CUE3_YEAST - dbPTM
CUE3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CUE3_YEAST
UniProt AC P53137
Protein Name CUE domain-containing protein 3
Gene Name CUE3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 624
Subcellular Localization Cytoplasm .
Protein Description
Protein Sequence MLSRYNRVIEINGGNADISLPIVKFPPFKLRAQLIEKDPVVWLHLIETYVTYFEYLMQGANVELLDESTLDHLRLFLRTYLHEIADEEGKLLSLGINHDVSEQLYLLKGWIFSLIKKCGLLHLQIFGDSLWNLIKVYVRRNPDSIRGLIDGSLKPRINTQRVQLDKSYQVQQHLKQLIESGKFKRIDLRCVEDLLSAKSMQPNKFAENFFTANWIEILEALWAKGQGRGHKEARELIIISLFSVSADRLLKITKELGISNFETLALYPLLGTMLINEGVHKRLPDLKSKLLFLNLGGLSMDEGDHMSYPTSSGTEVNEEQLSALMELFPQFSKYQLSQTLLAYDNNIELVTNKIFEDPTIIEAFSREPAEEEVEPVSDGDNASFTEELSILDRGDSSKNKELDKKIISEGVPDELRNKTLTRALKLLYEADEDERDDTYDEADVNRSDPSKRIGLQEDEESYDTKDDSNEVRQDHNYHIVEAYLWNLLKEDPKLFERSKRGTKVRKTMKEMTSWSDEKIEGWCRMLERSPTRARLLEKKFMFKGNSKTGKTSYVHNRDSQNDGNVVKEQAKQKKSENIKKHEPQSTEQKKRQHAKNEKRKGARANHNRKKGHDKKLARAGNNAI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
196PhosphorylationRCVEDLLSAKSMQPN
HHHHHHHHCCCCCCC		40.7329688323
198AcetylationVEDLLSAKSMQPNKF
HHHHHHCCCCCCCHH		42.9825381059
204AcetylationAKSMQPNKFAENFFT
CCCCCCCHHHHHCCH		53.2725381059
288PhosphorylationKRLPDLKSKLLFLNL
HHCCHHHHHHEEEEC		35.5121126336
377PhosphorylationEEEVEPVSDGDNASF
CCCCCCCCCCCCCCH		46.7428889911
383PhosphorylationVSDGDNASFTEELSI
CCCCCCCCHHHHHCC		38.6728889911
385PhosphorylationDGDNASFTEELSILD
CCCCCCHHHHHCCCC		26.5028889911
389PhosphorylationASFTEELSILDRGDS
CCHHHHHCCCCCCCC		25.1229688323
438PhosphorylationDEDERDDTYDEADVN
CCCCCCCCCCHHHCC		36.8428889911
461PhosphorylationGLQEDEESYDTKDDS
CCCCCHHHCCCCCCC		26.6830377154
465UbiquitinationDEESYDTKDDSNEVR
CHHHCCCCCCCCHHH		57.5523749301
529PhosphorylationWCRMLERSPTRARLL
HHHHHHHCHHHHHHH		22.6530377154
567UbiquitinationQNDGNVVKEQAKQKK
CCCCHHHHHHHHHHH		39.5623749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CUE3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CUE3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CUE3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YK03_YEASTYKR023Wphysical
16554755
PRP6_YEASTPRP6genetic
27708008
RPB7_YEASTRPB7genetic
27708008
CDC12_YEASTCDC12genetic
27708008
SEC22_YEASTSEC22genetic
27708008
TF2B_YEASTSUA7genetic
27708008
RV161_YEASTRVS161genetic
27708008
THRC_YEASTTHR4genetic
27708008
SIN3_YEASTSIN3genetic
27708008
YME1_YEASTYME1genetic
27708008
YK03_YEASTYKR023Wphysical
28223409
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CUE3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-383, AND MASSSPECTROMETRY.

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