RAD26_YEAST - dbPTM
RAD26_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAD26_YEAST
UniProt AC P40352
Protein Name DNA repair and recombination protein RAD26
Gene Name RAD26
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1085
Subcellular Localization Nucleus .
Protein Description May be involved in the preferential repair of active genes..
Protein Sequence MEDKEQQDNAKLENNESLKDLGVNVLSQSSLEEKIANDVTNFSNLQSLQQEETRLERSKTALQRYVNKKNHLTRKLNNTTRISVKQNLRDQIKNLQSDDIERVLKDIDDIQSRIKELKEQVDQGAENKGSKEGLQRPGETEKEFLIRTGKITAFGHKAGFSLDTANREYAKNDEQKDEDFEMATEQMVENLTDEDDNLSDQDYQMSGKESEDDEEEENDDKILKELEDLRFRGQPGEAKDDGDELYYQERLKKWVKQRSCGSQRSSDLPEWRRPHPNIPDAKLNSQFKIPGEIYSLLFNYQKTCVQWLYELYQQNCGGIIGDEMGLGKTIQVIAFIAALHHSGLLTGPVLIVCPATVMKQWCNEFQHWWPPLRTVILHSMGSGMASDQKFKMDENDLENLIMNSKPSDFSYEDWKNSTRTKKALESSYHLDKLIDKVVTDGHILITTYVGLRIHSDKLLKVKWQYAVLDEGHKIRNPDSEISLTCKKLKTHNRIILSGTPIQNNLTELWSLFDFIFPGKLGTLPVFQQQFVIPINIGGYANATNIQVQTGYKCAVALRDLISPYLLRRVKADVAKDLPQKKEMVLFCKLTKYQRSKYLEFLHSSDLNQIQNGKRNVLFGIDILRKICNHPDLLDRDTKRHNPDYGDPKRSGKMQVVKQLLLLWHKQGYKALLFTQSRQMLDILEEFISTKDPDLSHLNYLRMDGTTNIKGRQSLVDRFNNESFDVFLLTTRVGGLGVNLTGANRIIIFDPDWNPSTDMQARERAWRIGQKREVSIYRLMVGGSIEEKIYHRQIFKQFLTNRILTDPKQKRFFKIHELHDLFSLGGENGYSTEELNEEVQKHTENLKNSKSEESDDFEQLVNLSGVSKLESFYNGKEKKENSKTEDDRLIEGLLGGESNLETVMSHDSVVNSHAGSSSSNIITKEASRVAIEAVNALRKSRKKITKQYEIGTPTWTGRFGKAGKIRKRDPLKNKLTGSAAILGNITKSQKEASKEARQENYDDGITFARSKEINSNTKTLENIRAYLQKQNNFFSSSVSILNSIGVSLSDKEDVIKVRALLKTIAQFDKERKGWVLDEEFRNNNAS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationAKLENNESLKDLGVN
HHHCCCHHHHHHCCC		42.7319795423
19UbiquitinationLENNESLKDLGVNVL
HCCCHHHHHHCCCCC		61.2519722269
27PhosphorylationDLGVNVLSQSSLEEK
HHCCCCCCCHHHHHH		24.5928152593
29PhosphorylationGVNVLSQSSLEEKIA
CCCCCCCHHHHHHHH		33.2528889911
30PhosphorylationVNVLSQSSLEEKIAN
CCCCCCHHHHHHHHH		31.9628152593
97PhosphorylationDQIKNLQSDDIERVL
HHHHHCCHHHHHHHH		40.1828889911
184PhosphorylationDEDFEMATEQMVENL
HHHHHHHHHHHHHHC		25.9919779198
192PhosphorylationEQMVENLTDEDDNLS
HHHHHHCCCCCCCCC		49.2619779198
206PhosphorylationSDQDYQMSGKESEDD
CHHHHHHCCCCCCCC		31.0528889911
210PhosphorylationYQMSGKESEDDEEEE
HHHCCCCCCCCCHHH		50.2228889911
853PhosphorylationKNSKSEESDDFEQLV
HCCCCCCCCCHHHHH		38.1327214570
863PhosphorylationFEQLVNLSGVSKLES
HHHHHCHHHHHHHHH		31.7627017623
866PhosphorylationLVNLSGVSKLESFYN
HHCHHHHHHHHHHHC		34.7430377154
870PhosphorylationSGVSKLESFYNGKEK
HHHHHHHHHHCCCCC		43.3930377154
872PhosphorylationVSKLESFYNGKEKKE
HHHHHHHHCCCCCCC		32.0830377154
975PhosphorylationDPLKNKLTGSAAILG
CCCCCCCCCCHHHHH		30.6019823750
977PhosphorylationLKNKLTGSAAILGNI
CCCCCCCCHHHHHCC		14.8619823750
985PhosphorylationAAILGNITKSQKEAS
HHHHHCCCHHHHHHH		28.7419823750
1042PhosphorylationSSVSILNSIGVSLSD
HHHHHHHHCCCCCCC		19.7828889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
27SPhosphorylationKinaseMEC1P38111
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAD26_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAD26_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FPPS_YEASTERG20physical
11805837
MAM33_YEASTMAM33physical
11805837
VATA_YEASTVMA1physical
11805837
BIOA_YEASTBIO3physical
11805837
IF4E_YEASTCDC33physical
11805837
PMM_YEASTSEC53physical
11805837
ACON_YEASTACO1physical
11805837
QCR2_YEASTQCR2physical
11805837
IF4A_YEASTTIF2physical
11805837
ADH4_YEASTADH4physical
11805837
HSP7E_YEASTECM10physical
11805837
GPP1_YEASTGPP1physical
11805837
YSP2_YEASTYSP2physical
11805837
MDHM_YEASTMDH1physical
11805837
EF1G2_YEASTTEF4physical
11805837
GDI1_YEASTGDI1physical
11805837
ACH1_YEASTACH1physical
11805837
RAD3_YEASTRAD3physical
11805837
YM71_YEASTYMR226Cphysical
11805837
PP2C7_YEASTPTC7physical
11805837
ADH6_YEASTADH6physical
11805837
END3_YEASTEND3physical
11087867
DEF1_YEASTDEF1genetic
11859374
MSH2_YEASTMSH2genetic
8807287
SPT4_YEASTSPT4genetic
11101522
RAD16_YEASTRAD16genetic
12000839
RAD7_YEASTRAD7genetic
12000839
RRP6_YEASTRRP6genetic
15489286
REB1_YEASTREB1genetic
17314980
TF3B_YEASTBRF1genetic
17314980
RSC8_YEASTRSC8genetic
17314980
RPC10_YEASTRPC11genetic
17314980
NOT2_YEASTCDC36genetic
17314980
RAD23_YEASTRAD23genetic
17314980
SSF1_YEASTSSF1genetic
17314980
REI1_YEASTREI1genetic
17314980
RGP1_YEASTRGP1genetic
17314980
PAF1_YEASTPAF1genetic
17314980
ELOA1_YEASTELA1genetic
17296727
CUL3_YEASTCUL3genetic
17296727
ELOC_YEASTELC1genetic
17296727
APN2_YEASTAPN2genetic
12482989
APN1_YEASTAPN1genetic
12482989
ELOC_YEASTELC1genetic
18817898
RAD7_YEASTRAD7genetic
19384408
SPT5_YEASTSPT5genetic
20042611
SPT4_YEASTSPT4genetic
20042611
SIR1_YEASTSIR1genetic
20348017
SIR2_YEASTSIR2genetic
20348017
SIR3_YEASTSIR3genetic
20348017
SIR4_YEASTSIR4genetic
20348017
UBP3_YEASTUBP3genetic
18498751
TFS2_YEASTDST1genetic
11713297
SWD1_YEASTSWD1genetic
14690608
SDC1_YEASTSDC1genetic
14690608
SIN3_YEASTSIN3genetic
14690608
SEC22_YEASTSEC22genetic
14690608
MAD2_YEASTMAD2genetic
14690608
SRC1_YEASTSRC1genetic
14690608
SIZ1_YEASTSIZ1genetic
21968059
SIZ2_YEASTNFI1genetic
21968059
RPB1_YEASTRPO21genetic
22405652
GLU2B_YEASTGTB1physical
22875988
MED3_YEASTPGD1physical
22875988
TAF1_YEASTTAF1physical
22875988
CDC12_YEASTCDC12physical
22875988
MMR1_YEASTMMR1physical
22875988
SMY1_YEASTSMY1physical
22875988
RPB9_YEASTRPB9genetic
23307894
CMR1_YEASTCMR1genetic
22842922
RAD7_YEASTRAD7genetic
24603480
H4_YEASTHHF1genetic
23991048
SPT4_YEASTSPT4genetic
27179024
RAD14_YEASTRAD14genetic
27708008
THRC_YEASTTHR4genetic
27708008
PHB2_YEASTPHB2genetic
27708008
LST4_YEASTLST4genetic
27708008
POC2_YEASTADD66genetic
27708008
TRPG_YEASTTRP3genetic
27708008
FMP46_YEASTFMP46genetic
27708008
KTR2_YEASTKTR2genetic
27708008
FABD_YEASTMCT1genetic
27708008
YO223_YEASTDSC3genetic
27708008
DEF1_YEASTDEF1genetic
28521214
SRS2_YEASTSRS2genetic
28521214
TFS2_YEASTDST1genetic
28521214
RPB9_YEASTRPB9genetic
28521214
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAD26_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27 AND SER-29, AND MASSSPECTROMETRY.

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