dbPTM

CUZ1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CUZ1_YEAST
UniProt AC	P53899
Protein Name	CDC48-associated ubiquitin-like/zinc finger protein 1 {ECO:0000303\|PubMed:24121501}
Gene Name	CUZ1 {ECO:0000303\|PubMed:24121501}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	274
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	May have a role in the ubiquitin-proteasome system (UPS) protecting cells from metalloid-induced proteotoxicity..
Protein Sequence	MSAAIEKETGMLDVGKHCAYCRQLDFLPFHCSFCNEDFCSNHRLKEDHHCRWLLEHEEVHKTEKSPSKSRDGSSSNDEAYFKSLLPERASVRIQRVSETREPLRGSNTAKVSSTLNSKTLDKIFKFFQRNEKRKSNNKSKKNFGSSSNKIIQLANLKKIAKGDPKIPMQNRIYIWCYLVDGDETDIAKEDTRMPLYINKMWPVGRAMDYLSIQLNVKSSTLTNSSSNDKFQLCKLKEGKQVSFYNIGASLRVTNEIKDLDTLYLVHNNADEKSN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
61	Acetylation	LEHEEVHKTEKSPSK HHHHHHHCCCCCCCC	24489116
65	Phosphorylation	EVHKTEKSPSKSRDG HHHCCCCCCCCCCCC	28889911
69	Phosphorylation	TEKSPSKSRDGSSSN CCCCCCCCCCCCCCC	28889911
73	Phosphorylation	PSKSRDGSSSNDEAY CCCCCCCCCCCHHHH	21551504
74	Phosphorylation	SKSRDGSSSNDEAYF CCCCCCCCCCHHHHH	23749301
75	Phosphorylation	KSRDGSSSNDEAYFK CCCCCCCCCHHHHHH	28889911
80	Phosphorylation	SSSNDEAYFKSLLPE CCCCHHHHHHHHCCH	28889911
83	Phosphorylation	NDEAYFKSLLPERAS CHHHHHHHHCCHHHC	27017623
97	Phosphorylation	SVRIQRVSETREPLR CEEEEEEECCCCCCC	25704821
125	Acetylation	KTLDKIFKFFQRNEK HHHHHHHHHHHHHHH	24489116
139	Phosphorylation	KRKSNNKSKKNFGSS HHHCCCCCCCCCCCC	27017623
145	Phosphorylation	KSKKNFGSSSNKIIQ CCCCCCCCCHHHHHH	27017623
242	Phosphorylation	LKEGKQVSFYNIGAS CCCCCEEEEEECCCE	25752575
257	Acetylation	LRVTNEIKDLDTLYL EEECCCCCCCCEEEE	24489116
261	Phosphorylation	NEIKDLDTLYLVHNN CCCCCCCEEEEEECC	24961812
263	Phosphorylation	IKDLDTLYLVHNNAD CCCCCEEEEEECCCC	30377154
273	Phosphorylation	HNNADEKSN------ ECCCCCCCC------	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CUZ1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CUZ1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CUZ1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBX1_YEAST	SHP1	physical	16554755
NPL4_YEAST	NPL4	physical	16554755
CDC48_YEAST	CDC48	physical	16554755
SNU13_YEAST	SNU13	physical	16554755
RT107_YEAST	RTT107	physical	16554755
MRM1_YEAST	MRM1	physical	16554755
UBX1_YEAST	SHP1	physical	18719252
CDC48_YEAST	CDC48	physical	18719252
CDC48_YEAST	CDC48	physical	24121501
CUZ1_YEAST	CUZ1	physical	24121501
NPL4_YEAST	NPL4	physical	24121501
UBX1_YEAST	SHP1	physical	24121501
NADE_YEAST	QNS1	physical	24121501
RPN3_YEAST	RPN3	physical	24121501
PRS6B_YEAST	RPT3	physical	24121501
RGI2_YEAST	RGI2	physical	24121501
FDFT_YEAST	ERG9	physical	24121501
HXT6_YEAST	HXT6	physical	24121501
HXT7_YEAST	HXT7	physical	24121501
SPT5_YEAST	SPT5	physical	24121501
UBI4P_YEAST	UBI4	physical	24121501
PCKA_YEAST	PCK1	physical	24121501
YG5B_YEAST	YGR250C	physical	24121501
UBX2_YEAST	UBX2	physical	24121501
RMAR_YEAST	VAR1	physical	24121501
RPB2_YEAST	RPB2	physical	24121501
ARO1_YEAST	ARO1	physical	24121501
RPAB1_YEAST	RPB5	physical	24121501
FAS1_YEAST	FAS1	physical	24121501
RPN7_YEAST	RPN7	physical	24121501
FPS1_YEAST	FPS1	physical	24121501
F16P_YEAST	FBP1	physical	24121501
FRDS_YEAST	FRD1	physical	24121501
DCE_YEAST	GAD1	physical	24121501
RPB1_YEAST	RPO21	physical	24121501
SIC1_YEAST	SIC1	physical	24297164
UBI4P_YEAST	UBI4	physical	24297164
RPN8_YEAST	RPN8	physical	27662200
CDC48_YEAST	CDC48	physical	27662200
MRM2_YEAST	MRM2	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
RS8A_YEAST	RPS8A	genetic	27708008
RS8B_YEAST	RPS8A	genetic	27708008
TFS2_YEAST	DST1	genetic	27708008
SFL1_YEAST	SFL1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CUZ1_YEAST

Related Literatures of Post-Translational Modification