| UniProt ID | WHI2_YEAST | |
|---|---|---|
| UniProt AC | P12611 | |
| Protein Name | Growth regulation protein | |
| Gene Name | WHI2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 486 | |
| Subcellular Localization | ||
| Protein Description | Plays a role in the coordination of growth and proliferation. Required for entry into G0 phase under conditions of carbon limitation. Involved in the general stress response; acts together with PSR1 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.. | |
| Protein Sequence | MDDIITQVSPDNAESAPILQEQQQQQNSQYEGNEEDYGDSLIHLNIQENHYFITRDQLMSLPESLLLCLFPSGVFLDRCGQVITNLTRDDEVYIVNFPPDCFEYIMEIYTKAHDDLYNHPVEKFFDRPSSSFVSNAKGFFGLSSNNSISSNNEQDILHQKPAIIVLREDLDYYCVPQEEFQFDSTNEENNEDLLRHFMAQVKMAAGSYLTSKTSIFQGLYSSNRLKQQQQQQKIEKGSNSSSNTKSTSKKLGPAEQHLMDMLCSSGFTKETCWGNRTQETGKTVISSLSLCRLANETTEGFRQKFNEAKAKWEAEHKPSQDNFITPMQSNISINSLSASKSNSTISTARNLTSGSTAPATARDKRKSRLSKLADNVRSHSSSRHSSQTRSKPPELPKLYDLVPKPNINAKLLLFWRKPARKCWWGEEDIELEVEVFGSWKDESKKIIELILPTNVDPEAELHKIIVPVRLHIRRVWTLELSVIGVQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 123 | Acetylation | LYNHPVEKFFDRPSS HHCCCHHHHCCCCCH | 52.11 | 24489116 | |
| 129 | Phosphorylation | EKFFDRPSSSFVSNA HHHCCCCCHHHHCCC | 39.24 | 22369663 | |
| 130 | Phosphorylation | KFFDRPSSSFVSNAK HHCCCCCHHHHCCCC | 30.40 | 22369663 | |
| 131 | Phosphorylation | FFDRPSSSFVSNAKG HCCCCCHHHHCCCCC | 33.72 | 22369663 | |
| 134 | Phosphorylation | RPSSSFVSNAKGFFG CCCHHHHCCCCCCCC | 29.12 | 22369663 | |
| 143 | Phosphorylation | AKGFFGLSSNNSISS CCCCCCCCCCCCCCC | 31.25 | 21551504 | |
| 144 | Phosphorylation | KGFFGLSSNNSISSN CCCCCCCCCCCCCCC | 45.10 | 21551504 | |
| 147 | Phosphorylation | FGLSSNNSISSNNEQ CCCCCCCCCCCCCHH | 28.26 | 21440633 | |
| 149 | Phosphorylation | LSSNNSISSNNEQDI CCCCCCCCCCCHHHH | 27.17 | 22369663 | |
| 150 | Phosphorylation | SSNNSISSNNEQDIL CCCCCCCCCCHHHHH | 41.84 | 22369663 | |
| 319 | Phosphorylation | WEAEHKPSQDNFITP HHHCCCCCCCCCCCC | 55.77 | 24961812 | |
| 325 | Phosphorylation | PSQDNFITPMQSNIS CCCCCCCCCCCCCEE | 14.47 | 29734811 | |
| 329 | Phosphorylation | NFITPMQSNISINSL CCCCCCCCCEEEEEC | 29.85 | 28889911 | |
| 332 | Phosphorylation | TPMQSNISINSLSAS CCCCCCEEEEECCCC | 21.70 | 21440633 | |
| 335 | Phosphorylation | QSNISINSLSASKSN CCCEEEEECCCCCCC | 23.25 | 21440633 | |
| 337 | Phosphorylation | NISINSLSASKSNST CEEEEECCCCCCCCC | 30.25 | 24961812 | |
| 339 | Phosphorylation | SINSLSASKSNSTIS EEEECCCCCCCCCCC | 32.99 | 24961812 | |
| 341 | Phosphorylation | NSLSASKSNSTISTA EECCCCCCCCCCCCC | 33.25 | 21440633 | |
| 343 | Phosphorylation | LSASKSNSTISTARN CCCCCCCCCCCCCCC | 33.92 | 21440633 | |
| 344 | Phosphorylation | SASKSNSTISTARNL CCCCCCCCCCCCCCC | 24.17 | 28889911 | |
| 346 | Phosphorylation | SKSNSTISTARNLTS CCCCCCCCCCCCCCC | 18.99 | 24961812 | |
| 347 | Phosphorylation | KSNSTISTARNLTSG CCCCCCCCCCCCCCC | 26.28 | 21440633 | |
| 352 | Phosphorylation | ISTARNLTSGSTAPA CCCCCCCCCCCCCCC | 34.29 | 21551504 | |
| 353 | Phosphorylation | STARNLTSGSTAPAT CCCCCCCCCCCCCCC | 33.63 | 21440633 | |
| 356 | Phosphorylation | RNLTSGSTAPATARD CCCCCCCCCCCCHHH | 39.94 | 21440633 | |
| 371 | Acetylation | KRKSRLSKLADNVRS HHHHHHHHHHHHHHH | 52.89 | 25381059 | |
| 371 | Ubiquitination | KRKSRLSKLADNVRS HHHHHHHHHHHHHHH | 52.89 | 23749301 | |
| 378 | Phosphorylation | KLADNVRSHSSSRHS HHHHHHHHHCCCCCC | 24.36 | 24961812 | |
| 380 | Phosphorylation | ADNVRSHSSSRHSSQ HHHHHHHCCCCCCCC | 31.12 | 20377248 | |
| 381 | Phosphorylation | DNVRSHSSSRHSSQT HHHHHHCCCCCCCCC | 26.43 | 20377248 | |
| 382 | Phosphorylation | NVRSHSSSRHSSQTR HHHHHCCCCCCCCCC | 36.71 | 20377248 | |
| 385 | Phosphorylation | SHSSSRHSSQTRSKP HHCCCCCCCCCCCCC | 24.03 | 20377248 | |
| 386 | Phosphorylation | HSSSRHSSQTRSKPP HCCCCCCCCCCCCCC | 29.46 | 20377248 | |
| 388 | Phosphorylation | SSRHSSQTRSKPPEL CCCCCCCCCCCCCCC | 38.57 | 20377248 | |
| 390 | Phosphorylation | RHSSQTRSKPPELPK CCCCCCCCCCCCCCC | 53.56 | 24961812 | |
| 481 | Phosphorylation | RVWTLELSVIGVQ-- EEEEEEEEEECCC-- | 11.43 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WHI2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WHI2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WHI2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND SER-131, ANDMASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380 AND SER-386, ANDMASS SPECTROMETRY. | |
