ADH2_YEAST - dbPTM
ADH2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADH2_YEAST
UniProt AC P00331
Protein Name Alcohol dehydrogenase 2
Gene Name ADH2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 348
Subcellular Localization Cytoplasm.
Protein Description This isozyme preferentially catalyzes the conversion of ethanol to acetaldehyde. Acts on a variety of primary unbranched aliphatic alcohols..
Protein Sequence MSIPETQKAIIFYESNGKLEHKDIPVPKPKPNELLINVKYSGVCHTDLHAWHGDWPLPTKLPLVGGHEGAGVVVGMGENVKGWKIGDYAGIKWLNGSCMACEYCELGNESNCPHADLSGYTHDGSFQEYATADAVQAAHIPQGTDLAEVAPILCAGITVYKALKSANLRAGHWAAISGAAGGLGSLAVQYAKAMGYRVLGIDGGPGKEELFTSLGGEVFIDFTKEKDIVSAVVKATNGGAHGIINVSVSEAAIEASTRYCRANGTVVLVGLPAGAKCSSDVFNHVVKSISIVGSYVGNRADTREALDFFARGLVKSPIKVVGLSSLPEIYEKMEKGQIAGRYVVDTSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSIPETQKA
------CCCCCCCEE		47.029298649
2Phosphorylation------MSIPETQKA
------CCCCCCCEE		47.0219823750
6Phosphorylation--MSIPETQKAIIFY
--CCCCCCCEEEEEE		29.9819823750
15PhosphorylationKAIIFYESNGKLEHK
EEEEEEEECCCEEEC		39.2329734811
22AcetylationSNGKLEHKDIPVPKP
ECCCEEECCCCCCCC		48.2325381059
28UbiquitinationHKDIPVPKPKPNELL
ECCCCCCCCCCCCEE		66.9423749301
39UbiquitinationNELLINVKYSGVCHT
CCEEEEEEEECCCCC		29.2522817900
60UbiquitinationGDWPLPTKLPLVGGH
CCCCCCCCCCEECCC		46.2823749301
81UbiquitinationVGMGENVKGWKIGDY
EECCCCCCCCEECCC		71.3123749301
84UbiquitinationGENVKGWKIGDYAGI
CCCCCCCEECCCCCC		45.5423749301
92UbiquitinationIGDYAGIKWLNGSCM
ECCCCCCEEECCCEE		44.7217644757
212PhosphorylationPGKEELFTSLGGEVF
CCHHHHHHCCCCEEE		35.3528889911
213PhosphorylationGKEELFTSLGGEVFI
CHHHHHHCCCCEEEE		20.0628889911
223PhosphorylationGEVFIDFTKEKDIVS
CEEEEECCCHHHHEE		34.2528889911
226AcetylationFIDFTKEKDIVSAVV
EEECCCHHHHEEEEE		55.0725381059
249PhosphorylationGIINVSVSEAAIEAS
EEEEEEHHHHHHHHH		17.6318407956
279PhosphorylationPAGAKCSSDVFNHVV
CCCCCCCHHHHHHHH		47.46-
287UbiquitinationDVFNHVVKSISIVGS
HHHHHHHHHHHEECC		40.7717644757
288PhosphorylationVFNHVVKSISIVGSY
HHHHHHHHHHEECCC		15.2317330950
290PhosphorylationNHVVKSISIVGSYVG
HHHHHHHHEECCCCC		20.5021082442
294PhosphorylationKSISIVGSYVGNRAD
HHHHEECCCCCCCCC		13.0217287358
295PhosphorylationSISIVGSYVGNRADT
HHHEECCCCCCCCCH		13.3729136822
302PhosphorylationYVGNRADTREALDFF
CCCCCCCHHHHHHHH		29.4417287358
315UbiquitinationFFARGLVKSPIKVVG
HHHHCCCCCCCEEEE		56.4023749301
316PhosphorylationFARGLVKSPIKVVGL
HHHCCCCCCCEEEEC		25.1217330950
319UbiquitinationGLVKSPIKVVGLSSL
CCCCCCCEEEECCCC		33.9622817900
325PhosphorylationIKVVGLSSLPEIYEK
CEEEECCCCHHHHHH		53.6529734811
332UbiquitinationSLPEIYEKMEKGQIA
CCHHHHHHHHCCCCC		35.0722817900
332AcetylationSLPEIYEKMEKGQIA
CCHHHHHHHHCCCCC		35.0724489116
335UbiquitinationEIYEKMEKGQIAGRY
HHHHHHHCCCCCEEE		53.2522817900
335AcetylationEIYEKMEKGQIAGRY
HHHHHHHCCCCCEEE		53.2525381059
348UbiquitinationRYVVDTSK-------
EEEEECCC-------		67.4617644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADH2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADH2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADH2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LAM5_YEASTYFL042Cphysical
10688190
ADR1_YEASTADR1genetic
3302603
ADH3_YEASTADH3genetic
22033067
ADH4_YEASTADH4genetic
22033067
ADH5_YEASTADH5genetic
22033067
FADH_YEASTSFA1genetic
22033067
GPR1_YEASTGPR1genetic
27708008
ATG9_YEASTATG9genetic
27708008
NKP1_YEASTNKP1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
NAA38_YEASTMAK31genetic
27708008
THRC_YEASTTHR4genetic
27708008
MNN10_YEASTMNN10genetic
27708008
VAM7_YEASTVAM7genetic
27708008
MUP1_YEASTMUP1genetic
27708008
YHK5_YEASTYHR045Wgenetic
27708008
RS30A_YEASTRPS30Agenetic
27708008
RS30B_YEASTRPS30Agenetic
27708008
YL413_YEASTINA1genetic
27708008
SUCA_YEASTLSC1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADH2_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Proteome studies of Saccharomyces cerevisiae: identification andcharacterization of abundant proteins.";
Garrels J.I., McLaughlin C.S., Warner J.R., Futcher B., Latter G.I.,Kobayashi R., Schwender B., Volpe T., Anderson D.S.,Mesquita-Fuentes R., Payne W.E.;
Electrophoresis 18:1347-1360(1997).
Cited for: ACETYLATION AT SER-2.
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-290 ANDSER-316, AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290; SER-294 ANDTHR-302, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290, AND MASSSPECTROMETRY.

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