MEH1_YEAST - dbPTM
MEH1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MEH1_YEAST
UniProt AC Q02205
Protein Name Protein MEH1
Gene Name MEH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 184
Subcellular Localization Vacuole membrane .
Protein Description Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome. Component of the EGO complex, a complex involved in the regulation of microautophagy..
Protein Sequence MGAVLSCCRNHSGEENEALLREQQAGYGSQGNANDEYDAEQMRLKEHEHEQKLLAREQELRDIVANTNDKLIDISMINNSGIVIQGTDLQEALDKRQQEEGGDSREDERSAGDDNLSGHSVPSSGSAQATTHQTAPRTNTFTLLTSPDSAKISKEQLKKLHSNILNEIFSQSQVNKPGPLTVPF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Myristoylation------MGAVLSCCR
------CCCHHHCCC		25.1316732272
7S-palmitoylation-MGAVLSCCRNHSGE
-CCCHHHCCCCCCCH		1.9016751107
8S-palmitoylationMGAVLSCCRNHSGEE
CCCHHHCCCCCCCHH		4.3616751107
27PhosphorylationLREQQAGYGSQGNAN
HHHHHHCCCCCCCCC		19.3322369663
29PhosphorylationEQQAGYGSQGNANDE
HHHHCCCCCCCCCCC		26.8222369663
104PhosphorylationQQEEGGDSREDERSA
HHHHCCCCHHHHHHC		40.6228132839
110PhosphorylationDSREDERSAGDDNLS
CCHHHHHHCCCCCCC		34.2622890988
117PhosphorylationSAGDDNLSGHSVPSS
HCCCCCCCCCCCCCC		40.4922369663
120PhosphorylationDDNLSGHSVPSSGSA
CCCCCCCCCCCCCCC		38.9722369663
123PhosphorylationLSGHSVPSSGSAQAT
CCCCCCCCCCCCCCC		45.2122369663
124PhosphorylationSGHSVPSSGSAQATT
CCCCCCCCCCCCCCC		30.6022890988
126PhosphorylationHSVPSSGSAQATTHQ
CCCCCCCCCCCCCCC		21.1122369663
130PhosphorylationSSGSAQATTHQTAPR
CCCCCCCCCCCCCCC		16.8422890988
131PhosphorylationSGSAQATTHQTAPRT
CCCCCCCCCCCCCCC		18.2722890988
134PhosphorylationAQATTHQTAPRTNTF
CCCCCCCCCCCCCEE		30.9022890988
138PhosphorylationTHQTAPRTNTFTLLT
CCCCCCCCCEEEEEC		37.2422890988
140PhosphorylationQTAPRTNTFTLLTSP
CCCCCCCEEEEECCC		19.8622890988
142PhosphorylationAPRTNTFTLLTSPDS
CCCCCEEEEECCCCH		20.8622890988
145PhosphorylationTNTFTLLTSPDSAKI
CCEEEEECCCCHHCC		41.1322890988
146PhosphorylationNTFTLLTSPDSAKIS
CEEEEECCCCHHCCC		27.0417330950
149PhosphorylationTLLTSPDSAKISKEQ
EEECCCCHHCCCHHH		34.5417330950
151UbiquitinationLTSPDSAKISKEQLK
ECCCCHHCCCHHHHH		52.0123749301
153PhosphorylationSPDSAKISKEQLKKL
CCCHHCCCHHHHHHH		29.4521440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MEH1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MEH1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MEH1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SLM4_YEASTSLM4physical
11283351
SLM4_YEASTSLM4physical
10688190
GTR1_YEASTGTR1physical
16732272
GTR2_YEASTGTR2physical
16732272
SLM4_YEASTSLM4physical
16732272
GTR2_YEASTGTR2physical
15989961
SLM4_YEASTSLM4physical
15989961
GTR2_YEASTGTR2physical
11283351
GTR1_YEASTGTR1physical
18467557
COT1_YEASTCOT1physical
18467557
MEH1_YEASTMEH1physical
18467557
GTR1_YEASTGTR1physical
19748353
ARF1_YEASTARF1genetic
19325107
ERD1_YEASTERD1genetic
19325107
GLO3_YEASTGLO3genetic
19325107
HLJ1_YEASTHLJ1genetic
19325107
ILM1_YEASTILM1genetic
19325107
MGA2_YEASTMGA2genetic
19325107
OST3_YEASTOST3genetic
19325107
PER1_YEASTPER1genetic
19325107
PMT2_YEASTPMT2genetic
19325107
ATC6_YEASTSPF1genetic
19325107
SPT4_YEASTSPT4genetic
19325107
UBX2_YEASTUBX2genetic
19325107
BST1_YEASTBST1genetic
19325107
GTR1_YEASTGTR1physical
22615397
GTR2_YEASTGTR2physical
24702707
PDC2_YEASTPDC2genetic
27708008
SNU56_YEASTSNU56genetic
27708008
SYFB_YEASTFRS1genetic
27708008
AFG2_YEASTAFG2genetic
27708008
GPI12_YEASTGPI12genetic
27708008
WDR59_YEASTMTC5genetic
27708008
LSM6_YEASTLSM6genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
GTR1_YEASTGTR1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
RFA1_YEASTRFA1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
EXO84_YEASTEXO84genetic
27708008
GLE1_YEASTGLE1genetic
27708008
RS13_YEASTRPS13genetic
27708008
RMRP_YEASTSNM1genetic
27708008
PSB3_YEASTPUP3genetic
27708008
RSP5_YEASTRSP5genetic
27708008
COG3_YEASTCOG3genetic
27708008
ACT_YEASTACT1genetic
27708008
STT3_YEASTSTT3genetic
27708008
RPN1_YEASTRPN1genetic
27708008
BRL1_YEASTBRL1genetic
27708008
KOG1_YEASTKOG1genetic
27708008
ATC7_YEASTNEO1genetic
27708008
KTHY_YEASTCDC8genetic
27708008
RSC58_YEASTRSC58genetic
27708008
BOS1_YEASTBOS1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
TAF11_YEASTTAF11genetic
27708008
UTP15_YEASTUTP15genetic
27708008
LST8_YEASTLST8genetic
27708008
RPA1_YEASTRPA190genetic
27708008
DIM1_YEASTDIM1genetic
27708008
IF6_YEASTTIF6genetic
27708008
MED10_YEASTNUT2genetic
27708008
RS14A_YEASTRPS14Agenetic
27708008
BUD31_YEASTBUD31genetic
27708008
NHP10_YEASTNHP10genetic
27708008
YD012_YEASTYDL012Cgenetic
27708008
CYK3_YEASTCYK3genetic
27708008
IPT1_YEASTIPT1genetic
27708008
TPS2_YEASTTPS2genetic
27708008
RAD55_YEASTRAD55genetic
27708008
SWF1_YEASTSWF1genetic
27708008
DHAS_YEASTHOM2genetic
27708008
YD179_YEASTYDR179W-Agenetic
27708008
IPK1_YEASTIPK1genetic
27708008
XRS2_YEASTXRS2genetic
27708008
CP56_YEASTDIT2genetic
27708008
AK_YEASTHOM3genetic
27708008
METE_YEASTMET6genetic
27708008
IES1_YEASTIES1genetic
27708008
PIB2_YEASTPIB2genetic
27708008
YG036_YEASTYGL036Wgenetic
27708008
MRM2_YEASTMRM2genetic
27708008
MED5_YEASTNUT1genetic
27708008
SPO74_YEASTSPO74genetic
27708008
HXKB_YEASTHXK2genetic
27708008
SERB_YEASTSER2genetic
27708008
RSSA1_YEASTRPS0Agenetic
27708008
GOSR1_YEASTGOS1genetic
27708008
STB5_YEASTSTB5genetic
27708008
DAL81_YEASTDAL81genetic
27708008
VPS53_YEASTVPS53genetic
27708008
CUL8_YEASTRTT101genetic
27708008
RAD26_YEASTRAD26genetic
27708008
TOR1_YEASTTOR1genetic
27708008
YJ68_YEASTYJR098Cgenetic
27708008
MNS1_YEASTMNS1genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
ERG3_YEASTERG3genetic
27708008
SIC1_YEASTSIC1genetic
27708008
VIP1_YEASTVIP1genetic
27708008
WAR1_YEASTWAR1genetic
27708008
GAS1_YEASTGAS1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
BRE5_YEASTBRE5genetic
27708008
RTG1_YEASTRTG1genetic
27708008
SNC2_YEASTSNC2genetic
27708008
MRX11_YEASTYPL041Cgenetic
27708008
FMP30_YEASTFMP30genetic
27708008
NEW1_YEASTNEW1genetic
27708008
YAR1_YEASTYAR1genetic
27708008
CHMU_YEASTARO7genetic
27708008
MED1_YEASTMED1genetic
27708008
YC075_YEASTYCR075W-Aphysical
26609069
SLM4_YEASTSLM4physical
26609069
GTR1_YEASTGTR1physical
26609069
GTR2_YEASTGTR2physical
26609069
SLM4_YEASTSLM4physical
26206314
YC075_YEASTYCR075W-Aphysical
26206314
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MEH1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146 AND SER-149, ANDMASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, AND MASSSPECTROMETRY.

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