HBS1_YEAST - dbPTM
HBS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HBS1_YEAST
UniProt AC P32769
Protein Name Elongation factor 1 alpha-like protein
Gene Name HBS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 611
Subcellular Localization Cytoplasm .
Protein Description Involved in protein translation. Together with DOM34, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs..
Protein Sequence MAYSDYSDGADDMPDFHDEGEFDDYLNDDEYDLMNEVFPTLKAQLQDYQGWDNLSLKLALFDNNFDLESTLAELKKTLKKKKTPKKPIAAANGSANVTQKLANISISQQRPNDRLPDWLDEEESEGERNGEEANDEKTVQRYYKTTVPTKPKKPHDISAFVKSALPHLSFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRESETMGKSSFKFAWIMDQTNEERERGVTVSICTSHFSTHRANFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTNAFESGFDLDGQTKEHMLLASSLGIHNLIIAMNKMDNVDWSQQRFEEIKSKLLPYLVDIGFFEDNINWVPISGFSGEGVYKIEYTDEVRQWYNGPNLMSTLENAAFKISKENEGINKDDPFLFSVLEIIPSKKTSNDLALVSGKLESGSIQPGESLTIYPSEQSCIVDKIQVGSQQGQSTNHEETDVAIKGDFVTLKLRKAYPEDIQNGDLAASVDYSSIHSAQCFVLELTTFDMNRPLLPGTPFILFIGVKEQPARIKRLISFIDKGNTASKKKIRHLGSKQRAFVEIELIEVKRWIPLLTAHENDRLGRVVLRKDGRTIAAGKISEITQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
55PhosphorylationYQGWDNLSLKLALFD
CCCCCCCEEEEEEEC		29.7015665377
105PhosphorylationTQKLANISISQQRPN
HHHHHCCCCCCCCCC		18.9219823750
107PhosphorylationKLANISISQQRPNDR
HHHCCCCCCCCCCCC		17.3021440633
124PhosphorylationDWLDEEESEGERNGE
CCCCCCCCCCCCCCC		54.9322369663
248PhosphorylationSTHRANFTIVDAPGH
CCCCCCEEEEECCCC		21.6528889911
321PhosphorylationKMDNVDWSQQRFEEI
CCCCCCHHHHHHHHH		16.3927017623
414PhosphorylationEIIPSKKTSNDLALV
ECCCCCCCCCCEEEE		36.1821440633
543PhosphorylationARIKRLISFIDKGNT
HHHHHHHHHHHCCCC		22.2721440633
547AcetylationRLISFIDKGNTASKK
HHHHHHHCCCCCCHH		49.6024489116
605UbiquitinationGRTIAAGKISEITQ-
CCEEEEEEHHHCCC-		38.0323749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HBS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HBS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HBS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DOM34_YEASTDOM34physical
11909951
RS30A_YEASTRPS30Agenetic
11909951
RS30B_YEASTRPS30Agenetic
11909951
RS14A_YEASTRPS14Agenetic
11909951
RS28A_YEASTRPS28Agenetic
21102444
RS23A_YEASTRPS23Aphysical
21623367
RS23B_YEASTRPS23Aphysical
21623367
RS3_YEASTRPS3physical
21623367
CDC53_YEASTCDC53genetic
27708008
RPB1_YEASTRPO21genetic
27708008
NOP14_YEASTNOP14genetic
27708008
BOS1_YEASTBOS1genetic
27708008
XRN1_YEASTXRN1genetic
27708008
GBLP_YEASTASC1genetic
27708008
AAR2_YEASTAAR2genetic
27708008
EIF3A_YEASTRPG1genetic
27708008
ENP1_YEASTENP1genetic
27708008
CDC10_YEASTCDC10genetic
27708008
DAD1_YEASTDAD1genetic
27708008
FAL1_YEASTFAL1genetic
27708008
ERF3_YEASTSUP35genetic
27708008
UTP6_YEASTUTP6genetic
27708008
MOB2_YEASTMOB2genetic
27708008
SP105_YEASTSPC105genetic
27708008
DAM1_YEASTDAM1genetic
27708008
ARP3_YEASTARP3genetic
27708008
CDC11_YEASTCDC11genetic
27708008
ASK1_YEASTASK1genetic
27708008
SN114_YEASTSNU114genetic
27708008
UTP13_YEASTUTP13genetic
27708008
SPC24_YEASTSPC24genetic
27708008
RRP5_YEASTRRP5genetic
27708008
HAS1_YEASTHAS1genetic
27708008
NOG2_YEASTNOG2genetic
27708008
DIM1_YEASTDIM1genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
ODPB_YEASTPDB1genetic
27708008
RS14A_YEASTRPS14Agenetic
27708008
RS16A_YEASTRPS16Bgenetic
27708008
RS16B_YEASTRPS16Bgenetic
27708008
NOP6_YEASTNOP6genetic
27708008
RRP8_YEASTRRP8genetic
27708008
TRS85_YEASTTRS85genetic
27708008
SAC3_YEASTSAC3genetic
27708008
PLP1_YEASTPLP1genetic
27708008
PMT7_YEASTPMT7genetic
27708008
RS17B_YEASTRPS17Bgenetic
27708008
RS26B_YEASTRPS26Bgenetic
27708008
MAD1_YEASTMAD1genetic
27708008
ASK10_YEASTASK10genetic
27708008
RS23A_YEASTRPS23Agenetic
27708008
RS23B_YEASTRPS23Agenetic
27708008
RSSA1_YEASTRPS0Agenetic
27708008
MAD3_YEASTMAD3genetic
27708008
MAD2_YEASTMAD2genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
ERG3_YEASTERG3genetic
27708008
RS28B_YEASTRPS28Bgenetic
27708008
RS30A_YEASTRPS30Agenetic
27708008
RS30B_YEASTRPS30Agenetic
27708008
RS22B_YEASTRPS22Bgenetic
27708008
RS29A_YEASTRPS29Agenetic
27708008
TSR2_YEASTTSR2genetic
27708008
RS3A1_YEASTRPS1Agenetic
27708008
GIS4_YEASTGIS4genetic
27708008
SUR7_YEASTSUR7genetic
27708008
RS10B_YEASTRPS10Bgenetic
27708008
SKI7_YEASTSKI7genetic
28956756
GBLP_YEASTASC1genetic
28956756
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HBS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124, AND MASSSPECTROMETRY.

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