AP1B1_YEAST - dbPTM
AP1B1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AP1B1_YEAST
UniProt AC P36000
Protein Name AP-1 complex subunit beta-1
Gene Name APL2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 726
Subcellular Localization Cell membrane. Membrane, coated pit
Peripheral membrane protein
Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.
Protein Description Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin..
Protein Sequence MPPLDKRIKKFLKDSIRIAPKISGKGELSELRTGLVSQYPQTRKDAIKKTIQQMTLGKDVSSLFPDVLKNIATIDVEQKKLVYLYVMNYAETHPELCILAVNTFITDAQDPNPLIRCMAIRTMSMIRVDKILEYIETPLRRTLHDDNAYVRKTAVICVAKLFQLNKDLCVELGVVEDLVNALDDSNPLVIANATAALIEIHNMDMDAVDLSSLIQSHVSQFLLALNECTEWARIIILGTLSEYSAKDSLEAQDIIDRVTAHLQHVNPAVVLATIKVIVRNLPQIEYSSNSLIMKRLSSAFVSLMSTPPEMQYVALKNIRIILEKYPELLTKELRIFYVKFNDPLYVKLEKIDILVRLVDPSNLKQCTLLLTELKEYAMEYEPEFVSRAIQALSQLGIKYAQESFVSKVLDILLELLERQDTIKDDCCISLCDLLRHCPGNDKMAKQVCAVFNTWSNPEVLLQSDIAKCNYVWLLGQHPNNFSDLESKINIFIENFVQEEALTQMSLLMTIVRLHATLTGSMLQSVLELATQQTHELDVRDMAMMYWRCLSMPNNESLVNDLCQNKLPMISNTLEKFSPEVLEKLLMELGTISSIYFKPDSNRRKGKKYVQNIVKGKHIEELESMAKNEISSKANDDVLLDFDERDDVTNTNAGMLNTLTTLGDLDDLFDFGPSEDATQINTNDTKAVQGLKELKLGGDSNGISSGGKNNPDVSGGNIVSQDLLDLF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationIKKFLKDSIRIAPKI
HHHHHHHHHHCCCCC		16.5130377154
25AcetylationIAPKISGKGELSELR
CCCCCCCCCCHHHHH		42.2824489116
50PhosphorylationRKDAIKKTIQQMTLG
HHHHHHHHHHHHHCC		21.0021440633
73PhosphorylationDVLKNIATIDVEQKK
HHHHHCCEEEHHHHH		17.5728889911
130AcetylationMSMIRVDKILEYIET
HHHHCHHHHHHHCCC		46.4624489116
286PhosphorylationRNLPQIEYSSNSLIM
HCCCCCCCCCCCHHH		21.0128889911
287PhosphorylationNLPQIEYSSNSLIMK
CCCCCCCCCCCHHHH		15.3928889911
288PhosphorylationLPQIEYSSNSLIMKR
CCCCCCCCCCHHHHH		29.5424961812
290PhosphorylationQIEYSSNSLIMKRLS
CCCCCCCCHHHHHHH		22.6328889911
297PhosphorylationSLIMKRLSSAFVSLM
CHHHHHHHHHHHHHH		24.5328889911
305PhosphorylationSAFVSLMSTPPEMQY
HHHHHHHCCCHHHHH		42.9528889911
312PhosphorylationSTPPEMQYVALKNIR
CCCHHHHHHHHHHHH		6.0828889911
616AcetylationVQNIVKGKHIEELES
HHHHHCCCCHHHHHH		35.3724489116
623PhosphorylationKHIEELESMAKNEIS
CCHHHHHHHHHHHHH		36.3420377248
703PhosphorylationGGDSNGISSGGKNNP
CCCCCCCCCCCCCCC		25.0828889911
704PhosphorylationGDSNGISSGGKNNPD
CCCCCCCCCCCCCCC		50.0428889911
713PhosphorylationGKNNPDVSGGNIVSQ
CCCCCCCCCCCCCCH		48.6528889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AP1B1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AP1B1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AP1B1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AP1G1_YEASTAPL4physical
11805826
AP1M1_YEASTAPM1physical
11805826
APM2_YEASTAPM2physical
11805826
AP1S1_YEASTAPS1physical
11805826
C1TM_YEASTMIS1physical
11805826
RPA2_YEASTRPA135physical
11805826
CLH_YEASTCHC1physical
11489214
CLH_YEASTCHC1physical
10564262
AP1G1_YEASTAPL4physical
10564262
AP1S1_YEASTAPS1physical
10564262
AP2B_YEASTAPL1physical
10564262
APM2_YEASTAPM2physical
10564262
VPS27_YEASTVPS27genetic
11879634
YFD4_YEASTYFL034Wphysical
16554755
APM2_YEASTAPM2physical
16554755
AP1M1_YEASTAPM1physical
16554755
AP1G1_YEASTAPL4physical
16554755
AP1G1_YEASTAPL4physical
16429126
AP1M1_YEASTAPM1physical
16429126
APM2_YEASTAPM2physical
16429126
AP1S1_YEASTAPS1physical
16429126
C1TM_YEASTMIS1physical
16429126
RL11A_YEASTRPL11Aphysical
16429126
RL16B_YEASTRPL16Bphysical
16429126
RL3_YEASTRPL3physical
16429126
RL36B_YEASTRPL36Bphysical
16429126
RL6B_YEASTRPL6Bphysical
16429126
RL9A_YEASTRPL9Aphysical
16429126
INO4_YEASTINO4genetic
17090927
INO2_YEASTINO2genetic
17090927
AVL9_YEASTAVL9genetic
17229886
AP1M1_YEASTAPM1physical
18467557
AP1G1_YEASTAPL4physical
18467557
INP53_YEASTINP53physical
18467557
ARF1_YEASTARF1physical
18508916
GTR2_YEASTGTR2genetic
19897736
SLA1_YEASTSLA1genetic
20093466
GCS1_YEASTGCS1genetic
20093466
SWI5_YEASTSWI5genetic
20093466
ZRT1_YEASTZRT1genetic
20093466
GGA2_YEASTGGA2genetic
20093466
AGE2_YEASTAGE2genetic
20093466
PYR1_YEASTURA2genetic
20093466
VPS51_YEASTVPS51genetic
20093466
ERG3_YEASTERG3genetic
20093466
AVL9_YEASTAVL9genetic
20093466
VAC14_YEASTVAC14genetic
20093466
VIP1_YEASTVIP1genetic
20093466
PYRC_YEASTURA4genetic
20093466
GTR1_YEASTGTR1genetic
20093466
PML39_YEASTPML39genetic
20093466
PYRE_YEASTURA5genetic
20093466
ERG6_YEASTERG6genetic
20093466
TPM1_YEASTTPM1genetic
20093466
HDA1_YEASTHDA1genetic
20093466
PEX15_YEASTPEX15genetic
20093466
DFG16_YEASTDFG16genetic
20093466
TRS33_YEASTTRS33genetic
20093466
LIPA_YEASTLIP5genetic
20093466
AP3D_YEASTAPL5genetic
20093466
AIM44_YEASTAIM44genetic
20093466
KES1_YEASTKES1genetic
20093466
YP066_YEASTRGL1genetic
20093466
YP089_YEASTYPR089Wgenetic
20093466
VPS1_YEASTVPS1genetic
17229886
FKS1_YEASTFKS1genetic
17062999
PDR5_YEASTPDR5genetic
20461743
SNQ2_YEASTSNQ2genetic
20461743
ELO3_YEASTELO3genetic
23891562
GPI2_YEASTGPI2genetic
23891562
TPM1_YEASTTPM1genetic
23891562
KES1_YEASTKES1genetic
23891562
PDC2_YEASTPDC2genetic
27708008
DAL81_YEASTDAL81genetic
27708008
RPAB1_YEASTRPB5genetic
27708008
MCM7_YEASTMCM7genetic
27708008
TRS20_YEASTTRS20genetic
27708008
SCC1_YEASTMCD1genetic
27708008
GDI1_YEASTGDI1genetic
27708008
ACT_YEASTACT1genetic
27708008
SEC15_YEASTSEC15genetic
27708008
SDA1_YEASTSDA1genetic
27708008
CP51_YEASTERG11genetic
27708008
RHO3_YEASTRHO3genetic
27708008
EXO70_YEASTEXO70genetic
27708008
DCP2_YEASTDCP2genetic
27708008
CAP_YEASTSRV2genetic
27708008
ATC3_YEASTDRS2genetic
27708008
SLA1_YEASTSLA1genetic
27708008
STE50_YEASTSTE50genetic
27708008
SWI5_YEASTSWI5genetic
27708008
UBP3_YEASTUBP3genetic
27708008
IES1_YEASTIES1genetic
27708008
AP3B_YEASTAPL6genetic
27708008
GGA2_YEASTGGA2genetic
27708008
AGE2_YEASTAGE2genetic
27708008
VPS53_YEASTVPS53genetic
27708008
VPS51_YEASTVPS51genetic
27708008
ERG3_YEASTERG3genetic
27708008
AVL9_YEASTAVL9genetic
27708008
VIP1_YEASTVIP1genetic
27708008
ERG6_YEASTERG6genetic
27708008
GTR1_YEASTGTR1genetic
27708008
SUB1_YEASTSUB1genetic
27708008
HDA1_YEASTHDA1genetic
27708008
TPM1_YEASTTPM1genetic
27708008
RAS2_YEASTRAS2genetic
27708008
BRE5_YEASTBRE5genetic
27708008
SIN3_YEASTSIN3genetic
27708008
RLA2_YEASTRPP2Agenetic
27708008
WHI5_YEASTWHI5genetic
27708008
YP066_YEASTRGL1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
KES1_YEASTKES1genetic
27708008
AIM44_YEASTAIM44genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AP1B1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-286; SER-287 ANDSER-290, AND MASS SPECTROMETRY.

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