RRP8_YEAST - dbPTM
RRP8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RRP8_YEAST
UniProt AC P38961
Protein Name 25S rRNA (adenine(645)-N(1))-methyltransferase
Gene Name RRP8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 392
Subcellular Localization Nucleus, nucleolus . Chromosome, telomere .
Protein Description S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 645 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Also involved in telomere length regulation and maintenance..
Protein Sequence MALFNVEGWSIKTKTVAFDNKTNKSSKDKKKNNRKNGKLTREQKLKEETEAELKEQVEDIPSEGSVAKDIPKKNQEKSDQNETSKKRKHDEEAPLMQVKENIEKPTKKQLTPLQQKMMAKLTGSRFRWINEQLYTISSDEALKLIKEQPQLFDEYHDGFRSQVQAWPENPVDVFVDQIRYRCMKPVNAPGGLPGLKDSKEIVIADMGCGEAQLALEINNFFKNYNKKAKKYLKRRHKVHSFDLKKANERITVADIRNVPLPDESCTIVVFCLALMGTNFLDFIKEAYRILAPRGELWIAEIKSRFSDGKGNEFVDALKLMGFFHKKTFDENKMFTRFEFFKPPAEIIEERRQKLERRQKFIEVETEKEELEKKRRKIAEGKWLLKPCIYKRR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12AcetylationNVEGWSIKTKTVAFD
EEECEEEEEEEEEEE		38.1525381059
21AcetylationKTVAFDNKTNKSSKD
EEEEEECCCCCCHHH		56.1525381059
62PhosphorylationEQVEDIPSEGSVAKD
HHHHCCCCCCCCCCC		55.7325521595
65PhosphorylationEDIPSEGSVAKDIPK
HCCCCCCCCCCCCCC		18.1720377248
68AcetylationPSEGSVAKDIPKKNQ
CCCCCCCCCCCCCCH		54.7724489116
84PhosphorylationKSDQNETSKKRKHDE
HCCCCHHHHHHHCCC		29.9627017623
107AcetylationENIEKPTKKQLTPLQ
HHHCCCCHHHCCHHH		47.2325381059
196SuccinylationPGGLPGLKDSKEIVI
CCCCCCCCCCCEEEE		66.9123954790
359AcetylationQKLERRQKFIEVETE
HHHHHHHHHHHHHHH		46.6422865919
372AcetylationTEKEELEKKRRKIAE
HHHHHHHHHHHHHHC		65.2924489116
381AcetylationRRKIAEGKWLLKPCI
HHHHHCCCCCCCCCC		26.6122865919
385AcetylationAEGKWLLKPCIYKRR
HCCCCCCCCCCCCCC		35.3624489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RRP8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RRP8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RRP8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RRP8_YEASTRRP8physical
14759368
IMB1_YEASTKAP95physical
14759368
IMA1_YEASTSRP1physical
14759368
BUD21_YEASTBUD21genetic
19061648
RS8A_YEASTRPS8Agenetic
19061648
RS8B_YEASTRPS8Agenetic
19061648
MRM2_YEASTMRM2genetic
19061648
NMD5_YEASTNMD5genetic
19061648
IF2M_YEASTIFM1genetic
19061648
FKBP_YEASTFPR1genetic
19061648
SUV3_YEASTSUV3genetic
19061648
HSP71_YEASTSSA1physical
19536198
SLT11_YEASTECM2genetic
20093466
REI1_YEASTREI1genetic
20093466
DPB3_YEASTDPB3genetic
20093466
BUD31_YEASTBUD31genetic
20093466
ATG9_YEASTATG9genetic
20093466
TSA2_YEASTTSA2genetic
20093466
RL29_YEASTRPL29genetic
20093466
DBP3_YEASTDBP3genetic
20093466
PUF4_YEASTPUF4genetic
20093466
SLX9_YEASTSLX9genetic
20093466
LRP1_YEASTLRP1genetic
20093466
THP2_YEASTTHP2genetic
20093466
RL16A_YEASTRPL16Agenetic
20093466
YJQ3_YEASTYJL163Cgenetic
20093466
LTHAD_YEASTSRY1genetic
20093466
EF1G2_YEASTTEF4genetic
20093466
RL22A_YEASTRPL22Agenetic
20093466
PFD6_YEASTYKE2genetic
20093466
IOC4_YEASTIOC4genetic
20093466
FUS2_YEASTFUS2genetic
20093466
TMA23_YEASTTMA23genetic
20093466
SCS7_YEASTSCS7genetic
20093466
PLB3_YEASTPLB3genetic
20093466
BUD21_YEASTBUD21genetic
20093466
SUR1_YEASTSUR1genetic
20093466
SRS2_YEASTSRS2genetic
21459050
GAR1_YEASTGAR1genetic
23180764
SEC12_YEASTSEC12genetic
27708008
RL16A_YEASTRPL16Agenetic
27708008
PFD6_YEASTYKE2genetic
27708008
LGE1_YEASTLGE1genetic
27708008
ENP1_YEASTENP1genetic
27708008
RPN6_YEASTRPN6genetic
27708008
RRP42_YEASTRRP42genetic
27708008
NOP14_YEASTNOP14genetic
27708008
NHP2_YEASTNHP2genetic
27708008
RRP45_YEASTRRP45genetic
27708008
GPI11_YEASTGPI11genetic
27708008
FCF1_YEASTFCF1genetic
27708008
UTP5_YEASTUTP5genetic
27708008
UTP6_YEASTUTP6genetic
27708008
RPN11_YEASTRPN11genetic
27708008
RRP41_YEASTSKI6genetic
27708008
RRP3_YEASTRRP3genetic
27708008
UTP9_YEASTUTP9genetic
27708008
MTR4_YEASTMTR4genetic
27708008
NEP1_YEASTEMG1genetic
27708008
NOP56_YEASTNOP56genetic
27708008
UTP13_YEASTUTP13genetic
27708008
UTP15_YEASTUTP15genetic
27708008
HAS1_YEASTHAS1genetic
27708008
RRP44_YEASTDIS3genetic
27708008
HRP1_YEASTHRP1genetic
27708008
PRS10_YEASTRPT4genetic
27708008
ATG9_YEASTATG9genetic
27708008
RL29_YEASTRPL29genetic
27708008
PUF4_YEASTPUF4genetic
27708008
DBP3_YEASTDBP3genetic
27708008
SLX9_YEASTSLX9genetic
27708008
LRP1_YEASTLRP1genetic
27708008
YJQ3_YEASTYJL163Cgenetic
27708008
EF1G2_YEASTTEF4genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
GBLP_YEASTASC1genetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
RRP6_YEASTRRP6genetic
27708008
BUD21_YEASTBUD21genetic
27708008
SUR1_YEASTSUR1genetic
27708008
MDL2_YEASTMDL2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RRP8_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62, AND MASSSPECTROMETRY.

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