VPS64_YEAST - dbPTM
VPS64_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS64_YEAST
UniProt AC Q03944
Protein Name Vacuolar protein sorting-associated protein 64
Gene Name VPS64
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 604
Subcellular Localization Endoplasmic reticulum membrane
Single-pass type IV membrane protein .
Protein Description Participates in the control of the reentry into the cell cycle following pheromone treatment. Involved in vacuolar protein sorting..
Protein Sequence MVELEKRRRPPPQLQHSPYVRDQSNSQGMTKTPETSPPKRPMGRARSNSRSSGSRSNVDIDQYTIPPGLDLLPTASSPPSVHQVSQQQQLSPILANKIRSPFENQSQDQNDNSIDPTPAGQVTIPVEAVSPPALDELSKFQNGSTETLFRTGSPRKKHTHIIILKSLNATFETKFLVVPFKPDGLKLGRPVTNSVNKNNSGSKRDLFSQQVRPDNGNFDSRVLSRNHACLSCDPTSGKIYIRDLKSSNGTFVNGVKIRQNDVELKVGDTVDLGTDIDSKFEHRKISAYVEEISVIPLMNTVSDPTNLVMKKQDHTNKNNGNSTNINGIKIDRGHHNQHIPIRSHLKENYTEAGVTSATTAQRAAFEAAMFGDINNSELDDDILGPETEVLSGIFINNSAGTSINLINMIKTLTTELSLEKQELEKLHSMQNFMQNYTINLDFINKHMIDMNEKHLLKLSTALQKTLSENNDALLKESEDQLKEIKQQNNKVKSACSLKEKQNHEKLQELESELRELNLQIEEERGKNLVLTQSNFNGGINNDNNAKVKQNDSREEKKDTEDTLISTEELGVVEGKRTRVSKGMLFGVVAISFGLVATAVKQLPQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationPPPQLQHSPYVRDQS
CCCCCCCCCCCCCCC		12.6425704821
32PhosphorylationNSQGMTKTPETSPPK
CCCCCCCCCCCCCCC		19.7228889911
35PhosphorylationGMTKTPETSPPKRPM
CCCCCCCCCCCCCCC		47.9721440633
36PhosphorylationMTKTPETSPPKRPMG
CCCCCCCCCCCCCCC		37.2328889911
76PhosphorylationLDLLPTASSPPSVHQ
CCCCCCCCCCCCHHH		45.9421440633
85PhosphorylationPPSVHQVSQQQQLSP
CCCHHHHCCHHCHHH		18.7221440633
91PhosphorylationVSQQQQLSPILANKI
HCCHHCHHHHHHHHC		12.9327214570
144PhosphorylationLSKFQNGSTETLFRT
HHHCCCCCCCCEECC		30.5322369663
145PhosphorylationSKFQNGSTETLFRTG
HHCCCCCCCCEECCC		34.0922369663
151PhosphorylationSTETLFRTGSPRKKH
CCCCEECCCCCCCCC		34.3821440633
153PhosphorylationETLFRTGSPRKKHTH
CCEECCCCCCCCCEE		22.4017287358
467PhosphorylationTALQKTLSENNDALL
HHHHHHHHHCCHHHH		43.4330377154
511PhosphorylationEKLQELESELRELNL
HHHHHHHHHHHHHHH		55.3327214570
565PhosphorylationDTEDTLISTEELGVV
CCCCCEEEHHHHCEE		32.6427214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS64_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS64_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS64_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PIL1_YEASTPIL1physical
11805837
FAR8_YEASTFAR8physical
11805837
LSP1_YEASTLSP1physical
11805837
FET4_YEASTFET4physical
11805837
PHO84_YEASTPHO84physical
11805837
FAR7_YEASTFAR7physical
11805837
FAR3_YEASTFAR3physical
10688190
FAR11_YEASTFAR11physical
10688190
RGP1_YEASTRGP1genetic
17314980
SUS1_YEASTSUS1genetic
17314980
SGF29_YEASTSGF29genetic
17314980
SWD1_YEASTSWD1genetic
17314980
IWR1_YEASTIWR1genetic
17314980
RPA14_YEASTRPA14genetic
17314980
SWD3_YEASTSWD3genetic
17314980
NUP84_YEASTNUP84genetic
17314980
VPS8_YEASTVPS8genetic
17314980
RAD18_YEASTRAD18genetic
17314980
PAT1_YEASTPAT1genetic
17314980
DEP1_YEASTDEP1genetic
17314980
RXT2_YEASTRXT2genetic
17314980
SNT1_YEASTSNT1genetic
17314980
SPO19_YEASTSPO19physical
18467557
ITT1_YEASTITT1physical
18467557
SAC3_YEASTSAC3genetic
19547744
GEM1_YEASTGEM1genetic
20093466
MDM10_YEASTMDM10genetic
20093466
VPS8_YEASTVPS8genetic
20093466
KIP1_YEASTKIP1genetic
20093466
ETR1_YEASTETR1genetic
20093466
SSH1_YEASTSSH1genetic
20093466
ATG15_YEASTATG15genetic
20093466
PDP2_YEASTPTC6genetic
20093466
CSM1_YEASTCSM1genetic
20093466
ATG9_YEASTATG9genetic
20093466
PP2C1_YEASTPTC1genetic
20093466
HLR1_YEASTHLR1genetic
20093466
LSB3_YEASTLSB3genetic
20093466
MUP1_YEASTMUP1genetic
20093466
YG35_YEASTYGR125Wgenetic
20093466
CHO2_YEASTCHO2genetic
20093466
ATF2_YEASTATF2genetic
20093466
BIOB_YEASTBIO2genetic
20093466
HTD2_YEASTHTD2genetic
20093466
SDO1L_YEASTRTC3genetic
20093466
SNX4_YEASTSNX4genetic
20093466
FABG_YEASTOAR1genetic
20093466
ELM1_YEASTELM1genetic
20093466
UBI4P_YEASTUBI4genetic
20093466
VRP1_YEASTVRP1genetic
20093466
SRR1L_YEASTBER1genetic
20093466
ATG23_YEASTATG23genetic
20093466
SAM37_YEASTSAM37genetic
20093466
ATG3_YEASTATG3genetic
20093466
MDM12_YEASTMDM12genetic
20093466
PHO80_YEASTPHO80genetic
20093466
DGK1_YEASTDGK1genetic
20093466
VPS8_YEASTVPS8genetic
20526336
YPT35_YEASTYPT35genetic
20526336
FAR11_YEASTFAR11physical
22298706
NUF2_YEASTNUF2physical
22875988
MGA2_YEASTMGA2genetic
23891562
ELM1_YEASTELM1genetic
22282571
FAR11_YEASTFAR11physical
23625923
MOB2_YEASTMOB2genetic
27708008
CDK1_YEASTCDC28genetic
27708008
PSB3_YEASTPUP3genetic
27708008
RSP5_YEASTRSP5genetic
27708008
RPN11_YEASTRPN11genetic
27708008
PSB7_YEASTPRE4genetic
27708008
STT3_YEASTSTT3genetic
27708008
PRS8_YEASTRPT6genetic
27708008
NUP57_YEASTNUP57genetic
27708008
RPN1_YEASTRPN1genetic
27708008
DPB11_YEASTDPB11genetic
27708008
PRS7_YEASTRPT1genetic
27708008
SED5_YEASTSED5genetic
27708008
BOS1_YEASTBOS1genetic
27708008
SMC4_YEASTSMC4genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RU1C_YEASTYHC1genetic
27708008
UFE1_YEASTUFE1genetic
27708008
PRS10_YEASTRPT4genetic
27708008
PSA7_YEASTPRE10genetic
27708008
RPN7_YEASTRPN7genetic
27708008
VPS8_YEASTVPS8genetic
27708008
MDM10_YEASTMDM10genetic
27708008
GEM1_YEASTGEM1genetic
27708008
ATG8_YEASTATG8genetic
27708008
ETR1_YEASTETR1genetic
27708008
SSH1_YEASTSSH1genetic
27708008
ATG15_YEASTATG15genetic
27708008
PDP2_YEASTPTC6genetic
27708008
CSM1_YEASTCSM1genetic
27708008
CEM1_YEASTCEM1genetic
27708008
GET2_YEASTGET2genetic
27708008
MRM2_YEASTMRM2genetic
27708008
MDM34_YEASTMDM34genetic
27708008
FMP48_YEASTFMP48genetic
27708008
MUP1_YEASTMUP1genetic
27708008
CHO2_YEASTCHO2genetic
27708008
BIOB_YEASTBIO2genetic
27708008
HTD2_YEASTHTD2genetic
27708008
SDO1L_YEASTRTC3genetic
27708008
THIK_YEASTPOT1genetic
27708008
VPS35_YEASTVPS35genetic
27708008
ELM1_YEASTELM1genetic
27708008
FABG_YEASTOAR1genetic
27708008
EF1G2_YEASTTEF4genetic
27708008
UBI4P_YEASTUBI4genetic
27708008
LDB18_YEASTLDB18genetic
27708008
PFD6_YEASTYKE2genetic
27708008
LIPB_YEASTLIP2genetic
27708008
ATG23_YEASTATG23genetic
27708008
UBX2_YEASTUBX2genetic
27708008
NU188_YEASTNUP188genetic
27708008
SAM37_YEASTSAM37genetic
27708008
TGL3_YEASTTGL3genetic
27708008
CUZ1_YEASTCUZ1genetic
27708008
ATG3_YEASTATG3genetic
27708008
MDM12_YEASTMDM12genetic
27708008
TRM11_YEASTTRM11genetic
27708008
LIPA_YEASTLIP5genetic
27708008
FABD_YEASTMCT1genetic
27708008
DGK1_YEASTDGK1genetic
27708008
ATG5_YEASTATG5genetic
27708008
ATG41_YEASTICY2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS64_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, AND MASSSPECTROMETRY.

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