SPP1_YEAST - dbPTM
SPP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPP1_YEAST
UniProt AC Q03012
Protein Name COMPASS component SPP1
Gene Name SPP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 353
Subcellular Localization Nucleus .
Protein Description The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation..
Protein Sequence MSLPQWCPPHSTLKRNPTTGEDVYCICKRPDYGELMVGCDGCDDWFHFTCLHIPEQFKDLVFSFYCPYCQAGITGKNKDAIINGEGSLPKTLWKRKCRISDCYKPCLQDSKYCSEEHGREFVNDIWSRLKTDEDRAVVKKMVEQTGHIDKFKKFGQLDFIDNNIVVKTDDEKEIFDQIVVRDMTLKTLEDDLQEVQEISLPLFKKKLELLEVYLGWLDNVYTEMRKLDDDAASHVECGKEDSKGTKRKKKKNSSRSRARKNICGYCSTYERIPCSVEEFVRDFGSNEEATKIHEVCTKWKCNRHLDWVSTNQEQYLQQIDSLESMQERLQHLIQARKKQLNIQYYEEILRRGL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationSTLKRNPTTGEDVYC
CCCCCCCCCCCCEEE		51.4827214570
19PhosphorylationTLKRNPTTGEDVYCI
CCCCCCCCCCCEEEE		39.5730377154
87PhosphorylationAIINGEGSLPKTLWK
CEECCCCCCCHHHHH		36.8822369663
150AcetylationEQTGHIDKFKKFGQL
HHHCCHHHHHHHCCC		59.4822865919
233PhosphorylationKLDDDAASHVECGKE
CCCCCHHHCCCCCCC		29.7721551504
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SET1_YEASTSET1physical
11742990
BRE2_YEASTBRE2physical
11742990
SWD1_YEASTSWD1physical
11742990
SWD2_YEASTSWD2physical
11742990
SWD3_YEASTSWD3physical
11742990
SDC1_YEASTSDC1physical
11742990
SHG1_YEASTSHG1physical
11742990
ARP6_YEASTARP6genetic
15353583
H2AZ_YEASTHTZ1genetic
15353583
SWR1_YEASTSWR1genetic
15353583
VPS72_YEASTVPS72genetic
15353583
VPS71_YEASTVPS71genetic
15353583
YHI9_YEASTYHI9physical
16554755
SWD2_YEASTSWD2physical
16554755
POM33_YEASTPOM33physical
16554755
BRE2_YEASTBRE2physical
16429126
SWD1_YEASTSWD1physical
16429126
SWD2_YEASTSWD2physical
16429126
SWD3_YEASTSWD3physical
16429126
BRE2_YEASTBRE2genetic
16582434
SDC1_YEASTSDC1genetic
16582434
SET1_YEASTSET1physical
16787775
CSF1_YEASTCSF1genetic
17314980
GET2_YEASTGET2genetic
17314980
AHC1_YEASTAHC1genetic
17314980
RFC4_YEASTRFC4genetic
17314980
RGP1_YEASTRGP1genetic
17314980
PRI1_YEASTPRI1genetic
17314980
TOF2_YEASTTOF2genetic
17314980
MSN5_YEASTMSN5genetic
17314980
DOA1_YEASTDOA1genetic
17314980
RFC3_YEASTRFC3genetic
17314980
RPC7_YEASTRPC31genetic
17314980
SAC3_YEASTSAC3genetic
17314980
UMP1_YEASTUMP1genetic
17314980
RIC1_YEASTRIC1genetic
17314980
MNN11_YEASTMNN11genetic
17314980
SET1_YEASTSET1physical
16921172
BRE2_YEASTBRE2physical
16921172
SWD1_YEASTSWD1physical
16921172
SWD2_YEASTSWD2physical
16921172
SWD3_YEASTSWD3physical
16921172
H3_YEASTHHT1physical
17898715
H3_YEASTHHT1genetic
18676811
ORC2_YEASTORC2physical
18845545
ORC3_YEASTORC3physical
18845545
HSP78_YEASTHSP78physical
19536198
H3_YEASTHHT1physical
19270702
AF9_YEASTYAF9genetic
19547744
MET18_YEASTMET18genetic
19547744
SPT23_YEASTSPT23genetic
19547744
GET1_YEASTGET1genetic
19547744
NGG1_YEASTNGG1genetic
18931302
SGF73_YEASTSGF73genetic
18931302
DIA2_YEASTDIA2genetic
18931302
INP52_YEASTINP52genetic
18931302
H3_YEASTHHT1physical
17142463
SET1_YEASTSET1physical
19713935
H3_YEASTHHT1physical
20347846
H2B1_YEASTHTB1physical
20439497
LEO1_YEASTLEO1genetic
20959818
YPT6_YEASTYPT6genetic
20959818
GCR2_YEASTGCR2genetic
20959818
SCC2_YEASTSCC2physical
22875988
MAD1_YEASTMAD1physical
22875988
VAM7_YEASTVAM7physical
22875988
RE107_YEASTREC107physical
22875988
NNF1_YEASTNNF1physical
22875988
END3_YEASTEND3physical
22875988
SET1_YEASTSET1physical
23160953
RE107_YEASTREC107physical
23160953
RE107_YEASTREC107physical
23246437
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87, AND MASSSPECTROMETRY.

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