ACH1_YEAST - dbPTM
ACH1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACH1_YEAST
UniProt AC P32316
Protein Name Acetyl-CoA hydrolase
Gene Name ACH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 526
Subcellular Localization Cytoplasm .
Protein Description Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation. It may be involved in overall regulation of acetylation during melatonin synthesis..
Protein Sequence MTISNLLKQRVRYAPYLKKVKEAHELIPLFKNGQYLGWSGFTGVGTPKAVPEALIDHVEKNNLQGKLRFNLFVGASAGPEENRWAEHDMIIKRAPHQVGKPIAKAINQGRIEFFDKHLSMFPQDLTYGFYTRERKDNKILDYTIIEATAIKEDGSIVPGPSVGGSPEFITVSDKVIIEVNTATPSFEGIHDIDMPVNPPFRKPYPYLKVDDKCGVDSIPVDPEKVVAIVESTMRDQVPPNTPSDDMSRAIAGHLVEFFRNEVKHGRLPENLLPLQSGIGNIANAVIEGLAGAQFKHLTVWTEVLQDSFLDLFENGSLDYATATSVRLTEKGFDRAFANWENFKHRLCLRSQVVSNNPEMIRRLGVIAMNTPVEVDIYAHANSTNVNGSRMLNGLGGSADFLRNAKLSIMHAPSARPTKVDPTGISTIVPMASHVDQTEHDLDILVTDQGLADLRGLSPKERAREIINKCAHPDYQALLTDYLDRAEHYAKKHNCLHEPHMLKNAFKFHTNLAEKGTMKVDSWEPVD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Blocked amino end (Thr)------MTISNLLKQ
------CCHHHHHHH		32.87-
2Acetylation------MTISNLLKQ
------CCHHHHHHH		32.871970569
100AcetylationRAPHQVGKPIAKAIN
CCCHHCCHHHHHHHH		34.1025381059
104AcetylationQVGKPIAKAINQGRI
HCCHHHHHHHHCCCC		50.9825381059
241PhosphorylationRDQVPPNTPSDDMSR
CCCCCCCCCCHHHHH		29.9127214570
263AcetylationEFFRNEVKHGRLPEN
HHHHHHHHCCCCCCC		33.8825381059
298PhosphorylationGAQFKHLTVWTEVLQ
CCCCCCHHHHHHHHH		17.4529688323
301PhosphorylationFKHLTVWTEVLQDSF
CCCHHHHHHHHHHHH		16.3329688323
307PhosphorylationWTEVLQDSFLDLFEN
HHHHHHHHHHHHHHC		18.1029688323
316PhosphorylationLDLFENGSLDYATAT
HHHHHCCCCCEEEEE		29.6429688323
319PhosphorylationFENGSLDYATATSVR
HHCCCCCEEEEEEEE		15.9029688323
321PhosphorylationNGSLDYATATSVRLT
CCCCCEEEEEEEECC		25.0029688323
323PhosphorylationSLDYATATSVRLTEK
CCCEEEEEEEECCCC		24.3329688323
324PhosphorylationLDYATATSVRLTEKG
CCEEEEEEEECCCCC		11.6329688323
343AcetylationFANWENFKHRLCLRS
HCCHHHCCCHHHHHH		39.1224489116
350PhosphorylationKHRLCLRSQVVSNNP
CCHHHHHHHHHHCCH		17.8728889911
370PhosphorylationLGVIAMNTPVEVDIY
HCEEEECCCEEEEEE		18.6722369663
377PhosphorylationTPVEVDIYAHANSTN
CCEEEEEEECCCCCC		6.4622369663
382PhosphorylationDIYAHANSTNVNGSR
EEEECCCCCCCCCHH		23.3422369663
383PhosphorylationIYAHANSTNVNGSRM
EEECCCCCCCCCHHC		42.8922369663
388PhosphorylationNSTNVNGSRMLNGLG
CCCCCCCHHCCCCCC		14.8722369663
4592-HydroxyisobutyrylationDLRGLSPKERAREII
HHCCCCHHHHHHHHH		57.36-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ACH1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACH1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACH1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ODPB_YEASTPDB1genetic
20093466
CLPX_YEASTMCX1genetic
20093466
NUP59_YEASTASM4genetic
20093466
UBC13_YEASTUBC13genetic
20093466
ARO1_YEASTARO1genetic
20093466
ODO2_YEASTKGD2genetic
20093466
CEM1_YEASTCEM1genetic
20093466
VID30_YEASTVID30genetic
20093466
CUE3_YEASTCUE3genetic
20093466
NPY1_YEASTNPY1genetic
20093466
FMP48_YEASTFMP48genetic
20093466
YG2G_YEASTYGR079Wgenetic
20093466
PCP1_YEASTPCP1genetic
20093466
ODPX_YEASTPDX1genetic
20093466
SUCB_YEASTLSC2genetic
20093466
SLH1_YEASTSLH1genetic
20093466
YHJ3_YEASTYHR033Wgenetic
20093466
HTD2_YEASTHTD2genetic
20093466
PTPA1_YEASTRRD1genetic
20093466
HOS4_YEASTHOS4genetic
20093466
GVP36_YEASTGVP36genetic
20093466
VID28_YEASTVID28genetic
20093466
YIV5_YEASTYIR035Cgenetic
20093466
RPA34_YEASTRPA34genetic
20093466
IF4A_YEASTTIF2genetic
20093466
GLG2_YEASTGLG2genetic
20093466
DS1P1_YEASTLCB3genetic
20093466
LPLA_YEASTAIM22genetic
20093466
VTC4_YEASTVTC4genetic
20093466
YJY5_YEASTYJR015Wgenetic
20093466
PTK2_YEASTPTK2genetic
20093466
RM49_YEASTMRP49genetic
20093466
HAP4_YEASTHAP4genetic
20093466
FABG_YEASTOAR1genetic
20093466
RL14A_YEASTRPL14Agenetic
20093466
SET3_YEASTSET3genetic
20093466
PAM17_YEASTPAM17genetic
20093466
BAS1_YEASTBAS1genetic
20093466
FPS1_YEASTFPS1genetic
20093466
BPT1_YEASTBPT1genetic
20093466
LIPB_YEASTLIP2genetic
20093466
ERG6_YEASTERG6genetic
20093466
KAR5_YEASTKAR5genetic
20093466
SSO2_YEASTSSO2genetic
20093466
LSM7_YEASTLSM7genetic
20093466
FKBP_YEASTFPR1genetic
20093466
RAS2_YEASTRAS2genetic
20093466
ODP2_YEASTLAT1genetic
20093466
CISY1_YEASTCIT1genetic
20093466
RTG1_YEASTRTG1genetic
20093466
MSA1_YEASTMSA1genetic
20093466
YVC1_YEASTYVC1genetic
20093466
IDH2_YEASTIDH2genetic
20093466
SFL1_YEASTSFL1genetic
20093466
SUCA_YEASTLSC1genetic
20093466
LIPA_YEASTLIP5genetic
20093466
FABD_YEASTMCT1genetic
20093466
BEM4_YEASTBEM4genetic
20093466
CWC27_YEASTCWC27genetic
20093466
PMA2_YEASTPMA2genetic
20093466
ODP2_YEASTLAT1genetic
21623372
CBS_YEASTCYS4genetic
21623372
CEM1_YEASTCEM1genetic
21623372
ODPB_YEASTPDB1genetic
21623372
ODPA_YEASTPDA1genetic
21623372
FUMH_YEASTFUM1genetic
21623372
SUCB_YEASTLSC2genetic
21623372
ARO1_YEASTARO1genetic
21623372
DHOM_YEASTHOM6genetic
21623372
ADE_YEASTAAH1genetic
21623372
AROC_YEASTARO2genetic
21623372
SUCA_YEASTLSC1genetic
21623372
AATC_YEASTAAT2genetic
21623372
CISY1_YEASTCIT1genetic
21623372
CHMU_YEASTARO7genetic
21623372
HTD2_YEASTHTD2genetic
21623372
THDH_YEASTILV1genetic
21623372
GSH1_YEASTGSH1genetic
21623372
MCA1_YEASTMCA1genetic
22754872
SDS22_YEASTSDS22physical
23894419
ACS2_YEASTACS2genetic
24606900
ATG7_YEASTATG7genetic
24606900
YIV5_YEASTYIR035Cgenetic
27708008
VTC4_YEASTVTC4genetic
27708008
RM49_YEASTMRP49genetic
27708008
RRP6_YEASTRRP6genetic
27708008
ODPB_YEASTPDB1genetic
27708008
CLPX_YEASTMCX1genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
MDHP_YEASTMDH3genetic
27708008
S2538_YEASTYDL119Cgenetic
27708008
ARO1_YEASTARO1genetic
27708008
ODO2_YEASTKGD2genetic
27708008
BCS1_YEASTBCS1genetic
27708008
CEM1_YEASTCEM1genetic
27708008
DLDH_YEASTLPD1genetic
27708008
CUE3_YEASTCUE3genetic
27708008
VID30_YEASTVID30genetic
27708008
RS25A_YEASTRPS25Agenetic
27708008
FMP48_YEASTFMP48genetic
27708008
YG2G_YEASTYGR079Wgenetic
27708008
SUCB_YEASTLSC2genetic
27708008
MALX3_YEASTIMA1genetic
27708008
YHA8_YEASTYHL008Cgenetic
27708008
HTD2_YEASTHTD2genetic
27708008
VID28_YEASTVID28genetic
27708008
FYV10_YEASTFYV10genetic
27708008
PTPA1_YEASTRRD1genetic
27708008
IMPX_YEASTIMP2genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
LPLA_YEASTAIM22genetic
27708008
RPE_YEASTRPE1genetic
27708008
DS1P1_YEASTLCB3genetic
27708008
IF4A_YEASTTIF2genetic
27708008
RPA34_YEASTRPA34genetic
27708008
YJ24_YEASTKCH1genetic
27708008
BCA2_YEASTBAT2genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
FABG_YEASTOAR1genetic
27708008
MUD2_YEASTMUD2genetic
27708008
CYT2_YEASTCYT2genetic
27708008
HAP4_YEASTHAP4genetic
27708008
SET3_YEASTSET3genetic
27708008
PAM17_YEASTPAM17genetic
27708008
LIPB_YEASTLIP2genetic
27708008
ERG6_YEASTERG6genetic
27708008
IMP2_YEASTIMP2genetic
27708008
KAR5_YEASTKAR5genetic
27708008
SSO2_YEASTSSO2genetic
27708008
IDH1_YEASTIDH1genetic
27708008
YNE0_YEASTYNL040Wgenetic
27708008
ODP2_YEASTLAT1genetic
27708008
FKBP_YEASTFPR1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
CISY1_YEASTCIT1genetic
27708008
HOL1_YEASTHOL1genetic
27708008
HMI1_YEASTHMI1genetic
27708008
ERFD_YEASTSHR5genetic
27708008
YO159_YEASTYOL159Cgenetic
27708008
YVC1_YEASTYVC1genetic
27708008
COQ7_YEASTCAT5genetic
27708008
IDH2_YEASTIDH2genetic
27708008
SUCA_YEASTLSC1genetic
27708008
LIPA_YEASTLIP5genetic
27708008
FABD_YEASTMCT1genetic
27708008
PMA2_YEASTPMA2genetic
27708008
CWC27_YEASTCWC27genetic
27708008
CISY2_YEASTCIT2genetic
26895788
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACH1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350, AND MASSSPECTROMETRY.

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