GYP7_YEAST - dbPTM
GYP7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GYP7_YEAST
UniProt AC P48365
Protein Name GTPase-activating protein GYP7
Gene Name GYP7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 746
Subcellular Localization
Protein Description Most effectively accelerates the intrinsic GTPase activity of YPT7. It is also active, but to a lesser extent, on YPT31, YPT32, YPT1, YPT6 and SEC4..
Protein Sequence MSKILFCKSKVFLHPTSDARDNIAGFLLLTLEANKLSHQAILQYIPESGLSTLEISKLLKHEAKVGTCPTSTPFVIENSINFSNLVNTSLGQAFEISLSQIYCIQFRPPSPNGWYVGSLVIYPLTEQFTGFQPPVLFFHDQLCPSTTDKLKRLRKSMNPFDDSDELYWGGVDLRNKINELMELKKSNLEPEFWLVNPSLNDLRNFVSKDLLESYNNSKKDTTELATAGVKLNEKFQEWKWNVMSKIADVTTKSTNFIDSWLTNNSPIQKSQIDNEYLQKLLNNEKVKQIEQDYDSARVYLANWSLGVKQEAERYQKQNKLFDSYRNNIFNDLNLTDELSDTEINNALQRQFPLTEAKWNSLWDENDGRLRVTVNEVKDFIFHGGLENDSLRGKVWGFLLEIYPWDSSQDERVQIDQTLAAEYDQLKLTWSKDFLQFDDEDEEEYWNDQLFRISKDVRRCDRNLEIFQYNTIDGLPPPPQQLPANENNSTSPESANDESDDADDGVRNPHLIHLQNILITYNVYNTNLGYVQGMTDLLSPIYVIMKEEWKTFWCFTHFMDIMERNFLRDQSGIHEQMLTLVELVQLMLPELSEHLNKCDSGNLFFCFRMLLVWFKREFEMEDIMHIWENFWTFYYSSQFQLFFMLAILQKNSQAILQHLNQFDQILKFFNELNGKLDWNDLMVRAELLFKKFEKMMHVMERDLQNVSSSSSSSSTGVLPCQSERLTLLLSKKPIIRHEGQRSKNSVK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
262PhosphorylationNFIDSWLTNNSPIQK
CHHHHHHHCCCCCCH		26.5428889911
265PhosphorylationDSWLTNNSPIQKSQI
HHHHHCCCCCCHHHC		26.0021440633
285UbiquitinationQKLLNNEKVKQIEQD
HHHHCCHHHHHHHCC		57.7823749301
287UbiquitinationLLNNEKVKQIEQDYD
HHCCHHHHHHHCCHH		57.5423749301
339PhosphorylationLNLTDELSDTEINNA
CCCCCCCCHHHHHHH		40.2021440633
341PhosphorylationLTDELSDTEINNALQ
CCCCCCHHHHHHHHH		35.0730377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GYP7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GYP7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GYP7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SYTC_YEASTTHS1physical
16554755
MON1_YEASTMON1genetic
20797862
CCZ1_YEASTCCZ1genetic
20797862
MBA1_YEASTMBA1genetic
27708008
RIM1_YEASTRIM1genetic
27708008
THRC_YEASTTHR4genetic
27708008
XRN1_YEASTXRN1genetic
27708008
YGY5_YEASTYGL235Wgenetic
27708008
MTO1_YEASTMTO1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
PTH_YEASTPTH1genetic
27708008
RL17B_YEASTRPL17Bgenetic
27708008
DENR_YEASTTMA22genetic
27708008
TCTP_YEASTTMA19genetic
27708008
FEN1_YEASTRAD27genetic
27708008
SAC1_YEASTSAC1genetic
27708008
RS21A_YEASTRPS21Agenetic
27708008
ARPC3_YEASTARC18genetic
27708008
VHS3_YEASTVHS3genetic
27708008
CY1_YEASTCYT1genetic
27708008
MNE1_YEASTMNE1genetic
27708008
DAP1_YEASTDAP1genetic
27708008
MED1_YEASTMED1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GYP7_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-262, AND MASSSPECTROMETRY.

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