| UniProt ID | SIN3_YEAST | |
|---|---|---|
| UniProt AC | P22579 | |
| Protein Name | Transcriptional regulatory protein SIN3 | |
| Gene Name | SIN3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1536 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Catalytic component of the RPD3 histone deacetylase complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SIN3 has also a RPD3 independent function required for normal longevity.. | |
| Protein Sequence | MSQVWHNSNSQSNDVATSNDATGSNERNEKEPSLQGNKPGFVQQQQRITLPSLSALSTKEEDRRDSNGQQALTSHAAHILGYPPPHSNAMPSIATDSALKQPHEYHPRPKSSSSSPSINASLMNAGPAPLPTVGAASFSLSRFDNPLPIKAPVHTEEPKSYNGLQEEEKATQRPQDCKEVPAGVQPADAPDPSSNHADANDDNNNNENSHDEDADYRPLNVKDALSYLEQVKFQFSSRPDIYNLFLDIMKDFKSQAIDTPGVIERVSTLFRGYPILIQGFNTFLPQGYRIECSSNPDDPIRVTTPMGTTTVNNNISPSGRGTTDAQELGSFPESDGNGVQQPSNVPMVPSSVYQSEQNQDQQQSLPLLATSSGLPSIQQPEMPAHRQIPQSQSLVPQEDAKKNVDVEFSQAISYVNKIKTRFADQPDIYKHFLEILQTYQREQKPINEVYAQVTHLFQNAPDLLEDFKKFLPDSSASANQQVQHAQQHAQQQHEAQMHAQAQAQAQAQAQVEQQKQQQQFLYPASGYYGHPSNRGIPQQNLPPIGSFSPPTNGSTVHEAYQDQQHMQPPHFMPLPSIVQHGPNMVHQGIANENPPLSDLRTSLTEQYAPSSIQHQQQHPQSISPIANTQYGDIPVRPEIDLDPSIVPVVPEPTEPIENNISLNEEVTFFEKAKRYIGNKHLYTEFLKILNLYSQDILDLDDLVEKVDFYLGSNKELFTWFKNFVGYQEKTKCIENIVHEKHRLDLDLCEAFGPSYKRLPKSDTFMPCSGRDDMCWEVLNDEWVGHPVWASEDSGFIAHRKNQYEETLFKIEEERHEYDFYIESNLRTIQCLETIVNKIENMTENEKANFKLPPGLGHTSMTIYKKVIRKVYDKERGFEIIDALHEHPAVTAPVVLKRLKQKDEEWRRAQREWNKVWRELEQKVFFKSLDHLGLTFKQADKKLLTTKQLISEISSIKVDQTNKKIHWLTPKPKSQLDFDFPDKNIFYDILCLADTFITHTTAYSNPDKERLKDLLKYFISLFFSISFEKIEESLYSHKQNVSESSGSDDGSSIASRKRPYQQEMSLLDILHRSRYQKLKRSNDEDGKVPQLSEPPEEEPNTIEEEELIDEEAKNPWLTGNLVEEANSQGIIQNRSIFNLFANTNIYIFFRHWTTIYERLLEIKQMNERVTKEINTRSTVTFAKDLDLLSSQLSEMGLDFVGEDAYKQVLRLSRRLINGDLEHQWFEESLRQAYNNKAFKLYTIDKVTQSLVKHAHTLMTDAKTAEIMALFVKDRNASTTSAKDQIIYRLQVRSHMSNTENMFRIEFDKRTLHVSIQYIALDDLTLKEPKADEDKWKYYVTSYALPHPTEGIPHEKLKIPFLERLIEFGQDIDGTEVDEEFSPEGISVSTLKIKIQPITYQLHIENGSYDVFTRKATNKYPTIANDNTQKGMVSQKKELISKFLDCAVGLRNNLDEAQKLSMQKKWENLKDSIAKTSAGNQGIESETEKGKITKQEQSDNLDSSTASVLPASITTVPQDDNIETTGNTESSDKGAKIQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSQVWHNSN ------CCCCCCCCC | 44.75 | 22369663 | |
| 8 | Phosphorylation | MSQVWHNSNSQSNDV CCCCCCCCCCCCCCC | 25.60 | 24909858 | |
| 10 | Phosphorylation | QVWHNSNSQSNDVAT CCCCCCCCCCCCCCC | 34.50 | 22369663 | |
| 12 | Phosphorylation | WHNSNSQSNDVATSN CCCCCCCCCCCCCCC | 34.51 | 22369663 | |
| 17 | Phosphorylation | SQSNDVATSNDATGS CCCCCCCCCCCCCCC | 28.10 | 22369663 | |
| 18 | Phosphorylation | QSNDVATSNDATGSN CCCCCCCCCCCCCCC | 23.99 | 22369663 | |
| 22 | Phosphorylation | VATSNDATGSNERNE CCCCCCCCCCCCCCC | 43.96 | 22369663 | |
| 24 | Phosphorylation | TSNDATGSNERNEKE CCCCCCCCCCCCCCC | 31.03 | 22369663 | |
| 33 | Phosphorylation | ERNEKEPSLQGNKPG CCCCCCCCCCCCCCC | 34.12 | 28889911 | |
| 52 | Phosphorylation | QQRITLPSLSALSTK HHHEECCCHHHCCCC | 37.76 | 30377154 | |
| 54 | Phosphorylation | RITLPSLSALSTKEE HEECCCHHHCCCCHH | 31.34 | 30377154 | |
| 57 | Phosphorylation | LPSLSALSTKEEDRR CCCHHHCCCCHHHCC | 36.83 | 30377154 | |
| 59 | Acetylation | SLSALSTKEEDRRDS CHHHCCCCHHHCCCC | 56.59 | 24489116 | |
| 111 | Phosphorylation | EYHPRPKSSSSSPSI CCCCCCCCCCCCCCC | 37.83 | 21440633 | |
| 112 | Phosphorylation | YHPRPKSSSSSPSIN CCCCCCCCCCCCCCC | 40.12 | 21440633 | |
| 113 | Phosphorylation | HPRPKSSSSSPSINA CCCCCCCCCCCCCCH | 41.76 | 28889911 | |
| 114 | Phosphorylation | PRPKSSSSSPSINAS CCCCCCCCCCCCCHH | 48.49 | 19779198 | |
| 115 | Phosphorylation | RPKSSSSSPSINASL CCCCCCCCCCCCHHH | 25.31 | 19779198 | |
| 117 | Phosphorylation | KSSSSSPSINASLMN CCCCCCCCCCHHHHC | 30.35 | 21440633 | |
| 121 | Phosphorylation | SSPSINASLMNAGPA CCCCCCHHHHCCCCC | 24.54 | 19779198 | |
| 137 | Phosphorylation | LPTVGAASFSLSRFD CCCCCCCEEECCCCC | 18.16 | 28889911 | |
| 159 | Acetylation | PVHTEEPKSYNGLQE CCCCCCCCCCCCCHH | 69.70 | 24489116 | |
| 169 | Acetylation | NGLQEEEKATQRPQD CCCHHHHHHHCCCCC | 61.07 | 25381059 | |
| 193 | Phosphorylation | PADAPDPSSNHADAN CCCCCCCCCCCCCCC | 51.67 | 28889911 | |
| 194 | Phosphorylation | ADAPDPSSNHADAND CCCCCCCCCCCCCCC | 37.71 | 21440633 | |
| 209 | Phosphorylation | DNNNNENSHDEDADY CCCCCCCCCCCCCCC | 26.57 | 20377248 | |
| 253 | Ubiquitination | LDIMKDFKSQAIDTP HHHHHHHHHCCCCCC | 52.36 | 23749301 | |
| 293 | Phosphorylation | QGYRIECSSNPDDPI CCEEEECCCCCCCCC | 21.99 | 22369663 | |
| 294 | Phosphorylation | GYRIECSSNPDDPIR CEEEECCCCCCCCCE | 65.13 | 22369663 | |
| 303 | Phosphorylation | PDDPIRVTTPMGTTT CCCCCEEECCCCCEE | 18.48 | 22369663 | |
| 304 | Phosphorylation | DDPIRVTTPMGTTTV CCCCEEECCCCCEEE | 14.39 | 22369663 | |
| 308 | Phosphorylation | RVTTPMGTTTVNNNI EEECCCCCEEECCCC | 17.03 | 22369663 | |
| 309 | Phosphorylation | VTTPMGTTTVNNNIS EECCCCCEEECCCCC | 24.02 | 22369663 | |
| 310 | Phosphorylation | TTPMGTTTVNNNISP ECCCCCEEECCCCCC | 22.52 | 22369663 | |
| 316 | Phosphorylation | TTVNNNISPSGRGTT EEECCCCCCCCCCCC | 18.35 | 22369663 | |
| 318 | Phosphorylation | VNNNISPSGRGTTDA ECCCCCCCCCCCCCH | 34.04 | 22369663 | |
| 679 | Acetylation | AKRYIGNKHLYTEFL HHHHHCCHHHHHHHH | 29.76 | 24489116 | |
| 729 | Acetylation | NFVGYQEKTKCIENI HHCCHHHHHHHHHHH | 37.45 | 22865919 | |
| 756 | Acetylation | EAFGPSYKRLPKSDT HHHCCCCCCCCCCCC | 52.36 | 25381059 | |
| 760 | Acetylation | PSYKRLPKSDTFMPC CCCCCCCCCCCCCCC | 66.60 | 24489116 | |
| 846 | Ubiquitination | ENMTENEKANFKLPP HCCCCCCCCCCCCCC | 61.28 | 23749301 | |
| 896 | Acetylation | VTAPVVLKRLKQKDE CCHHHHHHHHHHCCH | 44.04 | 24489116 | |
| 922 | Acetylation | VWRELEQKVFFKSLD HHHHHHHHHHHHHHH | 31.47 | 24489116 | |
| 927 | Phosphorylation | EQKVFFKSLDHLGLT HHHHHHHHHHHHCCC | 33.60 | 21440633 | |
| 934 | Phosphorylation | SLDHLGLTFKQADKK HHHHHCCCHHHHHHH | 27.30 | 21440633 | |
| 946 | Acetylation | DKKLLTTKQLISEIS HHHHHCHHHHHHHHH | 37.56 | 24489116 | |
| 950 | Phosphorylation | LTTKQLISEISSIKV HCHHHHHHHHHCCEE | 37.15 | 29136822 | |
| 1041 | Phosphorylation | YSHKQNVSESSGSDD HHCCCCCCCCCCCCC | 39.03 | 22369663 | |
| 1043 | Phosphorylation | HKQNVSESSGSDDGS CCCCCCCCCCCCCCC | 32.28 | 22369663 | |
| 1044 | Phosphorylation | KQNVSESSGSDDGSS CCCCCCCCCCCCCCC | 37.96 | 22369663 | |
| 1046 | Phosphorylation | NVSESSGSDDGSSIA CCCCCCCCCCCCCHH | 34.18 | 22369663 | |
| 1050 | Phosphorylation | SSGSDDGSSIASRKR CCCCCCCCCHHHCCC | 26.09 | 22369663 | |
| 1051 | Phosphorylation | SGSDDGSSIASRKRP CCCCCCCCHHHCCCH | 27.92 | 22369663 | |
| 1054 | Phosphorylation | DDGSSIASRKRPYQQ CCCCCHHHCCCHHHH | 36.34 | 22369663 | |
| 1064 | Phosphorylation | RPYQQEMSLLDILHR CHHHHHHHHHHHHHH | 25.65 | 28889911 | |
| 1091 | Phosphorylation | DGKVPQLSEPPEEEP CCCCCCCCCCCCCCC | 42.69 | 21551504 | |
| 1100 | Phosphorylation | PPEEEPNTIEEEELI CCCCCCCCCCHHHHC | 40.24 | 21551504 | |
| 1126 | Phosphorylation | NLVEEANSQGIIQNR CHHHHHHHCCCCCCH | 36.51 | 27214570 | |
| 1170 | Ubiquitination | QMNERVTKEINTRST HHHHHHHHHCCCCCH | 54.46 | 23749301 | |
| 1244 | Acetylation | FKLYTIDKVTQSLVK CEEEEHHHHHHHHHH | 43.24 | 24489116 | |
| 1244 | Ubiquitination | FKLYTIDKVTQSLVK CEEEEHHHHHHHHHH | 43.24 | 24961812 | |
| 1251 | Acetylation | KVTQSLVKHAHTLMT HHHHHHHHHHHHHHH | 40.13 | 24489116 | |
| 1262 | Phosphorylation | TLMTDAKTAEIMALF HHHHCCCHHHHHHHH | 31.10 | 19823750 | |
| 1276 | Phosphorylation | FVKDRNASTTSAKDQ HEECCCCCCCCHHHH | 35.45 | 19823750 | |
| 1277 | Phosphorylation | VKDRNASTTSAKDQI EECCCCCCCCHHHHH | 23.51 | 19823750 | |
| 1278 | Phosphorylation | KDRNASTTSAKDQII ECCCCCCCCHHHHHH | 24.96 | 19823750 | |
| 1279 | Phosphorylation | DRNASTTSAKDQIIY CCCCCCCCHHHHHHH | 33.15 | 19823750 | |
| 1354 | Acetylation | TEGIPHEKLKIPFLE CCCCCHHHCCCHHHH | 52.63 | 24489116 | |
| 1356 | Ubiquitination | GIPHEKLKIPFLERL CCCHHHCCCHHHHHH | 60.44 | 23749301 | |
| 1356 | Acetylation | GIPHEKLKIPFLERL CCCHHHCCCHHHHHH | 60.44 | 24489116 | |
| 1413 | Acetylation | SYDVFTRKATNKYPT CEEEEEECCCCCCCC | 57.41 | 25381059 | |
| 1417 | Acetylation | FTRKATNKYPTIAND EEECCCCCCCCCCCC | 48.53 | 24489116 | |
| 1428 | Ubiquitination | IANDNTQKGMVSQKK CCCCCCCCCCCCHHH | 47.11 | 23749301 | |
| 1440 | Ubiquitination | QKKELISKFLDCAVG HHHHHHHHHHHHHHH | 42.84 | 23749301 | |
| 1440 | Acetylation | QKKELISKFLDCAVG HHHHHHHHHHHHHHH | 42.84 | 24489116 | |
| 1457 | Ubiquitination | NNLDEAQKLSMQKKW CCHHHHHHHHHHHHH | 49.96 | 23749301 | |
| 1457 | Acetylation | NNLDEAQKLSMQKKW CCHHHHHHHHHHHHH | 49.96 | 24489116 | |
| 1463 | Acetylation | QKLSMQKKWENLKDS HHHHHHHHHHHHHHH | 42.73 | 24489116 | |
| 1468 | Acetylation | QKKWENLKDSIAKTS HHHHHHHHHHHHHCC | 62.10 | 24489116 | |
| 1473 | Ubiquitination | NLKDSIAKTSAGNQG HHHHHHHHCCCCCCC | 41.14 | 23749301 | |
| 1474 | Phosphorylation | LKDSIAKTSAGNQGI HHHHHHHCCCCCCCC | 18.13 | 27214570 | |
| 1475 | Phosphorylation | KDSIAKTSAGNQGIE HHHHHHCCCCCCCCC | 33.21 | 27214570 | |
| 1483 | Phosphorylation | AGNQGIESETEKGKI CCCCCCCCCCCCCCC | 48.15 | 22369663 | |
| 1485 | Phosphorylation | NQGIESETEKGKITK CCCCCCCCCCCCCCH | 52.88 | 22369663 | |
| 1487 | Acetylation | GIESETEKGKITKQE CCCCCCCCCCCCHHH | 73.29 | 24489116 | |
| 1492 | Acetylation | TEKGKITKQEQSDNL CCCCCCCHHHHCCCC | 56.14 | 24489116 | |
| 1526 | Phosphorylation | NIETTGNTESSDKGA CCCCCCCCCCCCCCC | 38.29 | 21551504 | |
| 1531 | Acetylation | GNTESSDKGAKIQ-- CCCCCCCCCCCCC-- | 63.82 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SIN3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SIN3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SIN3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137; SER-294; THR-303;THR-304; THR-308; SER-316; SER-318; SER-1046 AND SER-1483, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1483, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-303 AND SER-316, ANDMASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-304, AND MASSSPECTROMETRY. | |
