JEN1_YEAST - dbPTM
JEN1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID JEN1_YEAST
UniProt AC P36035
Protein Name Carboxylic acid transporter protein homolog
Gene Name JEN1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 616
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Essential to lactate transport..
Protein Sequence MSSSITDEKISGEQQQPAGRKLYYNTSTFAEPPLVDGEGNPINYEPEVYNPDHEKLYHNPSLPAQSIQDTRDDELLERVYSQDQGVEYEEDEEDKPNLSAASIKSYALTRFTSLLHIHEFSWENVNPIPELRKMTWQNWNYFFMGYFAWLSAAWAFFCVSVSVAPLAELYDRPTKDITWGLGLVLFVRSAGAVIFGLWTDKSSRKWPYITCLFLFVIAQLCTPWCDTYEKFLGVRWITGIAMGGIYGCASATAIEDAPVKARSFLSGLFFSAYAMGFIFAIIFYRAFGYFRDDGWKILFWFSIFLPILLIFWRLLWPETKYFTKVLKARKLILSDAVKANGGEPLPKANFKQKMVSMKRTVQKYWLLFAYLVVLLVGPNYLTHASQDLLPTMLRAQLGLSKDAVTVIVVVTNIGAICGGMIFGQFMEVTGRRLGLLIACTMGGCFTYPAFMLRSEKAILGAGFMLYFCVFGVWGILPIHLAELAPADARALVAGLSYQLGNLASAAASTIETQLADRYPLERDASGAVIKEDYAKVMAILTGSVFIFTFACVFVGHEKFHRDLSSPVMKKYINQVEEYEADGLSISDIVEQKTECASVKMIDSNVSKTYEEHIETV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSSITDEK
------CCCCCCCCC		32.5627717283
2Acetylation------MSSSITDEK
------CCCCCCCCC		32.5622814378
3Phosphorylation-----MSSSITDEKI
-----CCCCCCCCCC		25.1827717283
4Phosphorylation----MSSSITDEKIS
----CCCCCCCCCCC		23.3828889911
6Phosphorylation--MSSSITDEKISGE
--CCCCCCCCCCCCC		39.8030377154
9UbiquitinationSSSITDEKISGEQQQ
CCCCCCCCCCCCCCC		45.0112872131
11PhosphorylationSITDEKISGEQQQPA
CCCCCCCCCCCCCCC		47.5529136822
57PhosphorylationNPDHEKLYHNPSLPA
CCCHHHHCCCCCCCH		15.6025371407
61PhosphorylationEKLYHNPSLPAQSIQ
HHHCCCCCCCHHHCC		52.9125005228
66PhosphorylationNPSLPAQSIQDTRDD
CCCCCHHHCCCCCCH		25.0725005228
70PhosphorylationPAQSIQDTRDDELLE
CHHHCCCCCCHHHHH		21.4425005228
80PhosphorylationDELLERVYSQDQGVE
HHHHHHHHCCCCCCC		13.5629136822
81PhosphorylationELLERVYSQDQGVEY
HHHHHHHCCCCCCCC		25.1521082442
88PhosphorylationSQDQGVEYEEDEEDK
CCCCCCCCCCCCCCC		23.3929136822
99PhosphorylationEEDKPNLSAASIKSY
CCCCCCCCHHHHHHH		28.5629136822
338UbiquitinationLILSDAVKANGGEPL
HHHHHHHHHCCCCCC		37.5412872131
525PhosphorylationYPLERDASGAVIKED
CCCCCCCCCCCCCHH		31.4130377154
533PhosphorylationGAVIKEDYAKVMAIL
CCCCCHHHHHHHHHH		14.9328889911
571PhosphorylationSSPVMKKYINQVEEY
CCHHHHHHHHHHHHH		10.2929136822
578PhosphorylationYINQVEEYEADGLSI
HHHHHHHHCCCCCCH		11.6929136822
584PhosphorylationEYEADGLSISDIVEQ
HHCCCCCCHHHHHHH		26.1025005228
586PhosphorylationEADGLSISDIVEQKT
CCCCCCHHHHHHHCC		20.2228889911
593PhosphorylationSDIVEQKTECASVKM
HHHHHHCCCCCEEEE		35.6728889911
597PhosphorylationEQKTECASVKMIDSN
HHCCCCCEEEECCCC		33.6527214570
603PhosphorylationASVKMIDSNVSKTYE
CEEEECCCCCCHHHH		28.3625005228
606PhosphorylationKMIDSNVSKTYEEHI
EECCCCCCHHHHHHH		24.4325005228
608PhosphorylationIDSNVSKTYEEHIET
CCCCCCHHHHHHHCC		28.7625005228
609PhosphorylationDSNVSKTYEEHIETV
CCCCCHHHHHHHCCC		24.0527214570
615PhosphorylationTYEEHIETV------
HHHHHHCCC------		30.8029734811
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of JEN1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of JEN1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of JEN1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RV161_YEASTRVS161genetic
20093466
BCS1_YEASTBCS1genetic
20093466
RV167_YEASTRVS167genetic
20093466
YGY5_YEASTYGL235Wgenetic
20093466
QCR9_YEASTQCR9genetic
20093466
FIS1_YEASTFIS1genetic
20093466
YJ24_YEASTKCH1genetic
20093466
MEH1_YEASTMEH1genetic
20093466
GTR1_YEASTGTR1genetic
20093466
MED9_YEASTCSE2genetic
20093466
CY1_YEASTCYT1genetic
20093466
MNE1_YEASTMNE1genetic
20093466
YIQ6_YEASTYIL166Cphysical
16093310
SSK1_YEASTSSK1genetic
20526336
SWA2_YEASTSWA2genetic
20526336
YPT31_YEASTYPT31genetic
20526336
ADY2_YEASTADY2genetic
22260735
ADY2_YEASTADY2genetic
22257278
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of JEN1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-11; SER-81;SER-584 AND SER-606, AND MASS SPECTROMETRY.
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, UBIQUITINATION ATLYS-9 AND LYS-338, AND MASS SPECTROMETRY.
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, UBIQUITINATION ATLYS-9 AND LYS-338, AND MASS SPECTROMETRY.

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