DAK1_YEAST - dbPTM
DAK1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DAK1_YEAST
UniProt AC P54838
Protein Name Dihydroxyacetone kinase 1
Gene Name DAK1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 584
Subcellular Localization
Protein Description Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde..
Protein Sequence MSAKSFEVTDPVNSSLKGFALANPSITLVPEEKILFRKTDSDKIALISGGGSGHEPTHAGFIGKGMLSGAVVGEIFASPSTKQILNAIRLVNENASGVLLIVKNYTGDVLHFGLSAERARALGINCRVAVIGDDVAVGREKGGMVGRRALAGTVLVHKIVGAFAEEYSSKYGLDGTAKVAKIINDNLVTIGSSLDHCKVPGRKFESELNEKQMELGMGIHNEPGVKVLDPIPSTEDLISKYMLPKLLDPNDKDRAFVKFDEDDEVVLLVNNLGGVSNFVISSITSKTTDFLKENYNITPVQTIAGTLMTSFNGNGFSITLLNATKATKALQSDFEEIKSVLDLLNAFTNAPGWPIADFEKTSAPSVNDDLLHNEVTAKAVGTYDFDKFAEWMKSGAEQVIKSEPHITELDNQVGDGDCGYTLVAGVKGITENLDKLSKDSLSQAVAQISDFIEGSMGGTSGGLYSILLSGFSHGLIQVCKSKDEPVTKEIVAKSLGIALDTLYKYTKARKGSSTMIDALEPFVKEFTASKDFNKAVKAAEEGAKSTATFEAKFGRASYVGDSSQVEDPGAVGLCEFLKGVQSAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSAKSFEVT
------CCCCCEEEC		44.3915665377
2Acetylation------MSAKSFEVT
------CCCCCEEEC		44.3915665377
5Phosphorylation---MSAKSFEVTDPV
---CCCCCEEECCCC		26.7622369663
9PhosphorylationSAKSFEVTDPVNSSL
CCCCEEECCCCCCCC		27.6428889911
14PhosphorylationEVTDPVNSSLKGFAL
EECCCCCCCCCCEEE		36.9630377154
15PhosphorylationVTDPVNSSLKGFALA
ECCCCCCCCCCEEEC		28.9729136822
25PhosphorylationGFALANPSITLVPEE
CEEECCCCEEEEEHH		28.1928889911
27PhosphorylationALANPSITLVPEEKI
EECCCCEEEEEHHHE		26.4921551504
33UbiquitinationITLVPEEKILFRKTD
EEEEEHHHEEEECCC		42.9424961812
105PhosphorylationVLLIVKNYTGDVLHF
EEEEEEECCCCCEEE		13.3422369663
106PhosphorylationLLIVKNYTGDVLHFG
EEEEEECCCCCEEEE		35.9822369663
178UbiquitinationYGLDGTAKVAKIIND
HCCCCHHHHHHHHCC		42.4323749301
189PhosphorylationIINDNLVTIGSSLDH
HHCCCEEEECCCCCC		23.8422369663
192PhosphorylationDNLVTIGSSLDHCKV
CCEEEECCCCCCCCC		24.7122369663
193PhosphorylationNLVTIGSSLDHCKVP
CEEEECCCCCCCCCC		32.3822369663
203UbiquitinationHCKVPGRKFESELNE
CCCCCCCHHHHHHHH		60.4423749301
203AcetylationHCKVPGRKFESELNE
CCCCCCCHHHHHHHH		60.4422865919
211AcetylationFESELNEKQMELGMG
HHHHHHHHHHHHCCC		54.6024489116
226AcetylationIHNEPGVKVLDPIPS
CCCCCCCEECCCCCC		42.8924489116
233PhosphorylationKVLDPIPSTEDLISK
EECCCCCCHHHHHHH		45.1922369663
234PhosphorylationVLDPIPSTEDLISKY
ECCCCCCHHHHHHHH		28.3229734811
240AcetylationSTEDLISKYMLPKLL
CHHHHHHHHCCHHHC		27.9024489116
245SuccinylationISKYMLPKLLDPNDK
HHHHCCHHHCCCCCC		58.6923954790
245AcetylationISKYMLPKLLDPNDK
HHHHCCHHHCCCCCC		58.6924489116
252SuccinylationKLLDPNDKDRAFVKF
HHCCCCCCCCCEEEC		56.6123954790
360UbiquitinationWPIADFEKTSAPSVN
CCHHHCCCCCCCCCC		48.0117644757
361PhosphorylationPIADFEKTSAPSVND
CHHHCCCCCCCCCCH		23.9522369663
362PhosphorylationIADFEKTSAPSVNDD
HHHCCCCCCCCCCHH		49.6122369663
365PhosphorylationFEKTSAPSVNDDLLH
CCCCCCCCCCHHHCC		33.0122369663
376PhosphorylationDLLHNEVTAKAVGTY
HHCCCCHHHHHHCCC		19.0922369663
378UbiquitinationLHNEVTAKAVGTYDF
CCCCHHHHHHCCCCH		33.9517644757
435AcetylationGITENLDKLSKDSLS
HHHHCHHHHCHHHHH		58.8024489116
4822-HydroxyisobutyrylationLIQVCKSKDEPVTKE
HHHHHCCCCCCCHHH		52.16-
482AcetylationLIQVCKSKDEPVTKE
HHHHHCCCCCCCHHH		52.1625381059
504AcetylationIALDTLYKYTKARKG
HHHHHHHHHHHHCCC		49.9424489116
512PhosphorylationYTKARKGSSTMIDAL
HHHHCCCCCCHHHHH		26.1828889911
524AcetylationDALEPFVKEFTASKD
HHHHHHHHHHHCCCC		47.7124489116
5372-HydroxyisobutyrylationKDFNKAVKAAEEGAK
CCHHHHHHHHHHHHC		46.90-
545PhosphorylationAAEEGAKSTATFEAK
HHHHHHCCCEEEEEH		23.8128889911
552AcetylationSTATFEAKFGRASYV
CCEEEEEHHCCCEEC		40.9524489116
557PhosphorylationEAKFGRASYVGDSSQ
EEHHCCCEECCCHHH		20.9921440633
558PhosphorylationAKFGRASYVGDSSQV
EHHCCCEECCCHHHC		13.8921440633
562PhosphorylationRASYVGDSSQVEDPG
CCEECCCHHHCCCCC		19.4230377154
563PhosphorylationASYVGDSSQVEDPGA
CEECCCHHHCCCCCH		42.8820190278
578UbiquitinationVGLCEFLKGVQSAL-
HHHHHHHHHHHHHC-		63.4617644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DAK1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DAK1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DAK1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DAK2_YEASTDAK2genetic
12401799
PP2C1_YEASTPTC1genetic
19269370
YPD1_YEASTYPD1genetic
19269370
MON1_YEASTMON1genetic
19269370
IPYR2_YEASTPPA2genetic
19269370
SSB1_YEASTSSB1physical
19536198
GPX3_YEASTHYR1physical
19715675
SRF1_YEASTSRF1genetic
20093466
PBP4_YEASTPBP4genetic
20093466
MTU1_YEASTSLM3genetic
20093466
NHP10_YEASTNHP10genetic
20093466
SOK1_YEASTSOK1genetic
20093466
RAD55_YEASTRAD55genetic
20093466
PUF6_YEASTPUF6genetic
20093466
KC13_YEASTYCK3genetic
20093466
ALK1_YEASTALK1genetic
20093466
PCP1_YEASTPCP1genetic
20093466
YG34_YEASTYGR122Wgenetic
20093466
PACC_YEASTRIM101genetic
20093466
NPR3_YEASTNPR3genetic
20093466
SDS3_YEASTSDS3genetic
20093466
DCOR_YEASTSPE1genetic
20093466
UTH1_YEASTUTH1genetic
20093466
LDB18_YEASTLDB18genetic
20093466
LSM7_YEASTLSM7genetic
20093466
CRZ1_YEASTCRZ1genetic
20093466
MDM12_YEASTMDM12genetic
20093466
SYC1_YEASTSYC1genetic
20093466
ISW2_YEASTISW2genetic
20093466
OMS1_YEASTOMS1genetic
27708008
GEM1_YEASTGEM1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
MTU1_YEASTSLM3genetic
27708008
PBP4_YEASTPBP4genetic
27708008
MRK1_YEASTMRK1genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
SOK1_YEASTSOK1genetic
27708008
VMS1_YEASTVMS1genetic
27708008
PUF6_YEASTPUF6genetic
27708008
GNP1_YEASTGNP1genetic
27708008
AK_YEASTHOM3genetic
27708008
KC13_YEASTYCK3genetic
27708008
ALK1_YEASTALK1genetic
27708008
MRM2_YEASTMRM2genetic
27708008
NPR3_YEASTNPR3genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
YKE44_YEASTYKL044Wgenetic
27708008
DCOR_YEASTSPE1genetic
27708008
UTH1_YEASTUTH1genetic
27708008
LDB18_YEASTLDB18genetic
27708008
YPS1_YEASTYPS1genetic
27708008
CRZ1_YEASTCRZ1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
MDM12_YEASTMDM12genetic
27708008
ADH1_YEASTADH1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DAK1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; SER-25; SER-233;SER-365 AND SER-563, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365, AND MASSSPECTROMETRY.

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