GNP1_YEAST - dbPTM
GNP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GNP1_YEAST
UniProt AC P48813
Protein Name High-affinity glutamine permease
Gene Name GNP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 663
Subcellular Localization Mitochondrion membrane
Multi-pass membrane protein .
Protein Description High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn..
Protein Sequence MTLGNRRHGRNNEGSSNMNMNRNDLDDVSHYEMKEIQPKEKQIGSIEPENEVEYFEKTVEKTIENMEYEGEHHASYLRRFIDSFRRAEGSHANSPDSSNSNGTTPISTKDSSSQLDNELNRKSSYITVDGIKQSPQEQEQKQENLKKSIKPRHTVMMSLGTGIGTGLLVGNSKVLNNAGPGGLIIGYAIMGSCVYCIIQACGELAVIYSDLIGGFNTYPLFLVDPALGFSVAWLFCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVVIFYVLIVVINVFGAKGYAEADFFFNCCKILMIVGFFILAIIIDCGGAGTDGYIGSKYWRDPGAFRGDTPIQRFKGVVATFVTAAFAFGMSEQLAMTASEQSNPRKAIPSAAKKMIYRILFVFLASLTLVGFLVPYTSDQLLGAAGSATKASPYVIAVSSHGVRVVPHFINAVILLSVLSVANGAFYTSSRILMSLAKQGNAPKCFDYIDREGRPAAAMLVSALFGVIAFCASSKKEEDVFTWLLAISGLSQLFTWITICLSHIRFRRAMKVQGRSLGEVGYKSQVGVWGSAYAVLMMVLALIAQFWVAIAPIGGGGKLSAQSFFENYLAMPIWIALYIFYKVWKKDWSLFIPADKVDLVSHRNIFDEELLKQEDEEYKERLRNGPYWKRVLDFWC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTLGNRRHG
------CCCCCCCCC		43.2921551504
15PhosphorylationHGRNNEGSSNMNMNR
CCCCCCCCCCCCCCC		16.6224909858
16PhosphorylationGRNNEGSSNMNMNRN
CCCCCCCCCCCCCCC		51.4525704821
29PhosphorylationRNDLDDVSHYEMKEI
CCCCCCCCHHHHHHC		27.6122369663
31PhosphorylationDLDDVSHYEMKEIQP
CCCCCCHHHHHHCCC		15.3722890988
34AcetylationDVSHYEMKEIQPKEK
CCCHHHHHHCCCCCC		39.4624489116
34UbiquitinationDVSHYEMKEIQPKEK
CCCHHHHHHCCCCCC		39.4623749301
39UbiquitinationEMKEIQPKEKQIGSI
HHHHCCCCCCCCCCC		62.2624961812
41UbiquitinationKEIQPKEKQIGSIEP
HHCCCCCCCCCCCCC		54.0323749301
41AcetylationKEIQPKEKQIGSIEP
HHCCCCCCCCCCCCC		54.0324489116
45PhosphorylationPKEKQIGSIEPENEV
CCCCCCCCCCCCCHH		25.9621440633
57UbiquitinationNEVEYFEKTVEKTIE
CHHHHHHHHHHHHHH		48.2323749301
57AcetylationNEVEYFEKTVEKTIE
CHHHHHHHHHHHHHH		48.2324489116
61UbiquitinationYFEKTVEKTIENMEY
HHHHHHHHHHHCCCC		50.9323749301
61AcetylationYFEKTVEKTIENMEY
HHHHHHHHHHHCCCC		50.9324489116
94PhosphorylationAEGSHANSPDSSNSN
HCCCCCCCCCCCCCC		30.7623749301
97PhosphorylationSHANSPDSSNSNGTT
CCCCCCCCCCCCCCC		34.5019779198
100PhosphorylationNSPDSSNSNGTTPIS
CCCCCCCCCCCCCCC		38.2922369663
103PhosphorylationDSSNSNGTTPISTKD
CCCCCCCCCCCCCCC		33.3822369663
104PhosphorylationSSNSNGTTPISTKDS
CCCCCCCCCCCCCCC		21.7422369663
107PhosphorylationSNGTTPISTKDSSSQ
CCCCCCCCCCCCHHH		30.5222369663
108PhosphorylationNGTTPISTKDSSSQL
CCCCCCCCCCCHHHH		39.3224909858
109UbiquitinationGTTPISTKDSSSQLD
CCCCCCCCCCHHHHC		49.1523749301
111PhosphorylationTPISTKDSSSQLDNE
CCCCCCCCHHHHCHH		33.1822369663
112PhosphorylationPISTKDSSSQLDNEL
CCCCCCCHHHHCHHH		32.0325521595
113PhosphorylationISTKDSSSQLDNELN
CCCCCCHHHHCHHHH		38.4222369663
122UbiquitinationLDNELNRKSSYITVD
HCHHHHHCCCCEEEC		42.5523749301
123PhosphorylationDNELNRKSSYITVDG
CHHHHHCCCCEEECC		25.7422369663
124PhosphorylationNELNRKSSYITVDGI
HHHHHCCCCEEECCC		24.4822369663
125PhosphorylationELNRKSSYITVDGIK
HHHHCCCCEEECCCC		14.0122890988
127PhosphorylationNRKSSYITVDGIKQS
HHCCCCEEECCCCCC		12.3322369663
132UbiquitinationYITVDGIKQSPQEQE
CEEECCCCCCHHHHH		50.7023749301
134PhosphorylationTVDGIKQSPQEQEQK
EECCCCCCHHHHHHH		24.4528889911
141UbiquitinationSPQEQEQKQENLKKS
CHHHHHHHHHHHHHH		59.8523749301
146UbiquitinationEQKQENLKKSIKPRH
HHHHHHHHHHCCHHH		56.9322817900
373UbiquitinationSEQSNPRKAIPSAAK
HHCCCHHHCCCHHHH		52.5023749301
465UbiquitinationRILMSLAKQGNAPKC
HHHHHHHHCCCCCCH		65.1223749301
471UbiquitinationAKQGNAPKCFDYIDR
HHCCCCCCHHHHHCC		45.1623749301
639AcetylationIFDEELLKQEDEEYK
CCCHHHHHHCCHHHH		65.3524489116
646AcetylationKQEDEEYKERLRNGP
HHCCHHHHHHHHHCH		39.3724489116
646UbiquitinationKQEDEEYKERLRNGP
HHCCHHHHHHHHHCH		39.3724961812
663S-palmitoylationKRVLDFWC-------
HHHHHHCC-------		3.9516751107
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GNP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GNP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GNP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AGP1_YEASTAGP1genetic
18408719
SHR3_YEASTSHR3physical
16093310
PHO88_YEASTPHO88physical
16093310
MKAR_YEASTIFA38physical
16093310
VDAC2_YEASTPOR2physical
16093310
YM8M_YEASTYMR279Cphysical
16093310
ALG6_YEASTALG6genetic
19325107
ALG8_YEASTALG8genetic
19325107
CCW12_YEASTCCW12genetic
19325107
COG5_YEASTCOG5genetic
19325107
GET2_YEASTGET2genetic
19325107
ILM1_YEASTILM1genetic
19325107
MGA2_YEASTMGA2genetic
19325107
PLMT_YEASTOPI3genetic
19325107
OST3_YEASTOST3genetic
19325107
SPC2_YEASTSPC2genetic
19325107
STE24_YEASTSTE24genetic
19325107
UBX2_YEASTUBX2genetic
19325107
VPS9_YEASTVPS9genetic
19325107
EOS1_YEASTEOS1genetic
19325107
SERB_YEASTSER2genetic
21623372
DHAS_YEASTHOM2genetic
21623372
DHOM_YEASTHOM6genetic
21623372
SERC_YEASTSER1genetic
21623372
THRC_YEASTTHR4genetic
21623372
THDH_YEASTILV1genetic
21623372
AK_YEASTHOM3genetic
21623372
C1TM_YEASTMIS1genetic
21623372
CBS_YEASTCYS4genetic
21623372
CISY3_YEASTCIT3genetic
21623372
SERA_YEASTSER3genetic
21623372
6PGD2_YEASTGND2genetic
21623372
KAD2_YEASTADK1genetic
21623372
IDH1_YEASTIDH1genetic
21623372
COQ4_YEASTCOQ4genetic
21623372
SCS7_YEASTSCS7genetic
21623372
HXKB_YEASTHXK2genetic
21623372
KCS1_YEASTKCS1genetic
21623372
ARO1_YEASTARO1genetic
21623372
6PGD1_YEASTGND1genetic
21623372
IF2B_YEASTSUI3physical
22940862
SSB1_YEASTSSB1physical
22940862
DED1_YEASTDED1physical
22940862
GRP78_YEASTKAR2physical
22940862
G3P3_YEASTTDH3physical
22940862
SSZ1_YEASTSSZ1physical
22940862
HSP71_YEASTSSA1physical
22940862
RS3_YEASTRPS3physical
22940862
EF1A_YEASTTEF2physical
22940862
HSP72_YEASTSSA2physical
22940862
KPYK1_YEASTCDC19physical
22940862
VATB_YEASTVMA2physical
22940862
RS17B_YEASTRPS17Bphysical
22940862
PUT4_YEASTPUT4genetic
23517290
AGP1_YEASTAGP1genetic
23517290
GAP1_YEASTGAP1genetic
23517290
ATC6_YEASTSPF1genetic
23891562
OST6_YEASTOST6genetic
23891562
HAC1_YEASTHAC1genetic
23891562
VAM6_YEASTVAM6genetic
23891562
TMEDA_YEASTERV25genetic
23891562
GET2_YEASTGET2genetic
23891562
RGP1_YEASTRGP1genetic
23891562
RIC1_YEASTRIC1genetic
23891562
VPS1_YEASTVPS1genetic
23891562
VPS8_YEASTVPS8genetic
23891562
VPS5_YEASTVPS5genetic
23891562
VPS17_YEASTVPS17genetic
23891562
VPS21_YEASTVPS21genetic
23891562
PHO86_YEASTPHO86genetic
23891562
AP1B1_YEASTAPL2genetic
23891562
CSG2_YEASTCSG2genetic
23891562
BPH1_YEASTBPH1genetic
23891562
MTU1_YEASTSLM3genetic
27708008
ASK10_YEASTASK10genetic
27708008
TSC3_YEASTTSC3genetic
27708008
ERF3_YEASTSUP35genetic
27708008
CDC1_YEASTCDC1genetic
27708008
TRS23_YEASTTRS23genetic
27708008
NMT_YEASTNMT1genetic
27708008
DBP9_YEASTDBP9genetic
27708008
RU1A_YEASTMUD1genetic
27708008
TPS1_YEASTTPS1genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
AGP1_YEASTAGP1genetic
27708008
APA1_YEASTAPA1genetic
27708008
RV161_YEASTRVS161genetic
27708008
THRC_YEASTTHR4genetic
27708008
TPS2_YEASTTPS2genetic
27708008
DHAS_YEASTHOM2genetic
27708008
RAV2_YEASTRAV2genetic
27708008
MNN10_YEASTMNN10genetic
27708008
PMP3_YEASTPMP3genetic
27708008
AK_YEASTHOM3genetic
27708008
RAD4_YEASTRAD4genetic
27708008
RIM15_YEASTRIM15genetic
27708008
AAKG_YEASTSNF4genetic
27708008
MRM2_YEASTMRM2genetic
27708008
SERB_YEASTSER2genetic
27708008
IGO2_YEASTIGO2genetic
27708008
STB5_YEASTSTB5genetic
27708008
CSK21_YEASTCKA1genetic
27708008
DAL81_YEASTDAL81genetic
27708008
JEM1_YEASTJEM1genetic
27708008
RPE_YEASTRPE1genetic
27708008
DHOM_YEASTHOM6genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
MRT4_YEASTMRT4genetic
27708008
FEN1_YEASTRAD27genetic
27708008
CBT1_YEASTCBT1genetic
27708008
BRE2_YEASTBRE2genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
AVL9_YEASTAVL9genetic
27708008
GTR1_YEASTGTR1genetic
27708008
GBLP_YEASTASC1genetic
27708008
GAT2_YEASTGAT2genetic
27708008
RIM11_YEASTRIM11genetic
27708008
FUS2_YEASTFUS2genetic
27708008
BUL1_YEASTBUL1genetic
27708008
HDA1_YEASTHDA1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
LSM7_YEASTLSM7genetic
27708008
BRE5_YEASTBRE5genetic
27708008
AIM39_YEASTAIM39genetic
27708008
GLO4_YEASTGLO4genetic
27708008
SERC_YEASTSER1genetic
27708008
VPH1_YEASTVPH1genetic
27708008
HUA2_YEASTHUA2genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
NEW1_YEASTNEW1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GNP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; SER-124 AND THR-127,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123 AND SER-124, ANDMASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124 AND THR-127, ANDMASS SPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124 AND THR-127, ANDMASS SPECTROMETRY.
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-34; LYS-41 AND LYS-132,AND MASS SPECTROMETRY.

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