| UniProt ID | SYTC_YEAST | |
|---|---|---|
| UniProt AC | P04801 | |
| Protein Name | Threonine--tRNA ligase, cytoplasmic | |
| Gene Name | THS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 734 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | ||
| Protein Sequence | MSASEAGVTEQVKKLSVKDSSNDAVKPNKKENKKSKQQSLYLDPEPTFIEERIEMFDRLQKEYNDKVASMPRVPLKIVLKDGAVKEATSWETTPMDIAKGISKSLADRLCISKVNGQLWDLDRPFEGEANEEIKLELLDFESDEGKKVFWHSSAHVLGESCECHLGAHICLGPPTDDGFFYEMAVRDSMKDISESPERTVSQADFPGLEGVAKNVIKQKQKFERLVMSKEDLLKMFHYSKYKTYLVQTKVPDGGATTVYRCGKLIDLCVGPHIPHTGRIKAFKLLKNSSCYFLGDATNDSLQRVYGISFPDKKLMDAHLKFLAEASMRDHRKIGKEQELFLFNEMSPGSCFWLPHGTRIYNTLVDLLRTEYRKRGYEEVITPNMYNSKLWETSGHWANYKENMFTFEVEKETFGLKPMNCPGHCLMFKSRERSYRELPWRVADFGVIHRNEFSGALSGLTRVRRFQQDDAHIFCTHDQIESEIENIFNFLQYIYGVFGFEFKMELSTRPEKYVGKIETWDAAESKLESALKKWGGNWEINAGDGAFYGPKIDIMISDALRRWHQCATIQLDFQLPNRFELEFKSKDQDSESYERPVMIHRAILGSVERMTAILTEHFAGKWPFWLSPRQVLVVPVGVKYQGYAEDVRNKLHDAGFYADVDLTGNTLQKKVRNGQMLKYNFIFIVGEQEMNEKSVNIRNRDVMEQQGKNATVSVEEVLKQLRNLKDEKRGDNVLA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSASEAGVT ------CCHHHHCCH | 40.27 | 22369663 | |
| 4 | Phosphorylation | ----MSASEAGVTEQ ----CCHHHHCCHHH | 22.22 | 22369663 | |
| 9 | Phosphorylation | SASEAGVTEQVKKLS CHHHHCCHHHHHCCC | 21.56 | 22369663 | |
| 13 | Succinylation | AGVTEQVKKLSVKDS HCCHHHHHCCCCCCC | 47.92 | 23954790 | |
| 13 | 2-Hydroxyisobutyrylation | AGVTEQVKKLSVKDS HCCHHHHHCCCCCCC | 47.92 | - | |
| 20 | Phosphorylation | KKLSVKDSSNDAVKP HCCCCCCCCCCCCCC | 25.89 | 28889911 | |
| 21 | Phosphorylation | KLSVKDSSNDAVKPN CCCCCCCCCCCCCCC | 49.19 | 28889911 | |
| 35 | Phosphorylation | NKKENKKSKQQSLYL CHHCCCCHHCCCCCC | 36.99 | 22369663 | |
| 36 | Ubiquitination | KKENKKSKQQSLYLD HHCCCCHHCCCCCCC | 62.32 | 15699485 | |
| 36 | Acetylation | KKENKKSKQQSLYLD HHCCCCHHCCCCCCC | 62.32 | 24489116 | |
| 39 | Phosphorylation | NKKSKQQSLYLDPEP CCCHHCCCCCCCCCC | 19.25 | 22369663 | |
| 41 | Phosphorylation | KSKQQSLYLDPEPTF CHHCCCCCCCCCCCH | 17.82 | 22369663 | |
| 47 | Phosphorylation | LYLDPEPTFIEERIE CCCCCCCCHHHHHHH | 35.27 | 22369663 | |
| 63 | Phosphorylation | FDRLQKEYNDKVASM HHHHHHHHHHHCCCC | 35.38 | 19795423 | |
| 66 | Acetylation | LQKEYNDKVASMPRV HHHHHHHHCCCCCCC | 35.74 | 24489116 | |
| 69 | Phosphorylation | EYNDKVASMPRVPLK HHHHHCCCCCCCCEE | 32.10 | 21440633 | |
| 76 | Acetylation | SMPRVPLKIVLKDGA CCCCCCEEEEECCCC | 25.38 | 24489116 | |
| 80 | Acetylation | VPLKIVLKDGAVKEA CCEEEEECCCCEEEC | 43.13 | 24489116 | |
| 85 | Ubiquitination | VLKDGAVKEATSWET EECCCCEEECCCCCC | 40.89 | 15699485 | |
| 99 | Ubiquitination | TTPMDIAKGISKSLA CCHHHHHHHHCHHHH | 58.05 | 15699485 | |
| 99 | Acetylation | TTPMDIAKGISKSLA CCHHHHHHHHCHHHH | 58.05 | 24489116 | |
| 103 | 2-Hydroxyisobutyrylation | DIAKGISKSLADRLC HHHHHHCHHHHHHHH | 47.79 | - | |
| 103 | Acetylation | DIAKGISKSLADRLC HHHHHHCHHHHHHHH | 47.79 | 22865919 | |
| 188 | Phosphorylation | YEMAVRDSMKDISES HHHHHHHHHHCHHHC | 19.71 | 21440633 | |
| 190 | Succinylation | MAVRDSMKDISESPE HHHHHHHHCHHHCCC | 56.73 | 23954790 | |
| 190 | Ubiquitination | MAVRDSMKDISESPE HHHHHHHHCHHHCCC | 56.73 | 15699485 | |
| 193 | Phosphorylation | RDSMKDISESPERTV HHHHHCHHHCCCCCC | 42.00 | 20377248 | |
| 195 | Phosphorylation | SMKDISESPERTVSQ HHHCHHHCCCCCCCC | 25.85 | 22369663 | |
| 199 | Phosphorylation | ISESPERTVSQADFP HHHCCCCCCCCCCCC | 23.89 | 25521595 | |
| 201 | Phosphorylation | ESPERTVSQADFPGL HCCCCCCCCCCCCCH | 21.02 | 25521595 | |
| 213 | Acetylation | PGLEGVAKNVIKQKQ CCHHHHHHHHHHHHH | 49.71 | 24489116 | |
| 213 | Ubiquitination | PGLEGVAKNVIKQKQ CCHHHHHHHHHHHHH | 49.71 | 17644757 | |
| 229 | Succinylation | FERLVMSKEDLLKMF HHHHHCCHHHHHHHH | 36.83 | 23954790 | |
| 229 | Acetylation | FERLVMSKEDLLKMF HHHHHCCHHHHHHHH | 36.83 | 24489116 | |
| 234 | Acetylation | MSKEDLLKMFHYSKY CCHHHHHHHHCHHCC | 46.98 | 24489116 | |
| 238 | Phosphorylation | DLLKMFHYSKYKTYL HHHHHHCHHCCEEEE | 8.80 | 27017623 | |
| 239 | Phosphorylation | LLKMFHYSKYKTYLV HHHHHCHHCCEEEEE | 22.42 | 27017623 | |
| 240 | Ubiquitination | LKMFHYSKYKTYLVQ HHHHCHHCCEEEEEE | 43.53 | 22817900 | |
| 240 | Acetylation | LKMFHYSKYKTYLVQ HHHHCHHCCEEEEEE | 43.53 | 22865919 | |
| 241 | Phosphorylation | KMFHYSKYKTYLVQT HHHCHHCCEEEEEEE | 11.56 | 27017623 | |
| 242 | Ubiquitination | MFHYSKYKTYLVQTK HHCHHCCEEEEEEEE | 34.14 | 22817900 | |
| 242 | Acetylation | MFHYSKYKTYLVQTK HHCHHCCEEEEEEEE | 34.14 | 24489116 | |
| 242 | Succinylation | MFHYSKYKTYLVQTK HHCHHCCEEEEEEEE | 34.14 | 23954790 | |
| 249 | Acetylation | KTYLVQTKVPDGGAT EEEEEEEECCCCCCE | 34.38 | 24489116 | |
| 249 | Ubiquitination | KTYLVQTKVPDGGAT EEEEEEEECCCCCCE | 34.38 | 23749301 | |
| 286 | Ubiquitination | IKAFKLLKNSSCYFL CHHHHHHCCCCEEEE | 66.28 | 23749301 | |
| 288 | Phosphorylation | AFKLLKNSSCYFLGD HHHHHCCCCEEEECC | 21.87 | 29136822 | |
| 289 | Phosphorylation | FKLLKNSSCYFLGDA HHHHCCCCEEEECCC | 23.41 | 28152593 | |
| 291 | Phosphorylation | LLKNSSCYFLGDATN HHCCCCEEEECCCCC | 12.09 | 29136822 | |
| 297 | Phosphorylation | CYFLGDATNDSLQRV EEEECCCCCHHHHHH | 44.28 | 29136822 | |
| 312 | Acetylation | YGISFPDKKLMDAHL HCCCCCCHHHHHHHH | 48.31 | 24489116 | |
| 313 | Acetylation | GISFPDKKLMDAHLK CCCCCCHHHHHHHHH | 57.32 | 24489116 | |
| 326 | Phosphorylation | LKFLAEASMRDHRKI HHHHHHHHHHHHHHH | 13.07 | 27017623 | |
| 381 | Phosphorylation | RGYEEVITPNMYNSK CCCCCCCCCCCCCCC | 17.49 | 28889911 | |
| 385 | Phosphorylation | EVITPNMYNSKLWET CCCCCCCCCCCCCCC | 23.95 | 21440633 | |
| 387 | Phosphorylation | ITPNMYNSKLWETSG CCCCCCCCCCCCCCC | 16.19 | 21440633 | |
| 388 | Ubiquitination | TPNMYNSKLWETSGH CCCCCCCCCCCCCCC | 54.72 | 17644757 | |
| 392 | Phosphorylation | YNSKLWETSGHWANY CCCCCCCCCCCCCCC | 28.55 | 24961812 | |
| 393 | Phosphorylation | NSKLWETSGHWANYK CCCCCCCCCCCCCCC | 19.69 | 24961812 | |
| 400 | Ubiquitination | SGHWANYKENMFTFE CCCCCCCCCCEEEEE | 42.28 | 17644757 | |
| 453 | Phosphorylation | VIHRNEFSGALSGLT EEECCCCHHHHCCHH | 19.58 | 27214570 | |
| 457 | Phosphorylation | NEFSGALSGLTRVRR CCCHHHHCCHHEEEE | 31.09 | 22369663 | |
| 460 | Phosphorylation | SGALSGLTRVRRFQQ HHHHCCHHEEEECCC | 30.55 | 28889911 | |
| 511 | Acetylation | ELSTRPEKYVGKIET EECCCCHHCCEEEEE | 48.17 | 24489116 | |
| 515 | Ubiquitination | RPEKYVGKIETWDAA CCHHCCEEEEEHHHH | 27.59 | 23749301 | |
| 515 | Succinylation | RPEKYVGKIETWDAA CCHHCCEEEEEHHHH | 27.59 | 23954790 | |
| 515 | Acetylation | RPEKYVGKIETWDAA CCHHCCEEEEEHHHH | 27.59 | 24489116 | |
| 525 | Acetylation | TWDAAESKLESALKK EHHHHHHHHHHHHHH | 48.02 | 24489116 | |
| 531 | 2-Hydroxyisobutyrylation | SKLESALKKWGGNWE HHHHHHHHHCCCCCE | 46.31 | - | |
| 531 | Ubiquitination | SKLESALKKWGGNWE HHHHHHHHHCCCCCE | 46.31 | 17644757 | |
| 531 | Acetylation | SKLESALKKWGGNWE HHHHHHHHHCCCCCE | 46.31 | 24489116 | |
| 531 | Succinylation | SKLESALKKWGGNWE HHHHHHHHHCCCCCE | 46.31 | 23954790 | |
| 532 | Ubiquitination | KLESALKKWGGNWEI HHHHHHHHCCCCCEE | 52.50 | 17644757 | |
| 550 | Ubiquitination | DGAFYGPKIDIMISD CCCEECCEEEEEHHH | 48.96 | 17644757 | |
| 605 | Phosphorylation | IHRAILGSVERMTAI HHHHHHHCHHHHHHH | 19.84 | 22369663 | |
| 610 | Phosphorylation | LGSVERMTAILTEHF HHCHHHHHHHHHHHH | 19.43 | 29688323 | |
| 614 | Phosphorylation | ERMTAILTEHFAGKW HHHHHHHHHHHCCCC | 22.69 | 29688323 | |
| 638 | Acetylation | LVVPVGVKYQGYAED EEEECCCCCCCCHHH | 26.40 | 24489116 | |
| 638 | Ubiquitination | LVVPVGVKYQGYAED EEEECCCCCCCCHHH | 26.40 | 24961812 | |
| 656 | Phosphorylation | KLHDAGFYADVDLTG HHHHCCEEEEEECCC | 10.85 | 28889911 | |
| 665 | Phosphorylation | DVDLTGNTLQKKVRN EEECCCCCHHHHHHC | 31.73 | 28889911 | |
| 668 | Acetylation | LTGNTLQKKVRNGQM CCCCCHHHHHHCCCC | 57.24 | 24489116 | |
| 707 | Ubiquitination | DVMEQQGKNATVSVE HHHHHHCCCCEECHH | 38.79 | 24961812 | |
| 718 | Acetylation | VSVEEVLKQLRNLKD ECHHHHHHHHHCCCC | 53.08 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYTC_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYTC_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYTC_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-195; THR-199; SER-201;SER-289; TYR-291; THR-381; SER-453; SER-457; THR-460 AND SER-605, ANDMASS SPECTROMETRY. | |
