dbPTM

FAS1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FAS1_YEAST
UniProt AC	P07149
Protein Name	Fatty acid synthase subunit beta
Gene Name	FAS1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	2051
Subcellular Localization
Protein Description	Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase..
Protein Sequence	MDAYSTRPLTLSHGSLEHVLLVPTASFFIASQLQEQFNKILPEPTEGFAADDEPTTPAELVGKFLGYVSSLVEPSKVGQFDQVLNLCLTEFENCYLEGNDIHALAAKLLQENDTTLVKTKELIKNYITARIMAKRPFDKKSNSALFRAVGEGNAQLVAIFGGQGNTDDYFEELRDLYQTYHVLVGDLIKFSAETLSELIRTTLDAEKVFTQGLNILEWLENPSNTPDKDYLLSIPISCPLIGVIQLAHYVVTAKLLGFTPGELRSYLKGATGHSQGLVTAVAIAETDSWESFFVSVRKAITVLFFIGVRCYEAYPNTSLPPSILEDSLENNEGVPSPMLSISNLTQEQVQDYVNKTNSHLPAGKQVEISLVNGAKNLVVSGPPQSLYGLNLTLRKAKAPSGLDQSRIPFSERKLKFSNRFLPVASPFHSHLLVPASDLINKDLVKNNVSFNAKDIQIPVYDTFDGSDLRVLSGSISERIVDCIIRLPVKWETTTQFKATHILDFGPGGASGLGVLTHRNKDGTGVRVIVAGTLDINPDDDYGFKQEIFDVTSNGLKKNPNWLEEYHPKLIKNKSGKIFVETKFSKLIGRPPLLVPGMTPCTVSPDFVAATTNAGYTIELAGGGYFSAAGMTAAIDSVVSQIEKGSTFGINLIYVNPFMLQWGIPLIKELRSKGYPIQFLTIGAGVPSLEVASEYIETLGLKYLGLKPGSIDAISQVINIAKAHPNFPIALQWTGGRGGGHHSFEDAHTPMLQMYSKIRRHPNIMLIFGSGFGSADDTYPYLTGEWSTKFDYPPMPFDGFLFGSRVMIAKEVKTSPDAKKCIAACTGVPDDKWEQTYKKPTGGIVTVRSEMGEPIHKIATRGVMLWKEFDETIFNLPKNKLVPTLEAKRDYIISRLNADFQKPWFATVNGQARDLATMTYEEVAKRLVELMFIRSTNSWFDVTWRTFTGDFLRRVEERFTKSKTLSLIQSYSLLDKPDEAIEKVFNAYPAAREQFLNAQDIDHFLSMCQNPMQKPVPFVPVLDRRFEIFFKKDSLWQSEHLEAVVDQDVQRTCILHGPVAAQFTKVIDEPIKSIMDGIHDGHIKKLLHQYYGDDESKIPAVEYFGGESPVDVQSQVDSSSVSEDSAVFKATSSTDEESWFKALAGSEINWRHASFLCSFITQDKMFVSNPIRKVFKPSQGMVVEISNGNTSSKTVVTLSEPVQGELKPTVILKLLKENIIQMEMIENRTMDGKPVSLPLLYNFNPDNGFAPISEVMEDRNQRIKEMYWKLWIDEPFNLDFDPRDVIKGKDFEITAKEVYDFTHAVGNNCEDFVSRPDRTMLAPMDFAIVVGWRAIIKAIFPNTVDGDLLKLVHLSNGYKMIPGAKPLQVGDVVSTTAVIESVVNQPTGKIVDVVGTLSRNGKPVMEVTSSFFYRGNYTDFENTFQKTVEPVYQMHIKTSKDIAVLRSKEWFQLDDEDFDLLNKTLTFETETEVTFKNANIFSSVKCFGPIKVELPTKETVEIGIVDYEAGASHGNPVVDFLKRNGSTLEQKVNLENPIPIAVLDSYTPSTNEPYARVSGDLNPIHVSRHFASYANLPGTITHGMFSSASVRALIENWAADSVSSRVRGYTCQFVDMVLPNTALKTSIQHVGMINGRKLIKFETRNEDDVVVLTGEAEIEQPVTTFVFTGQGSQEQGMGMDLYKTSKAAQDVWNRADNHFKDTYGFSILDIVINNPVNLTIHFGGEKGKRIRENYSAMIFETIVDGKLKTEKIFKEINEHSTSYTFRSEKGLLSATQFTQPALTLMEKAAFEDLKSKGLIPADATFAGHSLGEYAALASLADVMSIESLVEVVFYRGMTMQVAVPRDELGRSNYGMIAINPGRVAASFSQEALQYVVERVGKRTGWLVEIVNYNVENQQYVAAGDLRALDTVTNVLNFIKLQKIDIIELQKSLSLEEVEGHLFEIIDEASKKSAVKPRPLKLERGFACIPLVGISVPFHSTYLMNGVKPFKSFLKKNIIKENVKVARLAGKYIPNLTAKPFQVTKEYFQDVYDLTGSEPIKEIIDNWEKYEQS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDAYSTRP -------CCCCCCCC	31.46	22814378
39	Ubiquitination	QLQEQFNKILPEPTE HHHHHHHHHCCCCCC	47.08	17644757
56	Phosphorylation	AADDEPTTPAELVGK CCCCCCCCHHHHHHH	31.08	21551504
63	Ubiquitination	TPAELVGKFLGYVSS CHHHHHHHHHHHHHH	29.91	17644757
76	Ubiquitination	SSLVEPSKVGQFDQV HHHCCHHHHCCHHHH	62.19	17644757
107	Ubiquitination	DIHALAAKLLQENDT HHHHHHHHHHHCCCC	44.09	17644757
118	Acetylation	ENDTTLVKTKELIKN CCCCCEECHHHHHHH	57.92	24489116
118	Succinylation	ENDTTLVKTKELIKN CCCCCEECHHHHHHH	57.92	23954790
118	Ubiquitination	ENDTTLVKTKELIKN CCCCCEECHHHHHHH	57.92	17644757
124	Acetylation	VKTKELIKNYITARI ECHHHHHHHHHHHHH	57.21	24489116
124	Ubiquitination	VKTKELIKNYITARI ECHHHHHHHHHHHHH	57.21	17644757
126	Phosphorylation	TKELIKNYITARIMA HHHHHHHHHHHHHHC	8.47	21551504
128	Phosphorylation	ELIKNYITARIMAKR HHHHHHHHHHHHCCC	10.26	21551504
141	Phosphorylation	KRPFDKKSNSALFRA CCCCCCCCCHHHHHH	41.58	29734811
191	Phosphorylation	VGDLIKFSAETLSEL HHHHHHHCHHHHHHH	21.86	21440633
254	Ubiquitination	AHYVVTAKLLGFTPG HHHHHHHHHCCCCHH	34.57	17644757
355	Ubiquitination	QVQDYVNKTNSHLPA HHHHHHHHCCCCCCC	38.75	17644757
364	Acetylation	NSHLPAGKQVEISLV CCCCCCCCEEEEEEE	53.96	24489116
364	Ubiquitination	NSHLPAGKQVEISLV CCCCCCCCEEEEEEE	53.96	23749301
375	Ubiquitination	ISLVNGAKNLVVSGP EEEECCCCEEEEECC	52.81	17644757
395	Ubiquitination	GLNLTLRKAKAPSGL CCCEEEEECCCCCCC	58.30	17644757
397	Ubiquitination	NLTLRKAKAPSGLDQ CEEEEECCCCCCCCC	64.96	17644757
400	Phosphorylation	LRKAKAPSGLDQSRI EEECCCCCCCCCCCC	57.77	23749301
405	Phosphorylation	APSGLDQSRIPFSER CCCCCCCCCCCCCHH	31.66	23749301
410	Phosphorylation	DQSRIPFSERKLKFS CCCCCCCCHHCHHHC	31.01	21440633
413	Ubiquitination	RIPFSERKLKFSNRF CCCCCHHCHHHCCCC	52.56	17644757
415	Acetylation	PFSERKLKFSNRFLP CCCHHCHHHCCCCCC	50.19	25381059
417	Phosphorylation	SERKLKFSNRFLPVA CHHCHHHCCCCCCCC	26.05	24961812
425	Phosphorylation	NRFLPVASPFHSHLL CCCCCCCCCCCCCCC	28.47	24961812
429	Phosphorylation	PVASPFHSHLLVPAS CCCCCCCCCCCCCHH	19.06	24961812
441	Acetylation	PASDLINKDLVKNNV CHHHHCCHHHHHCCC	45.50	24489116
441	Ubiquitination	PASDLINKDLVKNNV CHHHHCCHHHHHCCC	45.50	17644757
445	Acetylation	LINKDLVKNNVSFNA HCCHHHHHCCCCCCC	50.53	24489116
445	Succinylation	LINKDLVKNNVSFNA HCCHHHHHCCCCCCC	50.53	23954790
445	Ubiquitination	LINKDLVKNNVSFNA HCCHHHHHCCCCCCC	50.53	23749301
449	Phosphorylation	DLVKNNVSFNAKDIQ HHHHCCCCCCCCCCC	18.20	28889911
453	Acetylation	NNVSFNAKDIQIPVY CCCCCCCCCCCCEEE	57.37	24489116
453	Ubiquitination	NNVSFNAKDIQIPVY CCCCCCCCCCCCEEE	57.37	17644757
489	Acetylation	CIIRLPVKWETTTQF HHCCCCCCCEECCCE	37.06	24489116
489	Ubiquitination	CIIRLPVKWETTTQF HHCCCCCCCEECCCE	37.06	24961812
497	Acetylation	WETTTQFKATHILDF CEECCCEEEEEEEEC	42.42	24489116
497	Ubiquitination	WETTTQFKATHILDF CEECCCEEEEEEEEC	42.42	17644757
556	Succinylation	DVTSNGLKKNPNWLE ECCCCCCCCCCCHHH	52.48	23954790
556	Ubiquitination	DVTSNGLKKNPNWLE ECCCCCCCCCCCHHH	52.48	17644757
557	Acetylation	VTSNGLKKNPNWLEE CCCCCCCCCCCHHHH	80.72	24489116
557	Ubiquitination	VTSNGLKKNPNWLEE CCCCCCCCCCCHHHH	80.72	17644757
568	Acetylation	WLEEYHPKLIKNKSG HHHHHCHHHHCCCCC	49.92	24489116
568	Ubiquitination	WLEEYHPKLIKNKSG HHHHHCHHHHCCCCC	49.92	17644757
576	Ubiquitination	LIKNKSGKIFVETKF HHCCCCCCEEEEECH	39.81	17644757
582	Acetylation	GKIFVETKFSKLIGR CCEEEEECHHHHHCC	33.85	24489116
582	Ubiquitination	GKIFVETKFSKLIGR CCEEEEECHHHHHCC	33.85	17644757
672	Ubiquitination	LIKELRSKGYPIQFL HHHHHHHCCCCEEEE	56.90	17644757
701	Ubiquitination	YIETLGLKYLGLKPG HHHHHCCHHCCCCCC	36.31	17644757
706	Acetylation	GLKYLGLKPGSIDAI CCHHCCCCCCCHHHH	45.60	24489116
706	Ubiquitination	GLKYLGLKPGSIDAI CCHHCCCCCCCHHHH	45.60	23749301
709	Phosphorylation	YLGLKPGSIDAISQV HCCCCCCCHHHHHHH	26.31	21440633
721	Ubiquitination	SQVINIAKAHPNFPI HHHHHHHHHCCCCCE	43.35	17644757
733	Phosphorylation	FPIALQWTGGRGGGH CCEEEEECCCCCCCC	19.46	22369663
754	Phosphorylation	HTPMLQMYSKIRRHP CCHHHHHHHHHHCCC	8.21	27017623
755	Phosphorylation	TPMLQMYSKIRRHPN CHHHHHHHHHHCCCC	19.10	27017623
756	Acetylation	PMLQMYSKIRRHPNI HHHHHHHHHHCCCCE	23.81	24489116
756	Ubiquitination	PMLQMYSKIRRHPNI HHHHHHHHHHCCCCE	23.81	23749301
809	Acetylation	GSRVMIAKEVKTSPD CCEEEEEEECCCCCC	52.71	22865919
809	Succinylation	GSRVMIAKEVKTSPD CCEEEEEEECCCCCC	52.71	23954790
812	Succinylation	VMIAKEVKTSPDAKK EEEEEECCCCCCHHH	44.36	23954790
819	Ubiquitination	KTSPDAKKCIAACTG CCCCCHHHHHHHHHC	32.37	17644757
831	Acetylation	CTGVPDDKWEQTYKK HHCCCCHHHHHCCCC	61.07	24489116
831	Ubiquitination	CTGVPDDKWEQTYKK HHCCCCHHHHHCCCC	61.07	23749301
837	Ubiquitination	DKWEQTYKKPTGGIV HHHHHCCCCCCCCEE	56.52	17644757
838	Ubiquitination	KWEQTYKKPTGGIVT HHHHCCCCCCCCEEE	37.08	23749301
840	Phosphorylation	EQTYKKPTGGIVTVR HHCCCCCCCCEEEEE	57.85	19823750
845	Phosphorylation	KPTGGIVTVRSEMGE CCCCCEEEEECCCCC	14.31	19823750
848	Phosphorylation	GGIVTVRSEMGEPIH CCEEEEECCCCCCHH	27.83	21440633
856	Acetylation	EMGEPIHKIATRGVM CCCCCHHHHHHCCEE	34.45	24489116
859	Phosphorylation	EPIHKIATRGVMLWK CCHHHHHHCCEEEHH	31.28	21440633
866	Ubiquitination	TRGVMLWKEFDETIF HCCEEEHHHCCHHHH	44.54	17644757
877	Acetylation	ETIFNLPKNKLVPTL HHHHCCCCCCCCCCH	70.63	24489116
877	Ubiquitination	ETIFNLPKNKLVPTL HHHHCCCCCCCCCCH	70.63	23749301
879	Acetylation	IFNLPKNKLVPTLEA HHCCCCCCCCCCHHH	57.92	24489116
879	Ubiquitination	IFNLPKNKLVPTLEA HHCCCCCCCCCCHHH	57.92	23749301
887	2-Hydroxyisobutyrylation	LVPTLEAKRDYIISR CCCCHHHHHHHHHHC	36.11	-
887	Acetylation	LVPTLEAKRDYIISR CCCCHHHHHHHHHHC	36.11	24489116
887	Ubiquitination	LVPTLEAKRDYIISR CCCCHHHHHHHHHHC	36.11	23749301
901	Acetylation	RLNADFQKPWFATVN CCCCCCCCCEEEEEC	44.18	24489116
901	Ubiquitination	RLNADFQKPWFATVN CCCCCCCCCEEEEEC	44.18	23749301
924	Acetylation	MTYEEVAKRLVELMF CCHHHHHHHHHHHHH	51.98	24489116
924	Ubiquitination	MTYEEVAKRLVELMF CCHHHHHHHHHHHHH	51.98	17644757
962	Ubiquitination	EERFTKSKTLSLIQS HHHHCCCHHHHHHHH	55.85	24961812
971	Phosphorylation	LSLIQSYSLLDKPDE HHHHHHHHCCCCHHH	27.92	25752575
975	Acetylation	QSYSLLDKPDEAIEK HHHHCCCCHHHHHHH	55.10	24489116
975	Ubiquitination	QSYSLLDKPDEAIEK HHHHCCCCHHHHHHH	55.10	17644757
982	Ubiquitination	KPDEAIEKVFNAYPA CHHHHHHHHHHHCHH	46.11	24961812
987	Phosphorylation	IEKVFNAYPAAREQF HHHHHHHCHHHHHHH	8.43	22369663
1013	Ubiquitination	MCQNPMQKPVPFVPV HCCCCCCCCCCCCEE	41.55	17644757
1030	Acetylation	RRFEIFFKKDSLWQS EEEEEEEECCCCCCC	44.94	24489116
1030	Succinylation	RRFEIFFKKDSLWQS EEEEEEEECCCCCCC	44.94	23954790
1031	Ubiquitination	RFEIFFKKDSLWQSE EEEEEEECCCCCCCH	47.60	17644757
1064	Acetylation	PVAAQFTKVIDEPIK HHHHHHHHHCCHHHH	38.18	24489116
1064	Ubiquitination	PVAAQFTKVIDEPIK HHHHHHHHHCCHHHH	38.18	17644757
1071	Acetylation	KVIDEPIKSIMDGIH HHCCHHHHHHHHCCC	44.65	24489116
1071	Ubiquitination	KVIDEPIKSIMDGIH HHCCHHHHHHHHCCC	44.65	17644757
1083	Acetylation	GIHDGHIKKLLHQYY CCCHHHHHHHHHHHH	31.52	22865919
1083	Ubiquitination	GIHDGHIKKLLHQYY CCCHHHHHHHHHHHH	31.52	17644757
1084	Ubiquitination	IHDGHIKKLLHQYYG CCHHHHHHHHHHHHC	56.53	17644757
1089	Phosphorylation	IKKLLHQYYGDDESK HHHHHHHHHCCCHHC	9.92	23607784
1090	Phosphorylation	KKLLHQYYGDDESKI HHHHHHHHCCCHHCC	13.91	23607784
1095	Phosphorylation	QYYGDDESKIPAVEY HHHCCCHHCCCEEEE	42.77	23607784
1096	Ubiquitination	YYGDDESKIPAVEYF HHCCCHHCCCEEEEC	51.14	17644757
1102	Phosphorylation	SKIPAVEYFGGESPV HCCCEEEECCCCCCC	10.83	22369663
1107	Phosphorylation	VEYFGGESPVDVQSQ EEECCCCCCCCCHHH	33.23	22369663
1113	Phosphorylation	ESPVDVQSQVDSSSV CCCCCCHHHCCCCCC	31.83	25521595
1117	Phosphorylation	DVQSQVDSSSVSEDS CCHHHCCCCCCCCCC	26.17	25521595
1118	Phosphorylation	VQSQVDSSSVSEDSA CHHHCCCCCCCCCCE	30.23	22369663
1119	Phosphorylation	QSQVDSSSVSEDSAV HHHCCCCCCCCCCEE	33.35	25521595
1121	Phosphorylation	QVDSSSVSEDSAVFK HCCCCCCCCCCEEEE	37.32	25521595
1124	Phosphorylation	SSSVSEDSAVFKATS CCCCCCCCEEEECCC	23.45	25521595
1128	Ubiquitination	SEDSAVFKATSSTDE CCCCEEEECCCCCCH	44.12	17644757
1131	Phosphorylation	SAVFKATSSTDEESW CEEEECCCCCCHHHH	35.78	27017623
1140	Ubiquitination	TDEESWFKALAGSEI CCHHHHHHHHHCCCC	35.91	17644757
1145	Phosphorylation	WFKALAGSEINWRHA HHHHHHCCCCCHHHH	29.69	22369663
1163	Ubiquitination	CSFITQDKMFVSNPI HHHHHCCCCCCCCCH	25.15	17644757
1172	Ubiquitination	FVSNPIRKVFKPSQG CCCCCHHHHCCCCCC	53.39	17644757
1177	Phosphorylation	IRKVFKPSQGMVVEI HHHHCCCCCCEEEEE	39.70	17287358
1189	Phosphorylation	VEISNGNTSSKTVVT EEEECCCCCCCEEEE	35.46	17287358
1190	Phosphorylation	EISNGNTSSKTVVTL EEECCCCCCCEEEEE	33.56	17287358
1191	Phosphorylation	ISNGNTSSKTVVTLS EECCCCCCCEEEEEC	30.24	17287358
1192	Ubiquitination	SNGNTSSKTVVTLSE ECCCCCCCEEEEECC	45.14	23749301
1193	Phosphorylation	NGNTSSKTVVTLSEP CCCCCCCEEEEECCC	23.35	23749301
1196	Phosphorylation	TSSKTVVTLSEPVQG CCCCEEEEECCCCCC	21.89	23749301
1198	Phosphorylation	SKTVVTLSEPVQGEL CCEEEEECCCCCCCC	30.41	23749301
1206	Acetylation	EPVQGELKPTVILKL CCCCCCCCHHHHHHH	34.05	24489116
1206	Succinylation	EPVQGELKPTVILKL CCCCCCCCHHHHHHH	34.05	23954790
1206	Ubiquitination	EPVQGELKPTVILKL CCCCCCCCHHHHHHH	34.05	17644757
1212	Acetylation	LKPTVILKLLKENII CCHHHHHHHHHHCCE	40.42	24489116
1212	Ubiquitination	LKPTVILKLLKENII CCHHHHHHHHHHCCE	40.42	17644757
1215	Acetylation	TVILKLLKENIIQME HHHHHHHHHCCEEEE	60.18	24489116
1215	Ubiquitination	TVILKLLKENIIQME HHHHHHHHHCCEEEE	60.18	23749301
1268	Ubiquitination	RIKEMYWKLWIDEPF HHHHHHHHHHCCCCC	19.22	17644757
1336	Acetylation	VGWRAIIKAIFPNTV ECHHHHHHHHCCCCC	29.35	24489116
1336	Ubiquitination	VGWRAIIKAIFPNTV ECHHHHHHHHCCCCC	29.35	17644757
1349	Acetylation	TVDGDLLKLVHLSNG CCCCCHHHHEECCCC	56.62	24489116
1349	Ubiquitination	TVDGDLLKLVHLSNG CCCCCHHHHEECCCC	56.62	17644757
1358	Succinylation	VHLSNGYKMIPGAKP EECCCCCEECCCCCC	31.58	23954790
1358	Ubiquitination	VHLSNGYKMIPGAKP EECCCCCEECCCCCC	31.58	17644757
1364	Ubiquitination	YKMIPGAKPLQVGDV CEECCCCCCCCCCCE	52.77	23749301
1388	Ubiquitination	VVNQPTGKIVDVVGT HHCCCCCCEEEEEEE	41.87	17644757
1425	Ubiquitination	DFENTFQKTVEPVYQ CCCCHHHHCCCEEEE	50.80	17644757
1436	Acetylation	PVYQMHIKTSKDIAV EEEECEEECCCCEEE	31.87	24489116
1436	Ubiquitination	PVYQMHIKTSKDIAV EEEECEEECCCCEEE	31.87	17644757
1439	2-Hydroxyisobutyrylation	QMHIKTSKDIAVLRS ECEEECCCCEEEHHC	59.39	-
1439	Acetylation	QMHIKTSKDIAVLRS ECEEECCCCEEEHHC	59.39	24489116
1439	Succinylation	QMHIKTSKDIAVLRS ECEEECCCCEEEHHC	59.39	23954790
1439	Ubiquitination	QMHIKTSKDIAVLRS ECEEECCCCEEEHHC	59.39	15699485
1447	Ubiquitination	DIAVLRSKEWFQLDD CEEEHHCCCCEECCH	53.16	17644757
1462	Ubiquitination	EDFDLLNKTLTFETE HHCHHHCCEEEEEEE	44.90	17644757
1463	Phosphorylation	DFDLLNKTLTFETET HCHHHCCEEEEEEEE	29.92	22369663
1465	Phosphorylation	DLLNKTLTFETETEV HHHCCEEEEEEEEEE	25.34	22369663
1468	Phosphorylation	NKTLTFETETEVTFK CCEEEEEEEEEEEEC	43.97	22369663
1470	Phosphorylation	TLTFETETEVTFKNA EEEEEEEEEEEECCC	43.08	22369663
1473	Phosphorylation	FETETEVTFKNANIF EEEEEEEEECCCCCC	23.74	22369663
1475	Ubiquitination	TETEVTFKNANIFSS EEEEEEECCCCCCCC	45.87	17644757
1481	Phosphorylation	FKNANIFSSVKCFGP ECCCCCCCCCEEECC	30.35	22369663
1482	Phosphorylation	KNANIFSSVKCFGPI CCCCCCCCCEEECCE	18.17	21440633
1484	Acetylation	ANIFSSVKCFGPIKV CCCCCCCEEECCEEE	26.29	24489116
1484	Ubiquitination	ANIFSSVKCFGPIKV CCCCCCCEEECCEEE	26.29	17644757
1490	Acetylation	VKCFGPIKVELPTKE CEEECCEEEECCCCC	32.56	24489116
1490	Ubiquitination	VKCFGPIKVELPTKE CEEECCEEEECCCCC	32.56	24961812
1525	Phosphorylation	DFLKRNGSTLEQKVN HHHHHCCCCHHHHCC	33.11	23749301
1530	Acetylation	NGSTLEQKVNLENPI CCCCHHHHCCCCCCC	24.58	24489116
1530	Ubiquitination	NGSTLEQKVNLENPI CCCCHHHHCCCCCCC	24.58	17644757
1545	Phosphorylation	PIAVLDSYTPSTNEP CEEEEECCCCCCCCC	23.49	28889911
1546	Phosphorylation	IAVLDSYTPSTNEPY EEEEECCCCCCCCCC	18.08	28889911
1549	Phosphorylation	LDSYTPSTNEPYARV EECCCCCCCCCCEEE	44.82	28889911
1571	Phosphorylation	HVSRHFASYANLPGT HHHHHHHHHCCCCCC	24.68	22369663
1572	Phosphorylation	VSRHFASYANLPGTI HHHHHHHHCCCCCCC	8.97	22369663
1608	Phosphorylation	VSSRVRGYTCQFVDM HHHHCCCCEEEEECE	8.19	21440633
1609	Phosphorylation	SSRVRGYTCQFVDMV HHHCCCCEEEEECEE	11.58	22369663
1620	Phosphorylation	VDMVLPNTALKTSIQ ECEECCCCCCCHHCE	31.28	22369663
1623	Ubiquitination	VLPNTALKTSIQHVG ECCCCCCCHHCEEEE	37.45	17644757
1636	Ubiquitination	VGMINGRKLIKFETR EEEECCEEEEEEEEC	56.83	17644757
1639	Acetylation	INGRKLIKFETRNED ECCEEEEEEEECCCC	47.81	24489116
1642	Phosphorylation	RKLIKFETRNEDDVV EEEEEEEECCCCCEE	41.76	28889911
1685	2-Hydroxyisobutyrylation	MDLYKTSKAAQDVWN CCHHHHHHHHHHHHH	53.63	-
1685	Acetylation	MDLYKTSKAAQDVWN CCHHHHHHHHHHHHH	53.63	24489116
1685	Ubiquitination	MDLYKTSKAAQDVWN CCHHHHHHHHHHHHH	53.63	23749301
1747	2-Hydroxyisobutyrylation	TIVDGKLKTEKIFKE HHHCCCCCHHHHHHH	59.11	-
1753	Acetylation	LKTEKIFKEINEHST CCHHHHHHHHHCCCC	62.24	24489116
1753	Ubiquitination	LKTEKIFKEINEHST CCHHHHHHHHHCCCC	62.24	24961812
1768	Acetylation	SYTFRSEKGLLSATQ CEEEECCCCCCCCCC	56.98	24489116
1768	Ubiquitination	SYTFRSEKGLLSATQ CEEEECCCCCCCCCC	56.98	23749301
1772	Phosphorylation	RSEKGLLSATQFTQP ECCCCCCCCCCCCHH	34.02	22369663
1774	Phosphorylation	EKGLLSATQFTQPAL CCCCCCCCCCCHHHH	22.34	22369663
1777	Phosphorylation	LLSATQFTQPALTLM CCCCCCCCHHHHHHH	24.67	22369663
1782	Phosphorylation	QFTQPALTLMEKAAF CCCHHHHHHHHHHHH	26.60	22369663
1786	Ubiquitination	PALTLMEKAAFEDLK HHHHHHHHHHHHHHH	30.92	23749301
1793	Succinylation	KAAFEDLKSKGLIPA HHHHHHHHHCCCCCC	63.54	23954790
1850	Phosphorylation	PRDELGRSNYGMIAI EHHHHCCCCCEEEEE	32.38	19779198
1918	Acetylation	TNVLNFIKLQKIDII HHHHHHHHHCCCCEE	40.50	24489116
1918	Succinylation	TNVLNFIKLQKIDII HHHHHHHHHCCCCEE	40.50	23954790
1918	Ubiquitination	TNVLNFIKLQKIDII HHHHHHHHHCCCCEE	40.50	17644757
1921	2-Hydroxyisobutyrylation	LNFIKLQKIDIIELQ HHHHHHCCCCEEEEC	53.43	-
1921	Acetylation	LNFIKLQKIDIIELQ HHHHHHCCCCEEEEC	53.43	24489116
1921	Succinylation	LNFIKLQKIDIIELQ HHHHHHCCCCEEEEC	53.43	23954790
1929	Ubiquitination	IDIIELQKSLSLEEV CCEEEECCCCCHHHH	67.02	17644757
1930	Phosphorylation	DIIELQKSLSLEEVE CEEEECCCCCHHHHC	15.38	23749301
1932	Phosphorylation	IELQKSLSLEEVEGH EEECCCCCHHHHCCH	40.60	23749301
1948	Phosphorylation	FEIIDEASKKSAVKP HHHHHHHHHCCCCCC	38.27	23749301
1949	Ubiquitination	EIIDEASKKSAVKPR HHHHHHHHCCCCCCC	58.77	17644757
1950	Ubiquitination	IIDEASKKSAVKPRP HHHHHHHCCCCCCCC	40.95	17644757
1959	Acetylation	AVKPRPLKLERGFAC CCCCCCCCCCCCEEE	51.49	24489116
1986	Acetylation	TYLMNGVKPFKSFLK HHHHCCCCCHHHHHH	46.25	24489116
1993	Ubiquitination	KPFKSFLKKNIIKEN CCHHHHHHHHHHHHH	41.59	17644757
1994	Ubiquitination	PFKSFLKKNIIKENV CHHHHHHHHHHHHHH	56.37	17644757
1998	Acetylation	FLKKNIIKENVKVAR HHHHHHHHHHHHHHH	39.16	22865919
1998	Ubiquitination	FLKKNIIKENVKVAR HHHHHHHHHHHHHHH	39.16	22817900
2002	Succinylation	NIIKENVKVARLAGK HHHHHHHHHHHHCCC	41.58	23954790
2002	Ubiquitination	NIIKENVKVARLAGK HHHHHHHHHHHHCCC	41.58	23749301
2009	Acetylation	KVARLAGKYIPNLTA HHHHHCCCCCCCCCC	34.11	24489116
2009	Ubiquitination	KVARLAGKYIPNLTA HHHHHCCCCCCCCCC	34.11	24961812
2017	Acetylation	YIPNLTAKPFQVTKE CCCCCCCCCCCCCHH	40.92	24489116
2017	Ubiquitination	YIPNLTAKPFQVTKE CCCCCCCCCCCCCHH	40.92	23749301
2023	Ubiquitination	AKPFQVTKEYFQDVY CCCCCCCHHHHHHHH	52.11	17644757
2039	Ubiquitination	LTGSEPIKEIIDNWE HCCCCCHHHHHHHHH	54.28	17644757
2047	Acetylation	EIIDNWEKYEQS--- HHHHHHHHHHCC---	45.78	22865919
2047	Ubiquitination	EIIDNWEKYEQS--- HHHHHHHHHHCC---	45.78	17644757

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FAS1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FAS1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FAS1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAS2_YEAST	FAS2	genetic	16233438
QCR9_YEAST	QCR9	genetic	21623372
TPS2_YEAST	TPS2	genetic	21623372
CSG2_YEAST	CSG2	genetic	21623372
GGPPS_YEAST	BTS1	genetic	21623372
NRT1_YEAST	NRT1	genetic	21623372
CYS3_YEAST	CYS3	genetic	21623372
SYSM_YEAST	DIA4	genetic	21623372
GAS4_YEAST	GAS4	genetic	21623372
DCE_YEAST	GAD1	genetic	21623372
CSG2_YEAST	CSG2	genetic	21987634
UGO1_YEAST	UGO1	genetic	21987634
MDM31_YEAST	MDM31	genetic	21987634
ILM1_YEAST	ILM1	genetic	21987634
INO4_YEAST	INO4	genetic	21987634
SLG1_YEAST	SLG1	genetic	21987634
FAS1_YEAST	FAS1	physical	22940862
ATG8_YEAST	ATG8	physical	25605918
PMP1_YEAST	PMP1	physical	26404137

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FAS1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1117; SER-1121 ANDSER-1124, AND MASS SPECTROMETRY.	18407956 [Abstract]
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1177; THR-1189; SER-1190AND SER-1191, AND MASS SPECTROMETRY.	17287358 [Abstract]