IDH2_YEAST - dbPTM
IDH2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IDH2_YEAST
UniProt AC P28241
Protein Name Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial
Gene Name IDH2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 369
Subcellular Localization Mitochondrion matrix .
Protein Description Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs..
Protein Sequence MLRNTFFRNTSRRFLATVKQPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIPDPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNHMGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationLATVKQPSIGRYTGK
EEEEECCCCCEECCC		34.8719823750
26PhosphorylationKQPSIGRYTGKPNPS
ECCCCCEECCCCCCC		18.0319823750
27PhosphorylationQPSIGRYTGKPNPST
CCCCCEECCCCCCCC		37.0519823750
29AcetylationSIGRYTGKPNPSTGK
CCCEECCCCCCCCCE		33.5524489116
33PhosphorylationYTGKPNPSTGKYTVS
ECCCCCCCCCEEEEE		57.3319823750
34PhosphorylationTGKPNPSTGKYTVSF
CCCCCCCCCEEEEEE		38.6619823750
36AcetylationKPNPSTGKYTVSFIE
CCCCCCCEEEEEEEE		37.5224489116
38PhosphorylationNPSTGKYTVSFIEGD
CCCCCEEEEEEEECC		17.1130377154
40PhosphorylationSTGKYTVSFIEGDGI
CCCEEEEEEEECCCC		16.8328889911
53AcetylationGIGPEISKSVKKIFS
CCCHHHHHHHHHHHH		66.0024489116
100AcetylationTKNLVALKGPLATPI
HCCHHHHCCCCCCCC		49.0624489116
105PhosphorylationALKGPLATPIGKGHR
HHCCCCCCCCCCCCC		24.1122369663
113PhosphorylationPIGKGHRSLNLTLRK
CCCCCCCCCCCCHHH		18.8822369663
117PhosphorylationGHRSLNLTLRKTFGL
CCCCCCCCHHHHHCE		24.3622369663
121PhosphorylationLNLTLRKTFGLFANV
CCCCHHHHHCEECCC		19.2625521595
132AcetylationFANVRPAKSIEGFKT
ECCCCCCCCCCCCEE		55.4324489116
133PhosphorylationANVRPAKSIEGFKTT
CCCCCCCCCCCCEEC		28.1621440633
153PhosphorylationLVLIRENTEGEYSGI
EEEEECCCCCCCCCC		40.3822369663
158PhosphorylationENTEGEYSGIEHIVC
CCCCCCCCCCCEEEC		29.0619779198
165GlutathionylationSGIEHIVCPGVVQSI
CCCCEEECCHHHHEE		2.1022833525
220SuccinylationGLFVNVAKELSKEYP
CCHHHHHHHHHHHCC		55.7123954790
220AcetylationGLFVNVAKELSKEYP
CCHHHHHHHHHHHCC		55.7124489116
224AcetylationNVAKELSKEYPDLTL
HHHHHHHHHCCCCEE		74.1024489116
298PhosphorylationIFEAVHGSAPDIAGQ
EEEHHHCCCCCCCCC		23.0421440633
311PhosphorylationGQDKANPTALLLSSV
CCCCCCHHHHHHHHH		29.7319779198
327PhosphorylationMLNHMGLTNHADQIQ
HHHHCCCCCCHHHHH		21.1619779198
339PhosphorylationQIQNAVLSTIASGPE
HHHHHHHHHHHCCCC		15.9219779198
340PhosphorylationIQNAVLSTIASGPEN
HHHHHHHHHHCCCCC		19.1928889911
343PhosphorylationAVLSTIASGPENRTG
HHHHHHHCCCCCCCC		51.5427017623
349PhosphorylationASGPENRTGDLAGTA
HCCCCCCCCCCCCCC		46.7828889911
358PhosphorylationDLAGTATTSSFTEAV
CCCCCCCCCHHHHHH		21.6530377154
359PhosphorylationLAGTATTSSFTEAVI
CCCCCCCCHHHHHHH		21.0627214570
360PhosphorylationAGTATTSSFTEAVIK
CCCCCCCHHHHHHHH		33.8125752575
362PhosphorylationTATTSSFTEAVIKRL
CCCCCHHHHHHHHHC		25.6130377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IDH2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IDH2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IDH2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IDH1_YEASTIDH1physical
11042198
CISY1_YEASTCIT1genetic
10224250
ODO1_YEASTKGD1genetic
10224250
ODO2_YEASTKGD2genetic
10224250
SUCA_YEASTLSC1genetic
10224250
SUCB_YEASTLSC2genetic
10224250
MDHM_YEASTMDH1genetic
10224250
RSSA2_YEASTRPS0Bphysical
16429126
TBA1_YEASTTUB1physical
16429126
RUVB2_YEASTRVB2physical
16429126
TBB_YEASTTUB2physical
16429126
KPYK1_YEASTCDC19physical
16429126
PYR1_YEASTURA2physical
16429126
CISY1_YEASTCIT1genetic
18359281
AMPL_YEASTAPE1physical
18719252
HSP71_YEASTSSA1physical
19536198
GPB2_YEASTGPB2genetic
20093466
ACH1_YEASTACH1genetic
20093466
TXTP_YEASTCTP1genetic
20093466
THRC_YEASTTHR4genetic
20093466
HOSC_YEASTLYS20genetic
20093466
IDHP_YEASTIDP1genetic
20093466
RMD1_YEASTRMD1genetic
20093466
TRM1_YEASTTRM1genetic
20093466
SWF1_YEASTSWF1genetic
20093466
OMS1_YEASTOMS1genetic
20093466
PUS3_YEASTDEG1genetic
20093466
SA155_YEASTSAP155genetic
20093466
AAKG_YEASTSNF4genetic
20093466
CHO2_YEASTCHO2genetic
20093466
VPS29_YEASTVPS29genetic
20093466
LSM1_YEASTLSM1genetic
20093466
GPI7_YEASTLAS21genetic
20093466
MAOM_YEASTMAE1genetic
20093466
UPS2_YEASTUPS2genetic
20093466
YL224_YEASTYLR224Wgenetic
20093466
MSS1_YEASTMSS1genetic
20093466
INO4_YEASTINO4genetic
20093466
IRA2_YEASTIRA2genetic
20093466
MDM38_YEASTMDM38genetic
20093466
VPH1_YEASTVPH1genetic
20093466
PDE2_YEASTPDE2genetic
20093466
DIP5_YEASTDIP5genetic
20093466
ISU1_YEASTISU1genetic
20093466
ULA1_YEASTULA1genetic
20093466
ATPN_YEASTATP20genetic
20093466
IDHC_YEASTIDP2genetic
15574419
IDHP_YEASTIDP1genetic
15574419
IDHP_YEASTIDP1genetic
21623372
ARO8_YEASTARO8genetic
21623372
TXTP_YEASTCTP1genetic
21623372
ATPK_YEASTATP17genetic
21623372
IDH1_YEASTIDH1genetic
21623372
NDK_YEASTYNK1genetic
21623372
AATC_YEASTAAT2genetic
21623372
ERG5_YEASTERG5genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
ADH2_YEASTADH2genetic
21623372
RTG1_YEASTRTG1genetic
21841001
SIR2_YEASTSIR2genetic
21902802
ALG3_YEASTALG3genetic
21987634
SHE3_YEASTSHE3genetic
21987634
SWC5_YEASTSWC5genetic
21987634
TXTP_YEASTCTP1genetic
21987634
FEN2_YEASTFEN2genetic
21987634
THRC_YEASTTHR4genetic
21987634
IDHP_YEASTIDP1genetic
21987634
MDHP_YEASTMDH3genetic
21987634
BUG1_YEASTBUG1genetic
21987634
HOSC_YEASTLYS20genetic
21987634
RS11A_YEASTRPS11Agenetic
21987634
RS11B_YEASTRPS11Agenetic
21987634
TPS2_YEASTTPS2genetic
21987634
ACL4_YEASTYDR161Wgenetic
21987634
IPK1_YEASTIPK1genetic
21987634
SWR1_YEASTSWR1genetic
21987634
NCS1_YEASTFRQ1genetic
21987634
VAC8_YEASTVAC8genetic
21987634
CAJ1_YEASTCAJ1genetic
21987634
PUS3_YEASTDEG1genetic
21987634
PIB2_YEASTPIB2genetic
21987634
SGF73_YEASTSGF73genetic
21987634
MTO1_YEASTMTO1genetic
21987634
HXKB_YEASTHXK2genetic
21987634
TNA1_YEASTTNA1genetic
21987634
YIH7_YEASTYIL077Cgenetic
21987634
MAOM_YEASTMAE1genetic
21987634
SAC1_YEASTSAC1genetic
21987634
GPT2_YEASTGPT2genetic
21987634
CDC42_YEASTCDC42genetic
21987634
YPT7_YEASTYPT7genetic
21987634
USA1_YEASTUSA1genetic
21987634
VPS71_YEASTVPS71genetic
21987634
GSF2_YEASTGSF2genetic
21987634
NDH1_YEASTNDE1genetic
21987634
AIM36_YEASTAIM36genetic
21987634
HFA1_YEASTHFA1genetic
21987634
YHM2_YEASTYHM2genetic
21987634
IDH1_YEASTIDH1genetic
21987634
MAS5_YEASTYDJ1genetic
21987634
IES2_YEASTIES2genetic
21987634
BNI4_YEASTBNI4genetic
21987634
ATG2_YEASTATG2genetic
21987634
CISY1_YEASTCIT1genetic
21987634
IF2M_YEASTIFM1genetic
21987634
IRA2_YEASTIRA2genetic
21987634
INO4_YEASTINO4genetic
21987634
GDE_YEASTGDB1genetic
21987634
IDH1_YEASTIDH1genetic
27708008
CKS1_YEASTCKS1genetic
27708008
GLE1_YEASTGLE1genetic
27708008
TIM22_YEASTTIM22genetic
27708008
UBC3_YEASTCDC34genetic
27708008
CDC1_YEASTCDC1genetic
27708008
ORC6_YEASTORC6genetic
27708008
DPB11_YEASTDPB11genetic
27708008
CFT2_YEASTCFT2genetic
27708008
SEC65_YEASTSEC65genetic
27708008
VTI1_YEASTVTI1genetic
27708008
LST8_YEASTLST8genetic
27708008
RRS1_YEASTRRS1genetic
27708008
TBF1_YEASTTBF1genetic
27708008
ASA1_YEASTASA1genetic
27708008
SRP54_YEASTSRP54genetic
27708008
BUR1_YEASTSGV1genetic
27708008
SEC23_YEASTSEC23genetic
27708008
GPT1_YEASTSCT1genetic
27708008
TXTP_YEASTCTP1genetic
27708008
IDHP_YEASTIDP1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
SWF1_YEASTSWF1genetic
27708008
XRN1_YEASTXRN1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
RPE_YEASTRPE1genetic
27708008
SFC1_YEASTSFC1genetic
27708008
MAOM_YEASTMAE1genetic
27708008
EF1G2_YEASTTEF4genetic
27708008
DCOR_YEASTSPE1genetic
27708008
PAM17_YEASTPAM17genetic
27708008
UPS2_YEASTUPS2genetic
27708008
ARV1_YEASTARV1genetic
27708008
ERG6_YEASTERG6genetic
27708008
VPH1_YEASTVPH1genetic
27708008
VTS1_YEASTVTS1genetic
27708008
ISU1_YEASTISU1genetic
27708008
AP1M1_YEASTAPM1genetic
27708008
DIP5_YEASTDIP5genetic
27708008
PMP1_YEASTPMP1physical
26404137
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IDH2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-105; THR-153 ANDSER-360, AND MASS SPECTROMETRY.
"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-349, AND MASSSPECTROMETRY.

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