708008
SLT2_YEASTSLT2genetic
27708008
DOA10_YEASTSSM4genetic
27708008
PSB6_YEASTPRE7genetic
27708008
CDC27_YEASTCDC27genetic
27708008
SLI15_YEASTSLI15genetic
27708008
NOT1_YEASTCDC39genetic
27708008
APC11_YEASTAPC11genetic
27708008
RPN6_YEASTRPN6genetic
27708008
CDC53_YEASTCDC53genetic
27708008
RPN5_YEASTRPN5genetic
27708008
CWC2_YEASTCWC2genetic
27708008
ERF3_YEASTSUP35genetic
27708008
CDC1_YEASTCDC1genetic
27708008
PSB3_YEASTPUP3genetic
27708008
ACT_YEASTACT1genetic
27708008
RPN11_YEASTRPN11genetic
27708008
RPN12_YEASTRPN12genetic
27708008
PRS8_YEASTRPT6genetic
27708008
RPN1_YEASTRPN1genetic
27708008
BIG1_YEASTBIG1genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
RFC2_YEASTRFC2genetic
27708008
MIF2_YEASTMIF2genetic
27708008
ERO1_YEASTERO1genetic
27708008
DPOA_YEASTPOL1genetic
27708008
DCP2_YEASTDCP2genetic
27708008
SGT1_YEASTSGT1genetic
27708008
IPL1_YEASTIPL1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
SEC23_YEASTSEC23genetic
27708008
YBB0_YEASTYBL010Cgenetic
27708008
VPS10_YEASTPEP1genetic
27708008
PIN4_YEASTPIN4genetic
27708008
RXT3_YEASTRXT3genetic
27708008
MNN10_YEASTMNN10genetic
27708008
CP56_YEASTDIT2genetic
27708008
ARO80_YEASTARO80genetic
27708008
UBP6_YEASTUBP6genetic
27708008
XRN1_YEASTXRN1genetic
27708008
SKI8_YEASTSKI8genetic
27708008
PSA3_YEASTPRE9genetic
27708008
AZR1_YEASTAZR1genetic
27708008
YG5B_YEASTYGR250Cgenetic
27708008
BGL2_YEASTBGL2genetic
27708008
SS100_YEASTSPS100genetic
27708008
AP18A_YEASTYAP1801genetic
27708008
HOS4_YEASTHOS4genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
DENR_YEASTTMA22genetic
27708008
DBR1_YEASTDBR1genetic
27708008
KKQ8_YEASTKKQ8genetic
27708008
DOA1_YEASTDOA1genetic
27708008
HBS1_YEASTHBS1genetic
27708008
FRE8_YEASTFRE8genetic
27708008
SIC1_YEASTSIC1genetic
27708008
SRL2_YEASTSRL2genetic
27708008
HMDH1_YEASTHMG1genetic
27708008
GBLP_YEASTASC1genetic
27708008
DOM34_YEASTDOM34genetic
27708008
TRM11_YEASTTRM11genetic
27708008
ASE1_YEASTASE1genetic
27708008
RS28A_YEASTRPS28Agenetic
27708008
LCF1_YEASTFAA1genetic
27708008
UBC11_YEASTUBC11genetic
27708008
CIN1_YEASTCIN1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
WDR6_YEASTRTT10genetic
27708008
YP260_YEASTYPL260Wgenetic
27708008
MDL2_YEASTMDL2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RS28B_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"The action of N-terminal acetyltransferases on yeast ribosomalproteins.";
Arnold R.J., Polevoda B., Reilly J.P., Sherman F.;
J. Biol. Chem. 274:37035-37040(1999).
Cited for: ACETYLATION AT MET-1 BY NATB.
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21 AND SER-37, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND MASSSPECTROMETRY.

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