AP1G1_YEAST - dbPTM
AP1G1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AP1G1_YEAST
UniProt AC Q12028
Protein Name AP-1 complex subunit gamma-1
Gene Name APL4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 832
Subcellular Localization Cytoplasm. Golgi apparatus membrane
Peripheral membrane protein
Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle membrane
Peripheral membrane protein
Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic si
Protein Description Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin..
Protein Sequence MGSSLRSFIKDVRGAKTLADERAIITKQSAKIRTKLRDDHLPHEKRRVNIQKLLYLYILGEKTHFGQVESINLIASDDFVDKRLGYLAATLLLDESEDLLTLLTNMLNNDLHHPNKYAVSLALTSLGFLSSPELARDLYPDVENIIKNSRDPFLLKKALQCAAKLIFKDVSLLEIFNIEDITKILSSHSICTHGVLLGVTKIIQSILLIGLNRKKDEDEDEDGIDYSNDILSPLSLLLRDFFIRLENMNSKNIEPGYDVQGICDPFLQCEIIYTLKLYFQVGELLNSNNVLDYKDNFCDLLTRIATNTDSTKNSGQAILYETVKTIFSLDLNQPLRVLGINILAKFLAGKDNNTKYVSLNTLLKVVPQEPTAVQRHRKFISHCLQDTDVSIRMRALELSFAILDDSNLVELVNELMKFLAKQDEDSKDLIIYTIDHLIDTFDTRVVKDESWKLDVFFNILKLVGSFINYEKINDILIIINNTSQLSDKSEFLRKMLTISLNGTSAEISEENIGWQLVLIWCIGEYGDLVLNEGNKNGADIINESSITDYLLTLQELYTATNLKIINYILTAALKLSVRFHDAKNIEKLRQLILSYTDSTDLSLQMKSNQYEIFFNQSISVKKIILETMPKFEKITEEQDNGKALSKNLISNEPVDLLSDLLGEDSKAESKASTGDNVKPIDILEEIFGEKNDIAQVPKNANKEESINHSSAVEANSGVTLPLDANKIYDSSSLNVYASLLSANSGLAHLDLYFQAKSLISDLKTFCAVPKAQKLTLGQLYPSSTINASQICKQSLKISGSGKLKLRVKLDFHLNGSSSITNEQFDHKFDETL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
96PhosphorylationATLLLDESEDLLTLL
HHHHHCCCHHHHHHH		35.7619779198
214UbiquitinationLLIGLNRKKDEDEDE
HHHCCCCCCCCCCCC		64.6022106047
215UbiquitinationLIGLNRKKDEDEDED
HHCCCCCCCCCCCCC		64.2122106047
310PhosphorylationRIATNTDSTKNSGQA
HHHCCCCCCCCCCCC		38.9621440633
311PhosphorylationIATNTDSTKNSGQAI
HHCCCCCCCCCCCCH		36.7321440633
322PhosphorylationGQAILYETVKTIFSL
CCCHHHCHHHHHHHC		17.4723749301
324UbiquitinationAILYETVKTIFSLDL
CHHHCHHHHHHHCCC		43.2423749301
356PhosphorylationGKDNNTKYVSLNTLL
CCCCCCCEEEHHHHH		8.0121126336
358PhosphorylationDNNTKYVSLNTLLKV
CCCCCEEEHHHHHHH		16.8921126336
617PhosphorylationYEIFFNQSISVKKII
EEEEEECCCCHHHHH		20.2427017623
619PhosphorylationIFFNQSISVKKIILE
EEEECCCCHHHHHHH		32.8827017623
658PhosphorylationNEPVDLLSDLLGEDS
CCCHHHHHHHHCCCH		33.2521440633
669PhosphorylationGEDSKAESKASTGDN
CCCHHHHHHCCCCCC		38.0819823750
672PhosphorylationSKAESKASTGDNVKP
HHHHHHCCCCCCCCH		36.3429136822
673PhosphorylationKAESKASTGDNVKPI
HHHHHCCCCCCCCHH		54.1121440633
690UbiquitinationLEEIFGEKNDIAQVP
HHHHHCCCCCCCCCC		61.3723749301
705PhosphorylationKNANKEESINHSSAV
CCCCCCHHCCCCCCC		29.7717563356
709PhosphorylationKEESINHSSAVEANS
CCHHCCCCCCCCCCC		18.5917563356
716PhosphorylationSSAVEANSGVTLPLD
CCCCCCCCCCEEECC		41.5117563356
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AP1G1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AP1G1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AP1G1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLH_YEASTCHC1physical
11489214
ENT3_YEASTENT3physical
12483220
ENT5_YEASTENT5physical
12483220
AP1B1_YEASTAPL2physical
16429126
AP1M1_YEASTAPM1physical
16429126
AP1S1_YEASTAPS1physical
16429126
G6PI_YEASTPGI1physical
16429126
IRC6_YEASTIRC6physical
11283351
AP1B1_YEASTAPL2physical
11283351
AP1S1_YEASTAPS1physical
11283351
AP1G1_YEASTAPL4physical
18467557
ATC3_YEASTDRS2physical
18508916
ODPB_YEASTPDB1genetic
20093466
CRD1_YEASTCRD1genetic
20093466
BRE1_YEASTBRE1genetic
20093466
SLX5_YEASTSLX5genetic
20093466
SWI5_YEASTSWI5genetic
20093466
MNN10_YEASTMNN10genetic
20093466
IPK1_YEASTIPK1genetic
20093466
ERD1_YEASTERD1genetic
20093466
SLX8_YEASTSLX8genetic
20093466
PCP1_YEASTPCP1genetic
20093466
TIM13_YEASTTIM13genetic
20093466
BGL2_YEASTBGL2genetic
20093466
PTH_YEASTPTH1genetic
20093466
SDP1_YEASTSDP1genetic
20093466
APQ12_YEASTAPQ12genetic
20093466
DHOM_YEASTHOM6genetic
20093466
YJ9J_YEASTYJR142Wgenetic
20093466
RM49_YEASTMRP49genetic
20093466
RL14A_YEASTRPL14Agenetic
20093466
DBP7_YEASTDBP7genetic
20093466
SA190_YEASTSAP190genetic
20093466
SET3_YEASTSET3genetic
20093466
PAM17_YEASTPAM17genetic
20093466
BPT1_YEASTBPT1genetic
20093466
ERG3_YEASTERG3genetic
20093466
AVL9_YEASTAVL9genetic
20093466
ACE2_YEASTACE2genetic
20093466
UPS2_YEASTUPS2genetic
20093466
DPH5_YEASTDPH5genetic
20093466
PEX13_YEASTPEX13genetic
20093466
ELO3_YEASTELO3genetic
20093466
SRR1L_YEASTBER1genetic
20093466
PEX12_YEASTPEX12genetic
20093466
MUB1_YEASTMUB1genetic
20093466
ERG2_YEASTERG2genetic
20093466
HFA1_YEASTHFA1genetic
20093466
YHM2_YEASTYHM2genetic
20093466
COX7_YEASTCOX7genetic
20093466
ELP6_YEASTELP6genetic
20093466
CYB5_YEASTCYB5genetic
20093466
IDH1_YEASTIDH1genetic
20093466
HDA1_YEASTHDA1genetic
20093466
IPB2_YEASTPBI2genetic
20093466
MED9_YEASTCSE2genetic
20093466
ATP23_YEASTATP23genetic
20093466
PEX15_YEASTPEX15genetic
20093466
SGT2_YEASTSGT2genetic
20093466
CSK22_YEASTCKA2genetic
20093466
AIM44_YEASTAIM44genetic
20093466
QCR2_YEASTQCR2genetic
20093466
ALY1_YEASTALY1physical
20739461
ALY2_YEASTALY2physical
20739461
AP1G1_YEASTAPL4physical
22615397
RL4A_YEASTRPL4Aphysical
22940862
AP1B1_YEASTAPL2physical
22940862
HSP72_YEASTSSA2physical
22940862
AP1S1_YEASTAPS1physical
22940862
AP1M1_YEASTAPM1physical
22940862
AP1G1_YEASTAPL4physical
22940862
YFD4_YEASTYFL034Wphysical
26658609
SLX5_YEASTSLX5genetic
27708008
VPS24_YEASTVPS24genetic
27708008
FABG_YEASTOAR1genetic
27708008
NAP1_YEASTNAP1genetic
27708008
PEX13_YEASTPEX13genetic
27708008
MAC1_YEASTMAC1genetic
27708008
PEX12_YEASTPEX12genetic
27708008
GID8_YEASTGID8genetic
27708008
HFA1_YEASTHFA1genetic
27708008
YHM2_YEASTYHM2genetic
27708008
ELP6_YEASTELP6genetic
27708008
PEX15_YEASTPEX15genetic
27708008
RTC1_YEASTRTC1genetic
27708008
CSK22_YEASTCKA2genetic
27708008
SLA1_YEASTSLA1genetic
27708008
SIF2_YEASTSIF2genetic
27708008
ODPB_YEASTPDB1genetic
27708008
MGR1_YEASTMGR1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
MTU1_YEASTSLM3genetic
27708008
BRE1_YEASTBRE1genetic
27708008
QRI7_YEASTQRI7genetic
27708008
CYK3_YEASTCYK3genetic
27708008
CRD1_YEASTCRD1genetic
27708008
RM01_YEASTMRPL1genetic
27708008
MNN10_YEASTMNN10genetic
27708008
IPK1_YEASTIPK1genetic
27708008
MRX8_YEASTYDR336Wgenetic
27708008
BEM2_YEASTBEM2genetic
27708008
ODPA_YEASTPDA1genetic
27708008
RTF1_YEASTRTF1genetic
27708008
CBP4_YEASTCBP4genetic
27708008
TIM13_YEASTTIM13genetic
27708008
BGL2_YEASTBGL2genetic
27708008
SDS3_YEASTSDS3genetic
27708008
BCK1_YEASTBCK1genetic
27708008
PEX2_YEASTPEX2genetic
27708008
DHOM_YEASTHOM6genetic
27708008
YJ9J_YEASTYJR142Wgenetic
27708008
AIM26_YEASTAIM26genetic
27708008
MDM35_YEASTMDM35genetic
27708008
DBP7_YEASTDBP7genetic
27708008
SA190_YEASTSAP190genetic
27708008
SET3_YEASTSET3genetic
27708008
MMM1_YEASTMMM1genetic
27708008
COX12_YEASTCOX12genetic
27708008
ERG3_YEASTERG3genetic
27708008
AVL9_YEASTAVL9genetic
27708008
ACE2_YEASTACE2genetic
27708008
UPS2_YEASTUPS2genetic
27708008
ELO3_YEASTELO3genetic
27708008
SKI2_YEASTSKI2genetic
27708008
RM39_YEASTMRPL39genetic
27708008
MUB1_YEASTMUB1genetic
27708008
RIM13_YEASTRIM13genetic
27708008
ERG2_YEASTERG2genetic
27708008
COX7_YEASTCOX7genetic
27708008
HDA1_YEASTHDA1genetic
27708008
IDH1_YEASTIDH1genetic
27708008
CYB5_YEASTCYB5genetic
27708008
ATP23_YEASTATP23genetic
27708008
IRA2_YEASTIRA2genetic
27708008
FRE7_YEASTFRE7genetic
27708008
CYC2_YEASTCYC2genetic
27708008
MSC6_YEASTMSC6genetic
27708008
RTC6_YEASTRTC6genetic
27708008
QCR2_YEASTQCR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AP1G1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-705; SER-709 ANDSER-716, AND MASS SPECTROMETRY.

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