| UniProt ID | HFA1_YEAST | |
|---|---|---|
| UniProt AC | P32874 | |
| Protein Name | Acetyl-CoA carboxylase, mitochondrial | |
| Gene Name | HFA1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 2273 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Catalyzes the rate-limiting reaction in the mitochondrial fatty acid synthesis (FAS) type II pathway. Responsible for the production of the mitochondrial malonyl-CoA, used for the biosynthesis of the cofactor lipoic acid. This protein carries three functions: biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase.. | |
| Protein Sequence | KGKTITHGQSWGARRIHSHFYITIFTITCIRIGQYKLALYLDPYRFYNITGSQIVRLKGQRPEYRKRIFAHSYRHSSRIGLNFPSRRRYSNYVDRGNIHKHTRLPPQFIGLNTVESAQPSILRDFVDLRGGHTVISKILIANNGIAAVKEMRSIRKWAYETFNDEKIIQFVVMATPDDLHANSEYIRMADQYVQVPGGTNNNNYANIDLILDVAEQTDVDAVWAGWGHASENPCLPELLASSQRKILFIGPPGRAMRSLGDKISSTIVAQSAKIPCIPWSGSHIDTIHIDNKTNFVSVPDDVYVRGCCSSPEDALEKAKLIGFPVMIKASEGGGGKGIRRVDNEDDFIALYRQAVNETPGSPMFVMKVVTDARHLEVQLLADQYGTNITLFGRDCSIQRRHQKIIEEAPVTITKPETFQRMERAAIRLGELVGYVSAGTVEYLYSPKDDKFYFLELNPRLQVEHPTTEMISGVNLPATQLQIAMGIPMHMISDIRKLYGLDPTGTSYIDFKNLKRPSPKGHCISCRITSEDPNEGFKPSTGKIHELNFRSSSNVWGYFSVGNNGAIHSFSDSQFGHIFAVGNDRQDAKQNMVLALKDFSIRGEFKTPIEYLIELLETRDFESNNISTGWLDDLILKNLSSDSKLDPTLAIICGAAMKAYVFTEKVRNKYLELLRRGQVPPKDFLKTKFPVDFIFDNNRYLFNVAQSSEEQFILSINKSQCEVNVQKLSSDCLLISVDGKCHTVYWKDDIRGTRLSIDSNTIFLEAELNPTQVISPTPGKLVKYLVRSGDHVFAGQQYAEIEIMKMQMPLVAKSDGVIELLRQPGSIIEAGDVIAKLTLDSPSKANESSLYRGELPVLGPPLIEGSRPNHKLRVLINRLENILNGYHENSGIETTLKELIKILRDGRLPYSEWDSQISTVRNRLPRQLNEGLGNLVKKSVSFPAKELHKLMKRYLEENTNDHVVYVALQPLLKISERYSEGLANHECEIFLKLIKKYYAVEKIFENHDIHEERNLLNLRRKDLTNLKKILCISLSHANVVAKNKLVTAILHEYEPLCQDSSKMSLKFRAVIHDLASLESKWAKEVAVKARSVLLRGIFPPIKKRKEHIKTLLQLHIKDTGAENIHSRNIYSCMRDFGNLIHSNLIQLQDLFFFFGHQDTALSSIASEIYARYAYGNYQLKSIKIHKGAPDLLMSWQFSSLRNYLVNSDGESDEFTKLSKPPSTSGKSSANSFGLLVNMRALESLEKTLDEVYEQIHIPEERLSSGENSLIVNILSPIRYRSENDLIKTLKIKLHENERGLSKLKVNRITFAFIAANAPAVKFYSFDGTTYDEISQIRNMDPSYEAPLELGKMSNYKIRSLPTYDSSIRIFEGISKFTPLDKRFFVRKIINSFMYNDQKTTEENLKAEINAQVVYMLEHLGAVDISNSDLNHIFLSFNTVLNIPVHRLEEIVSTILKTHETRLFQERITDVEICISVECLETKKPAPLRLLISNKSGYVVKIETYYEKIGKNGNLILEPCSEQSHYSQKSLSLPYSVKDWLQPKRYKAQFMGTTYVYDFPGLFHQAAIQQWKRYFPKHKLNDSFFSWVELIEQNGNLIKVNREPGLNNIGMVAFEIMVQTPEYPEGRNMIVISNDITYNIGSFGPREDLFFDRVTNYARERGIPRIYLAANSGAKLGIAEELIPLFRVAWNDPSDPTKGFQYLYLAPKDMQLLKDSGKGNSVVVEHKMVYGEERYIIKAIVGFEEGLGVECLQGSGLIAGATSKAYRDIFTITAVTCRSVGIGSYLVRLGQRTIQVEDKPIILTGASAINKVLGTDIYTSNLQIGGTQIMYKNGIAHLTASNDMKAIEKIMTWLSYVPAKRDMSPPLLETMDRWDRDVDFKPAKQVPYEARWLIEGKWDSNNNFQSGLFDKDSFFETLSGWAKGVIVGRARLGGIPVGVIAVETKTIEEIIPADPANLDSSEFSVKEAGQVWYPNSAFKTAQTINDFNYGEQLPLIILANWRGFSGGQRDMYNEVLKYGSFIVDALVDYKQPILIYIPPFGELRGGSWVVIDPTINPEQMEMYADVESRGGVLEPDGVVSIKYRKEKMIETMIRLDSTYGHLRRTLTEKKLSLEKQNDLTKRLKIRERQLIPIYNQISIQFADLHDRSTRMLVKGVIRNELEWKKSRRFLYWRLRRRLNEGQVIKRLQKKTCDNKTKMKYDDLLKIVQSWYNDLDVNDDRAVVEFIERNSKKIDKNIEEFEISLLIDELKKKFEDRRGNIVLEELTRLVDSKRKR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 112 | Ubiquitination | PPQFIGLNTVESAQP CCCCCCCCCCCCCCC | 36.54 | 23749301 | |
| 178 | Ubiquitination | VVMATPDDLHANSEY EEECCCCCCCCCHHH | 41.37 | 23749301 | |
| 262 | Ubiquitination | AMRSLGDKISSTIVA HHHHHHHHHHHHHHH | 42.56 | - | |
| 262 | Acetylation | AMRSLGDKISSTIVA HHHHHHHHHHHHHHH | 42.56 | 24489116 | |
| 328 | Acetylation | IGFPVMIKASEGGGG HCCCEEEEECCCCCC | 27.97 | 24489116 | |
| 328 | Ubiquitination | IGFPVMIKASEGGGG HCCCEEEEECCCCCC | 27.97 | - | |
| 804 | N6-biotinyllysine | YAEIEIMKMQMPLVA EEEEEEEECCCCEEE | 31.48 | - | |
| 804 | Biotinylation | YAEIEIMKMQMPLVA EEEEEEEECCCCEEE | 31.48 | - | |
| 1208 | Phosphorylation | NYLVNSDGESDEFTK HHHHCCCCCCCCCCC | 35.81 | 19779198 | |
| 1214 | Phosphorylation | DGESDEFTKLSKPPS CCCCCCCCCCCCCCC | 29.09 | 19779198 | |
| 1358 | Phosphorylation | MSNYKIRSLPTYDSS CCCCEECCCCCCCCC | 42.02 | 19779198 | |
| 1361 | Phosphorylation | YKIRSLPTYDSSIRI CEECCCCCCCCCEEE | 45.30 | 19779198 | |
| 1362 | Phosphorylation | KIRSLPTYDSSIRIF EECCCCCCCCCEEEE | 16.34 | 19779198 | |
| 1364 | Phosphorylation | RSLPTYDSSIRIFEG CCCCCCCCCEEEEEC | 19.76 | 19779198 | |
| 1378 | Phosphorylation | GISKFTPLDKRFFVR CHHCCCCCCHHHHHH | 12.61 | 21177495 | |
| 1528 | Phosphorylation | QSHYSQKSLSLPYSV CCCCCCCCCCCCCCH | 18.63 | 28889911 | |
| 1853 | Phosphorylation | EKIMTWLSYVPAKRD HHHHHHHHCCCCCCC | 18.69 | 28889911 | |
| 1898 | Phosphorylation | LIEGKWDSNNNFQSG EEECCCCCCCCCCCC | 40.10 | 19779198 | |
| 2047 | Ubiquitination | ELRGGSWVVIDPTIN CCCCCCEEEECCCCC | 2.64 | 22106047 | |
| 2061 | Phosphorylation | NPEQMEMYADVESRG CHHHHHHHEEHHHCC | 6.07 | 27017623 | |
| 2066 | Phosphorylation | EMYADVESRGGVLEP HHHEEHHHCCCCCCC | 35.75 | 27017623 | |
| 2080 | Acetylation | PDGVVSIKYRKEKMI CCCEEEEEECHHHHH | 31.34 | 22865919 | |
| 2197 | Ubiquitination | CDNKTKMKYDDLLKI CCCCCCCCHHHHHHH | 47.27 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HFA1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HFA1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HFA1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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