dbPTM

UGO1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UGO1_YEAST
UniProt AC	Q03327
Protein Name	Mitochondrial fusion and transport protein UGO1
Gene Name	UGO1 {ECO:0000312\|SGD:S000002878}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	502
Subcellular Localization	Mitochondrion outer membrane Single-pass type II membrane protein .
Protein Description	Required for mitochondrial fusion as well as normal mitochondrial morphology by bridging the essential interaction between FZO1 and MGM1. May coordinate fusion of inner and outer membranes during mitochondrial fusion..
Protein Sequence	MNNNNVTEATSRAQIRPYYDPDSFNAGYSAVFKPDEGVVDPHGYTIASKLNVINSSPTTKRMANALFKSSPMKKLSNSVNDGLSLEGSNGEITGLNNFEWAELVNIQKWRKIFEQLLDMFFRKYFQLLIQQPFDVARLLIQVGEFKIFKTTVDTNKPQAPIILRDEEGDGAAREGEEDAYDEEEIDFFPIERKIAEANSTAPIMAEETDHSHHEPTDISLTIAPQSLHTIDVINALFDQEGIRGLWKANNTTFIYNFLSLSIDTWFTGLLSSFLGVPDPYFMEVINSPDISKSFILALGAGVFTSIILLPVDLIRTRLIVTSFKKKKNVKTDGKNMVTNTRSLRQLIRCWSWRKNGVSIPLDMWSLTILQSINNSFFNKLFDLVIYNQFHIEKYSQTVMYNTMKFFSKSLELFIKLPLENLLRRCQLNYLLNDQRLSFKVDSTELIVKPKKYNGIWDVIRNNSNTNRGQLWNGWKVGVISLICGYGLQMMNKVDINMEQEKF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
1	Acetylation	-------MNNNNVTE -------CCCCCCCH	12.51	22814378
56	Phosphorylation	KLNVINSSPTTKRMA HHCCCCCCCCHHHHH	23.06	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UGO1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UGO1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UGO1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FZO1_YEAST	FZO1	physical	12808034
FZO1_YEAST	FZO1	physical	15087460
MGM1_YEAST	MGM1	physical	12808034
MGM1_YEAST	MGM1	physical	15087460
FZO1_YEAST	FZO1	physical	12566426
DNM1_YEAST	DNM1	genetic	12808034
UGO1_YEAST	UGO1	physical	19237599
MDM30_YEAST	MDM30	genetic	21385840
MIM1_YEAST	MIM1	physical	21825073
TOM40_YEAST	TOM40	physical	21825073
TOM70_YEAST	TOM70	physical	21825073
TOM22_YEAST	TOM22	physical	21825073
RFC5_YEAST	RFC5	genetic	27708008
PRS4_YEAST	RPT2	genetic	27708008
CDC7_YEAST	CDC7	genetic	27708008
GLE1_YEAST	GLE1	genetic	27708008
CDC14_YEAST	CDC14	genetic	27708008
PSA1_YEAST	SCL1	genetic	27708008
TEL2_YEAST	TEL2	genetic	27708008
PSB5_YEAST	PRE2	genetic	27708008
GET3_YEAST	GET3	genetic	27708008
GYP7_YEAST	GYP7	genetic	27708008
INO2_YEAST	INO2	genetic	27708008
SWF1_YEAST	SWF1	genetic	27708008
SND1_YEAST	YDR186C	genetic	27708008
H2A1_YEAST	HTA1	genetic	27708008
PEX5_YEAST	PEX5	genetic	27708008
PMP3_YEAST	PMP3	genetic	27708008
CSK2B_YEAST	CKB1	genetic	27708008
GET1_YEAST	GET1	genetic	27708008
PSA3_YEAST	PRE9	genetic	27708008
MEH1_YEAST	MEH1	genetic	27708008
VPS13_YEAST	VPS13	genetic	27708008
AVL9_YEAST	AVL9	genetic	27708008
YPT7_YEAST	YPT7	genetic	27708008
ERG6_YEAST	ERG6	genetic	27708008
YOX1_YEAST	YOX1	genetic	27708008
YM39_YEAST	YMR166C	genetic	27708008
AEP2_YEAST	AEP2	genetic	27708008
SWS2_YEAST	SWS2	genetic	27708008
EXO1_YEAST	EXO1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UGO1_YEAST

Related Literatures of Post-Translational Modification