| UniProt ID | SPT23_YEAST | |
|---|---|---|
| UniProt AC | P35210 | |
| Protein Name | Protein SPT23 | |
| Gene Name | SPT23 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1082 | |
| Subcellular Localization | ||
| Protein Description | Dosage-dependent suppressor of Ty-induced promoter mutations. May exert its suppression effect through protein-protein interactions since does not present any of the motifs generally found in transcriptional activators or DNA binding proteins.. | |
| Protein Sequence | MMSGTGNVSSMLHSYSANIQHNDGSPDLDLLESELLDIALLNSGSSLQDPGLLSLNQEKMITAGTTTPGKEDEGELRDDIASLQGLLDRHVQFGRKLPLRTPYANPLDFININPQSLPLSLEIIGLPKVSRVETQMKLSFRIRNAHARKNFFIHLPSDCIAKDKFFTSSDDPTNLTIPNRDINERTLFLDAFLLCASNNNSNNFKQTYVCNRCINREKRRASRRKSGLNDNSIWQNNENKRAIIFNSKQLFIISNNGLSGNSNCINFDLPTRIVCYCRHHKATNGFVVLFLLRDHNGDILAKTITDPIMIMDKKNASNTTTPTSTSNAQVSPMTNDTRSFSSPQSDLNFPSEFPLPSNSKNFVISTNCMLDSNCNNNNNDNDNKNNIKTNTAMMNNNRHFPSPNSSSEDSNHSFSDIHFSNNNDNNLHRSLDSWSSTGFNSSSNPALTTLTSDFSAASARHTGKRQRSVNEPFMSTPNTFSRLPQKFIDSSKDISNHNSVPVALNNKPSIQRVIPAQGSINGGIEVTLLGSKFKQGLIIKFGENIALSSQCWNESTMVTYLPPSSKPGPVLVTIVDPSETSMRNNSNSSVSTSNSTNDILHLNKYTGEKAIFTYVDDTDRQLIELALQIVGLKMNGKLEDARNIAKRIVGSDSSPSNNNAGLHSQNSSLNSYTNMMRNINDEQLITEVIKSFKRNNNLSTVNLSMCDVRGRTLLHLAAFNNWYSLVSLLIKYGSHLNDQDLFGFTPLHMACINGDLRIIRLLLECNVNIMKKTRNGFIAKQFFLMNYTVNKTRYSNYETSLFDDILTRLTKNTTGSSDTQPFERNVSQSSFNSSLFDDDDADHDYVQERKYLLADSAALAPEQSNCNDNTSFSILDSDSGYDISDCESSSDEIALEFFNTHKIKDFSSKPNEIPKTTKTSIEPDGSLWNRMLTRLNDELPKYEDLFPKKPKNWELGSKSVEIGPDNSAQMTVDDSQTSSEDDELEALQVGFNTIFSKKQNFQNDKMLLFFWIPLTLVLLLCFTLSNLGKDDDMFHNLSKIVQEYLRIGLAKVLLGNERMKTSFKMQLSKFQNNNILNDMRVN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 62 | Phosphorylation | LNQEKMITAGTTTPG CCCCCEECCCCCCCC | 18.61 | 22369663 | |
| 65 | Phosphorylation | EKMITAGTTTPGKED CCEECCCCCCCCCCC | 25.65 | 22369663 | |
| 66 | Phosphorylation | KMITAGTTTPGKEDE CEECCCCCCCCCCCC | 30.03 | 22369663 | |
| 67 | Phosphorylation | MITAGTTTPGKEDEG EECCCCCCCCCCCCC | 29.86 | 22369663 | |
| 82 | Phosphorylation | ELRDDIASLQGLLDR CHHHHHHHHHHHHHH | 22.89 | 22369663 | |
| 205 | Ubiquitination | NNNSNNFKQTYVCNR CCCCCCCEEEEECHH | 43.80 | 17644757 | |
| 303 | Phosphorylation | NGDILAKTITDPIMI CCCEEEEECCCCEEE | 24.41 | 27017623 | |
| 305 | Phosphorylation | DILAKTITDPIMIMD CEEEEECCCCEEEEE | 40.74 | 27017623 | |
| 313 | Ubiquitination | DPIMIMDKKNASNTT CCEEEEECCCCCCCC | 30.46 | 17644757 | |
| 314 | Ubiquitination | PIMIMDKKNASNTTT CEEEEECCCCCCCCC | 54.18 | 17644757 | |
| 317 | Phosphorylation | IMDKKNASNTTTPTS EEECCCCCCCCCCCC | 44.07 | 23749301 | |
| 319 | Phosphorylation | DKKNASNTTTPTSTS ECCCCCCCCCCCCCC | 29.56 | 22369663 | |
| 320 | Phosphorylation | KKNASNTTTPTSTSN CCCCCCCCCCCCCCC | 34.72 | 22369663 | |
| 321 | Phosphorylation | KNASNTTTPTSTSNA CCCCCCCCCCCCCCC | 23.64 | 22369663 | |
| 323 | Phosphorylation | ASNTTTPTSTSNAQV CCCCCCCCCCCCCEE | 42.41 | 22369663 | |
| 324 | Phosphorylation | SNTTTPTSTSNAQVS CCCCCCCCCCCCEEC | 30.92 | 22369663 | |
| 325 | Phosphorylation | NTTTPTSTSNAQVSP CCCCCCCCCCCEECC | 28.60 | 22369663 | |
| 326 | Phosphorylation | TTTPTSTSNAQVSPM CCCCCCCCCCEECCC | 29.90 | 22369663 | |
| 331 | Phosphorylation | STSNAQVSPMTNDTR CCCCCEECCCCCCCC | 9.25 | 22369663 | |
| 334 | Phosphorylation | NAQVSPMTNDTRSFS CCEECCCCCCCCCCC | 33.07 | 22369663 | |
| 337 | Phosphorylation | VSPMTNDTRSFSSPQ ECCCCCCCCCCCCCC | 30.22 | 22369663 | |
| 339 | Phosphorylation | PMTNDTRSFSSPQSD CCCCCCCCCCCCCCC | 31.41 | 29734811 | |
| 341 | Phosphorylation | TNDTRSFSSPQSDLN CCCCCCCCCCCCCCC | 42.21 | 23749301 | |
| 342 | Phosphorylation | NDTRSFSSPQSDLNF CCCCCCCCCCCCCCC | 25.58 | 23749301 | |
| 345 | Phosphorylation | RSFSSPQSDLNFPSE CCCCCCCCCCCCCCC | 47.66 | 23749301 | |
| 351 | Phosphorylation | QSDLNFPSEFPLPSN CCCCCCCCCCCCCCC | 47.97 | 28889911 | |
| 357 | Phosphorylation | PSEFPLPSNSKNFVI CCCCCCCCCCCCEEE | 62.51 | 28889911 | |
| 430 | Phosphorylation | NDNNLHRSLDSWSST CCCCCEECHHCHHCC | 26.27 | 27017623 | |
| 437 | Phosphorylation | SLDSWSSTGFNSSSN CHHCHHCCCCCCCCC | 40.03 | 21440633 | |
| 443 | Phosphorylation | STGFNSSSNPALTTL CCCCCCCCCCCCHHH | 46.80 | 21440633 | |
| 468 | Phosphorylation | HTGKRQRSVNEPFMS HCCCCCCCCCCCCCC | 22.43 | 25752575 | |
| 476 | Phosphorylation | VNEPFMSTPNTFSRL CCCCCCCCCCHHHCC | 14.58 | 23749301 | |
| 486 | Acetylation | TFSRLPQKFIDSSKD HHHCCCHHHHCCCCC | 42.20 | 22865919 | |
| 486 | Ubiquitination | TFSRLPQKFIDSSKD HHHCCCHHHHCCCCC | 42.20 | 23749301 | |
| 491 | Phosphorylation | PQKFIDSSKDISNHN CHHHHCCCCCCCCCC | 30.51 | 30377154 | |
| 492 | Ubiquitination | QKFIDSSKDISNHNS HHHHCCCCCCCCCCC | 64.13 | 17644757 | |
| 495 | Phosphorylation | IDSSKDISNHNSVPV HCCCCCCCCCCCCCE | 42.02 | 30377154 | |
| 507 | Ubiquitination | VPVALNNKPSIQRVI CCEECCCCCCCEEEE | 38.78 | 17644757 | |
| 586 | Phosphorylation | ETSMRNNSNSSVSTS HHCCCCCCCCCCCCC | 41.46 | 23749301 | |
| 588 | Phosphorylation | SMRNNSNSSVSTSNS CCCCCCCCCCCCCCC | 31.75 | 21551504 | |
| 589 | Phosphorylation | MRNNSNSSVSTSNST CCCCCCCCCCCCCCH | 25.08 | 23749301 | |
| 591 | Phosphorylation | NNSNSSVSTSNSTND CCCCCCCCCCCCHHC | 28.24 | 22369663 | |
| 592 | Phosphorylation | NSNSSVSTSNSTNDI CCCCCCCCCCCHHCE | 29.76 | 22369663 | |
| 593 | Phosphorylation | SNSSVSTSNSTNDIL CCCCCCCCCCHHCEE | 22.68 | 22369663 | |
| 595 | Phosphorylation | SSVSTSNSTNDILHL CCCCCCCCHHCEEEE | 28.49 | 22369663 | |
| 596 | Phosphorylation | SVSTSNSTNDILHLN CCCCCCCHHCEEEEC | 40.95 | 22369663 | |
| 637 | Ubiquitination | VGLKMNGKLEDARNI HCHHHCCCHHHHHHH | 43.64 | 23749301 | |
| 811 | Ubiquitination | DILTRLTKNTTGSSD HHHHHHHCCCCCCCC | 57.81 | 23749301 | |
| 819 | Phosphorylation | NTTGSSDTQPFERNV CCCCCCCCCCCCCCC | 39.84 | 21551504 | |
| 827 | Phosphorylation | QPFERNVSQSSFNSS CCCCCCCCHHHCCCH | 28.08 | 17563356 | |
| 829 | Phosphorylation | FERNVSQSSFNSSLF CCCCCCHHHCCCHHC | 29.41 | 21551504 | |
| 830 | Phosphorylation | ERNVSQSSFNSSLFD CCCCCHHHCCCHHCC | 22.32 | 21440633 | |
| 834 | Phosphorylation | SQSSFNSSLFDDDDA CHHHCCCHHCCCCCC | 33.87 | 28889911 | |
| 909 | Ubiquitination | KIKDFSSKPNEIPKT CCCCCCCCCCCCCCC | 51.14 | 23749301 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPT23_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPT23_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-595 AND SER-827, ANDMASS SPECTROMETRY. | |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-66, AND MASSSPECTROMETRY. | |
