HXT7_YEAST - dbPTM
HXT7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HXT7_YEAST
UniProt AC P39004
Protein Name High-affinity hexose transporter HXT7
Gene Name HXT7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 570
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description High-affinity glucose transporter..
Protein Sequence MSQDAAIAEQTPVEHLSAVDSASHSVLSTPSNKAERDEIKAYGEGEEHEPVVEIPKRPASAYVTVSIMCIMIAFGGFVFGWDTGTISGFINQTDFIRRFGMKHKDGTNYLSKVRTGLIVSIFNIGCAIGGIILSKLGDMYGRKVGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHLRGTLVSCYQLMITAGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWALFMIGGMTFVPESPRYLAEVGKIEEAKRSIAVSNKVAVDDPSVLAEVEAVLAGVEAEKLAGNASWGELFSSKTKVLQRLIMGAMIQSLQQLTGDNYFFYYGTTIFKAVGLSDSFETSIVLGIVNFASTFVGIYVVERYGRRTCLLWGAASMTACMVVYASVGVTRLWPNGQDQPSSKGAGNCMIVFACFYIFCFATTWAPIPYVVVSETFPLRVKSKAMSIATAANWLWGFLIGFFTPFITGAINFYYGYVFMGCLVFMFFYVLLVVPETKGLTLEEVNTMWEEGVLPWKSASWVPPSRRGANYDAEEMTHDDKPLYKRMFSTK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSQDAAIAE
------CCHHHHHHH		36.4522369663
11PhosphorylationDAAIAEQTPVEHLSA
HHHHHHCCCHHHHHH		22.3222369663
17PhosphorylationQTPVEHLSAVDSASH
CCCHHHHHHHCCCCC		28.3122369663
21PhosphorylationEHLSAVDSASHSVLS
HHHHHHCCCCCCCCC		25.6822369663
23PhosphorylationLSAVDSASHSVLSTP
HHHHCCCCCCCCCCC		21.9022369663
25PhosphorylationAVDSASHSVLSTPSN
HHCCCCCCCCCCCCC		23.4324909858
28PhosphorylationSASHSVLSTPSNKAE
CCCCCCCCCCCCHHH		35.8022369663
29PhosphorylationASHSVLSTPSNKAER
CCCCCCCCCCCHHHH		26.9522369663
31PhosphorylationHSVLSTPSNKAERDE
CCCCCCCCCHHHHHH		51.5622369663
33UbiquitinationVLSTPSNKAERDEIK
CCCCCCCHHHHHHHH		56.8324961812
40UbiquitinationKAERDEIKAYGEGEE
HHHHHHHHHCCCCCC		33.2423749301
91N-linked_GlycosylationGTISGFINQTDFIRR
CCHHHHCCHHHHHHH		36.12-
177PhosphorylationYFIGRIISGLGVGGI
HHHHHHHCCCCCCHH		26.1223749301
193PhosphorylationVLSPMLISEVSPKHL
HHCCHHHCCCCHHHH		28.1623749301
198UbiquitinationLISEVSPKHLRGTLV
HHCCCCHHHHHHHHH		48.0023749301
228N-linked_GlycosylationCTNFGTKNYSNSVQW
HCCCCCCCCCCCCCC		45.35-
229PhosphorylationTNFGTKNYSNSVQWR
CCCCCCCCCCCCCCC		15.7028889911
268UbiquitinationRYLAEVGKIEEAKRS
HHHHHHCCHHHHHHH		52.7123749301
288PhosphorylationKVAVDDPSVLAEVEA
CEECCCHHHHHHHHH		36.4421440633
318UbiquitinationWGELFSSKTKVLQRL
HHHHHCCHHHHHHHH		51.6812872131
544PhosphorylationSASWVPPSRRGANYD
CCCCCCCCCCCCCCC		28.6519779198
550PhosphorylationPSRRGANYDAEEMTH
CCCCCCCCCHHHCCC		18.9219779198
556PhosphorylationNYDAEEMTHDDKPLY
CCCHHHCCCCCCHHH		25.9828889911
560UbiquitinationEEMTHDDKPLYKRMF
HHCCCCCCHHHHHHH		42.8723749301
560AcetylationEEMTHDDKPLYKRMF
HHCCCCCCHHHHHHH		42.8724489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRSP5P39940
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HXT7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HXT7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PHO88_YEASTPHO88physical
16093310
ADH3_YEASTADH3genetic
21623372
TPS2_YEASTTPS2genetic
21623372
DCAM_YEASTSPE2genetic
21623372
IDH2_YEASTIDH2genetic
21623372
INV2_YEASTSUC2genetic
21623372
FTHC_YEASTFAU1genetic
21623372
AROC_YEASTARO2genetic
21623372
THRC_YEASTTHR4genetic
21623372
ARO1_YEASTARO1genetic
21623372
CSG2_YEASTCSG2genetic
21623372
ADE_YEASTAAH1genetic
21623372
PYC2_YEASTPYC2genetic
21623372
COX5A_YEASTCOX5Agenetic
21623372
SSB1_YEASTSSB1physical
22940862
HSP71_YEASTSSA1physical
22940862
MAS5_YEASTYDJ1physical
22940862
RL4A_YEASTRPL4Aphysical
22940862
RS17B_YEASTRPS17Bphysical
22940862
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HXT7_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND MASSSPECTROMETRY.
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-40; LYS-318 AND LYS-560,AND MASS SPECTROMETRY.

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