| UniProt ID | DCOR_YEAST | |
|---|---|---|
| UniProt AC | P08432 | |
| Protein Name | Ornithine decarboxylase | |
| Gene Name | SPE1 {ECO:0000303|PubMed:2669750} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 466 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.. | |
| Protein Sequence | MSSTQVGNALSSSTTTLVDLSNSTVTQKKQYYKDGETLHNLLLELKNNQDLELLPHEQAHPKIFQALKARIGRINNETCDPGEENSFFICDLGEVKRLFNNWVKELPRIKPFYAVKCNPDTKVLSLLAELGVNFDCASKVEIDRVLSMNISPDRIVYANPCKVASFIRYAASKNVMKSTFDNVEELHKIKKFHPESQLLLRIATDDSTAQCRLSTKYGCEMENVDVLLKAIKELGLNLAGVSFHVGSGASDFTSLYKAVRDARTVFDKAANEYGLPPLKILDVGGGFQFESFKESTAVLRLALEEFFPVGCGVDIIAEPGRYFVATAFTLASHVIAKRKLSENEAMIYTNDGVYGNMNCILFDHQEPHPRTLYHNLEFHYDDFESTTAVLDSINKTRSEYPYKVSIWGPTCDGLDCIAKEYYMKHDVIVGDWFYFPALGAYTSSAATQFNGFEQTADIVYIDSELD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 11 | Phosphorylation | TQVGNALSSSTTTLV CHHHHCCCCCCEEEE | 21.60 | 30377154 | |
| 12 | Phosphorylation | QVGNALSSSTTTLVD HHHHCCCCCCEEEEE | 32.33 | 24961812 | |
| 13 | Phosphorylation | VGNALSSSTTTLVDL HHHCCCCCCEEEEEC | 26.79 | 24961812 | |
| 14 | Phosphorylation | GNALSSSTTTLVDLS HHCCCCCCEEEEECC | 26.25 | 24961812 | |
| 15 | Phosphorylation | NALSSSTTTLVDLSN HCCCCCCEEEEECCC | 21.78 | 24961812 | |
| 16 | Phosphorylation | ALSSSTTTLVDLSNS CCCCCCEEEEECCCC | 25.52 | 24961812 | |
| 46 | Ubiquitination | HNLLLELKNNQDLEL HHHHHHHHCCCCCCC | 44.47 | 17644757 | |
| 62 | Ubiquitination | PHEQAHPKIFQALKA CHHHHCHHHHHHHHH | 46.41 | 17644757 | |
| 62 | Acetylation | PHEQAHPKIFQALKA CHHHHCHHHHHHHHH | 46.41 | 24489116 | |
| 104 | Acetylation | RLFNNWVKELPRIKP HHHHHHHHHCCCCCC | 45.18 | 24489116 | |
| 116 | N6-(pyridoxal phosphate)lysine | IKPFYAVKCNPDTKV CCCEEEEECCCCHHH | 21.81 | - | |
| 116 | Other | IKPFYAVKCNPDTKV CCCEEEEECCCCHHH | 21.81 | - | |
| 169 | Phosphorylation | KVASFIRYAASKNVM HHHHHHHHHHCCCCH | 11.16 | 28889911 | |
| 172 | Phosphorylation | SFIRYAASKNVMKST HHHHHHHCCCCHHHC | 19.32 | 28889911 | |
| 188 | Acetylation | DNVEELHKIKKFHPE CCHHHHHHHHHHCCH | 69.69 | 24489116 | |
| 232 | Ubiquitination | DVLLKAIKELGLNLA HHHHHHHHHHCCCCC | 52.31 | 17644757 | |
| 257 | Ubiquitination | SDFTSLYKAVRDART HHHHHHHHHHHHHHH | 45.78 | 17644757 | |
| 291 | Phosphorylation | GGGFQFESFKESTAV CCCCCCCCHHHCHHH | 42.79 | 27017623 | |
| 337 | Ubiquitination | LASHVIAKRKLSENE HHHHHHHHCCCCCCC | 38.65 | 17644757 | |
| 395 | Ubiquitination | AVLDSINKTRSEYPY HHHHHHHCCCCCCCE | 43.58 | 23749301 | |
| 403 | Ubiquitination | TRSEYPYKVSIWGPT CCCCCCEEEEEECCC | 25.63 | 23749301 | |
| 419 | Ubiquitination | DGLDCIAKEYYMKHD CCHHHHHHHHHHHCC | 26.74 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DCOR_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DCOR_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DCOR_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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