dbPTM

SIM1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SIM1_YEAST
UniProt AC	P40472
Protein Name	Probable secreted beta-glucosidase SIM1
Gene Name	SIM1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	476
Subcellular Localization	Secreted, cell wall . Non-covalently bound to the cell wall.
Protein Description	Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions. Required for the maintenance of the CLB5 kinase activity..
Protein Sequence	MKFSTAVTTLISSGAIVSALPHVDVHQEDAHQHKRAVAYKYVYETVVVDSDGHTVTPAASEVATAATSAIITTSVLAPTSSAAAADSSASIAVSSAALAKNEKISDAAASATASTSQGASSSSSSSSATSTLESSSVSSSSEEAAPTSTVVSTSSATQSSASSATKSSTSSTSPSTSTSTSTSSTSSSSSSSSSSSSSSSGSGSIYGDLADFSGPSEKFQDGTIPCDKFPSGQGVISIDWIGEGGWSGVENTDTSTGGSCKEGSYCSYSCQPGMSKTQWPSDQPSDGRSVGGLLCKNGYLYRSNTDADYLCEWGVEAAYVVSKLSKGVAICRTDYPGTENMVIPTYVEGGSSLPLTVVDQDTYFTWEGKKTSAQYYVNNAGVSVEDGCIWGTSGSGIGNWAPLNFGAGSTGGVTYLSLIPNPNNSDALNYNVKIVAADDSSNVIGECVYENGEFSGGADGCTVSVTSGKAHFVLYN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
289	Phosphorylation	DQPSDGRSVGGLLCK CCCCCCCCCCCEEEE	30.55	19779198
423	N-linked_Glycosylation	LSLIPNPNNSDALNY EECCCCCCCCCCCCC	68.24	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SIM1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SIM1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SIM1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WWM1_YEAST	WWM1	genetic	27708008
TFS2_YEAST	DST1	genetic	27708008
ANR2_YEAST	ANR2	genetic	27708008
SLA1_YEAST	SLA1	genetic	27708008
AVT5_YEAST	AVT5	genetic	27708008
SEC66_YEAST	SEC66	genetic	27708008
RS6A_YEAST	RPS6B	genetic	27708008
RS6B_YEAST	RPS6B	genetic	27708008
BUD31_YEAST	BUD31	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
PALF_YEAST	RIM8	genetic	27708008
AAKG_YEAST	SNF4	genetic	27708008
ATC1_YEAST	PMR1	genetic	27708008
HUR1_YEAST	HUR1	genetic	27708008
RTF1_YEAST	RTF1	genetic	27708008
PTH_YEAST	PTH1	genetic	27708008
BNA3_YEAST	BNA3	genetic	27708008
IME2_YEAST	IME2	genetic	27708008
YJY1_YEAST	YJR011C	genetic	27708008
HOC1_YEAST	HOC1	genetic	27708008
IME1_YEAST	IME1	genetic	27708008
AVT3_YEAST	AVT3	genetic	27708008
SAC1_YEAST	SAC1	genetic	27708008
UTH1_YEAST	UTH1	genetic	27708008
SRN2_YEAST	SRN2	genetic	27708008
CHS5_YEAST	CHS5	genetic	27708008
ROM2_YEAST	ROM2	genetic	27708008
COX7_YEAST	COX7	genetic	27708008
DIA1_YEAST	DIA1	genetic	27708008
SWS2_YEAST	SWS2	genetic	27708008
LSM7_YEAST	LSM7	genetic	27708008
TOP1_YEAST	TOP1	genetic	27708008
MDM12_YEAST	MDM12	genetic	27708008
WHI2_YEAST	WHI2	genetic	27708008
IDH2_YEAST	IDH2	genetic	27708008
PALA_YEAST	RIM20	genetic	27708008
MRX11_YEAST	YPL041C	genetic	27708008
LGE1_YEAST	LGE1	genetic	27708008
AIM44_YEAST	AIM44	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SIM1_YEAST

Related Literatures of Post-Translational Modification