FUS2_YEAST - dbPTM
FUS2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FUS2_YEAST
UniProt AC Q05670
Protein Name Nuclear fusion protein FUS2
Gene Name FUS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 677
Subcellular Localization Cell tip. Localizes at the mating projection tip (shmoo).
Protein Description Promotes cell fusion during zygote formation..
Protein Sequence MFKTSYNLYDLNYPKNDSLTPIRDYKNDYFHKNDDKLPEIVRKPTRKLSKHENKLNDKKFTNKRPASLDLHSIVESLSNKKIYSPINTEIFQNVVRLNLSPQIPNSPHEGCKFYKIVQEFYLSEVEYYNNLLTANNVYRKALNSDPRFKNKLVKLDSSDELLLFGNIDTIASISKILVTAIKDLLLAKQRGKMLDANEWQKIFTKNEVQQQLYSTFDISEAFEQHLLRIKSTYTSYFVSHQKQMELFTTLRMNKNHFFNKWYEYCLKESGCIKLEDILKSPMKRLTQWIDTLETLESCYEDILSPELGLKLSPTRRKYSLFSNKLETEVSEYKSNSMYNFSLTPSEIIQSYDEDQFTHLLKPPDKQNKNICNASRQESNLDNSRVPSLLSGSSSYYSDVSGLEIVTNTSTASAEMINLKMDEETEFFTLADHISKFKKVMKGLLELKKNLLKNDLSGIIDISLRRINAWKKVIECERPSGAFFAHDNLISTMCSSYIDKLHEQKNQVTILKLTELETDVMNPLERIIAHCTTVKSKLKDLQALKKDYMLFLQEKKANVRDIKRDLLGMHFQNLQNQMKRELPVFITLIHDTIECILLNYIKVFLKYLEIIAGGKKYLQKDLENMSLNDSIATGQIKNLDILQCYSKSRYMTKRMVRKDWPFPGDPSGSRVVRKLFEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20PhosphorylationYPKNDSLTPIRDYKN
CCCCCCCCCHHHCCC		22.1817330950
67PhosphorylationFTNKRPASLDLHSIV
CCCCCCCCCCHHHHH		25.7117330950
72PhosphorylationPASLDLHSIVESLSN
CCCCCHHHHHHHHCC		35.3117330950
76PhosphorylationDLHSIVESLSNKKIY
CHHHHHHHHCCCCCC		26.6317330950
78PhosphorylationHSIVESLSNKKIYSP
HHHHHHHCCCCCCCC		56.7528889911
83PhosphorylationSLSNKKIYSPINTEI
HHCCCCCCCCCCHHH		19.7817330950
84PhosphorylationLSNKKIYSPINTEIF
HCCCCCCCCCCHHHH		23.8319188495
88PhosphorylationKIYSPINTEIFQNVV
CCCCCCCHHHHHCHH		31.0417330950
100PhosphorylationNVVRLNLSPQIPNSP
CHHHCCCCCCCCCCC		17.4319188495
106PhosphorylationLSPQIPNSPHEGCKF
CCCCCCCCCCCCCHH		23.4517330950
254AcetylationFTTLRMNKNHFFNKW
HHHHCCCCHHHHHHH		42.3225381059
319PhosphorylationSPTRRKYSLFSNKLE
CCCHHHHHHHCCCCC		26.4417330950
341PhosphorylationSNSMYNFSLTPSEII
CCCCCCCCCCHHHHH		27.9127017623
343PhosphorylationSMYNFSLTPSEIIQS
CCCCCCCCHHHHHHH		24.4627017623
357PhosphorylationSYDEDQFTHLLKPPD
HCCCCCCHHHCCCCC		13.1427017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FUS2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FUS2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FUS2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RV161_YEASTRVS161physical
9566960
FUS1_YEASTFUS1genetic
9614182
SPA2_YEASTSPA2genetic
9614182
FUS1_YEASTFUS1genetic
3302672
RV161_YEASTRVS161physical
11283351
YEL1_YEASTYEL1genetic
20093466
RL4A_YEASTRPL4Agenetic
20093466
IST2_YEASTIST2genetic
20093466
RIM1_YEASTRIM1genetic
20093466
S2538_YEASTYDL119Cgenetic
20093466
RRP8_YEASTRRP8genetic
20093466
RL11B_YEASTRPL11Bgenetic
20093466
ASK10_YEASTASK10genetic
20093466
PCP1_YEASTPCP1genetic
20093466
AZR1_YEASTAZR1genetic
20093466
PHB2_YEASTPHB2genetic
20093466
LRP1_YEASTLRP1genetic
20093466
SIM1_YEASTSIM1genetic
20093466
MNS1_YEASTMNS1genetic
20093466
SKG3_YEASTSKG3genetic
20093466
YL281_YEASTYLR281Cgenetic
20093466
EXG1_YEASTEXG1genetic
20093466
ATP10_YEASTATP10genetic
20093466
GIS4_YEASTGIS4genetic
20093466
MUB1_YEASTMUB1genetic
20093466
SWS2_YEASTSWS2genetic
20093466
EOS1_YEASTEOS1genetic
20093466
PET8_YEASTPET8genetic
20093466
ATG19_YEASTATG19genetic
20093466
PHO80_YEASTPHO80genetic
20093466
PDE2_YEASTPDE2genetic
20093466
NEW1_YEASTNEW1genetic
20093466
RU2A_YEASTLEA1genetic
20093466
MED1_YEASTMED1genetic
20093466
LRG1_YEASTLRG1genetic
15514049
BEM1_YEASTBEM1genetic
15514049
FUS1_YEASTFUS1genetic
15514049
MTU1_YEASTSLM3genetic
27708008
LSM7_YEASTLSM7genetic
27708008
GEM1_YEASTGEM1genetic
27708008
YEL1_YEASTYEL1genetic
27708008
ETR1_YEASTETR1genetic
27708008
RL4A_YEASTRPL4Agenetic
27708008
REI1_YEASTREI1genetic
27708008
STE50_YEASTSTE50genetic
27708008
MRC1_YEASTMRC1genetic
27708008
RRP8_YEASTRRP8genetic
27708008
RL11B_YEASTRPL11Bgenetic
27708008
CBP4_YEASTCBP4genetic
27708008
AZR1_YEASTAZR1genetic
27708008
PHB2_YEASTPHB2genetic
27708008
WSC4_YEASTWSC4genetic
27708008
BZZ1_YEASTBZZ1genetic
27708008
SIM1_YEASTSIM1genetic
27708008
FLX1_YEASTFLX1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
IF4A_YEASTTIF2genetic
27708008
MNS1_YEASTMNS1genetic
27708008
SKG3_YEASTSKG3genetic
27708008
COA4_YEASTCOA4genetic
27708008
EXG1_YEASTEXG1genetic
27708008
ATP10_YEASTATP10genetic
27708008
TSR2_YEASTTSR2genetic
27708008
GIS4_YEASTGIS4genetic
27708008
PET8_YEASTPET8genetic
27708008
SWS2_YEASTSWS2genetic
27708008
PHO23_YEASTPHO23genetic
27708008
PHO80_YEASTPHO80genetic
27708008
CYC2_YEASTCYC2genetic
27708008
CY1_YEASTCYT1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
KEL1_YEASTKEL1genetic
26865368
MPS1_YEASTMPS1genetic
26865368
MPS1_YEASTMPS1physical
26865368
CDC42_YEASTCDC42physical
29066609
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FUS2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20; SER-67; SER-72;SER-84; THR-88; SER-100 AND SER-106, AND MASS SPECTROMETRY.

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